4.7 Article Proceedings Paper

APRP, the Second Peptide Encoded by the Adipokinetic Hormone Gene(s), Is Highly Conserved in Evolution A Role in Control of Ecdysteroidogenesis?

Journal

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY
Volume 1163, Issue -, Pages 376-378

Publisher

BLACKWELL PUBLISHING
DOI: 10.1111/j.1749-6632.2008.03638.x

Keywords

adipokinetic peptides; APRP; insects; (small) PTTH; ecdysone; larval gonads; Locusta migratoria; sex hormones

Funding

  1. Fonds voor Wetenschappelijk Onderzoek (FWO)
  2. Instituut voor Innovatic door Wetenschap en Technologic (IWT)
  3. Onderzoeksfonds of the K.U. Leuven (Geconcerteerde Onderzoeksacties (GOA))
  4. EC
  5. JH
  6. SJH

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Since the early days of cloning the first adipokinetic hormone (AKH) gene, researchers recognized that this gene also codes for a joining region and for a second peptide called adipokinetic hormone precursor related peptide (APRP). In species with more than one AKH gene, such as locusts, APRPs can form both homodimers and heterodimers. Database analysis showed that APRPs might belong to the ancient family of growth hormone releasing factor but they still are functionally orphan. We investigated whether some of the APRP forms play a role in control of reproduction or/and growth via stimulation of ecdysteroidogenesis.

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