Review
Medicine, General & Internal
Ioannis Mavroudis, Alin Ciobica, Alina Costina Luca, Ioana-Miruna Balmus
Summary: Post-traumatic headache (PTH) is a common and debilitating consequence of mild traumatic brain injury (mTBI) that can occur over one year after the head impact event. Understanding the pathophysiology and risk factors of PTH is crucial for early identification and management. Risk factors for PTH include history of migraines or headaches, female gender, younger age, greater severity of the head injury, and co-occurring psychological symptoms. PTH can present in various clinical profiles and treatment options include pharmacological interventions and non-pharmacological approaches such as cognitive behavioral therapy and physical therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Respiratory System
Tracey H. Fan, Merry Huang, Aron Gedansky, Carrie Price, Chiara Robba, Adrian Hernandez, Sung-Min Cho
Summary: In general, around one in five patients developed ARDS shortly after TBI, with 31% of patients achieving good neurological outcomes at any time; TBI patients without ARDS had higher survival and better neurological outcomes.
Review
Clinical Neurology
Cassidy Q. B. Mostert, Ranjit D. Singh, Maxime Gerritsen, Erwin J. O. Kompanje, Gerard M. Ribbers, Wilco C. Peul, Jeroen T. J. M. van Dijck
Summary: This systematic review investigated the long-term outcome after severe traumatic brain injury (sTBI) and found limited and heterogeneous literature in this area. Mortality and unfavorable outcome rates were high, but a considerable proportion of survivors achieved favorable outcomes.
ACTA NEUROCHIRURGICA
(2022)
Article
Psychology, Clinical
Jennifer Bogner, John D. Corrigan, Juan Peng, Chelsea Kane, Kathryn Coxe
Summary: The adapted Screening, Education, and Brief Intervention (Adapted SBI) may help slow the resumption of alcohol use following traumatic brain injury (TBI), but did not significantly impact the amount of alcohol consumed each week.
REHABILITATION PSYCHOLOGY
(2021)
Article
Rehabilitation
Eric Xie, Michael Pellegrini, Zhibin Chen, Laura Jolliff, Maria Crotty, Julie Ratcliffe, Jacqui Morarty, Terence J. O'Brien, Natasha A. Lannin
Summary: This study aimed to determine the potential benefit of rehabilitation and the influence of substance use on outcomes in patients with traumatic brain injury (TBI). It found that a history of substance use was associated with lower reported quality of life at 12 months post-TBI.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Review
Clinical Neurology
Omaima Al Alyani, Faris Al-Farsi, Tariq Al-Saadi
Summary: Opioid use disorder among individuals with traumatic brain injury (TBI) is a global concern. This systematic review found that opioid use in TBI patients is associated with the severity of the injury and suggests the need for stronger regulation and alternative pain management strategies.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Yu Qing Huang, Sophie Weiss, Priti Gros, Edwin Wong, Pierre-Philippe Piche, Manav V. Vyas, Alan Ka Ho Tam, Jennifer Ann Watt
Summary: This systematic review examines the effectiveness and safety of non-pharmacologic and pharmacologic interventions in preventing or treating traumatic brain injury (TBI)-related delirium in acute care. The study found that rosuvastatin and aripiprazole were more efficacious than placebo, and dexmedetomidine was more efficacious than propofol and haloperidol for preventing TBI-related delirium. However, these findings should be interpreted with caution due to the moderate-to-high risk of bias in the included studies.
