Article
Oncology
Beatriz Costeira, Francisca B. da Silva, Rodrigo Oom, Cristina Costa, Joao Moniz, Nuno Abecasis, Catarina R. Santos
Summary: The study of 461 patients revealed that skin- and nipple-sparing mastectomies are a safe approach with a LRR rate of 3.0%, where high histological grade, negative estrogen receptor status, and high Ki67 are predictive factors.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Nisha Parmeshwar, Catherine L. Dugan, Laura L. Barnes, Justin K. Cheng, Anne K. Patterson, Amanda Miller, Rita Mukhtar, Merisa Piper
Summary: This study evaluated the outcomes of nipple-sparing mastectomy in patients over the age of 60 and found that the surgery had acceptable results in this age group.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Trine Tramm, Peer Christiansen, Birgitte Vrou Offersen, Karen Berenth Madsen, Philip Poortmans, Orit Kaidar-Person
Summary: Skin-sparing and nipple-sparing mastectomies with immediate reconstruction for breast cancer are becoming more common. It is important to report on the superficial margin status in these procedures to understand its association with local recurrence risks.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Meghan Garstka, Anthony Henriquez, Bridget N. Kelly, Alexandra Webster, Jasmine A. Khubchandani, Kevin Hughes, Anvy Nguyen, Tawakalitu Oseni, Michelle Specht, Suzanne B. Coopey, Michele A. Gadd, Barbara L. Smith
Summary: The risk of new ipsilateral breast cancers is extremely low after NSM in BRCA1 and BRCA2 mutation carriers. NSM is an effective risk-reducing strategy for BRCA gene mutations.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Pathology
Lucy X. Ma, Aya Y. Michaels, Paula S. Ginter
Summary: This study investigates the factors associated with a positive subareolar tissue biopsy during nipple-sparing mastectomy and the rate of residual malignancy in subsequent nipple excisions. The study also evaluates the value of intraoperative frozen section (IOF) in subareolar tissue biopsy. The findings indicate that a positive subareolar tissue biopsy predicts residual carcinoma in the excised nipples in 51% of cases. IOF is accurate and reliable.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Oncology
Dung H. Nguyen, Danielle H. Rochlin, Peter L. Deptula, Yulia Zak, Monica Dua, Irene L. Wapnir
Summary: The omental fat-augmented free flap (O-FAFF) is a new alternative for breast reconstruction, suitable for women with lower BMI, which can significantly increase the number of candidates for autologous breast reconstruction.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Tammy Ju, Julia Chandler, Arash Momeni, Geoffrey Gurtner, Jacqueline Tsai, Dung Nguyen, Irene Wapnir
Summary: Two-stage NSM results in fewer NAC ischemic complications and no nipple loss compared to one-stage NSM. Ischemic events are less likely to occur when the interval between devascularization and NSM is 20 days or longer.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Katherine Kopkash, Kevin Novak, Raquel Murphy, Amanda Deliere, Kristine Kuchta, Sarah Rabbitt, Catherine Pesce, David Winchester, Katharine Yao
Summary: The study found that implementing an EOPP reduced muscle workload for surgeons performing NSM, but did not affect their perception of mental/physical workload. Further research is needed to improve surgeon ergonomics.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Tracy-Ann Moo, Jonas A. Nelson, Varadan Sevilimedu, Jillian Charyn, Tiana Le, Robert J. Allen, Babak J. Mehrara, Andrea Barrio, Deborah M. Capko, Melissa Pilewskie, Alexandra S. Heerdt, Audree B. Tadros, Mary L. Gemignani, Monica Morrow, Virgilio Sacchini
Summary: This study examines the relationship between intraoperative variables and the development of mastectomy skin-flap necrosis in patients undergoing nipple-sparing mastectomy. The results suggest that modifiable intraoperative factors, such as incision placement, vessel preservation, and tissue expander volume, may decrease the likelihood of necrosis.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Nicole K. Le, Sara E. Soni, Paul D. Smith, Ambuj Kumar, Deniz Dayicioglu
Summary: Comparing the complication rates of nipple- and implant-sparing mastectomies (NISMs) versus nipple-sparing mastectomies (NSMs) in a subgroup of patients, it was found that NISMs had a lower overall complication rate compared to NSMs. However, this difference was not statistically significant.
ANNALS OF PLASTIC SURGERY
(2021)
Article
Surgery
Miki Yamada, Hiromitsu Jinno, Saki Naruse, Yuka Isono, Daisuke Tsukahara, Yasuko Umemoto, Akiko Matsumoto, Kyoko Dogo, Yuko Sasajima
Summary: This study suggests that a large nipple volume could be a significant risk factor for NAC necrosis following NSM. Smoking and immediate breast reconstruction are also independently associated with NAC necrosis.
WORLD JOURNAL OF SURGERY
(2022)
Article
Oncology
Ayat ElSherif, Daniela Cocco, Sherif Armanyous, Andi Cummins, Kristina Shaffer, Eliana F. R. Duraes, Steven Bernard, Risal Djohan, Graham Schwarz, Chao Tu, Stephanie A. Valente
Summary: Infection after NSM and IBR is a devastating complication, with the nipple acting as a potential source. This study found that antibiotic choice did not affect SSI rates, with patient and treatment factors posing the highest risk for infection.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Cicero Urban, Eduardo Gonzalez, Alessandra Fornazari, Gaston Berman, Cleverton Spautz, Flavia Kuroda, Karina Furlan Anselmi, Iris Rabinovich, Maira Doria, Leonardo Nissen, Eduardo Schunemann, Bernardo Sobreiro, Rubens Lima
Summary: This study reports the outcomes of prepectoral direct-to-implant reconstruction in nipple-sparing mastectomy without the use of acellular dermal matrices or mesh. The results show that this technique is safe and economically advantageous, and the cosmetic outcomes are generally considered good or excellent.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Oncology
Francesca Serio, Elena Manna, Massimo La Pinta, Francesca Arienzo, Leopoldo Costarelli, Emanuele Zarba Meli, Andrea Loreti, Tiziana Mastropietro, Laura Broglia, Alessandra Ascarelli, Giuseppina Apicella, Rosalinda Rossi, Gianmarco Piccolino, Lucio Fortunato
Summary: A retrospective analysis found that in patients undergoing nipple-sparing mastectomy (NSM) without the presence of neoplastic cells in the inked retroareolar margin (RAM), the preservation rate of Nipple-Areola-Complex (NAC) was 94%, and potential associated factors may include tumor-to-nipple distance and Ki67 label index. Therefore, IERM is not necessary in NSM surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Zhen-Yu Wu, Hyun Ho Han, Hee Jeong Kim, Jongwon Lee, Il Yong Chung, Jisun Kim, Saebyeol Lee, Jing Han, Jin Sup Eom, Sung-Bae Kim, Gyungyub Gong, Hak Hee Kim, Byung-Ho Son, Sei-Hyun Ahn, BeomSeok Ko
Summary: This study retrospectively analyzed 1696 patients with primary breast cancer who underwent NSM with immediate reconstruction and found that NCR is more likely to be detected as a non-invasive recurrence, with more favorable overall outcomes compared to other LRR types. The interval to LRR and its site of onset seem to be associated with prognostic outcomes.