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Fabio Russo, Antonio Citro, Giorgia Squeri, Francesca Sanvito, Paolo Monti, Silvia Gregori, Maria Grazia Roncarolo, Andrea Annoni
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Biochemistry & Molecular Biology
Nina L. Kikel-Coury, Jacob P. Brandt, Isabel A. Correia, Michael R. O'Dea, Dana F. DeSantis, Felicity Sterling, Kevin Vaughan, Gulberk Ozcebe, Pinar Zorlutuna, Cody J. Smith
Summary: Glial cells are essential for the functionality of the nervous system, and recent research has identified nexus glia in peripheral organs, derived from the neural crest, that play a crucial role in driving differentiation and regulating heart rate and rhythm. These glial cells exhibit characteristics of astroglia and are critical regulators of cardiac homeostasis.
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Neurosciences
Alison Xiaoqiao Xie, Sarah Taves, Ken McCarthy
Summary: Chronic neuropathic pain causes long-term changes in sensitivity of peripheral and central nociceptive neurons. Glial fibrillary acidic protein (GFAP)-positive glial cells, such as astrocytes in the central nervous system (CNS), satellite glial cells (SGCs) in the sensory ganglia, and non-myelinating Schwann cells (NMSCs) in the peripheral nerves, are closely associated with nociceptive neurons and play a role in the maintenance of chronic pain through inflammatory cytokines regulated by NF kappa B and COX2. Inhibiting GFAP-positive glial signaling can alleviate chronic pain. Both central and peripheral GFAP-positive cells contribute to the maintenance of chronic pain, with NF kappa B-COX2 signaling pathway in NMSCs being necessary for neuropathic pain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jonathan H. P. Dawes, Robert N. Kelsh
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Multidisciplinary Sciences
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Summary: Unmyelinated non-peptidergic nociceptors receive axoaxonic synaptic input from inhibitory calretinin-expressing interneurons, which provides feedback inhibition and controls input from the nociceptors and pruritoceptors. These interneurons also form axodendritic synapses, allowing for feedforward inhibition and potential therapeutic targeting for chronic pain and itch treatment.
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Biochemistry & Molecular Biology
Hubert Tsui, Rozita Razavi, Yin Chan, Jason Yantha, H-Michael Dosch
TRENDS IN MOLECULAR MEDICINE
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Biochemistry & Molecular Biology
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