Article
Radiology, Nuclear Medicine & Medical Imaging
Sonia Mahajan, Christopher A. Barker, Audrey Mauguen, Sandra P. D'Angelo, Randy Yeh, Neeta Pandit-Taskar
Summary: The purpose of this study was to investigate the diagnostic and prognostic value of F-18-FDG PET/CT for surveillance imaging in patients treated for stage III Merkel cell carcinoma (MCC). The results showed that F-18-FDG PET/CT can detect unsuspected recurrences and has prognostic value. Performing F-18-FDG PET/CT surveillance within the first 6 months after definitive treatment can be used for monitoring and early detection of recurrence.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shan-Shan Yang, Yi-Shan Wu, Wei-Chao Chen, Jun Zhang, Su-Ming Xiao, Bao-Yu Zhang, Zhi-Qiao Liu, En-Ni Chen, Xu Zhang, Pu-Yun Ouyang, Fang-Yun Xie
Summary: The study found that PET/CT outperformed MRI in diagnosing lymph nodes and staging nasopharyngeal carcinoma, leading to better survival rates and informed treatment decisions. Patients staged with PET/CT and MRI had higher survival rates, and a radiologic score model effectively stratified patients based on risk factors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tiuri E. Kroese, Jelle P. Ruurda, Anne S. Bakker, Jasvir Jairam, Stella Mook, Sylvia van der Horst, Gert J. Meijer, Nadia Haj Mohammad, Peter S. N. van Rossum, Richard van Hillegersberg
Summary: This study investigated the feasibility of omitting PET/CT restaging after nCRT for esophageal cancer based on clinical stage and a prediction model. The results showed that the existing prediction model cannot accurately identify patients at risk for interval distant metastases. However, PET/CT restaging may be omitted in patients with clinical stage II esophageal cancer.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yuhua Yang, Lisha Liu, Juyi Lin, Shengcai Huang
Summary: A 46-year-old woman presented with menorrhagia, abdominal distension, and neck mass, which led to the diagnosis of uterine follicular dendritic cell sarcoma. After 6 cycles of CHOP-like chemotherapy, complete resolution was observed on F-18-FDG PET/CT scan.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Woo Seog Ko, Seong-Jang Kim
Summary: This study aimed to evaluate the accuracy of F-18-FDG PET/CT in predicting tumor response to neoadjuvant chemotherapy in bladder cancer patients. The results showed that F-18-FDG PET/CT has good diagnostic performance in predicting tumor response.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Romain-David Seban, Emilie Arnaud, Delphine Loirat, Luc Cabel, Paul Cottu, Lounes Djerroudi, Segolene Hescot, Pierre Loap, Claire Bonneau, Francois-Clement Bidard, Virginie Huchet, Nina Jehanno, Arnaud Berenbaum, Laurence Champion, Irene Buvat
Summary: This study retrospectively investigated whether [18F]FDG PET/CT examination before neoadjuvant chemotherapy could predict complete pathological complete response (pCR) in patients with early-stage triple-negative breast cancer (TNBC). The results showed that high tumor metabolism and low tumor burden could predict pCR after neoadjuvant chemotherapy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bernies van der Hiel, Stephanie A. Blankenstein, Else A. Aalbersberg, Maurits Wondergem, Marcel P. M. Stokkel, Bart A. van de Wiel, W. Martin C. Klop, Alexander C. J. van Akkooi, John B. Haanen
Summary: The aim of this study was to investigate the predictive value of F-18-EDG PET/CT in BRAF-mutated unresectable stage III melanoma patients who underwent neoadjuvant BRAF/MEK inhibitors treatment. The study found that PET parameters before surgery were not useful in predicting pathologic response, but PET/CT was valuable in detecting early recurrence after surgery.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adrien Holzgreve, Julian Taugner, Lukas Kaesmann, Philipp Mueller, Amanda Tufman, Niels Reinmuth, Minglun Li, Michael Winkelmann, Lena M. Unterrainer, Alexander E. Nieto, Peter Bartenstein, Wolfgang G. Kunz, Jens Ricke, Claus Belka, Chukwuka Eze, Marcus Unterrainer, Farkhad Manapov
