Article
Endocrinology & Metabolism
Sarah M. Gray, Andrew L. Hoselton, Radha Krishna, Cris A. Slentz, David A. D'Alessio
Summary: GLP-1r signaling contributes to insulin secretion during alpha-cell activation, independent of increased circulating GLP-1, and may be affected by DPP4 inhibition.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Neil Tanday, Peter R. Flatt, Nigel Irwin
Summary: GLP-1, as an important incretin hormone, has made significant progress in drug development and clinical application, offering a wide range of metabolic benefits. With the clinical approval and continuous evolution of GLP-1 receptor ligands, it is expected that GLP-1 has great potential in treating diseases beyond diabetes and obesity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yibo Zong, Wenjing Chen, Yongsen Zhao, Xiaoyi Suo, Xiaojing Yang
Summary: In this study, a model of Salmonella-infected piglets was established to investigate the effects of Salmonella infection on enteroendocrine L cell function. The results showed that Salmonella infection can reduce GLP-1 secretion by inducing pyroptosis of intestinal L cells, which may eventually result in hyperglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bo Ahren
Summary: In this study, the contribution of GIP and GLP-1 to insulin response to oral glucose in female mice was investigated using receptor antagonists. It was found that both GIP and GLP-1 are required for a normal incretin effect in female mice, and no other incretin hormone is likely present in this species.
Article
Biochemistry & Molecular Biology
Seung-Hyeon Lee, Hyun Min Ko, Wona Jee, Hyungsuk Kim, Won-Seok Chung, Hyeung-Jin Jang
Summary: Bitter taste receptors (TAS2Rs) are potential therapeutic targets that may play a role in various organs. The agonist isosinensetin (ISS) can activate hTAS2R50 and stimulate Glucagon-like peptide 1 (GLP-1) secretion. This activation occurs through the G(beta gamma)-mediated pathway and is PLC-dependent, suggesting the possibility of using ISS as a therapeutic agent for diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Michael A. Nauck, Daniel R. Quast, Jakob Wefers, Andreas F. H. Pfeiffer
Summary: Incretin hormones GIP and GLP-1 play a significant role in insulin secretion and glucose tolerance in the gut-endocrine pancreas axis. They also have additional effects on bone remodelling, lipid storage, gastric emptying, and may provide benefits for cardiovascular complications and neurodegenerative disorders. Recent research on GIP/GLP-1 receptor co-agonists has renewed interest in the potential therapeutic applications of incretin hormones.
DIABETES OBESITY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Kok-Hou Lok, Nicholas J. Wareham, Rajesh Sreedharan Nair, Chee Wun How, Lay-Hong Chuah
Summary: This paper discusses the expression of enteroendocrine L-cell hormones, nutrient-sensing mechanisms, and other physiological characteristics in patients with type 2 diabetes, explores L-cell targeted therapies, and provides a new direction for T2DM treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Psychiatry
Daniel H. Cooper, Ranuk Ramachandra, Felicia Ceban, Joshua D. Di Vincenzo, Taeho Greg Rhee, Rodrigo B. Mansur, Kayla M. Teopiz, Hartej Gill, Roger Ho, Bing Cao, Leanna M. W. Lui, Muhammad Youshay Jawad, Juliet Arsenault, Gia Han Le, Diluk Ramachandra, Ziji Guo, Roger S. McIntyre
Summary: This study aimed to investigate whether GLP-1 receptor agonists can be used prophylactically to lower the risk of incident depression in patients with diabetes mellitus (DM). The results showed mixed findings regarding the effect of GLP-1 receptor agonists on lowering the risk of incident depression. Further research is needed to better understand the potential neuroprotective effects of GLP-1 receptor agonists on depression in patients with DM.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ting-Ting Huang, Pan-Pan Gu, Ting Zheng, Ling-Shan Gou, Yao-Wu Liu
Summary: The study found that piperine could promote GLP-1 secretion in Caco-2 cells through the activation of TAS2R14 signaling, suggesting TAS2R14 as a potential target for alleviating metabolic diseases.