JOURNAL OF NEUROLOGY
(2023)
Review
Critical Care Medicine
David Hacker, Christopher A. Jones, Eyrsa Yasin, Sophie Preece, Holly Davies, Andrew Hawkins, Antonio Belli, Emily Paton
Summary: Cognitive outcomes were compared between mild traumatic brain injury (mTBI) with positive brain imaging (complicated mTBI) and mTBI with normal imaging (uncomplicated mTBI) as well as moderate to severe TBI. The findings showed that complicated mTBI had poorer cognitive outcomes than uncomplicated mTBI, but the deficits were not as severe as in moderate-severe TBI. The deficits in complicated mTBI were present in processing speed, memory, executive function, and language beyond 3 months post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Neurosciences
Hazem S. Ghaith, Asmaa Ahmed Nawar, Mohamed Diaa Gabra, Mohamed Essam Abdelrahman, Mohamed H. Nafady, Eshak Bahbah, Mahmoud Ahmed Ebada, Ghulam Md Ashraf, Ahmed Negida, George E. Barreto
Summary: Research into TBI biomarkers has accelerated in the past decade, but there is still a need to develop novel biomarkers entirely correlating with TBI pathologies; extracellular vesicles and miRNA are considered as promising candidates to overcome the limitations of traditional blood and CSF assays.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Medicine, General & Internal
Daniel G. Lynch, Raj K. Narayan, Chunyan Li
Summary: Traumatic brain injury is a leading cause of death and disability worldwide. Current monotherapy approaches have not shown significant benefit, possibly due to the complex pathophysiology of TBI. This article reviews combination therapies for TBI, including pharmacologic, non-pharmacologic, and combined interventions. While promising results have been found in animal models, clinical trials have not yet shown clear benefit, highlighting the need for improved treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Maria Daglas, Phan H. Truong, Linh Q. Miles, Sydney M. A. Juan, Shalini S. Rao, Paul A. Adlard
Summary: Iron plays a detrimental role in the injured brain, and the use of an iron chelator like deferiprone may be a promising therapeutic approach to improve survival, functional outcomes, and quality of life in TBI patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Mart Kals, Kevin Kunzmann, Livia Parodi, Farid Radmanesh, Lindsay Wilson, Saef Izzy, Christopher D. Anderson, Ava M. Puccio, David O. Okonkwo, Nancy Temkin, Ewout W. Steyerberg, Murray B. Stein, Geoff T. Manley, Andrew I. R. Maas, Sylvia Richardson, Ramon Diaz-Arrastia, Aarno Palotie, Samuli Ripatti, Jonathan Rosand, David K. Menon
Summary: This study is the first genome-and transcriptome-wide association studies of genetic effects on outcome in traumatic brain injury (TBI). While no genetic variants with genome-wide significance were found, the overall heritability estimate is consistent with the hypothesis that common genetic variation substantially contributes to inter-individual variability in TBI outcome.
Review
Clinical Neurology
Mahlet Mekonnen, Vera Ong, Timothy J. Florence, Khashayar Mozaffari, Natalie Mahgerefteh, Shivam Rana, Courtney Duong, David S. Plurad, Isaac Yang
Summary: This article reviewed clinical protocols regarding the use of hypertonic saline (HTS) in the treatment of traumatic brain injury (TBI). The study found that 3% and 7.5% concentrations of HTS were the most commonly used and demonstrated efficacy in reducing intracranial pressure (ICP) and improving Glasgow Coma Scale (GCS) score. Lower concentrations of HTS were also found to be more effective in reducing ICP. Therefore, the use of lower concentrations of HTS may be a practical approach in the treatment of TBI.
WORLD NEUROSURGERY
(2022)
Review
Clinical Neurology
John Gerrard Hanrahan, Charlotte Burford, Palani Nagappan, Gideon Adegboyega, Shivani Rajkumar, Angelos Kolias, Adel Helmy, Peter John Hutchinson
Summary: This article systematically reviews the association between traumatic brain injury (TBI) and dementia. It finds a relationship between the two, but cannot determine the risk of dementia for an individual following TBI. The article also highlights limitations and issues in current studies and suggests using standardized methods to define TBI, establish criteria for dementia diagnosis, and conduct longer-term follow-up studies.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Grace M. Turner, Christel McMullan, Olalekan Lee Aiyegbusi, Danai Bem, Tom Marshall, Melanie Calvert, Jonathan Mant, Antonio Belli
Summary: This study found that traumatic brain injury is an independent risk factor for stroke, with patients experiencing significantly increased risk of stroke post-traumatic brain injury which may persist up to five years. Meta-analysis results also indicate that traumatic brain injury may increase the risk of stroke, and certain medications may be associated with either reduced or increased risk of stroke.
INTERNATIONAL JOURNAL OF STROKE
(2021)