Review
Oncology
Wei Zhang, Bixiang Zhang, Xiao-ping Chen
Summary: Several adjuvant treatments have been evaluated for preventing HCC recurrence after curative liver resection, with antiviral therapy and postoperative adjuvant transarterial chemoembolization showing promising results. However, further large-scale randomized controlled trials are needed to confirm their efficacy in different patient populations.
FRONTIERS OF MEDICINE
(2021)
Article
Surgery
Hayato Abe, Yutaka Midorikawa, Tokio Higaki, Shintaro Yamazaki, Osamu Aramaki, Hisashi Nakayama, Masamichi Moriguchi, Tatsuo Kanda, Mitsuhiko Moriyama, Masahiro Okada, Haruna Nishimaki, Masahiko Sugitani, Shingo Tsuji, Tadatoshi Takayama
Summary: This study found that preoperative liver stiffness measurement using magnetic resonance elastography can predict intrahepatic recurrence after curative resection for hepatocellular carcinoma, and it was identified as an independent predictor along with vascular invasion.
Article
Medicine, General & Internal
Indah Jamtani, Kwang-Woong Lee, Yunhee Choi, YoungRok Choi, Jeong-Moo Lee, Eui-Soo Han, Kwangpyo Hong, Gyu-Seong Choi, Jong Man Kim, Nam-Joon Yi, Suk Kyun Hong, Jeik Byun, Su Young Hong, Sanggyeun Suh, Jae-Won Joh, Kyung-Suk Suh
Summary: This study aimed to develop a tailored prediction model of HCC-specific survival after transplantation, validated internally and externally. By combining multiple risk factors, the model showed good accuracy in predicting HCC-specific survival tailored for patients undergoing transplantation. The calculated SALT predictor provided accurate information on expected survival rates based on risk scores and specific characteristics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Jun-Cheng Wang, Jing-Yu Hou, Jian-Cong Chen, Cai-Ling Xiang, Xian-Hai Mao, Bing Yang, Qiang Li, Qing-Bo Liu, Jinbin Chen, Zhi-Wei Ye, Wei Peng, Xu-Qi Sun, Min-Shan Chen, Qun-Fang Zhou, Yao-Jun Zhang
Summary: In this study, novel nomograms were developed to predict postoperative recurrence and survival of patients with single large and huge hepatocellular carcinoma. The nomograms showed high accuracy and reliability in predicting outcomes for these patients, as confirmed by validation in internal and external cohorts.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Jing-Houng Wang, Wei-Feng Li, Chee-Chien Yong, Yueh-Wei Liu, Sheng-Nan Lu, Chih-Chi Wang
Summary: This study investigated the role of LS and metabolic factors in predicting HCC recurrence for patients with early stage HCC. It was found that LS was positively correlated with fibrosis stage, and patients with LS>8.5 kPa and HOMA-IR>2.3 had the highest recurrence rate after 1-year post resection.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Huang, Mei-Qing Cheng, Dan-Ni He, Meng-Fei Xian, Dan Zeng, Shao-Hong Wu, Chao-Qun Li, Si-Min Ruan, Ming-De Li, Man-Xia Lin, Ming-De Lu, Ming Kuang, Wei Wang, Li-Da Chen
Summary: This study investigated the performance of US LI-RADS in surveillance for recurrent hepatocellular carcinoma (RHCC) after curative treatment. Four criteria using US LI-RADS or Alpha-fetoprotein (AFP) as the surveillance algorithm were evaluated. The criterion of US-2/3 or AFP ≥ 20μg/L had higher sensitivity and negative predictive value, but lower specificity.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Rui Liao, Xu-Fu Wei, Ping Che, Kun-Li Yin, Lei Liu
Summary: This study developed two nomograms based on the China liver cancer staging system to predict the outcomes of patients with hepatocellular carcinoma after curative resection. The nomograms showed better prognostic abilities for postoperative survival and recurrence-free survival compared to the Tumor-Node-Metastasis 8th edition and Barcelona Clinic Liver Cancer staging systems.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shih-Yu Yang, Chih-Chi Wang, Kuang-Den Chen, Yueh-Wei Liu, Chih-Che Lin, Ching-Hui Chuang, Yu-Chieh Tsai, Chih-Chien Yao, Yi-Hao Yen, Chang-Chun Hsiao, Tsung-Hui Hu, Ming-Chao Tsai
Summary: This study revealed that statin use may have a chemopreventive effect on HCC recurrence after curative resection. Factors such as age, liver cirrhosis, diabetes, number of tumors, tumor size, and vascular invasion were identified as independent risk factors for HCC recurrence, while statin use and antiviral therapy significantly reduced the risk of recurrence.