Review
Food Science & Technology
Yanan Wang, Ruixuan Geng, Yuhan Zhao, Jingjing Fang, Mengjie Li, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: Odorant receptors and taste receptors are expressed in the nose and tongue, and now it is discovered that they are also present in the gut cells. Gut cells sense dietary components through chemoreceptors and regulate hormonal secretion to maintain physiological homeostasis. The understanding of how gut receptors respond to dietary components can lead to potential treatments for various human diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Neurosciences
Elena von Molitor, Katja Riedel, Michael Krohn, Mathias Hafner, Rudiger Rudolf, Tiziana Cesetti
Summary: This paper reviews the milestone discovery of the sweet taste receptor 20 years ago and discusses the major findings of the canonical sweet taste pathway. It also focuses on molecular details and the existence of an alternative sugar sensing pathway independent of the sweet taste receptor.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Immunology
Syed Faizan Mehdi, Suma Pusapati, Muhammad Saad Anwar, Durga Lohana, Parkash Kumar, Savitri Aninditha Nandula, Fatima Kausar Nawaz, Kevin Tracey, Huan Yang, Derek LeRoith, Michael J. Brownstein, Jesse Roth
Summary: Inflammation is involved in many chronic conditions and stimulates the release of pro-inflammatory cytokines and immune cells. GLP-1 levels are associated with disease severity and can serve as markers of inflammation. Previous studies have investigated the anti-inflammatory properties of oxytocin, hCG, ghrelin, alpha-MSH and ACTH, while the anti-inflammatory effects of GLP-1 have only recently been recognized. GLP-1 has been shown to be beneficial in treating type-2 diabetes, metabolic syndrome, and hyperglycemia by reducing inflammation and cell death.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Nikolaus Marx, Mansoor Husain, Michael Lehrke, Subodh Verma, Naveed Sattar
Summary: Multiple large cardiovascular outcome trials have shown that SGLT2 inhibitors and GLP-1 receptor agonists significantly reduce cardiovascular disease risk in patients with type 2 diabetes, including major adverse cardiovascular events and heart failure. These drugs have received strong recommendations in diabetes and cardiology guidelines, but their usage remains low.
Article
Multidisciplinary Sciences
Tomonobu Hatoko, Norio Harada, Shinsuke Tokumoto, Shunsuke Yamane, Eri Ikeguchi-Ogura, Tomoko Kato, Takuma Yasuda, Hisato Tatsuoka, Satoko Shimazu-Kuwahara, Daisuke Yabe, Yoshitaka Hayashi, Nobuya Inagaki
Summary: The study evaluated intestinal morphology and cells, including incretin-producing cells, in reporter mice using optical tissue clearing for three-dimensional imaging. The results provided important insights into the detailed intestinal structure and the localization and number of specific cells.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Manfredi Rizzo, Andrej Janez
Summary: GLP-1 is involved in taste perception, particularly in sweet taste, through its interaction with GLP-1 receptors in taste bud cells and nerves. While the impact of GLP-1-based therapies on gustatory coding in humans remains largely unaddressed, further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies is encouraged. Pharmacological manipulation of gustatory coding may present a new potential strategy against obesity and diabetes, highlighting the topic's clinical relevance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Pu Feng, Jinghua Chai, Huilan Yi, Kevin Redding, Robert F. Margolskee, Liquan Huang, Hong Wang
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Neurosciences
Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Robert F. Margolskee, Noriatsu Shigemura, Yuzo Ninomiya
Article
Multidisciplinary Sciences
Weiwei Lei, Wenwen Ren, Makoto Ohmoto, Joseph F. Urban, Ichiro Matsumoto, Robert F. Margolskee, Peihua Jiang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Genetics & Heredity
