Editorial Material
Plant Sciences
Guangyuan Xu, Xiangzong Meng, Daolong Dou
Summary: BIK1 plays a central role in plant immunity, with its ubiquitination state determining the strength of immune signaling.
TRENDS IN PLANT SCIENCE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Marta Bjornson, Cyril Zipfel
Summary: Plant immunity has traditionally been divided into two tiers, but recent research shows that both cell-surface and intracellular immune receptors are needed for maximum immune response.
Article
Biochemistry & Molecular Biology
Anja Hofmann, Frieda Frank, Steffen Wolk, Albert Busch, Anna Klimova, Pamela Sabarstinski, Michael Gerlach, Dmitry Egorov, Irakli Kopaliani, Sonke Weinert, Bianca Hamann, David M. Poitz, Coy Brunssen, Henning Morawietz, Katrin Schroder, Christian Reeps
Summary: The study found that low NOX4 mRNA expression is associated with an increased risk for symptomatic carotid artery stenosis and reduced plaque stabilizing mechanisms, suggesting protective effects of NOX4 in human advanced atherosclerosis.
Editorial Material
Microbiology
Lei Li
Summary: In the past two decades, there have been exciting developments in the field of plant immunity, and the author's three publications in Cell Host & Microbe have provided a new perspective on future research in the area.
CELL HOST & MICROBE
(2022)
Article
Neurosciences
Shaunik Sharma, Steven Carlson, Adriana Gregory-Flores, Andy Hinojo-Perez, Ashley Olson, Thimmasettappa Thippeswamy
Summary: The study demonstrated that the Fyn/Src tyrosine kinase inhibitor SAR had a significant disease-modifying effect in the rat TLE model, reducing seizures and epileptiform spikes while modulating neuroinflammation and oxidative stress response.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Hematology
Sahra Amel Belambri, Viviana Marzaioli, Margarita Hurtado-Nedelec, Coralie Pintard, Shiyu Liang, Yezhou Liu, Tarek Boussetta, Marie-Anne Gougerot-Pocidalo, Richard D. Ye, Pham My-Chan Dang, Jamel El-Benna
Summary: This study discovered that p67phox and p40phox are novel regulators of p47phox phosphorylation at specific sites, which is essential for superoxide production by phagocytes and immune response.
Article
Cell Biology
Feng-Liu Wang, Ya-Lan Tan, Lukas Wallrad, Xin-Qiao Du, Anna Eickelkamp, Zhi-Fang Wang, Ge-Feng He, Felix Rehms, Zhen Li, Jian-Pu Han, Ina Schmitz-Thom, Wei-Hua Wu, Joerg Kudla, Yi Wang
Summary: The mechanisms underlying plant K+ sensing and downstream responses have been revealed in this study, showing a defined K+ sensing niche and a low-K+ signaling axis that trigger ROS signals and related pathways. These mechanisms coordinate plant growth and development while regulating nutrient uptake by roots.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Bruno Pok Man Ngou, Hee-Kyung Ahn, Pingtao Ding, Jonathan D. G. Jones
Summary: Research shows that intracellular receptors and cell-surface receptors in plant immunity interact and enhance each other to activate strong defense mechanisms against pathogens. The immune system of plant cells plays a crucial role in pathogen recognition and the activation of proteins.
Review
Biochemistry & Molecular Biology
Misbah Hussain, Wajiha Ikram, Usama Ikram
Summary: Oxidative stress affects the redox state of various target proteins, including tyrosine kinases, mitogen-activated protein kinases, and tyrosine phosphatases. c-Src is a non-receptor tyrosine kinase that can activate NADPH oxidases in response to different stimuli. The interaction between c-Src and Noxs is influenced by cell type and primary messengers. Additionally, c-Src and ROS have a bidirectional relationship in the pathobiology of cardiac fibrosis.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Pharmacology & Pharmacy
Cheng-Zhe Wu, Xiang Li, Lan Hong, Zhuo-Na Han, Ying Liu, Cheng-Xi Wei, Xun Cui
Summary: NOX4 modulated by ET-1 regulates ANP secretion by activating ERK1/2 and Akt/GATA4 signaling in isolated beating rat hypoxic atria.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiashu Chu, Isabel Monte, Thomas A. DeFalco, Philipp Koster, Paul Derbyshire, Frank L. H. Menke, Cyril Zipfel
Summary: In this study, the researchers discovered that MpRBOH1 and MpPBLa, single members of the RBOH and PBL families in the liverwort Marchantia polymorpha, are essential for chitin-induced ROS production. MpPBLa directly interacts with and phosphorylates MpRBOH1, and this phosphorylation is crucial for chitin-induced ROS production mediated by MpRBOH1.
Article
Biology
Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans
Summary: This study reveals that LBK1 is a critical regulator of carotid body chemosensing, highlighting a difference in dependency on LKB1 and AMPK between the carotid body and the hypoxic ventilatory response.
