Article
Biochemistry & Molecular Biology
Alessandra Pulliero, Luca Mastracci, Letizia Tarantini, Zumama Khalid, Valentina Bollati, Alberto Izzotti
Summary: This study reveals the relationship between KRAS mutation and let-7a downregulation in cigarette smoke-induced lung carcinogenesis. Long-term exposure to cigarette smoke leads to a significant decrease in let-7a expression and an increase in KRAS mutation, resulting in a higher incidence of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ryan H. Nguyen, Laura B. Vater, Lava R. Timsina, Gregory A. Durm, Katelin Rupp, Keylee Wright, Miranda H. Spitznagle, Brandy Paul, Shadia Jalal, Lisa Carter-Harris, Karen S. Hudmon, Nasser H. Hanna, Patrick J. Loehrer, DuyKhanh P. Ceppa
Summary: The study found that counties with stronger smoke-free air ordinances had lower smoking rates and fewer new lung cancer cases per year. Therefore, strengthening smoke-free air ordinances is crucial for reducing lung cancer incidence.
Article
Critical Care Medicine
Farzad Moazed, Carolyn Hendrickson, Alejandra Jauregui, Jeffrey Gotts, Amanda Conroy, Kevin Delucchi, Hanjing Zhuo, Mikhaela Arambulo, Kathryn Vessel, Serena Ke, Thomas Deiss, Amy Ni, Aleksandra Leligdowicz, Jason Abbott, Mitchell J. Cohen, Pratik Sinha, Antonio Gomez, Kirsten Kangelaris, Lucy Kornblith, Michael Matthay, Neal Benowitz, Kathleen Liu, Carolyn S. Calfee
Summary: Cigarette smoke exposure is associated with an increased risk of developing ARDS in both pulmonary and nonpulmonary sepsis patients. Among ARDS patients, those with exposure to cigarette smoke have lower systemic inflammation levels, and active smokers also have lower severity of illness compared to non-smokers, indicating that smoking contributes to biological heterogeneity in ARDS.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jun Liu, Szu-Jung Chen, Ssu-Wei Hsu, Jun Zhang, Ji-Min Li, David C. Yang, Shenwen Gu, Kent E. Pinkerton, Ching-Hsien Chen
Summary: The study found that MARCKS was activated in response to cigarette smoke in human lung cancer cells, specimens, and non-human primate airway epithelium. By investigating its interaction with NF-kappa B-activating protein (NKAP), it revealed MARCKS as a novel NF-kappa B activator in smoke-mediated lung cancer progression.
Article
Oncology
Jody Vykoukal, Johannes F. Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J. Ostrin, Jennifer B. Dennison, Cristina Ivan, Gary E. Goodman, Mark D. Thornquist, Matt J. Barnett, Ziding Feng, George A. Calin, Samir M. Hanash
Summary: Blood-based cancer biomarkers, including miRNA and four protein marker panel, have shown utility in improving the assessment and early detection of lung cancer.
Article
Medicine, Research & Experimental
Tingting Wu, Keye Xu, Chaobo Liu, Yan Li, Mingcai Li
Summary: This study aimed to investigate the effect of interleukin-37 (IL-37) on cigarette smoke-induced lung inflammation. By administering IL-37-expressing lentivirus to mice, it was found that IL-37 can alleviate weight loss and pulmonary inflammation induced by cigarette smoke. IL-37 also significantly inhibited inflammatory cell recruitment, reduced inflammatory cell increase, and suppressed the production of pro-inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Physiology
Marta Schiliro, Elizabeth R. Vogel, Lucia Paolini, Christina M. Pabelick
Summary: The detrimental effects of tobacco exposure on children's health are well known, and the prevalence of secondhand or direct cigarette smoke exposure in the pediatric population has not significantly decreased over time. Additionally, the rapid increase in e-cigarette use among adolescents has raised public health concerns.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Tiantian Cen, Yifeng Mai, Jie Jin, Minxuan Huang, Mingcai Li, Shanshan Wang, Hongying Ma
Summary: Our study aimed to investigate the ability of IL-41 to protect against CS-induced lung inflammation in vivo. The results showed that IL-41 pre-treatment alleviated pulmonary inflammatory infiltration and lung tissue lesions, limited CS-induced weight loss, and promoted the polarization of M2 macrophages. IL-41 also increased the levels of IL-10 and reduced the production of TNF-α, IL-6, and IL-1β.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Serena Di Vincenzo, Claudia Sangiorgi, Maria Ferraro, Marco Buscetta, Chiara Cipollina, Elisabetta Pace
Summary: This study investigated the effects of cigarette smoke on different types of lung cancer cell lines and found that it induces oxidative stress and mitochondrial damage, leading to metabolic reprogramming. Cigarette smoke exposure also downregulates the tumor suppressor FOXO3a, promoting tumor migration and progression.
