Treatment of systemic lupus erythematosus: new advances in targeted therapy

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

B7RP-1 Blockade Ameliorates Autoimmunity through Regulation of Follicular Helper T Cells

(2014) Y.-L. Hu et al.   JOURNAL OF IMMUNOLOGY

Current state and future directions of autologous hematopoietic stem cell transplantation in systemic lupus erythematosus

(2011) G. G. Illei et al.   ANNALS OF THE RHEUMATIC DISEASES

Rituximab-Associated Progressive Multifocal Leukoencephalopathy in Rheumatoid Arthritis

(2011) David B. Clifford   ARCHIVES OF NEUROLOGY

Calcium signaling in systemic lupus erythematosus T cells: A treatment target

(2011) Vasileios C. Kyttaris et al.   ARTHRITIS AND RHEUMATISM

Treatment for Lupus, First in 50 Years, Offers Modest Benefits, Hope to Patients

(2011) Mike Mitka   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Promoter Hypomethylation Results in Increased Expression of Protein Phosphatase 2A in T Cells from Patients with Systemic Lupus Erythematosus

(2011) Katsue Sunahori et al.   JOURNAL OF IMMUNOLOGY

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

(2011) A. Kuznik et al.   JOURNAL OF IMMUNOLOGY

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

(2011) Kamran Ghoreschi et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER)

(2011) JT Merrill et al.   LUPUS

Pfizer's JAK inhibitor sails through phase 3 in rheumatoid arthritis

(2011) Ken Garber   NATURE BIOTECHNOLOGY

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine

(2010) P. M. Izmirly et al.   ANNALS OF THE RHEUMATIC DISEASES

Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity

(2010) José C. Crispín et al.   ARTHRITIS AND RHEUMATISM

The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial

(2010) J. T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Tocilizumab in systemic lupus erythematosus: Data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study

(2010) Gabor G. Illei et al.   ARTHRITIS AND RHEUMATISM

Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV

(2010) Kunihiro Ichinose et al.   ARTHRITIS AND RHEUMATISM

Interleukin-6 promoter polymorphism −174 G/C is associated with nephritis in Portuguese Caucasian systemic lupus erythematosus patients

(2010) Maria José Santos et al.   CLINICAL RHEUMATOLOGY

Pathogenetic aspects of systemic lupus erythematosus with an emphasis on regulatory T cells

(2010) Clemens Scheinecker et al.   JOURNAL OF AUTOIMMUNITY

Hypomethylation ofIL10andIL13Promoters in CD4+T Cells of Patients with Systemic Lupus Erythematosus

(2010) Ming Zhao et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

(2010) Partha S. Biswas et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-CD40L Immune Complexes Potently Activate Platelets In Vitro and Cause Thrombosis in FCGR2A Transgenic Mice

(2010) L. Robles-Carrillo et al.   JOURNAL OF IMMUNOLOGY

Interleukin 6 Gene Polymorphisms Are Associated with Systemic Lupus Erythematosus in Koreans

(2010) J.-Y. JEON et al.   JOURNAL OF RHEUMATOLOGY

New drugs for aggressive B-cell and T-cell lymphomas

(2010) Niels Murawski et al.   LANCET ONCOLOGY

Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis

(2010) Christopher E.M. Griffiths et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis

(2010) Michael E. Weinblatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

Belatacept-Based Regimens Versus a Cyclosporine A-Based Regimen in Kidney Transplant Recipients: 2-Year Results From the BENEFIT and BENEFIT-EXT Studies

(2010) Christian P. Larsen et al.   TRANSPLANTATION

Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus

(2010) Capucine Daridon et al.   ARTHRITIS RESEARCH & THERAPY

Use of Hydroxychloroquine to Prevent Thrombosis in Systemic Lupus Erythematosus and in Antiphospholipid Antibody–Positive Patients

(2010) Michelle Petri   Current Rheumatology Reports

Neutralization of interferon-α/β-inducible genes and downstream effect in a phase I trial of an anti-interferon-α monoclonal antibody in systemic lupus erythematosus

(2009) Yihong Yao et al.   ARTHRITIS AND RHEUMATISM

A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at university college london hospital: The first fifty patients

(2009) Tim Y.-T. Lu et al.   ARTHRITIS AND RHEUMATISM

Rituximab and lupus: Good in real life, bad in controlled trials. comment on the article by Lu et al

(2009) Manuel Ramos-Casals et al.   ARTHRITIS AND RHEUMATISM

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

(2009) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Ipilimumab: controversies in its development, utility and autoimmune adverse events

(2009) Jeffrey Weber   CANCER IMMUNOLOGY IMMUNOTHERAPY

Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases

(2009) D. Farge et al.   HAEMATOLOGICA

Treatment of lupus patients with a tolerogenic peptide, hCDR1 (Edratide): Immunomodulation of gene expression

(2009) Zev M. Sthoeger et al.   JOURNAL OF AUTOIMMUNITY

The Role of IL-23/IL-17 Axis in Lupus Nephritis

(2009) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Activation of Mammalian Target of Rapamycin Controls the Loss of TCR  in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation

(2009) D. R. Fernandez et al.   JOURNAL OF IMMUNOLOGY

Mycophenolate Mofetil versus Cyclophosphamide for Induction Treatment of Lupus Nephritis

(2009) G. B. Appel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Very long-term outcome of pure lupus membranous nephropathy treated with glucocorticoid and azathioprine

(2009) CC Mok et al.   LUPUS

An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept in patients with systemic lupus erythematosus

(2009) C Pena-Rossi et al.   LUPUS

Rituximab in systemic lupus erythematosusA systematic review of off-label use in 188 cases

(2009) M Ramos-Casals et al.   LUPUS

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

(2009) J. Y. Humrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of race/ethnicity on response to lupus nephritis treatment: the ALMS study

(2009) David Isenberg et al.   RHEUMATOLOGY

Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review

(2008) G Ruiz-Irastorza et al.   ANNALS OF THE RHEUMATIC DISEASES

Dose-related patterns of glucocorticoid-induced side effects

(2008) D Huscher et al.   ANNALS OF THE RHEUMATIC DISEASES

Abetimus sodium for renal flare in systemic lupus erythematosus: Results of a randomized, controlled phase III trial

(2008) Mario H. Cardiel et al.   ARTHRITIS AND RHEUMATISM

Steroid-sparing effects of methotrexate in systemic lupus erythematosus: A double-blind, randomized, placebo-controlled trial

(2008) Paul R. Fortin et al.   ARTHRITIS AND RHEUMATISM

The effect of anti-CD40 ligand in immune thrombocytopenic purpura

(2008) Vivek L. Patel et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity

(2008) Chun Kwok Wong et al.   CLINICAL IMMUNOLOGY

Clinical pharmacology and pharmacogenetics of thiopurines

(2008) Srikumar Sahasranaman et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus

(2008) Damien Chaussabel et al.   IMMUNITY

The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice

(2008) Christopher M. Reilly et al.   JOURNAL OF AUTOIMMUNITY

Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice

(2008) SL Lui et al.   LUPUS

Cyclosporine (CsA) in lupus nephritis: assessing the evidence

(2008) G. Moroni et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mycophenolate Mofetil: Ten Years' Experience of a Renal Transplant Unit

(2008) S. Jorge et al.   TRANSPLANTATION PROCEEDINGS