Article
Gastroenterology & Hepatology
Ahmed Shehta, Ahmed Farouk, Rami Said, Ayman El Nakeeb, Ahmed Aboelenin, Mohamed Elshobary, Amgad Fouad, Ahmed Nabieh Elghawalby
Summary: This study evaluated the incidence and predictive factors for bile leakage (BL) after hepatic resection for hepatocellular carcinoma (HCC), as well as its impact on long-term survival outcomes. The results showed that BL did not significantly impair long-term outcomes after surgery, and the main risk factors for BL included Child-Pugh class, macroscopic portal vein invasion, liver resection extent, and Pringle's maneuver use.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
Hiroji Shinkawa, Shogo Tanaka, Shigekazu Takemura, Ryosuke Amano, Kenjiro Kimura, Masahiko Kinoshita, Kanae Takahashi, Shuichiro Matsuzaki, Shoji Kubo
Summary: The study developed two reliable nomograms to predict extrahepatic recurrence and early intrahepatic recurrence of hepatocellular carcinoma after hepatic resection. These nomograms showed good predictive performance and could guide the selection of treatment strategies for hepatocellular carcinoma patients by surgeons.
Article
Oncology
Jiang Li, Hai-su Tao, Jian Li, Wen-qiang Wang, Wei-wei Sheng, Zhi-yong Huang, Er-lei Zhang
Summary: This study compared the efficacy of liver resection (LR) and percutaneous microwave coagulation therapy (PMCT) for small hepatocellular carcinoma (HCC) with different degrees of liver cirrhosis. LR provided better surgical outcomes but PMCT had similar long-term results and lower surgical complications in HCC patients with severe cirrhosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mitsuru Yanagaki, Koichiro Haruki, Jungo Yasuda, Kenei Furukawa, Shinji Onda, Masashi Tsunematsu, Yoshihiro Shirai, Takeshi Gocho, Tomohiko Taniai, Ryoga Hamura, Toru Ikegami
Summary: This study examined the prognostic significance of rapid turnover proteins in patients with hepatocellular carcinoma after hepatic resection. Results showed that a high RTP score was associated with both disease-free and overall survival, indicating the importance of RTP in assessing nutritional status in cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Ahmed Shehta, Ahmed Farouk, Ahmed Nabieh Elghawalby, Mohamed Elshobary, Ahmed Aboelenin, Amgad Fouad, Mahmoud Abdelwahab Ali
Summary: The study evaluated the experience of liver resection for hepatocellular carcinoma patients with macroscopic portal vein invasion and found that patients with macroscopic PVI had lower overall survival rates and higher incidence of post-operative morbidities. However, there were no significant differences in terms of recurrence rate and disease-free survival rates between the two groups.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
Fasih A. Ahmed, Sameer A. Khan, Muhammad S. Hafeez, Faisal S. Jehan, Hassan Aziz
Summary: Hepatic resection is associated with improved survival for well-selected elderly patients with HCC, challenging the notion that age should be a determining factor in treatment decisions.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Dong Ho Lee, Jin Wook Chung, Ijin Joo, Kyung-Suk Suh, Seong Hoon Kim, Young Hwan Koh, Ju Hee Lee, Yun Ku Cho, Joong-Won Park
Summary: The aim of the study was to evaluate whether the presence of varices on CT could predict treatment outcomes for hepatocellular carcinoma patients. The study found that the presence of CT-enhanced CSPH surrogate, including varices on CT, was a significant predictive factor for poor overall survival, providing better predictive power than the standard surrogate.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Mitsuru Yanagaki, Yoshihiro Shirai, Ryoga Hamura, Tomohiko Taniai, Yoshiaki Tanji, Koichiro Haruki, Kenei Furukawa, Shinji Onda, Hiroaki Shiba, Toru Ikegami
Summary: This study examined the prognostic significance of the combination of the FIB-4 index and PIVKA-II in patients who underwent curative resection for hepatocellular carcinoma (HCC). The results showed that high PIVKA-II and FIB-4 index values were independent predictors of both disease-free survival and overall survival. The PIVKA-II-FIB-4 index score could be used to assess liver fibrosis status in cancer cases.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Eun Ko, Min Woo Lee, Soohyun Ahn, Hyunchul Rhim, Tae Wook Kang, Kyoung Doo Song, Jong Man Kim, Gyu-Seong Choi, Dong Ik Cha, Ji Hye Min, Dong Hyun Sinn, Moon Seok Choi, Hyo Keun Lim
