☆ 4.7 Article Proceedings Paper

Reflex conditioning: a new strategy for improving motor function after spinal cord injury

DISCOVERIES IN SPINAL CORD INJURY RESEARCH: FROM BENCH TO BEDSIDE (2010)

Journal

DISCOVERIES IN SPINAL CORD INJURY RESEARCH: FROM BENCH TO BEDSIDE

Volume 1198, Issue S1, Pages E12-E21

Publisher

WILEY-BLACKWELL

DOI: 10.1111/j.1749-6632.2010.05565.x

Keywords

spinal cord injury; reflex conditioning; plasticity; H-reflex; learning and memory; locomotion; rehabilitation

Categories

Multidisciplinary Sciences Clinical Neurology Rehabilitation

Funding

New York State Spinal Cord Injury Trust Fund
National Institutes of Health [HD36020, NS061823, NS22189]
Christopher Reeve Paralysis Foundation
International Spinal Research Trust
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD036020] Funding Source: NIH RePORTER
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS061823, R01NS022189] Funding Source: NIH RePORTER

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Abstract

Spinal reflex conditioning changes reflex size, induces spinal cord plasticity, and modifies locomotion. Appropriate reflex conditioning can improve walking in rats after spinal cord injury (SCI). Reflex conditioning offers a new therapeutic strategy for restoring function in people with SCI. This approach can address the specific deficits of individuals with SCI by targeting specific reflex pathways for increased or decreased responsiveness. In addition, once clinically significant regeneration can be achieved, reflex conditioning could provide a means of reeducating the newly (and probably imperfectly) reconnected spinal cord.

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