Article
Biology
Kyung Soo Kim, Il-Youp Kwak, Hyun Jin Min
Summary: This study aimed to evaluate the PEA-based sniffing bead test as a screening tool for olfactory dysfunction. Significant correlations were found between the PEA bead test and conventional psychophysical olfactory function testing. The PEA bead test showed high sensitivity and specificity for discriminating olfactory dysfunction. These results suggest that the PEA bead test could be a valuable screening tool for olfactory dysfunction.
Article
Otorhinolaryngology
T. Hummel, N. Power Guerra, N. Gunder, A. Haehner, S. Menzel
Summary: The sense of smell is crucial for human beings, as it warns us of danger and enhances our quality of life through perceiving flavors. Olfactory disorders have diverse causes and require thorough diagnosis and treatment options. Olfactory training and drug therapies are effective, and communication with patients is paramount.
LARYNGO-RHINO-OTOLOGIE
(2023)
Article
Behavioral Sciences
Valentina Parma, Mackenzie E. Hannum, Maureen O'Leary, Robert Pellegrino, Nancy E. Rawson, Danielle R. Reed, Pamela H. Dalton
Summary: The SCENTinel 1.0 test, which evaluates three olfactory functions rapidly, demonstrates a high accuracy in discriminating individuals with smell loss. It shows potential for practical clinical applications, including COVID-19 symptom screening.
Article
Behavioral Sciences
Valentina Parma, Mackenzie E. Hannum, Maureen O'Leary, Robert Pellegrino, Nancy E. Rawson, Danielle R. Reed, Pamela H. Dalton
Summary: The SCENTinel 1.0 test, which evaluates olfactory functions rapidly, shows excellent performance in normosmic individuals and can accurately discriminate individuals with smell loss, potentially useful in clinical situations such as COVID-19 symptom screening.
Article
Multidisciplinary Sciences
Michael Z. Khan, Alejandra Mondino, Katharine Russell, Beth Case, Gilad Fefer, Hope Woods, Natasha Olby, Margaret Gruen
Summary: This study explores the changes in canine olfaction by using a novel test involving hidden food treat and spontaneous behaviors. The results show that senior/geriatric dogs perform worse in the dark-phase but still above chance, while control dogs perform better. In addition, a positive correlation is found between performance in the dark-phase and cognitive decline based on an owner questionnaire.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Robert Pellegrino, Joel D. Mainland, Christine E. Kelly, Jane K. Parker, Thomas Hummel
Summary: Odor distortions such as parosmia and phantosmia are common among individuals with reduced odor sensitivity, affecting their quality of life. Parosmia tends to be more severe than phantosmia and has distinct patterns in demographics, medical history, and impact on quality of life.
Article
Otorhinolaryngology
Sophie S. Jang, Janet S. Choi, James H. Kim, Natalie Kim, Elisabeth H. Ference
Summary: The study found that the majority of participants correctly classified impairment of smell and taste, with older age associated with underreporting smell impairment. Persistent cold symptoms were linked to overreporting smell impairment. However, no factors were associated with under- or overreporting of taste impairment.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Medicine, Research & Experimental
David T. Liu, Maha Sabha, Michael Damm, Carl Philpott, Anna Oleszkiewicz, Antje Haehner, Thomas Hummel
Summary: The study found that the presence of parosmia is associated with clinically relevant recovery in olfactory discrimination and identification function in patients with PIOD receiving olfactory training, with patients who have lower baseline olfactory function being more likely to show significant improvements.
Article
Radiology, Nuclear Medicine & Medical Imaging
Duzgun Yildirim, Sedat Giray Kandemirli, Deniz Esin Tekcan Sanli, Ozlem Akinci, Aytug Altundag
Summary: This study evaluated the imaging findings of COVID-19 related anosmia and compared them with post-infectious anosmia. The results showed significantly higher olfactory bulb volumes in COVID-19 related anosmia patients compared to post-infectious anosmia patients, which may be related to differences in central olfactory system damage.
ACADEMIC RADIOLOGY
(2022)
Article
Otorhinolaryngology
P. Dorig, N. Gunder, M. Witt, A. Welge-Lussen, T. Hummel
Summary: Olfactory disorders can be temporary or permanent and have various causes. Many COVID-19 patients currently experience reduced or complete loss of olfactory function. Treatment options investigated in the past include olfactory training, acupuncture, medical therapy, transcranial magnetic stimulation, and surgical excision of olfactory epithelium. Future treatments may involve the development of a bioelectric nose, utilizing direct electrical stimulation or transplantation of olfactory epithelium or stem cells.
Review
Otorhinolaryngology
N. Gunder, P. Dorig, M. Witt, A. Welge-Lussen, S. Menzel, T. Hummel
Summary: Olfactory disorders, whether temporary or permanent, can occur due to various reasons. COVID-19 patients frequently experience a decreased or complete loss of the sense of smell. Different treatment options, including olfactory training, acupuncture, medication, transcranial magnetic stimulation, and surgical removal of olfactory epithelium, have been explored in the past. The future may involve the development of a bioelectric nose, which could be achieved through direct electrical stimulation or transplantation of olfactory epithelium or stem cells. This paper discusses the foundations and current knowledge of these advancements.