Summary: This study compared the therapeutic outcomes of laparoscopic hepatic resection (LHR) and laparoscopic radiofrequency ablation (LRFA) for single subcapsular hepatocellular carcinoma (HCC) measuring 1-3 cm. The results showed no significant difference in therapeutic outcomes between the two methods.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mitsuru Yanagaki, Koichiro Haruki, Tomohiko Taniai, Yosuke Igarashi, Jungo Yasuda, Kenei Furukawa, Shinji Onda, Yoshihiro Shirai, Masashi Tsunematsu, Toru Ikegami
Summary: Preoperative osteosarcopenia may be a prognostic factor in patients with hepatocellular carcinoma after hepatic resection. Our results suggest that the preoperative maintenance of skeletal muscle and bone density may potentially improve prognosis in hepatocellular carcinoma patients.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Oncology
Munetoshi Akaoka, Koichiro Haruki, Tomohiko Taniai, Mitsuru Yanagaki, Yosuke Igarashi, Kenei Furukawa, Shinji Onda, Masashi Tsunematsu, Yoshihiro Shirai, Norimitsu Okui, Takeshi Gocho, Toru Ikegami
Summary: This study investigated the prognostic value of the cachexia index (CXI) in patients with hepatocellular carcinoma (HCC). The results showed that CXI was associated with disease-free survival and overall survival in HCC patients, emphasizing the importance of comprehensive biomarkers including skeletal muscle, inflammation, and nutritional status.
SURGICAL ONCOLOGY-OXFORD
(2022)
Article
Geriatrics & Gerontology
Jinhuan Yang, Kaiwen Chen, Chongming Zheng, Kaiyu Chen, Jian Lin, Qishan Meng, Ziyan Chen, Liming Deng, Haitao Yu, Tuo Deng, Zhiyuan Bo, Qikuan He, Yi Wang, Gang Chen
Summary: This study found that sarcopenia is associated with adverse outcomes after liver resection for HCC, with higher rates of major complications, blood transfusion, hospitalization expenses, and longer hospital stay. Evaluating sarcopenia upon admission can help classify high-risk patients and reduce the risk of major complications.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Oncology
Lingbo Hu, Yu Zheng, Jiangyin Lin, Xingpeng Shi, Aidong Wang
Summary: This meta-analysis showed that postoperative adjuvant hepatic artery infusion chemotherapy (HAIC) is beneficial to HCC patients with portal vein invasion (PVI) and microvascular invasion (MVI). However, it remains uncertain whether HAIC can improve the survival outcome in all HCC patients after hepatic resection.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Wei Zhang, Bixiang Zhang, Xiao-ping Chen
Summary: Several adjuvant treatments have been evaluated for preventing HCC recurrence after curative liver resection, with antiviral therapy and postoperative adjuvant transarterial chemoembolization showing promising results. However, further large-scale randomized controlled trials are needed to confirm their efficacy in different patient populations.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Ambria S. Moten, Paxton Dickson, Jeremiah L. Deneve, David Shibata, Ansley G. Stanfill, Evan S. Glazer
Summary: This study aimed to determine the impact of social determinants of health (SDoH) on outcomes of patients undergoing resection for hepatocellular carcinoma (HCC). The results showed that patients with higher education levels, Medicare, Medicaid, or private insurance had lower length of stay, readmission rates, and 30-day overall mortality.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kei Hagiwara, Norifumi Harimoto, Takahiro Yamanaka, Norihiro Ishii, Takehiko Yokobori, Mariko Tsukagoshi, Akira Watanabe, Kenichiro Araki, Tomoharu Yoshizumi, Ken Shirabe
Summary: This study investigates the role of HSC-derived M2BPGi in activating KCs and how it impacts liver regeneration. The findings suggest that the M2BPGi-activated KCs secrete GRP78, which promotes hepatocyte proliferation and facilitates liver regeneration. The administration of GRP78 improves the survival rate in a lethal mouse model of liver failure.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
R. Nakanishi, K. Morooka, K. Omori
DISEASES OF THE COLON & RECTUM
(2023)
Article
Oncology
Katsuya Toshida, Shinji Itoh, Noboru Harada, Akinari Morinaga, Kyohei Yugawa, Takahiro Tomiyama, Yukiko Kosai-Fujimoto, Takahiro Tomino, Takeshi Kurihara, Yoshihiro Nagao, Kazutoyo Morita, Yoshinao Oda, Tomoharu Yoshizumi
Summary: The association between tumor microenvironment (TME) and cancer-associated fibroblasts (CAFs) in intrahepatic cholangiocarcinoma (ICC) progression is poorly understood. This study aimed to investigate the role of specific microRNAs (miRNAs) in extracellular vesicles (EVs) derived from CAFs in ICC progression. The results showed that miR-493-5p in CAF-derived EVs promoted tumor cell proliferation by suppressing CARTPT expression in ICC cells.