Article
Multidisciplinary Sciences
Ya-Jing Jiang, Chia-Chia Chao, An-Chen Chang, Po-Chun Chen, Fang-Ju Cheng, Ju-Fang Liu, Po- Liu, Chang-Lun Huang, Jeng-Hung Guo, Wei-Chien Huang, Chih-Hsin Tang
Summary: Cigarette smoking, as a main risk factor for lung cancer, increases the expression levels of OPN through the JAK2/STAT3 signaling pathway, thereby promoting the recruitment and adhesion of MSCs to lung cancer cells, and facilitating lung cancer metastasis and invasion.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Cell Biology
Mounica Bandela, Eleftheria Letsiou, Viswanathan Natarajan, Lorraine B. Ware, Joe G. N. Garcia, Sunit Singla, Steven M. Dudek
Summary: The study suggests that cigarette smoke or e-cigarette vapor-induced apoptosis in lung endothelial cells is related to the protein Cortactin (CTTN), with reduced levels of CTTN potentially increasing the risk of vascular damage and exacerbating the development of COPD.
Article
Toxicology
Rui Xiong, Leihong Wu, Yue Wu, Levan Muskhelishvili, Qiangen Wu, Ying Chen, Tao Chen, Matthew Bryant, Hans Rosenfeldt, Sheila M. Healy, Xuefei Cao
Summary: Exposure to cigarette smoke has been shown to impair mucociliary clearance and is associated with chronic obstructive pulmonary diseases. In this study, miRNAs associated with impaired mucociliary clearance in an in vitro airway tissue model exposed to cigarette smoke were identified. The downregulation of miR-449a by cigarette smoke may interfere with ciliogenesis and derepress cell-cycle proteins, potentially serving as an early biomarker for cigarette smoke exposure and harm.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jelena Mustra Rakic, Chun Liu, Sudipta Veeramachaneni, Dayong Wu, Ligi Paul, Lynne M. Ausman, Xiang-Dong Wang
Summary: The study suggests that cigarette smoke (CS) may promote the development of nonalcoholic steatohepatitis (NASH) and liver fibrosis in ferrets, which is associated with the downregulation of a key lycopene cleavage enzyme. However, dietary lycopene can inhibit CS-promoted NASH development through various mechanisms. Additionally, CS exposure may decrease the expression of an important lycopene cleavage enzyme, while dietary lycopene can reverse this decrease.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Health Care Sciences & Services
Carlos Perez-Sanchez, Nuria Barbarroja, Lucas C. Pantaleao, Laura M. Lopez-Sanchez, Susan E. Ozanne, Bernabe Jurado-Gamez, Enrique Aranda, Chary Lopez-Pedrera, Antonio Rodriguez-Ariza
Summary: This study provides evidence for the clinical utility of miRNAs from exhaled breath condensate as biomarkers of lung cancer. Genome-wide miRNA profiling and machine learning analysis revealed altered miRNA levels in lung cancer patients, with specific signatures accurately distinguishing patient types and predicting clinical outcomes. Dysregulated EBC miRNAs also showed associations with clinical features and potential target genes related to lung cancer pathogenesis.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Siddhi Jain, Sneha Durugkar, Pritam Saha, Sharad B. Gokhale, V. G. M. Naidu, Pawan Sharma