Article
Food Science & Technology
Elisabeth M. Weir, Danielle R. Reed, M. Yanina Pepino, Maria G. Veldhuizen, John E. Hayes
Summary: This article describes the establishment of the Global Consortium of Chemosensory Research (GCCR), the tools and approaches used, and the findings to date. The study provides insights into chemosensation and COVID-19, including potential mechanisms of loss. Additionally, it discusses in detail the current Open Science approaches and practices used by the GCCR to enhance transparency, rigor, and reproducibility.
FOOD QUALITY AND PREFERENCE
(2022)
Article
Otorhinolaryngology
Ben Chen, Cara Benzien, Vanda Faria, Yuping Ning, Mandy Cuevas, Jana Linke, Ilona Croy, Antje Haehner, Thomas Hummel
Summary: This study aimed to investigate the impact of different types, severity, duration, or causes of chemosensory dysfunction on symptoms of depression. Results showed that patients with mixed olfactory/gustatory dysfunction had the highest depression scores, and anosmia patients exhibited more severe depression symptoms. Multiple linear regression analyses indicated a negative correlation between reduced olfactory function and depression symptoms.
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Alessandra Morano, Emanuele Cerulli Irelli, Martina Fanella, Biagio Orlando, Enrico Michele Salamone, Emanuele Tinelli, Gabriele Ruffolo, Luigi Zuliani, Jinane Fattouch, Mario Manfredi, Anna Teresa Giallonardo, Carlo Di Bonaventura
Summary: This study investigated olfaction in a population of patients with autoimmune encephalitis (AE). It found that a significant proportion of AE cases had impaired olfaction, and this appeared to be more common in patients with severe AE, suggesting that olfactory deficits may be an additional feature of immune-mediated encephalitis.
JOURNAL OF NEUROLOGY
(2022)
Article
Otorhinolaryngology
Bo Yoon Choi, Hamin Jeong, Haemin Noh, Joon Yong Park, Jae Hoon Cho, Jin Kook Kim
Summary: This study demonstrated the efficacy of olfactory training (OT) in postinfectious olfactory dysfunction (PIOD) patients using odorants familiar to Koreans and including a control group. OT improved olfactory function in approximately 40% of patients over 12 weeks, with the OT group showing significantly better results in olfactory tests compared to the non-OT group.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2021)
Article
Neurosciences
Nouhaila Bouguiyoud, Florence Roullet, Gilles Bronchti, Johannes Frasnelli, Syrina Al Ain
Summary: This study using a mouse model found that early visual deprivation can lower anxiety levels and lead to increased exploratory behavior, but it does not induce depressive symptoms.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Gozde Filiz, Daphnee Poupon, Sarah Banks, Pauline Fernandez, Johannes Frasnelli
Summary: Brain plasticity is crucial for experts to acquire necessary abilities. In this study, a longitudinal design was used to investigate the brain plasticity of sommelier students. It was found that the volume of the olfactory bulb increased in sommelier students, while there were no significant changes in cortical thickness and olfactory performance. This is the first longitudinal study to report the effects of training-related brain plasticity on the olfactory bulb volume in olfaction experts.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Antje Haehner, Gudrun Gossrau, Franziska Bock, Thomas Hummel, Emilia Iannilli
Summary: This study investigates the alterations in trigeminal activation in migraine using EEG-derived event-related potentials (ERP). The results reveal changes in trigeminal-sensory response patterns in different brain regions in migraine patients, which are correlated with clinical characteristics and disease duration. The study also identifies specific trigeminal responses in patients with aura. These findings suggest the presence of dysfunctional central pain processing in migraine and indicate that EEG patterns can serve as biomarkers for the condition.
Article
Otorhinolaryngology
Simon Berube, Claudia Demers, Nicholas Bussiere, Frank Cloutier, Valerie Pek, Angela Chen, Josiane Bolduc-Begin, Johannes Frasnelli
Summary: Olfactory training (OT) shows subjective improvement in post-COVID-19 olfactory dysfunction, but no significant effect on objective olfactory function. OT also reduces the frequency of parosmia.
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY
(2023)
Article
Behavioral Sciences
Mary Lou Smith, Gail Risse, Viviane Sziklas, Sarah Banks, Dana Small, Johannes Frasnelli, Denise Klein
Summary: This article summarizes selected presentations from a session held to honor the work of Dr. Marilyn Jones-Gotman, focusing on cognition and sensory systems in healthy and diseased subjects. The session presented research on epilepsy and sensory systems by colleagues and former trainees of Dr. Jones-Gotman. The extended summaries provide an overview of historical and current work in the neuropsychology of epilepsy, brain organization, sex differences in neurological disorders, dietary influences on brain function, and olfactory training and language experiences.
