Journal
CONTEMPORARY CHALLENGES IN AUTOIMMUNITY
Volume 1173, Issue -, Pages 378-383Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1749-6632.2009.04760.x
Keywords
Sjogren's syndrome; salivary gland; SSA and SSB antibodies; T cells; sex differences; IL-17; Th17; BAFF; NOD.H2(h4) mouse
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Sex differences in a NOD.H2(h4) murine model of Sjogren's syndrome were analyzed. Compared to males, female NOD.H2(h4) mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4(+) T cells in salivary gland infiltrates. CD4(+) T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sjogren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.
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