Yumei Qin, Sunil K. Sukumaran, Masafumi Jyotaki, Kevin Redding, Peihua Jiang, Robert F. Margolskee
Article
Multidisciplinary Sciences
Ya-Wen Du, Qun Liu, Xiao-Cui Luo, Dong-Xiao Zhao, Jian-Bo Xue, Pu Feng, Robert F. Margolskee, Hong Wang, Liquan Huang
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Behavioral Sciences
Yi Wang, Amanda L. Zajac, Weiwei Lei, Carol M. Christensen, Robert F. Margolskee, Cedric Bouysset, Jerome Golebiowski, Huabin Zhao, Sebastien Fiorucci, Peihua Jiang
Article
Multidisciplinary Sciences
Shingo Takai, Yu Watanabe, Keisuke Sanematsu, Ryusuke Yoshida, Robert F. Margolskee, Peihua Jiang, Ikiru Atsuta, Kiyoshi Koyano, Yuzo Ninomiya, Noriatsu Shigemura
Article
Multidisciplinary Sciences
Xin Zheng, Marco Tizzano, Kevin Redding, Jinzhi He, Xian Peng, Peihua Jiang, Xin Xu, Xuedong Zhou, Robert F. Margolskee
NATURE COMMUNICATIONS
(2019)
Article
Behavioral Sciences
Shan Feng, Leyitha Achoute, Robert F. Margolskee, Peihua Jiang, Hong Wang
Article
Physiology
Keiko Yasumatsu, Tadahiro Ohkuri, Ryusuke Yoshida, Shusuke Iwata, Robert F. Margolskee, Yuzo Ninomiya
Article
Gastroenterology & Hepatology
Megan T. Hoffman, Samantha B. Kemp, Daniel J. Salas-Escabillas, Yaqing Zhang, Nina G. Steele, Stephanie The, Daniel Long, Simone Benitz, Wei Yan, Robert F. Margolskee, Filip Bednar, Marina Pasca di Magliano, Hui-Ju Wen, Howard C. Crawford
Summary: This study demonstrates that inhibiting GNAT3 can increase the release of tumor-promoting cytokines, alter the MDSC population, and promote the progression of metastatic PDA.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaoli Lin, Chanyi Lu, Makoto Ohmoto, Katarzyna Choma, Robert F. Margolskee, Ichiro Matsumoto, Peihua Jiang
Summary: The neuron-supplied niche factor, R-spondin-2, plays a crucial role in taste bud cell regeneration and maintenance by promoting the generation of differentiated taste cells. It can substitute for neuronal input to maintain taste bud cells and tissues. The absence of R-spondin in culture medium inhibits the generation of taste bud cells ex vivo.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Developmental Biology
Yumei Qin, Sunil K. Sukumaran, Robert F. Margolskee
Summary: In mammals, the transcription factor Nkx2-2 plays a crucial role in the development of the taste system, specifically in type III taste cells; Nkx2-2 is expressed in endoderm-derived taste papillae and cells expressing Nkx2-2 differentiate into type III taste cells; Nkx2-2-expressing cells are committed to the type III lineage in the posterior tongue, indicating a key difference in cell lineage specification between ectoderm- and endoderm-derived taste fields.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Toshiaki Yasuo, G. Craig Wood, Xin Chu, Peter Benotti, Christopher D. Still, David D. K. Rolston, Robert F. Margolskee, Yuzo Ninomiya, Peihua Jiang
Summary: This study shows that taste-signaling proteins are dysregulated in the jejunal tissues of patients with extreme obesity, suggesting their involvement in obesity.
JOURNAL OF ORAL BIOSCIENCES
(2022)
Article
Biology
Nanako Atsumi, Keiko Yasumatsu, Yuriko Takashina, Chiaki Ito, Norihisa Yasui, Robert F. Margolskee, Atsuko Yamashita
Summary: The perception of salt taste is complex, with NaCl at low and high concentrations being preferentially or aversively perceived through different pathways. Cl- is believed to participate in taste sensation through an unknown mechanism. This study found that Cl- ions specifically bind to the ligand-binding domain (LBD) of taste receptor type 1 (T1r), inducing a conformational change in the receptor. The oral application of Cl- to mice increased the activity of taste nerves connected to T1r-expressing taste cells and influenced their behavioral preferences, which could be attenuated by blocking T1r or knocking out T1r3.