Article
Oncology
Hong-Fan Ding, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Yi Lv, Timothy M. Pawlik
Summary: The study found that the AFP model is more accurate in identifying which HCC patients may benefit the most from surgical resection, and is superior to the BCLC system in predicting tumor recurrence and patient survival.
Article
Gastroenterology & Hepatology
Xi Chen, Ming Kuang, Zhao-Hui Hu, Yong-Hai Peng, Ning Wang, Hua Luo, Pei Yang
Summary: This study found that liver stiffness measurement (LSM) is related to the occurrence of post-hepatectomy liver failure (PHLF) after hepatocellular carcinoma (HCC) surgery. Patients with higher LSM levels may have a higher risk of developing more severe PHLF after surgery. Additionally, LSM may aid in predicting long-term survival after liver resection in patients with HCC.
ARAB JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Hamzah Adwan, Lars Hammann, Thomas J. Vogl
Summary: This study evaluated the efficacy and safety of microwave ablation (MWA) as a treatment for recurrent hepatocellular carcinoma (HCC) after initial surgical resection. The results showed that MWA treatment is effective and safe for recurrent HCC lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Sang Jin Kim, Jong Man Kim
Summary: Liver transplantation is an effective treatment for hepatocellular carcinoma, but some patients still experience recurrence after transplantation. Prediction models for HCC recurrence after transplantation have been published, but a standard has not been established. This review summarizes the latest prediction models for HCC recurrence after liver transplantation, focusing on radiologic, serologic, and pathologic factors, and includes studies on living donor and deceased donor transplantation.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Surgery
Wei-Feng Li, Sin-Hua Moi, Yueh-Wei Liu, Chee-Chien Yong, Chih-Chi Wang, Yi-Hao Yen, Chih-Yun Lin
Summary: Predicting recurrence patterns of hepatocellular carcinoma (HCC) is important for surveillance strategies. This study used the hazard function to analyze recurrence hazard and peak recurrence time transitions in patients with HCC undergoing liver resection (LR). The results showed significant variations in recurrence hazard, patterns, and peak rates based on different risk factors of HCC recurrence.
UPDATES IN SURGERY
(2023)
Article
Health Care Sciences & Services
Yu-Syuan Chen, Shih-Yu Yang, Pei-Ming Wang, Chih-Chi Wang, Chee-Chien Yong, Ding-Wei Chen, Yueh-Wei Liu, Ching-Hui Chuang, Pao-Yuan Huang, Chih-Chien Yao, Yen-Po Lin, Ming-Chao Tsai
Summary: Concurrent cholecystectomy may reduce recurrence in early-stage HCC after curative resection, but does not significantly impact overall survival. Further studies are needed to confirm these results.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yujia Zhao, Linyong Wu, Hui Qin, Qing Li, Chanliang Shen, Yun He, Hong Yang
Summary: The study indicated that preoperative combi-elastography analysis could serve as a potential prognostic tool for early recurrence of hepatocellular carcinoma, assisting in clinical decision-making.