Article
Surgery
Koichi Morisaki, Daisuke Matsuda, Yutaka Matsubara, Shun Kurose, Shinichiro Yoshino, Go Kinoshita, Kenichi Honma, Terutoshi Yamaoka, Tadashi Furuyama, Tomoharu Yoshizumi
Summary: This study aimed to analyze the influence of the Global Anatomic Staging System (GLASS) and inframalleolar (IM) disease on the treatment outcomes of patients with chronic limb threatening ischaemia (CLTI) who undergo endovascular treatment (EVT). The study found that IM disease and GLASS stage were associated with major amputation, major adverse limb events (MALE), and wound healing, while GLASS stage was only associated with MALE.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Editorial Material
Surgery
Koichi Morisaki, Daisuke Matsuda, Yutaka Matsubara, Terutoshi Yamaoka, Tadashi Furuyama, Tomoharu Yoshizumi
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Oncology
Taichi Nagano, Naoki Haratake, Kyoto Matsudo, Asato Hashinokuchi, Kenji Watanabe, Shinkichi Takamori, Mikihiro Kohno, Naoko Miura, Tomoyoshi Takenaka, Tomoharu Yoshizumi
Summary: This case report describes a case of improved congestion in the residual lung after left upper trisegmentectomy with conservative treatment under careful observation. The patient developed blood sputum after surgery, and CT scan showed consolidation and stenosis in the left lung. Conservative treatment with antibiotics and close follow-up by CT led to gradual improvement of pulmonary congestion and inflammation, and the patient was discharged home on day 26 after surgery.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Physiology
Shun Kurose, Yutaka Matsubara, Shinichiro Yoshino, Keiji Yoshiya, Koichi Morisaki, Tadashi Furuyama, Tomoaki Hoshino, Tomoharu Yoshizumi
Summary: Macrophages play crucial roles in AAA formation through inflammation and matrix degradation. IL-38, which has an anti-inflammatory effect, may suppress AAA formation by regulating macrophages. In this study, IL-38 treatment reduced M1 macrophage accumulation and MMP-2 and -9 expression in the AAA wall, leading to a decreased incidence of AAA. Additionally, p38 phosphorylation was found to be involved in the protective effects of IL-38 on regulating macrophages and reducing AAA incidence.
PHYSIOLOGICAL REPORTS
(2023)
Article
Gastroenterology & Hepatology
Atsushi Fukunaga, Kazuhide Takata, Shinji Itoh, Ryo Yamauchi, Takashi Tanaka, Keiji Yokoyama, Satoshi Shakado, Kenichi Kohashi, Tomoharu Yoshizumi, Fumihito Hirai
Summary: A combined therapy of atezolizumab and bevacizumab showed efficacy in treating an unresectable advanced-stage hepatocellular carcinoma (HCC) patient with lung metastases. Despite the side effects during treatment, the patient's tumor shrank significantly after multiple cycles, leading to a successful curative hepatic resection and no cancer recurrence.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Yoshihiko Maehara, Eiji Oki, Mitsuhiko Ota, Norifumi Harimoto, Koji Ando, Ryota Nakanishi, Tetsuro Kawazoe, Yoshiaki Fujimoto, Kentaro Nonaka, Hiroyuki Kitao, Makoto Iimori, Kunio Makino, Teiji Takechi, Takeshi Sagara, Kazutaka Miyadera, Kazuaki Matsuoka, Hiroshi Tsukihara, Yuki Kataoka, Takeshi Wakasa, Hiroaki Ochiiwa, Yoshihiro Kamahori, Eriko Tokunaga, Hiroshi Saeki, Tomoharu Yoshizumi, Yoshihiro Kakeji, Ken Shirabe, Hideo Baba, Mitsuo Shimada
Summary: Professor Setsuro Fujii achieved significant results in drug discovery research, developing nine well-known drugs that include anticancer drugs and therapeutic drugs for various diseases. He brought hope to patients worldwide and continues to inspire ongoing drug discovery research.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Surgery
