Journal
STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES I
Volume 1317, Issue -, Pages 57-69Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12410
Keywords
vitamin D; asthma; immunoregulatory; therapeutic
Categories
Funding
- Medical Research Council (MRC)
- Asthma U.K. Center in Allergic Mechanisms of Asthma
- MRC Centenary Fellowship
- Wellcome Trust Clinical Research Training Fellowship
- Medical Research Council [G1000758] Funding Source: researchfish
- Asthma UK [AUK-IG-2014-296, 11/040, MRC-AsthmaUKCentre, 08/019] Funding Source: researchfish
Ask authors/readers for more resources
Vitamin D deficiency is prevalent among people with various immune-mediated conditions, including autoimmune diseases and asthma. Serum 25(OH) D levels inversely correlate with asthma severity, glucocorticoid responsiveness/dosage, and markers of pathogenesis, such as airway remodeling, IgE, and eosinophilia. Trials involving supplementation with active vitamin D or a precursor are beginning to emerge with variable results that, in part, reflect differences in study design. This review looks at the mechanisms by which vitamin D may protect against asthma, including increasing glucocorticoid responsiveness, skewing immune cells towards a regulatory phenotype, reducing the incidence of infections, airway remodeling, eosinophilia, and lowering the levels of IgE. Also discussed is the therapeutic potential for vitamin D, which is likely to be applicable to immune-mediated conditions beyond simply asthma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available