Journal
SKELETAL BIOLOGY AND MEDICINE I
Volume 1237, Issue -, Pages 11-18Publisher
BLACKWELL SCIENCE PUBL
DOI: 10.1111/j.1749-6632.2011.06197.x
Keywords
ATF4; FIAT; alpha NAC; osteoblast; transcription
Categories
Funding
- Shriners of North America
- Network for Oral and Bone Health Research
- U.S. National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR53287]
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Osteoblast-specific gene transcription requires interaction between bone cell-specific transcription factors and more widely expressed transcriptional regulators. This is particularly evident for the basic domain-leucine zipper factor activating transcription factor 4 (ATF4), whose activity can be enhanced or inhibited through interaction with other leucine zipper proteins, intermediate filament proteins, components of the basic transcriptional machinery, nuclear matrix attachment molecules, or ubiquitously expressed transcription factors. We discuss the results supporting the relevance of these interactions and present the first evidence of a functional interaction between ATF4, FIAT (factor-inhibiting ATF4-mediated transcription), and alpha NAC (nascent polypeptide-associated complex and coactivator alpha), three proteins that have been previously shown to associate using various protein-protein interaction assays.
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