Koichi Morisaki, Daisuke Matsuda, Atsushi Guntani, Yutaka Matsubara, Go Kinoshita, Shogo Kawanami, Sho Yamashita, Kenichi Honma, Tadashi Furuyama, Terutoshi Yamaoka, Shinsuke Mii, Kimihiro Komori, Tomoharu Yoshizumi
Summary: This study compared the outcomes of bypass surgery and endovascular therapy (EVT) in patients with chronic limb-threatening ischemia (CLTI). It was found that bypass surgery, which is preferred according to global vascular guidelines, can achieve better limb salvage and wound healing compared to EVT.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Eiji Oki, Mitsuhiko Ota, Tomonori Nakanoko, Yasushi Tanaka, Satoshi Toyota, Qingjiang Hu, Yu Nakaji, Ryota Nakanishi, Koji Ando, Yasue Kimura, Yuichi Hisamatsu, Koshi Mimori, Yoshiya Takahashi, Hajime Morohashi, Takahiro Kanno, Kotaro Tadano, Kenji Kawashima, Hironobu Takano, Yuma Ebihara, Masaki Shiota, Junichi Inokuchi, Masatoshi Eto, Tomoharu Yoshizumi, Kenichi Hakamada, Satoshi Hirano, Masaki Mori
Summary: This study describes the first application of a double-surgeon cockpit system to telesurgery. Non-specialized surgeons were able to safely perform cholecystectomy and renal vein ligation with remote assistance using the system, and the system also received higher technical scores compared to telesurgery performed by specialized surgeons.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Shotaro Kinoshita, Yo-ichi Yamashita, Yuki Kitano, Hiromitsu Hayashi, Keishi Sugimachi, Takashi Nishizaki, Kengo Fukuzawa, Kiyoshi Kajiyama, Nobutomo Miyanari, Tomoharu Yoshizumi, Hiroshi Takamori, Hideo Baba
Summary: This study aimed to assess the clinical outcomes of pancreatic resection for metastatic tumors in the pancreas, including prognostic factors. The results showed that the prognosis of pancreatic resection was relatively good for selected patients, but it was prone to recurrence after surgery, therefore it should only be considered in patients with good condition.
SURGICAL ONCOLOGY-OXFORD
(2023)
Article
Oncology
Fumihiko Kinoshita, Mototsugu Shimokawa, Tomoyoshi Takenaka, Tatsuro Okamoto, Kenichi Taguchi, Yoshinao Oda, Tomoharu Yoshizumi
Summary: The presence of noninvasive areas in lung adenocarcinoma has a prognostic impact due to differences in clinicopathological factors. Ground-glass opacity on computed tomography imaging serves as a favorable prognostic factor in non-small-cell lung cancer.
Article
Surgery
Koichi Morisaki, Atsushi Guntani, Go Kinoshita, Shogo Kawanami, Sho Yamashita, Yutaka Matsubara, Tadashi Furuyama, Shinsuke Mii, Kimihiro Komori, Tomoharu Yoshizumi
Summary: This study aimed to evaluate the influence of change in ambulatory status on the prognosis of patients with chronic limb-threatening ischemia (CLTI) undergoing infrainguinal bypass surgery or endovascular therapy (EVT). The results showed that improved ambulatory status is associated with better overall survival in patients with preoperative nonambulatory status after infrainguinal revascularization for CLTI.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Andrology
Takashi Nagai, Taku Naiki, Yosuke Sugiyama, Toshiki Etani, Maria Aoki, Masakazu Gonda, Toshiharu Morikawa, Keitaro Iida, Nami Tomiyama, Ryosuke Ando, Noriyasu Kawai, Takahiro Yasui
Summary: This review summarizes the parameters reflecting the status of aUC patients treated with immune checkpoint inhibitors (ICIs) based on current evidence. These parameters obtained from routine blood tests are useful for predicting the effectiveness of ICIs and the prognosis of patients.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2023)
