Journal
Stress, Neurotransmitters, and Hormones: Neuroendocrine and Genetic Mechanisms
Volume 1148, Issue -, Pages 331-337Publisher
BLACKWELL PUBLISHING
DOI: 10.1196/annals.1410.023
Keywords
IP3 receptors; cold; hypoxia; catecholamines
Funding
- [APVV 51-0397-07]
- [VEGA 2/6078]
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Type 1 and 2 inositol 1,4,5-trisphosphate (IP3) receptors have been found in cardiac tissue, although they are localized in different types of cells. While the type 1 predominates in neuronal cells and cardiac ganglia, type 2 IP3 receptor is localized mainly in cardiomyocytes. In the heart, gene expression of the type 1 IP3 receptor is modulated by catecholamines, while type 2 is not affected. In this study we compared the effects of two stressors-cold exposure and hypoxia-on gene expression and protein levels of type 1 and 2 IP3 receptors. We found that both types of IP3 receptors were increased by these stressors, although the response of the type 2 IP3 receptor was delayed. We propose that regulation of these types of IP3 receptors in the heart might differ in control conditions and during stress.
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