Summary: In patients with unresectable stage III NSCLC, durvalumab maintenance treatment after CRT leads to diverging tumoral metabolic changes and increases splenic metabolism compared to patients undergoing CRT alone. The proportion of findings suggestive of irAE is also higher in CRT-IO patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Esra Arslan, Aytul Hande Yardimci, Enver Yarikkaya, Goksel Alcin, Tevfik Fikret Cermik
Summary: Hyalinizing cholecystitis is a rare subtype of chronic cholecystitis characterized by moderate inflammatory cell infiltration in the gallbladder wall. When observing gallbladder wall thickening with intense F-18-FDG uptake, hyalinizing cholecystitis should be considered in the differential diagnosis.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Guohua Shen, Rang Wang, Lili Pan, Anren Kuang
Summary: Glomus tumors are vascular neoplasms arising from glomus bodies, typically found in tissues concentrated with these bodies. We reported the MRI and FDG PET/CT findings of a glomus tumor presenting as an axillary mass in a 25-year-old woman.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Jang Yoo, Jaeho Lee, Miju Cheon, Hojoong Kim, Yong Soo Choi, Hongryull Pyo, Myung-Ju Ahn, Joon Young Choi
Summary: Assessing radiomic features from F-18-FDG PET/CT can predict the overall survival (OS) in patients with stage III NSCLC undergoing neoadjuvant CCRT, and demonstrate better prognostic implications than conventional PET parameters. The newly developed LASSO score using radiomic features performs better for individualized OS estimation.
Article
Oncology
Jang Yoo, Jaeho Lee, Miju Cheon, Sang-Keun Woo, Myung-Ju Ahn, Hong Ryull Pyo, Yong Soo Choi, Joung Ho Han, Joon Young Choi
Summary: This study aimed to compare the accuracy of F-18-FDG PET/CT predictions using machine learning (ML) model with conventional PET parameters and physicians' predictions in assessing the response to neoadjuvant CCRT in patients with stage III NSCLC. The results showed that the ML model provided higher predictive accuracy than conventional PET parameters and physicians' assessments.
Article
Medicine, General & Internal
Nazmi Ozer, Abdullah Sahin
Summary: This study found that SUVmax values increase in parallel with the biological aggressiveness of breast cancer tumors, serving as an important guide in determining axillary metastasis and treatment strategies for patients.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Biochemistry & Molecular Biology
Imke E. Karsten, Gabriele Reinartz, Michaela Pixberg, Kai Kroeger, Michael Oertel, Birte Friedrichs, Georg Lenz, Hans Theodor Eich
Summary: This study demonstrates the important role of F-18-FDG-PET/CT in stage-related therapy of FL, especially for patients in stages I and II. Patients staged with F-18-FDG-PET/CT showed better survival rates and lower risk of recurrence.
Article
Biochemistry & Molecular Biology
Wookjin Choi, Chia-Ju Liu, Sadegh Riyahi Alam, Jung Hun Oh, Raj Vaghjiani, John Humm, Wolfgang Weber, Prasad S. Adusumilli, Joseph O. Deasy, Wei Lu
Summary: This study aims to non-invasively identify aggressive subtypes of lung adenocarcinoma (ADC) using preoperative 18F-FDG PET/CT and diagnostic CT radiomics analysis. The proposed radiomics approach significantly outperformed the conventional predictor SUVmax and demonstrated high accuracy and negative predictive value in identifying aggressive subtypes. It has the potential to improve surgical decision-making for early-stage lung ADC patients.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Annemiek van Ommen-Nijhof, Tessa G. Steenbruggen, Laura Capel, Michel Vergouwen, Marie-Jeanne T. Vrancken Peeters, Terry G. Wiersma, Gabe S. Sonke
Summary: This study reports on the overall survival (OS), event-free survival (EFS), and prognostic factors in a large real-world cohort of patients with oligometastatic breast cancer (OMBC). Multimodality treatment including polychemotherapy and local ablative treatment (LAT) is propagating for OMBC to achieve disease remission or cure. Early optimal systemic therapy is associated with favorable OS and EFS, indicating the importance of early treatment in OMBC. The value of LAT in OMBC requires further study.
