Article
Infectious Diseases
Ling Yang, Yu Fu, Si Li, Chang Liu, Donghua Liu
Summary: By detecting TP DNA and CXCL13 concentration in the cerebrospinal fluid (CSF) of HIV-negative syphilis patients, this study provides evidence for the diagnosis and treatment of neurosyphilis (NS). CSF CXCL13 levels may be a useful marker to distinguish NS from non-NS syphilis.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Immunology
Christina M. Marra, Clare L. Maxwell, Sharon K. Sahi, Lauren C. Tantalo, Shelia B. Dunaway, Sheila A. Lukehart
Summary: Previous syphilis was found to attenuate the manifestations of subsequent T. pallidum infection, with reduced detection of the pathogen in blood and cerebrospinal fluid, as well as a decreased risk of neurosyphilis in individuals with a history of syphilis.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Public, Environmental & Occupational Health
Zheng-Xiang Gao, Yu Gou, Xiao-Qin Liu, Lei-Wen Peng
Summary: With the increasing rate of latent syphilis infection, the clinical manifestations of neurosyphilis have become more diverse. Cerebrospinal fluid testing plays an important role in the diagnosis of neurosyphilis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Immunology
Matthew M. Hamill, Khalil G. Ghanem, Susan Tuddenham
Summary: We reviewed the key concepts of diagnosis, treatment, and follow-up of neurosyphilis. We discussed the epidemiology of syphilis in the US, focusing on affected populations and estimating the burden of neurosyphilis. We described the clinical features, significance of asymptomatic neurosyphilis, indications for cerebrospinal fluid examination, performance characteristics of different assays, and future biomarkers and imaging.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Medicine, General & Internal
Jia Zhou, Hanlin Zhang, Keyun Tang, Runzhu Liu, Jun Li
Summary: This review article provides an overview of recent advances in neurosyphilis, including epidemiology, clinical manifestations, laboratory findings, diagnosis, treatment, and more. The increase in neurosyphilis incidence is mainly attributed to the expansion of men who have sex with men and the infection of human immunodeficiency virus. Exploring biomarkers of neurosyphilis may help uncover its pathogenesis.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Noah Kojima, Kelika A. Konda, Jeffrey D. Klausner
Summary: Efforts to develop a syphilis vaccine have been ongoing for nearly a century, but significant progress has yet to be made. In recent years, however, advances in understanding the outer membrane proteins (OMPs) of the syphilis pathogen have led to increased efforts in vaccine development. While current vaccine formulations have shown partial protection in animal models, there are still important knowledge gaps to be addressed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Marija Djukic, Helmut Eiffert, Peter Lange, Ioanna Giotaki, Jana Seele, Roland Nau
Summary: This study found that approximately 1% of geriatric patients with cognitive decline or neuropathy have antibodies against Treponema pallidum in their serum, indicating a need for further diagnostic testing and potential antibiotic therapy.
Editorial Material
Microbiology
Linda Grillova
Summary: This article highlights the use of population genomic strategies in the development of an effective syphilis vaccine.
NATURE REVIEWS MICROBIOLOGY
(2022)
Article
Dermatology
Romain Salle, Philippe A. Grange, Guillaume Ollagnier, Nadjet Benhaddou, Ugo Heller, Nicolas Dupin
Summary: This study evaluated different molecular and serological assays used in neurosyphilis (NS) diagnosis and found that there is no "gold standard" method. Molecular techniques have excellent specificity but lack sufficient diagnostic performance. A combination of clinical and biological parameters, combining PCR and serology in cerebrospinal fluid (CSF), is a feasible approach for NS diagnosis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Multidisciplinary Sciences
Zhenzhou Luo, Yi Ding, Jun Yuan, Lishan Tian, Li Zhang, Qiuhong Wu, Jinsong Mou
Summary: The study found that a higher percentage of early syphilis patients achieved serological cure two years after treatment. The results indicated that syphilis stage and baseline serum titer were crucial factors associated with serological cure.
Article
Immunology
Naokatsu Ando, Daisuke Mizushima, Kazumi Omata, Takashi Nemoto, Natsumi Inamura, Saori Hiramoto, Misao Takano, Takahiro Aoki, Koji Watanabe, Haruka Uemura, Daisuke Shiojiri, Yasuaki Yanagawa, Junko Tanuma, Katsuji Teruya, Yoshimi Kikuchi, Hiroyuki Gatanaga, Shinichi Oka
Summary: In this study, low-dose amoxicillin monotherapy was compared with the combination of amoxicillin and probenecid for treating syphilis. The results showed that low-dose amoxicillin was not as effective as the combination regimen, but it could still be used as an alternative with fewer side effects.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Ramona Andreea Codreanu Balaban, Any Axelerad, Daniela Musat, Anabella Cristiana Cioabla, Alina Zorina Stuparu, Silviu Docu Axelerad, Lavinia Florenta Muja
Summary: In recent decades, it was believed that syphilis and its complications, including neurological damage, could be controlled through proper epidemiological management. However, changes in socio-economic factors and the issue of antibiotic resistance have brought it back to the attention of clinicians. This study presents cases of three male patients from different backgrounds and occupations who were diagnosed with neurosyphilis, highlighting the potential complications and benefits of targeted therapy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Medicine, General & Internal
Andreia M. Teixeira, Elsa Meireles, Carla Pereira Fontes, Micaela Manuel
Summary: Neurosyphilis refers to the central nervous system involvement caused by Treponema pallidum. Ocular syphilis, the most common manifestation, can occur at any stage of acquired syphilis. Multiple tests are available for the diagnosis of syphilis, and the treatment depends on the disease stage. Recent recommendations suggest treating ocular syphilis similarly to neurosyphilis, even with a normal liquor examination. This article describes a case of ocular syphilis in a 57-year-old male patient.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Immunology
Chenyan Yuan, Wei Xu, Chenggui Zhao, Wei Gao, Guoqiu Wu
Summary: This study reports the detection of T. phagedenis sequence in the cerebrospinal fluid of a patient, which is the first report of its kind. The patient was diagnosed with neurosyphilis, and T. phagedenis was identified as the sole microorganism in the cerebrospinal fluid through metagenomic sequencing. The patient's symptoms did not improve after a round of benzathine penicillin therapy, but resolved after treatment with penicillin G sodium.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Xiaoli Zhou, Shengkun Peng, Tiange Song, Dandan Tie, Xiaoyan Tao, Li Jiang, Jie Zhang
Summary: The rapid and accurate identification of pathogenic agents is crucial for the diagnosis and treatment of intractable diseases like neurosyphilis. Using mNGS technology, Treponema pallidum was detected for the first time in patients with ocular involvement, highlighting the importance of this method for the diagnosis and differential diagnosis of neurosyphilis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
