Article
Medicine, General & Internal
Dilhan J. Perera, Adam S. Hassan, Sunny S. Liu, Seyyed Mehdy Elahi, Christine Gadoury, Risini D. Weeratna, RenaId Gilbert, Momar Ndao
Summary: Schistosomiasis is a underestimated neglected tropical disease that affects over 236.6 million people worldwide. The lack of a prophylactic vaccine and the inability of current drugs to prevent reinfection highlight the need for alternative treatment options. Our study suggests that Schistosoma mansoni Cathepsin B could be a potential vaccine target.
Review
Cell Biology
Verena von Buelow, Jakob Lichtenberger, Christoph G. Grevelding, Franco H. Falcone, Elke Roeb, Martin Roderfeld
Summary: Schistosomiasis is a prominent parasitic infectious disease that causes significant medical and socioeconomic problems, with S. mansoni infection potentially predisposing patients to or promoting cancer development. Further research is needed to fully understand the association between S. mansoni infection and human cancer.
Article
Immunology
Lijun Lu, Lijing Bu, Si-Ming Zhang, Sarah K. Buddenborg, Eric S. Loker
Summary: This study provides a comprehensive overview of the transcriptomics responses of the gastropod Biomphalaria glabrata (Bg) following exposure to the trematode Schistosoma mansoni (Sm). The study identified differences in gene expression between schistosome-susceptible and -resistant Bg strains and revealed distinct response patterns at different time points post-exposure. The findings also highlight shared stress responses and specific gene expression patterns in both resistant and susceptible snails.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Jan Pieter R. Koopman, Emma L. Houlder, Jacqueline J. Janse, Miriam Casacuberta-Partal, Olivia A. C. Lamers, Jeroen C. Sijtsma, Claudia de Dood, Stan T. Hilt, Arifa Ozir-Fazalalikhan, Vincent P. Kuiper, Geert V. T. Roozen, Laura M. de Bes-Roeleveld, Yvonne C. M. Kruize, Linda J. Wammes, Hermelijn H. Smits, Lisette van Lieshout, Govert J. van Dam, Inge M. van Amerongen-Westra, Pauline Meij, Paul L. A. M. Corstjens, Simon P. Jochems, Angela van Diepen, Maria Yazdanbakhsh, Cornelis H. Hokke, Meta Roestenberg
Summary: A single-sex female-only CHI-S model for schistosomiasis was established in this study, providing a tool for vaccine development and understanding early immune responses. The results showed that female-only infections exhibit similar clinical and immunological profiles as male-only infections but are more resistant to treatment with praziquantel.
Article
Immunology
Cecile Crosnier, Cornelis H. Hokke, Anna Protasio, Cordelia Brandt, Gabriel Rinaldi, Marijke C. C. Langenberg, Simon Clare, Jacqueline J. Janse, Shona Wilson, Matthew Berriman, Meta Roestenberg, Gavin J. Wright
Summary: In this study, a library of recombinant parasite proteins was created and several markers were identified that can detect low levels of primary infection and as early as 5 weeks post-infection. These markers have the potential to be valuable tools for detecting ongoing and previous Schistosoma mansoni infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Juan Hernandez-Goenaga, Julio Lopez-Aban, Adrian Blanco-Gomez, Belen Vicente, Francisco Javier Burguillo, Jesus Perez-Losada, Antonio Muro
Summary: The genetic basis of susceptibility to schistosomiasis and the location of chromosomal regions involved were investigated using a backcross strategy. 19 new quantitative trait loci (QTL) associated with parasite burden, liver lesions, white blood cell populations, and antibody responses were identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ho Yin Pekkle Lam, Ting-Ruei Liang, Yi-Chia Lan, Kai-Chih Chang, Po-Ching Cheng, Shih-Yi Peng
