Head and neck cancer: from research to therapy and cure

Human Viral Oncogenesis: A Cancer Hallmarks Analysis

(2014) Enrique A. Mesri et al.   Cell Host & Microbe

Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas

(2014) Tanguy Y. Seiwert et al.   CLINICAL CANCER RESEARCH

The Cancer Genome Atlas findings in head and neck cancer

(2014) Gilberto de Castro et al.   CURRENT OPINION IN ONCOLOGY

Nonendemic HPV-Positive Nasopharyngeal Carcinoma: Association With Poor Prognosis

(2014) Matthew H. Stenmark et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer

(2014) Yang Sui Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

(2014) G. Paolo Dotto   JOURNAL OF CLINICAL INVESTIGATION

Characterization of HPV and host genome interactions in primary head and neck cancers

(2014) M. Parfenov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

(2014) V. W. Y. Lui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma

(2013) Simion I Chiosea et al.   BMC CANCER

Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma

(2013) R. G. Liao et al.   CANCER RESEARCH

Is open surgery for head and neck cancers truly declining?

(2013) Dana M. Hartl et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Decision making in the management of recurrent head and neck cancer

(2013) Allen S. Ho et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial

(2013) Jan B Vermorken et al.   LANCET ONCOLOGY

Outcomes in head and neck oncologic surgery at academic medical centers in the united states

(2013) Scharukh Jalisi et al.   LARYNGOSCOPE

T4a laryngeal cancer survival: Retrospective institutional analysis and systematic review

(2013) Evana Francis et al.   LARYNGOSCOPE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis

(2013) X. Ding et al.   Science Signaling

TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF-Mutant Melanoma

(2013) R. B. Corcoran et al.   Science Translational Medicine

Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer

(2013) Sandro Goruppi et al.   TRENDS IN CELL BIOLOGY

Identification of Targetable FGFR Gene Fusions in Diverse Cancers

(2013) Yi-Mi Wu et al.   Cancer Discovery

Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers

(2013) V. W. Y. Lui et al.   Cancer Discovery

Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors

(2013) Matthias Lechner et al.   Genome Medicine

Long-term regional control and survival in patients with “low-risk,” early stage oral tongue cancer managed by partial glossectomy and neck dissection without postoperative radiation

(2012) Ian Ganly et al.   CANCER

Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma

(2012) C. Liang et al.   CANCER RESEARCH

Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling

(2012) Bing Hu et al.   CELL

The molecular pathogenesis of head and neck squamous cell carcinoma

(2012) S. Michael Rothenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

(2012) Malabika Sen et al.   Cancer Discovery

The binary oral dysplasia grading system: validity testing and suggested improvement

(2012) Paul Nankivell et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants

(2011) Troy E. Daniels et al.   ARTHRITIS AND RHEUMATISM

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?

(2011) Christina Scheel et al.   INTERNATIONAL JOURNAL OF CANCER

Zalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: an open-label, randomised phase 3 trial

(2011) Jean-Pascal Machiels et al.   LANCET ONCOLOGY

Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer

(2011) Amit Dutt et al.   PLoS One

Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming

(2011) Margaret E. McLaughlin-Drubin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Another NOTCH for Cancer

(2011) R. H. Brakenhoff   SCIENCE

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

A Genome-Wide Screen for Microdeletions Reveals Disruption of Polarity Complex Genes in Diverse Human Cancers

(2010) S. M. Rothenberg et al.   CANCER RESEARCH

Tobacco Use in Human Papillomavirus-Positive Advanced Oropharynx Cancer Patients Related to Increased Risk of Distant Metastases and Tumor Recurrence

(2010) J. H. Maxwell et al.   CLINICAL CANCER RESEARCH

Critical Impact of Radiotherapy Protocol Compliance and Quality in the Treatment of Advanced Head and Neck Cancer: Results From TROG 02.02

(2010) Lester J. Peters et al.   JOURNAL OF CLINICAL ONCOLOGY

Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer

(2010) K. Kian Ang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Transoral robotic surgery: does the ends justify the means?

(2009) Gregory S Weinstein et al.   Current Opinion in Otolaryngology & Head and Neck Surgery

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Tempol Protects against Oxidative Damage and Delays Epithelial Tumor Onset in Fanconi Anemia Mice

(2008) Q.-S. Zhang et al.   CANCER RESEARCH

Chemoselection As a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated With HPV16 Copy Number

(2008) Francis P. Worden et al.   JOURNAL OF CLINICAL ONCOLOGY

Improved Survival of Patients With Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial

(2008) C. Fakhry et al.   JNCI-Journal of the National Cancer Institute

Distinct Risk Factor Profiles for Human Papillomavirus Type 16–Positive and Human Papillomavirus Type 16–Negative Head and Neck Cancers

(2008) Maura L. Gillison et al.   JNCI-Journal of the National Cancer Institute

Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer

(2008) Jan B. Vermorken et al.   NEW ENGLAND JOURNAL OF MEDICINE