COMMUNICATIONS BIOLOGY
(2022)
Article
Plant Sciences
Dominique Arnaud, Michael J. Deeks, Nicholas Smirnoff
Summary: Reactive oxygen species are generated in plants in response to pathogens and pathogen-associated molecular patterns. Using biosensors, researchers observed oxidative events in various cell compartments during the immune response to flg22 and Pseudomonas syringae. The oxidative burst in the cytosol is partially suppressed by bacterial effectors, while the extracellular oxidative burst requires the involvement of NADPH oxidase and specific signaling components.
Article
Biochemistry & Molecular Biology
Mingjun Gao, Yang He, Xin Yin, Xiangbin Zhong, Bingxiao Yan, Yue Wu, Jin Chen, Xiaoyuan Li, Keran Zhai, Yifeng Huang, Xiangyu Gong, Huizhong Chang, Shenghan Xie, Jiyun Liu, Jiaxing Yue, Jianlong Xu, Guiquan Zhang, Yiwen Deng, Ertao Wang, Didier Tharreau, Guo-Liang Wang, Weibing Yang, Zuhua He
Summary: The discovery of a conserved immune suppression network in cereals centered on the Ca2+-sensor ROD1 is significant in understanding how plants fine-tune immune homeostasis. ROD1 promotes reactive oxygen species scavenging and its disruption confers resistance to multiple pathogens. The fungal effector AvrPiz-t structurally mimics ROD1 to suppress host immunity and promote virulence, revealing a molecular framework for breeding disease-resistant, high-yield crops.
Article
Biochemistry & Molecular Biology
Ping Li, Lulu Zhao, Fan Qi, Nang Myint Phyu Sin Htwe, Qiuying Li, Dawei Zhang, Fucheng Lin, Keke Shang-Guan, Yan Liang
Summary: The study revealed that RIPK plays a crucial role in regulating ROS production in various layers of the plant immune system, contributing to immune responses. RIPK mutants showed reduced ROS production in response to immune elicitors and increased susceptibility to necrotrophic bacteria.
Article
Entomology
Jordan P. Cuff, Lorna E. Drake, Maximillian P. T. G. Tercel, Jennifer E. Stockdale, Pablo Orozco-Terwengel, James R. Bell, Ian P. Vaughan, Carsten T. Mueller, William O. C. Symondson
Summary: Money spiders play an important role in conservation biological control in cereal crops, and their prey choice dynamics can help maintain a consistent dietary intake. They tend to consume each other more than expected, showing a propensity towards intraguild predation, while also consuming common pest families.
ECOLOGICAL ENTOMOLOGY
(2021)
Article
Biodiversity Conservation
Jordan Patrick Cuff, Carsten Theodor Mueller, Emma Christine Gilmartin, Lynne Boddy, Thomas Hefin Jones
Summary: The decreasing number of veteran trees in Europe threatens old-growth habitats and the fauna they support. Variations in water content within tree hollows could potentially improve habitat surveys. Volatile organic compounds were found to be significantly associated with habitats of Limoniscus violaceus.
INSECT CONSERVATION AND DIVERSITY
(2021)
Article
Ecology
Jade O'Leary, Katie L. Journeaux, Kas Houthuijs, Jasper Engel, Ulf Sommer, Mark R. Viant, Daniel C. Eastwood, Carsten Mueller, Lynne Boddy
Summary: The space in which organisms live determines their health and physicality, influencing their interactions with peers. Quantifying space-defined parameters is challenging but vital for studying ecological processes, as spatial dynamics drive community function.
Editorial Material
Primary Health Care
Ruth Mears, Karen D. Coulman, Dimitri J. Pournaras, Deborah Sharp
BRITISH JOURNAL OF GENERAL PRACTICE
(2021)
Article
Agriculture, Multidisciplinary
Maria Greco, Natasha Spadafora, Martin Shine, Ann Smith, Antonella Muto, Innocenzo Muzzalupo, Adriana Chiappetta, Leonardo Bruno, Carsten Muller, Hilary Rogers, M. Beatrice Bitonti
Summary: This study aimed to investigate the effects of cultivar, location, and fruit maturity stage on the flavor and composition of olive oil. The results showed that specific markers could distinguish olive oils from different cultivars, locations, and fruit maturity stages, which is of great importance for quality control of olive oil.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Environmental Sciences
Meaghan N. Evans, Simon Waller, Carsten T. Muller, Benoit Goossens, Jeremy A. Smith, Mohd Soffian Abu Bakar, Peter Kille
Summary: Patterns and practices of agricultural expansion pose a threat to global biodiversity. In this study, the impacts of the global palm oil industry on wildlife species were investigated, with a focus on the wild Malay civets in a degraded landscape in Malaysian Borneo. The levels of metals in the civets' hair were measured, and their association with biological and environmental factors was examined. The study found that metal concentrations were influenced by civet age, weight, proximity to a tributary, and access to oxbow lakes.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Elizabeth H. Hart, Sarah R. Christofides, Teri E. Davies, Pauline Rees Stevens, Christopher J. Creevey, Carsten T. Mueller, Hilary J. Rogers, Alison H. Kingston-Smith
Summary: This study investigated how the plant response to climate change affects forage quality and subsequent rumen fermentation. The results indicate that breeding future forage varieties should target tolerance of acute stress rather than long term climate.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Sarah R. Christofides, Anita Setarehnejad, Ruth Fairchild, Innocenzo Muzzalupo, Leonardo Bruno, Antonella Muto, Adriana Chiappetta, Maria B. Bitonti, Carsten T. Muller, Hilary J. Rogers, Natasha D. Spadafora
Summary: This study compared the appreciation and purchase decision factors of nectarines between Italy and the UK. The study found that named varieties were more important to Italian respondents, while ripeness, price, and taste were more important to UK respondents. Additionally, fruits at the commercial harvest stage were preferred.
