Journal
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
Volume 36, Issue 11, Pages 867-871Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1550045
Keywords
high-altitude; troponin; foot race
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Funding
- department of Family Medicine at the University of Colorado School of Medicine
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Serum biomarkers fluctuate as a result of running marathons, but their changes during ultramarathons have not been adequately studied. We collected blood samples from 20 participants before and 21 participants after the 161-km ultramarathon in Leadville, Colorado in August 2013. Using a portable analyzer, we measured cardiac troponin I (cTnl), hematologic, and metabolic biomarkers. Out of 10 runners for whom we collected both pre- and post-race samples, 8 were able to successfully complete the race. Mean cTnl increased from 0.001 to 0.047ng/mL (p=0.005). Mean sodium decreased from 141 to 138mmol/L (p<0.01). However, all runners had a sodium of 135 mmol/L post-race (reference range 138-146mmol/L). Mean creatinine increased from 0.93 to 1.17mg/dL (p<0.05). Only one out of 10 runners had an abnormal creatinine level of 1.8 mg/dL post-race (reference range 0.6-1.3mg/dL). The other parameters did not reach statistical significance. Analyzing the samples from 21 runners after the race revealed that runners who finished the race in faster time had higher cTnl levels compared to those who finished the race close to the 30-hour cut-off finish time (P=0.005). Running an ultramarathon caused significant changes in cardiac and metabolic parameters. Ultramarathon running intensity and finish time may have effects on post-race cTnl level.
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