Article
Oncology
Anouk H. Eijkelboom, Linda de Munck, C. Willemien Menke-van der Houven Van Oordt, Mireille J. M. Broeders, Desiree H. J. G. van den Bongard, Luc J. A. Strobbe, Marc A. M. Mureau, Marc B. Lobbes, Pieter J. Westenend, Linetta B. Koppert, Agnes Jager, Ester J. M. Siemerink, Jelle Wesseling, Helena M. Verkooijen, Marie-Jeanne T. F. D. Vrancken Peeters, Marjolein L. Smidt, Vivianne C. G. Tjan-Heijnen, Sabine Siesling
Summary: This study compared the treatments and time intervals between treatments of breast cancer patients diagnosed during and before the COVID-19 pandemic, and the number of treatments started during and before the pandemic. The results showed that patients diagnosed during the transition period were less likely to receive neo-adjuvant chemotherapy for stage I, stage II, and hormone receptor+/HER2- tumors compared to 2018/2019. The time between diagnosis and first treatment decreased for patients diagnosed during the lockdown period. Additionally, there was an increase in the number of neo-adjuvant endocrine therapies and surgeries starting in week 14 of 2020, while the number of adjuvant chemotherapies decreased in week 15 and increased in week 22.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Ariane A. van Loevezijn, Hillegonda A. O. Winter-Warnars, Genevieve S. Hernandez, Christiaan M. de Bloeme, Frederieke H. van Duijnhoven, Marie-Jeanne T. F. D. Vrancken Peeters
Summary: This study retrospectively selected early-stage breast cancer patients who underwent neoadjuvant systemic therapy (NST) and found that MRI could detect additional lesions in some patients, which could impact surgical treatment. Among them, 31% of patients had lesions detected in the ipsilateral breast, and 26% of patients underwent more extensive surgery after the detection of lesions on MRI.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Ariane A. A. van Loevezijn, Charissa S. S. Geluk, Marieke J. J. van den Berg, Erik D. D. van Werkhoven, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke H. H. van Duijnhoven, Marije J. J. Hoornweg
Summary: This study aimed to evaluate the surgical outcomes of immediate and delayed oncoplastic surgery (OPS). The study found that selecting delayed OPS allowed for re-excision of margins without dismantling the reconstruction, achieving excellent breast conservation rates.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Nansi Maliko, Thomas Schok, Nina Bijker, Michel W. J. M. Wouters, Luc J. A. Strobbe, Marije J. Hoornweg, Marie-Jeanne T. F. D. Vrancken Peeters
Summary: OPBCS is a major part of daily clinical practice of Dutch breast surgeons treating BC patients. A clear definition and standardization is necessary to improve the quality of BC care.
Article
Oncology
Sanne A. L. Bartels, Mila Donker, Coralie Poncet, Nicolas Sauve, Marieke E. E. Straver, Cornelis J. H. van de Velde, Robert E. E. Mansel, Charlotte Blanken, Lorenzo Orzalesi, Jean H. G. Klinkenbijl, Huub C. J. van der Mijle, Grard A. P. Nieuwenhuijzen, Sanne C. C. Veltkamp, Thijs van Dalen, Andreas Marinelli, Herman Rijna, Marko Snoj, Nigel J. J. Bundred, Jos W. S. Merkus, Yazid Belkacemi, Patrick Petignat, Dominic A. X. Schinagl, Corneel Coens, Geertjan van Tienhoven, Frederieke van Duijnhoven, Emiel J. T. Rutgers
Summary: This clinical trial compared axillary lymph node dissection (ALND) with axillary radiotherapy (ART) in patients with cT1-2, node-negative breast cancer. The study found that both modalities had comparable axillary control, but ART was associated with less morbidity. Additionally, patients in the ART group had a higher risk of developing second primary cancers.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Josephine M. N. L. Cardozo, Irene L. E. Andrulis, Stig E. Bojesen, Thilo M. Doerk, Diana M. A. Eccles, Peter A. J. Fasching, Maartje J. Hooning, Renske Keeman, Heli Nevanlinna, Emiel J. T. F. Rutgers, Douglas F. Easton, Per Hall, Paul D. P. J. Pharoah, Laura J. K. van't Veer, Marjanka K. Schmidt
Summary: A polygenic risk score (PRS) consisting of 313 common genetic variants (PRS313) is associated with risk of breast cancer and contralateral breast cancer. This study aimed to evaluate the association of the PRS313 with clinicopathologic characteristics of, and survival following, breast cancer. The results showed that PRS313 is associated with favorable tumor characteristics but not independently associated with prognosis. Rating: 8/10.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Surgery