Summary: This study found that Casticin can effectively attenuate schistosomiasis-induced liver fibrosis and also has an anthelmintic effect.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Immunology
Ho Yin Pekkle Lam, Wen-Jui Wu, Ting-Ruei Liang, Hui -Chun Li, Kai-Chih Chang, Shih-Yi Peng
Summary: In most developing or undeveloped countries, patients often suffer from coinfection with multiple pathogens. However, the underlying mechanism and pathogenesis caused by coinfection of Schistosoma with Salmonella are still unknown.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Microbiology
Poliane Silva Maciel, Ricardo Goncalves, Lis Ribeiro do Valle Antonelli, Cristina Toscano Fonseca
Summary: The study evaluated the impact of malnutrition on experimental schistosomiasis infection, finding that a 3% low-protein diet induced malnutrition in mice and affected the cytokine milieu in the liver and granuloma formation. This malnutrition model will enable future studies to better understand the complex relationships between nutrition, immune responses, and infection outcomes.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Immunology
Emmanuella Driciru, Jan Pieter R. Koopman, Stephen Cose, Afzal A. Siddiqui, Maria Yazdanbakhsh, Alison M. Elliott, Meta Roestenberg
Summary: The development of schistosomiasis vaccines faces immunological challenges, with prior exposure impacting vaccine response. Factors such as age, exposure levels, and co-infections contribute to the complexity of vaccine responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Risoleta Nogueira Soares, Eulalia Camelo Pessoa de Azevedo Ximenes, Sidcley Bernardino Araujo, Romildo Luciano da Silva, Valdenia Maria Oliveira de Souza, Luana Cassandra Breitenbach Barroso Coelho, Jose Lourenco de Freitas Neto, Pedro Jose Rolim Neto, Hallysson Douglas Andrade de Araujo, Andre de Lima Aires, Monica Camelo Pessoa de Azevedo Albuquerque
Summary: In this study, the in vivo effect of 8-lapachone complexed with methyl-8-cyclodextrin (M8CD) on the stages of Schistosoma mansoni in a murine model was evaluated. The results showed that 8-lap:M8CD significantly reduced the number of worms and the damage caused by eggs, possibly through reducing the granuloma size.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Parasitology
Silvia Goncalves Mesquita, Floria Gabriela dos Santos Neves, Ronaldo Guilherme Carvalho Scholte, Omar dos Santos Carvalho, Cristina Toscano Fonseca, Roberta Lima Caldeira
Summary: This study validated the use of LAMP for detecting Schistosoma mansoni infection in snails of the genus Biomphalaria in Brazil. The results indicated that LAMP was three times as effective as traditional parasitological methods and showed 100% specificity, 85.7% sensitivity, and a kappa index of 0.88.
PARASITES & VECTORS
(2021)
Article
Immunology
Adebayo J. Molehin, Sean A. Gray, Cheri Turner, Jennifer Davis, Weidong Zhang, Sabiha Khatoon, Madison Rattan, Rebecca Kernen, Christopher Peterson, Souad R. Sennoune, Darrick Carter, Afzal A. Siddiqui
Summary: The study aimed to develop a veterinary vaccine against Asiatic schistosomiasis caused by Schistosoma japonicum. The research successfully demonstrated the effectiveness of a minimally purified vaccine based on Sj-p80 in mice, laying the foundation for further testing in bovines in endemic areas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Renan M. de Mori, Mariana A. A. Aleixo, Luana C. C. Zapata, Felipe A. Calil, Flavio S. Emery, M. Cristina Nonato
Summary: This study focuses on targeting the enzyme dihydroorotate dehydrogenase (DHODH) as a potential drug target for treating schistosomiasis. The researchers identified atovaquone and its analogues as potent inhibitors against Schistosoma mansoni DHODH (SmDHODH), providing insights into the catalytic mechanism of class 2 DHODHs and potential for structure-guided drug design.