EPILEPSY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Benoit Jobin, Frederique Roy-Cote, Johannes Frasnelli, Benjamin Boller
Summary: Olfactory identification and detection threshold are associated with declarative memory in older adults, and age moderates the relationship between olfactory detection threshold and memory performance.
Article
Medicine, General & Internal
Martin Bendszus, Jens Fiehler, Fabien Subtil, Susanne Bonekamp, Anne Hege Aamodt, Blanca Fuentes, Elke R. Gizewski, Michael D. Hill, Antonin Krajina, Laurent Pierot, Claus Z. Simonsen, Kamil Zelenak, Rolf A. Blauenfeldt, Bastian Cheng, Angelique Denis, Hannes Deutschmann, Franziska Dorn, Fabian Flottmann, Susanne Gellissen, Johannes C. Gerber, Mayank Goyal, Jozef Haring, Christian Herweh, Silke Hopf-Jensen, Vi Tuan Hua, Maerit Jensen, Andreas Kastrup, Christiane Fee Keil, Andrej Klepanec, Egon Kurca, Ronni Mikkelsen, Markus Moehlenbruch, Stefan Mueller-Huelsbeck, Nico Muennich, Paolo Pagano, Panagiotis Papanagiotou, Gabor C. Petzold, Mirko Pham, Volker Puetz, Jan Raupach, Gernot Reimann, Peter Arthur Ringleb, Maximilian Schell, Eckhard Schlemm, Silvia Schoenenberger, Bjorn Tennoe, Christian Ulfert, Katerina Valis, Eva Vitkova, Dominik F. Vollherbst, Wolfgang Wick, Goetz Thomalla
Summary: Endovascular thrombectomy is associated with improved functional outcome and lower mortality in patients with acute ischemic stroke from large vessel occlusion using non-contrast CT as the primary imaging modality for patient selection.
Article
Clinical Neurology
Daniel P. O. Kaiser, Tilman Reiff, Ulrich Mansmann, Daniela Schoene, Davide Strambo, Patrik Michel, Mohamad Abdalkader, Thanh N. Nguyen, Matthias Gawlitza, Markus A. Moehlenbruch, Peter A. Ringleb, Volker Puetz, Johannes C. Gerber, Simon Nagel
Summary: This study compared the clinical and safety outcomes of best medical treatment (BMT) versus EVT + BMT in patients with stroke due to isolated occlusion of the internal carotid artery (ICA). Although the benefit on functional outcome did not reach statistical significance, the results for NIHSS score improvement and safety support the use of EVT in patients with stroke due to isolated ICA occlusion.
CLINICAL NEURORADIOLOGY
(2023)
Meeting Abstract
Behavioral Sciences
Simon Berube, Claudia Demers, Valerie Pek, Angela Chen, Nicholas Bussiere, Frank Cloutier, Gozde Filiz, Josiane Begin-Bolduc, Johannes Frasnelli
Meeting Abstract
Behavioral Sciences
Nouhaila Bouguiyoud, Giles Bronchti, Daniel Galino, Mallar Chakravarty, Johannes Frasnelli, Syrina Al Ain
Meeting Abstract
Behavioral Sciences
Sarah Brosse, Cecilia Tremblay, Ines Merida, Johannes Frasnelli
Meeting Abstract
Behavioral Sciences
Nicholas Bussiere, Jie Mei, Mathieu Blais, Sara Carazo, Francois Gros-Louis, Gaston De Serres, Nicolas Dupre, Johannes Frasnelli
Article
Health Care Sciences & Services
Kevin Hadrich, Pawel Krukowski, Jessica Barlinn, Matthias Gawlitza, Johannes C. Gerber, Volker Puetz, Jennifer Linn, Daniel P. O. Kaiser
Summary: This study aimed to identify factors contributing to delays in the management of stroke patients transferred from primary hospitals to a comprehensive stroke center for endovascular therapy. The findings revealed that longer transfer time, greater transfer distance, and the use of general anesthesia were independently associated with delayed treatment. By assessing the processes and times involved in patient transfers, potentially modifiable factors for improving the workflow of stroke patients can be identified.
Article
Behavioral Sciences
Nicholas Bussiere, Jie Mei, Cindy Levesque-Boissonneault, Mathieu Blais, Sara Carazo, Francois Gros-Louis, Robert Laforce, Gaston De Serres, Nicolas Dupre, Johannes Frasnelli
Summary: This study found that olfactory and gustatory dysfunctions persist in about a third of COVID-19 patients 11 months after the infection. Olfactory dysfunction appears to be a common symptom post-COVID-19 and should be considered when treating patients.
Meeting Abstract
Neurosciences
Olivier Fortier-Lebel, Benoit Jobin, Fanny Lecuyer-Giguere, Malo Gaubert, Jean-Francois Giguere, Jean-Francois Gagnon, Benjamin Boller, Johannes Frasnelli