Summary: This study examined the efficacy of azithromycin alone and in combination with dexamethasone in treating cigarette smoke-induced acute lung inflammation. The results showed that azithromycin inhibited airway fibrosis, inflammation, and cell toxicity caused by cigarette smoke, and improved lung function. Further research is needed to validate the therapeutic efficacy of azithromycin as a treatment for COPD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Environmental Sciences
Marta Geretto, Marco Ferrari, Roberta De Angelis, Filippo Crociata, Nicola Sebastiani, Alessandra Pulliero, William Au, Alberto Izzotti
Summary: Military personnel are frequently exposed to environmental pollutants that can cause a variety of diseases. Evaluation of environmental and individual exposures to pollutants is crucial but often omitted. Biomarkers are important tools to explore relationships between exposures and diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Annalaura Carducci, Maria Fiore, Antonio Azara, Guglielmo Bonaccorsi, Martina Bortoletto, Giuseppina Caggiano, Andrea Calamusa, Antonella De Donno, Osvalda De Giglio, Marco Dettori, Pamela Di Giovanni, Angela Di Pietro, Alessio Facciola, Ileana Federigi, Iolanda Grappasonni, Alberto Izzotti, Giovanni Libralato, Chiara Lorini, Maria Teresa Montagna, Liberata Keti Nicolosi, Grazia Paladino, Giacomo Palomba, Fabio Petrelli, Tiziana Schiliro, Stefania Scuri, Francesca Serio, Marina Tesauro, Marco Verani, Marco Vinceti, Federica Violi, Margherita Ferrante
Summary: This study found that the majority of Italian university students have positive attitudes towards pro-environmental behaviors, which are positively correlated with health risk perception, internal locus of control, and health literacy. However, the actual adoption of pro-environmental behaviors is relatively low and may be influenced by external obstacles.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Alberto Izzotti, Enzo Fracchia, William Au, Monica Colombo, Ulrich Pfeffer, Laura Emionite, Simone Pavan, Daniele Miotto, Paola Lova, Elena Grasselli, Emanuela Faelli, Ruggeri Piero, Micaela Tiso, Alessandra Pulliero
Summary: A new chemoprophylactic/therapeutic strategy using HOO/HOOws was developed to effectively prevent and treat COVID-19 infection. In vitro and in vivo studies demonstrated the efficacy and safety of this treatment, showing promising results in preventing infection and accelerating recovery in COVID-19 patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Paolo Degan, Katia Cortese, Alessandra Pulliero, Silvia Bruno, Maria Cristina Gagliani, Matteo Congiu, Alberto Izzotti
Summary: The exposure of A549 cells to microgravity causes the generation of polynucleated cells, cell cycle imbalance, growth inhibition, and morphological abnormalities, especially in damaged mitochondria. Global miRNA analysis reveals miRNAs associated with mu G mainly involved in cell cycle regulation, apoptosis, and stress response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Assiya Kussainova, Olga Bulgakova, Akmaral Aripova, Zumama Khalid, Rakhmetkazhi Bersimbaev, Alberto Izzotti
Summary: This review discusses the role of mitochondrial miRNAs in the pathogenesis of lung cancer, with a particular focus on their association with radon exposure.
