Journal
MOLECULAR STRUCTURE AND FUNCTION OF THE TIGHT JUNCTION: FROM BASIC MECHANISMS TO CLINICAL MANIFESTATIONS
Volume 1165, Issue -, Pages 53-57Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.04023.x
Keywords
tight junction; claudin; paracellular; ion channel; cation selectivity
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Funding
- NIDDK NIH HHS [DK062283] Funding Source: Medline
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Claudius are transmembrane tight junction proteins that form paracellular pores. Claudius regulate the permeability of small inorganic ions and are selective on the basis of charge. We have developed an inducible expression system to measure the permeability of claudin-2 and have found that claudin-2 forms highly cation-selective paracellular pores. The basis of this charge selectivity is likely to be the presence of a negatively charged binding site within the lumen of the pore. This may be a general mechanism by which claudins achieve selectivity.
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