Article
Public, Environmental & Occupational Health
Hagen Frickmann, Lisa-Maria Lunardon, Andreas Hahn, Ulrike Loderstaedt, Andreas K. Lindner, Soeren L. Becker, Frank P. Mockenhaupt, Christoph Weber, Egbert Tannich
Summary: A new one-tube multiplex real-time PCR method was evaluated for detecting DNA of Schistosoma species in serum samples, showing high reliability in diagnosing schistosomiasis in travelers and migrants. The agreement between different diagnostic methods depends on whether serology is included as a parameter.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Mohd Adnan, Saleha Anwar, Debarati DasGupta, Mitesh Patel, Abdelbaset Mohamed Elasbali, Hassan H. Alhassan, Alaa Shafie, Arif Jamal Siddiqui, Fevzi Bardakci, Mejdi Snoussi, Md. Imtaiyaz Hassan
Summary: In this study, the alkaloid Harmaline (HAR) was investigated for its potential as a MARK4 inhibitor. Molecular docking and fluorescence binding studies showed a strong binding affinity between HAR and MARK4, and HAR significantly inhibited the kinase activity of MARK4. Structural investigations revealed that HAR binds to the active site pocket of MARK4 and forms multiple non-covalent interactions with biologically important residues. These findings suggest that HAR could be a potential therapeutic agent for MARK4-related diseases, including Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Arif Jamal Siddiqui, Vikash Kumar, Sadaf Jahan, Mohammed Merae Alshahrani, Ahmed Abdullah Al Awadh, Maqsood Ahmed Siddiqui, Walid Sabri Hamadou, Abdelmushin Abdelgadir, Juhi Saxena, Riadh Badraoui, Mejdi Snoussi, Mohd Adnan
Summary: Two drugs, C22 and C27, have been found to selectively inhibit human ELOVL1 enzyme, blocking the binding of long-chain fatty acids. This study provides important insights for the discovery and design of novel, selective, and potent ELOVL1 inhibitors.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nouha Bouali, Iqrar Ahmad, Harun Patel, Elham Bader Alhejaili, Walid Sabri Hamadou, Riadh Badraoui, Ramzi Hadj Lajimi, Mousa Alreshidi, Arif Jamal Siddiqui, Mohd Adnan, Mohammad A. Abdulhakeem, Abdulrahman S. Bazaid, Mitesh Patel, Mohd Saeed, Mejdi Snoussi, Emira Noumi
Summary: This study aimed to investigate the antimicrobial potential of Ziziphus honey (ZH) against clinical bacterial strains and yeasts and molds. The results showed that ZH was able to inhibit the growth of both Gram-positive and Gram-negative bacteria. Computational simulations revealed that certain compounds in ZH had good affinity for targeted receptors. These findings highlight the potential pharmacological applications of ZH and its identified compounds.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Arif Jamal Siddiqui, Sadaf Jahan, Mitesh Patel, Abdelmushin Abdelgadir, Wael Alturaiki, Fevzi Bardakci, Manojkumar Sachidanandan, Riadh Badraoui, Mejdi Snoussi, Mohd Adnan
Summary: This study identifies six new inhibitors against the EGFR protein using computational approaches. These molecules show high docking scores and FEC values, as well as stable RMSD plots and strong hydrogen interactions. These findings have potential implications for developing new drugs to treat breast cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Editorial Material
Immunology
Arif Jamal Siddiqui, Mohd Adnan, Fevzi Bardakci, Adebayo James Molehin
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Arif Jamal Siddiqui, Jyoti Bhardwaj, Juhi Saxena, Sadaf Jahan, Mejdi Snoussi, Fevzi Bardakci, Riadh Badraoui, Mohd Adnan
Summary: Malaria and schistosomiasis are two leading causes of morbidity and mortality worldwide. Co-infections are common in the tropics, and clinical consequences are influenced by various factors. While effective drugs exist, genetic mutations can lead to drug resistance, and vaccines are currently lacking. Therefore, highlighting current vaccine candidates and progress is crucial.
Article
Infectious Diseases
Amir Mahgoub Awadelkareem, Arif Jamal Siddiqui, Emira Noumi, Syed Amir Ashraf, Sibte Hadi, Mejdi Snoussi, Riadh Badraoui, Fevzi Bardakci, Mohammad Saquib Ashraf, Corina Danciu, Mitesh Patel, Mohd Adnan
Summary: In recent years, there has been a global threat to human health and environment due to the development of antimicrobial resistance (AMR) in bacterial pathogens. In this study, silver nanoparticles derived from Lactobacillus rhamnosus (AgNPs-LR) were tested against three Gram-negative bacteria to determine their effects on biofilm formation and virulence factors controlled by quorum sensing (QS). The results demonstrated that AgNPs-LR effectively inhibited the development of biofilms and QS-mediated virulent traits of these bacteria.
Article
Chemistry, Multidisciplinary
Arif Jamal Siddiqui, Sadaf Jahan, Swati Chaturvedi, Maqsood Ahmed Siddiqui, Mohammed Merae Alshahrani, Abdelmushin Abdelgadir, Walid Sabri Hamadou, Juhi Saxena, Bharath K. Sundararaj, Mejdi Snoussi, Riadh Badraoui, Mohd Adnan
Summary: Fatty acids play a crucial role in energy balance regulation in mammals, with both exogenous ingestion and endogenous de novo lipogenesis contributing to their production. Enzymatic elongation of fatty acids beyond 16 carbons can lead to the formation of very long chain fatty acids (VLCFA), regulated by rate-limiting condensation. Among the seven elongases identified in mammals, ELOVL1 has garnered recent interest as a potential therapeutic target for various diseases, including neurological disorders associated with the elongation of specific monounsaturated and saturated acyl-CoAs. ELOVL1 and VLCFAs have direct implications for neurological diseases, and other symptoms such as ichthyotic keratoderma, spasticity, and hypomyelination are also linked to the key enzyme. This review provides unique insights into the therapeutic potential of ELOVL1 and its role in neurological disorders.