Article
Agronomy
Richard A. Ludlow, Gareth Evans, Michael Graz, Gracia Marti, Puri Castillo Martinez, Hilary J. Rogers, Carsten T. Muller
Summary: This study investigates the storage issue of garlic. By measuring the quality traits and volatile organic compounds (VOCs), the study identifies predictive markers for cold stress and emphasizes the need for realistic warehouse experiments.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Correction
Multidisciplinary Sciences
Elizabeth H. Hart, Sarah R. Christofides, Teri E. Davies, Pauline Rees Stevens, Christopher J. Creevey, Carsten T. Muller, Hilary J. Rogers, Alison H. Kingston-Smith
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Antonella Muto, Sarah R. Christofides, Tiziana Maria Sirangelo, Lucia Bartella, Carsten Muller, Leonardo Di Donna, Innocenzo Muzzalupo, Leonardo Bruno, Antonio Ferrante, Adriana A. C. Chiappetta, Maria Beatrice Bitonti, Hilary J. Rogers, Natasha Damiana Spadafora
Summary: This study investigated the quality changes of six peach and nectarine cultivars during cold storage. The results showed that different cultivars responded differently to storage conditions, and sensory parameters were correlated with various compounds. Acidity and firmness were negatively correlated with mouthfeel and sweetness, while Brix value and β-carotene were positively correlated with sweetness and harmony.
Article
Plant Sciences
Antonella Muto, Leonardo Bruno, Maria Letizia Madeo, Richard Ludlow, Michele Ferrari, Louise Stimpson, Claudio LoGiudice, Ernesto Picardi, Antonio Ferrante, Luisa Pasti, Carsten T. Muller, Adriana Ada Ceverista Chiappetta, Hilary J. Rogers, Maria Beatrice Bitonti, Natasha Damiana Spadafora
Summary: This study used transcriptomic analysis to investigate the regulatory pathways involved in fruit deterioration before chilling injury occurs in peach and nectarine. Common pathways were activated in both cultivars during cold storage, but there were also cultivar-specific differences.
FRONTIERS IN PLANT SCIENCE
(2022)
Proceedings Paper
Agricultural Engineering
A. Muto, C. T. Muller, L. Bruno, M. Ferrari, A. Ferrante, E. Picardi, A. A. C. Chiappetta, M. B. Bitonti, H. J. Rogers, N. D. Spadafora
Summary: Both peaches and nectarines are susceptible to chilling injury during chilled storage, but nectarines show more resistance. Transcriptome analysis of peach and nectarine cultivars revealed that differentially expressed genes (DEGs) increased with storage, with more DEGs in nectarines. Some of these DEGs may serve as useful markers to predict chilling injury development.
X INTERNATIONAL PEACH SYMPOSIUM
(2022)
Proceedings Paper
Agricultural Engineering
A. Muto, C. Muller, I. Muzzalupo, L. Bruno, T. M. Sirangelo, A. Chiappetta, M. B. Bitonti, H. J. Rogers, N. D. Spadafora
Summary: This study assessed the effects of cold storage on the volatilome and sensory evaluation of the peach fruit cultivar 'Sagittaria'. The results showed correlations between certain volatile organic compounds (VOCs) and flavor traits, suggesting potential use in improving the sensory changes during cold storage. These findings could be valuable for peach breeders and for assessing fruit quality in the supply chain.
X INTERNATIONAL PEACH SYMPOSIUM
(2022)
Article
Pharmacology & Pharmacy
Polina L. Yarova, Ping Huang, Martin W. Schepelmann, Richard Bruce, Rupert Ecker, Robert Nica, Vsevolod Telezhkin, Daniela Traini, Larissa Gomes Dos Reis, Emma J. Kidd, William R. Ford, Kenneth J. Broadley, Benson M. Kariuki, Christopher J. Corrigan, Jeremy P. T. Ward, Paul J. Kemp, Daniela Riccardi
Summary: The study demonstrates that four CaSR NAMs are suitable for topical inhalation treatment of asthma, with the ability to abolish AHR, suppress airway inflammation, and prevent airway remodeling. These drugs can safely and effectively control and prevent asthma, providing a new direction for asthma treatment.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
