Journal
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1434, Issue 1, Pages 156-163Publisher
WILEY
DOI: 10.1111/nyas.13951
Keywords
regenerative medicine; esophagus; tissue engineering; decellularized scaffold; cell sheet technology; clinical trials
Categories
Funding
- Fondation de l'Avenir [ETO-579]
- Association Francaise de l'Atresie de l'OEsophage (AFAO)
- Fondation pour le Recherche Medicale [DBS20140930773]
- Agence de la Biomedecine
- Academie Nationale de Medecine
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For various esophageal diseases, the search for alternative techniques for tissue repair has led to significant developments in basic and translational research in the field of tissue engineering. Applied to the esophagus, this concept is based on the in vitro combination of elements judged necessary for in vivo implantation to promote esophageal tissue remodeling. Different methods are currently being explored to develop substitutes using cells, scaffolds, or a combination of both, according to the severity of lesions to be treated. In this review, we discuss recent advances in (1) cell sheet technology for preventing stricture after extended esophageal mucosectomy and (2) full-thickness circumferential esophageal replacement using tissue-engineered substitutes.
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