Article
Health Care Sciences & Services
Alessandra Pulliero, Deborah Traversi, Elena Franchitti, Martina Barchitta, Alberto Izzotti, Antonella Agodi
Summary: Environmental pollutants can affect the diversity of microbiota, which has significant implications for overall organism health. Changes in microbiota are associated with the progression of diseases in high-risk individuals, and epigenetic modifications are influenced by microbiota metabolites. Monitoring environmental stimuli to maintain a balanced microbiota presents a novel approach for disease prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Giuseppe Valacchi, Erika Pambianchi, Simona Coco, Alessandra Pulliero, Alberto Izzotti
Summary: Epigenetic alterations are important in carcinogenesis, with microRNAs playing a role in protecting cells against genotoxic damages. While the effects of environmental pollutants on lung tissue have been well investigated, more research is needed to understand their impact on skin tissue. Our study found that exposure to diesel fumes, ozone, and UV light caused specific patterns of microRNA alterations in skin, with each pollutant affecting different cellular mechanisms.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Alessandra Pulliero, Simona Iodice, Angela Cecilia Pesatori, Luisella Vigna, Zumama Khalid, Valentina Bollati, Alberto Izzotti
Summary: The study found an inverse association between long-term PM10 exposure and DNA adduct levels in adults with an unhealthy BMI, possibly due to an atypical reaction to airborne pollutants in this population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Alberto Izzotti, Enzo Fracchia, Camillo Rosano, Antonio Comite, Liliana Belgioia, Salvatore Sciacca, Zumama Khalid, Matteo Congiu, Cristina Colarossi, Giusi Blanco, Antonio Santoro, Massimo Chiara, Alessandra Pulliero
Summary: Ozonized oils can effectively decrease the risk of cancer relapses by damaging cancer cells and triggering apoptosis. Administering ozonized oil orally can significantly decrease blood antioxidants in cancer patients, resulting in improved survival rate and decreased relapses.
Editorial Material
Health Care Sciences & Services
Alessandra Pulliero, Alberto Izzotti
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Imene Ben Toumia, Marco Ponassi, Paola Barboro, Erika Iervasi, Gabriela Coronel Vargas, Barbara Banelli, Stefano Fiordoro, Leila Chekir Ghedira, Franz Heinrich Kohnke, Alberto Izzotti, Camillo Rosano
Summary: The macrocyclic compounds meso-(p-acetamidophenyl)-calix[4]pyrrole and meso-(m-acetamidophenyl)-calix[4]pyrrole have been found to inhibit cell growth in prostate cancer cell lines and show potential as therapeutic tools for the treatment of prostate cancer.
INVESTIGATIONAL NEW DRUGS
(2022)
Review
Environmental Sciences
Alberto Izzotti, Paola Spatera, Zumama Khalid, Alessandra Pulliero
Summary: Particulate matter (PM) pollution is a significant global public health issue, mainly caused by daily fuel use, industrial emissions, and vehicular traffic. This article investigates the causes of PM pollution, classifies different particle sizes, and discusses the health effects of PM exposure. The measurement method in risk assessment is emphasized as a concern.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Oncology
Alberto Izzotti
Review
Health Care Sciences & Services
Irena Velkova, Martina Pasino, Zumama Khalid, Paola Menichini, Emanuele Martorana, Alberto Izzotti, Alessandra Pulliero
Summary: Ferroptosis is a cell death pathway triggered by an imbalance between oxidant and antioxidant production, which plays an emerging role in tumorigenesis. It is regulated at three levels: iron metabolism, the antioxidant response, and lipid metabolism. Epigenetic dysregulation, involving microRNA mutations, is a hallmark of human cancer, and microRNAs have been found to modulate cancer growth and development through the ferroptosis pathway. This review summarizes the mechanism of ferroptosis initiation, the potential role of microRNAs in controlling this process, and the impact of treatments on ferroptosis in cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Serena Varesano, Alessandra Pulliero, Emanuele Martorana, Gabriele Pizzino, Gabriele Raciti, Simona Coco, Valerio Gaetano Vellone, Alberto Izzotti
Summary: Cervical cancer is the second most common cancer among women aged 15 to 44, affecting more than 500,000 women each year. The aim of the proposed study is to implement routine diagnostics of HPV precancerous cervical lesions by introducing new molecular diagnostic tools. MicroRNA analysis panel can improve early diagnosis, understand the nature of the lesion, and improve the clinical management of patients with HPV precancerous cervical lesions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