Article
Mathematics
Arif Jamal Siddiqui, Sadaf Jahan, Maqsood Ahmed Siddiqui, Andleeb Khan, Mohammed Merae Alshahrani, Riadh Badraoui, Mohd Adnan
Summary: Neurological disorders are characterized by neuron loss and disability. Neurotransmitters are regulated by monoamine oxidase (MAO), and treating disorders like Alzheimer's and Parkinson's involves MAOIs. This study used computational tools to find new MAO-B inhibitors, identifying five molecules with high binding affinity.
Review
Food Science & Technology
Syed Amir Ashraf, Danish Mahmood, Abd Elmoneim O. Elkhalifa, Arif Jamal Siddiqui, Mohammad Idreesh Khan, Fauzia Ashfaq, Mitesh Patel, Mejdi Snoussi, Marek Kieliszek, Mohd Adnan
Summary: This review discusses the issue of pesticide contamination in honey and its impact on human health. It highlights the consequences of uncontrolled pesticide use in agriculture and apiculture and calls for stricter regulation and monitoring.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mohd Adnan, Debarati Dasgupta, Saleha Anwar, Anas Shamsi, Arif Jamal Siddiqui, Mejdi Snoussi, Fevzi Bardakci, Mitesh Patel, Md Imtaiyaz Hassan
Summary: This study showed that galantamine, an acetylcholinesterase inhibitor, binds to MARK4 with strong affinity and significantly inhibits its kinase activity. These results suggest that galantamine could be a potential inhibitor of MARK4 and a promising therapeutic target for AD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Mohd Adnan, Arif Jamal Siddiqui, Syed Amir Ashraf, Mohammad Saquib Ashraf, Sarah Owdah Alomrani, Mousa Alreshidi, Bektas Tepe, Manojkumar Sachidanandan, Corina Danciu, Mitesh Patel
Summary: The saponin-derived silver nanoparticles obtained from Ajwa dates showed strong antibacterial, antibiofilm, and anti-quorum-sensing activities. They inhibited bacterial growth by disrupting the bacterial cell membranes and leakage of nucleic acid and protein contents, and prevented biofilm formation and quorum-sensing activity by interfering with signaling molecules. Additionally, the nanoparticles exhibited antioxidant activity and cytotoxicity against lung cancer cells.
Article
Chemistry, Medicinal
Walid Sabri Hamadou, Nouha Bouali, Elham Bader Alhejaili, Zohra Soua, Mitesh Patel, Mohd Adnan, Arif Jamal Siddiqui, Abdel-Muhsin Abdel-Gadir, Abdel Moneim Elhadi Sulieman, Mejdi Snoussi, Riadh Badraoui
Summary: This study assessed the interaction between bioactive compounds derived from honey and the apoptotic protein p53, which could trigger apoptosis. The results showed that certain compounds in honey have a strong binding ability to p53 and may possess anti-cancer activity, potentially serving as alternative therapy for breast cancer.
PHARMACOGNOSY MAGAZINE
(2023)
Article
Microbiology
Mohd Adnan, Arif Jamal Siddiqui, Syed Amir Ashraf, Fevzi Bardakci, Mousa Alreshidi, Riadh Badraoui, Emira Noumi, Bektas Tepe, Manojkumar Sachidanandan, Mitesh Patel
Summary: This study explores the anti-fungal potential of phytochemicals from Ajwa dates using network pharmacology, molecular docking, and dynamics simulations, revealing the molecular mechanisms underlying their activity and providing a rational basis for developing new therapeutic strategies against candidiasis in humans.
Article
Medicine, Research & Experimental
Mohd Adnan, Arif Jamal Siddiqui, Emira Noumi, Syed Amir Ashraf, Amir Mahgoub Awadelkareem, Sibte Hadi, Mejdi Snoussi, Riadh Badraoui, Fevzi Bardakci, Manojkumar Sachidanandan, Mitesh Patel
Summary: The study demonstrates that a biosurfactant derived from L. acidophilus can effectively inhibit virulence factors, biofilm formation, and quorum sensing in Gram-negative pathogenic bacteria. This provides a promising approach for tackling antimicrobial resistance.
BIOMOLECULES AND BIOMEDICINE
(2023)