Martine A. van Huizum, J. Joris Hage, Astrid N. Scholten, Emiel J. Rutgers
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Surgery
Babette E. Becherer, Erik A. Heeg, Danny A. Young-Afat, Marie-Jeanne T. F. D. Vrancken Peeters, Hinne A. Rakhorst, Marc A. M. Mureau
Summary: In this population-based study in the Netherlands, the incidence of unplanned revision surgery was lower in immediate implant-based breast reconstruction using a direct-to-implant approach compared to a two-stage approach. Additionally, more breasts were reconstructed within the planned number of operations in the direct-to-implant group.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Jonathan Spoor, Marc A. M. Mureau, Juliette Hommes, Hinne Rakhorst, Anneriet E. Dassen, Hester S. A. Oldenburg, Yvonne L. J. Vissers, Esther M. Heuts, Linetta B. Koppert, Laura H. Zaal, Rene R. W. J. van der Hulst, Marie-Jeanne T. F. D. Vrancken Peeters, Eveline M. A. Bleiker, Flora E. van Leeuwen
Summary: This article introduces the Areola study, which aims to assess the risks of breast implant illness (BII) and autoimmune diseases in Dutch breast cancer survivors with silicone breast implants. The study design includes a retrospective cohort of breast cancer survivors who underwent implant-based reconstruction surgery between 2000 and 2015 in six major hospitals in the Netherlands. A comparison group of breast cancer survivors without breast implants and a group of women who received breast augmentation surgery will also be included. The study will collect data through a web-based questionnaire and link it with population-based databases to evaluate the prevalence, incidence, and risk factors of BII and autoimmune disorders.
ANNALS OF EPIDEMIOLOGY
(2023)
Editorial Material
Oncology
Annemiek K. E. van Hemert, Frederieke H. van Duijnhoven, Ariane A. van Loevezijn, Claudette E. Loo, Terry Wiersma, Emilie J. Groen, Marie-Jeanne T. F. D. Vrancken Peeters
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Annemiek K. E. van Hemert, Frederieke H. H. van Duijnhoven, Ariane A. A. van Loevezijn, Claudette E. E. Loo, Terry Wiersma, Emilie J. J. Groen, Marie-Jeanne T. F. D. Vrancken Peeters
Summary: The study aims to assess the residual disease in patients who had a favorable response on MRI and no residual disease detected through biopsy after neoadjuvant systemic treatment (NST) for breast cancer. The findings showed that substantial residual invasive disease remains in all molecular subtypes, suggesting the need for surgical excision until better imaging and biopsy techniques are developed.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Annemiek K. E. van Hemert, Josefien P. P. van Olmen, Liesbeth J. J. Boersma, John H. H. Maduro, Nicola S. S. Russell, Jolien Tol, Ellen G. G. Engelhardt, Emiel J. Th. Rutgers, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke H. H. van Duijnhoven
Summary: The purpose of this study is to show that omitting adjuvant radiotherapy in breast cancer patients with pCR after NST can result in low rates of local recurrence and good quality of life.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Oncology
Marjanka K. Schmidt, Jennifer E. Kelly, Anne Bredart, David A. Cameron, Jana de Boniface, Douglas F. Easton, Birgitte Offersen, Fiorita Poulakaki, Isabel T. Rubio, Francesco Sardanelli, Rita Schmutzler, Tanja Spanic, Britta Weigelt, Emiel J. T. Rutgers
Summary: After a unilateral breast cancer diagnosis, more and more patients are choosing to have contralateral prophylactic mastectomy (CPM), the removal of the healthy breast. Breast cancer specialists need to provide guidance to women considering CPM. This manifesto discusses the challenges of CPM and offers recommendations to improve outcomes for women with unilateral breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Dinusha Veluponnar, Lisanne L. de Boer, Freija Geldof, Lynn-Jade S. Jong, Marcos Da Silva Guimaraes, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke van Duijnhoven, Theo Ruers, Behdad Dashtbozorg
Summary: During breast-conserving surgeries, accurate evaluation of tumor margins is challenging, leading to potential need for additional surgery or boost radiotherapy. The use of computer-aided delineation of tumor boundaries in ultrasound images shows promising results in predicting positive and close margins. There is a clinical need for an accurate and rapid margin assessment tool, and computer-aided ultrasound evaluation offers a potential solution.