Article
Gastroenterology & Hepatology
Byungyoon Yun, Juyeon Oh, Sang Hoon Ahn, Jin-Ha Yoon, Beom Kyung Kim
Summary: Asian patients with chronic hepatitis B receiving antiviral therapy had a similar risk of all-cause mortality and non-HCC malignancies, but a lower risk of cardiovascular disease compared to the general population.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Editorial Material
Oncology
Seung Soo Hong, Dai Hoon Han, Kyung Sik Kim, Jin Sub Choi, Gi Hong Choi
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ho Soo Chun, Minjong Lee, Hye Ah Lee, Sejin Lee, Soyeon Kim, Ye Jun Jung, Chaewon Lee, Hyoeun Kim, Han Ah Lee, Hwi Young Kim, Kwon Yoo, Tae Hun Kim, Sang Hoon Ahn, Seung Up Kim
Summary: This study aimed to determine the relationship between sarcopenic obesity (SO) and the risk of significant liver fibrosis or cardiovascular disease (CVD) in nonalcoholic fatty liver disease (NAFLD). Through a multicenter retrospective study, it was found that high-risk subjects with SO had a higher risk of liver fibrosis and CVD development. The results demonstrated that high-risk subjects with SO had significantly increased risks of liver fibrosis and CVD development.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mi Na Kim, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Se Young Jang, Won Young Tak, Young -Oh Kweon, Soo Young Park, Seung Up Kim
Summary: In patients with HBV-related cirrhosis, baseline and on-treatment ALT levels during ETV therapy are not associated with achieving subcirrhotic LS or the risk of HCC development. However, achieving subcirrhotic LS at 5 years of ETV therapy is independently associated with a lower risk of HCC development beyond 5 years of ETV therapy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuna Kim, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Myung Ji Goh, Wonseok Kang, Seung Up Kim
Summary: This study compared the outcomes of sorafenib and nivolumab as second-line agents after failed lenvatinib treatment in patients with advanced HCC. The results showed that lenvatinib-sorafenib sequential treatment resulted in significantly better survival than lenvatinib-nivolumab sequential treatment.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ho Soo Chun, Minjong Lee, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Yong-Ho Lee, Ji-Hye Kim, Seung Up Kim
Summary: There is an association between metabolic dysfunction-associated fatty liver disease (MAFLD) or NAFLD and cardiovascular disease (CVD) risk, with MAFLD potentially being a better identifier for CVD risk than NAFLD. Fibrosis assessment can provide helpful prognostic information for subjects with MAFLD.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Hee Seung Lee, Dai Hoon Han, Kyungjoo Cho, Soo Been Park, Chanyang Kim, Galam Leem, Dawoon E. Jung, Soon Sung Kwon, Chul Hoon Kim, Jung Hyun Jo, Hye Won Lee, Si Young Song, Jun Yong Park
Summary: The study developed organoids for two ICC subtypes, which revealed distinct transcriptional profiles and potential therapeutic targets.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Jae Seung Lee, Tae Seop Lim, Hye Won Lee, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Hyun Woong Lee, Jung Il Lee, Ja Kyung Kim, In Kyung Min, Beom Kyung Kim
Summary: This study evaluated the predictive performance of pre-existing well-validated hepatocellular carcinoma (HCC) prediction models in patients with HBV-related cirrhosis who started potent antiviral therapy (AVT). The results showed that the existing risk prediction models for patients with chronic hepatitis B had suboptimal predictive performances for assessing HCC development in patients with HBV-related cirrhosis. Although the models were not highly accurate, they were still able to stratify patients into low-, intermediate-, or high-risk groups.
Article
Gastroenterology & Hepatology
Du Hyun Song, Nayoung Kim, Hyeong Ho Jo, Sangbin Kim, Yonghoon Choi, Hyeon Jeong Oh, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, So Hyun Kang, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim, Ji-Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Jin Won Kim, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Soyeon Ahn, Young-Joon Surh
Summary: This study aimed to identify risk factors for synchronous multiple gastric cancer (SMGC). Data from 14,603 patients with gastric cancer were analyzed, and the incidence of SMGC was found to be 4.04%, which was associated with male sex, age ≥65 years, and early gastric cancer. Unlike single gastric cancer, SMGC had a high survival rate.
Article
Gastroenterology & Hepatology
Hye Kyung Hyun, Hye Won Lee, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Seung Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Jae Hee Cheon
Summary: This study investigated the effects of nonalcoholic fatty liver disease (NAFLD) on the outcome of inflammatory bowel disease (IBD) patients. The results showed that the presence of NAFLD may increase the risk of clinical relapse in patients with IBD. Additionally, the study found that hepatic steatosis was significantly associated with increased risks of clinical relapse in patients with ulcerative colitis and Crohn's disease, while fibrotic burden in the liver was not.
Article
Gastroenterology & Hepatology
Hye Yeon Chon, Han Ah Lee, Soo Young Park, Yeon Seok Seo, Sang Gyune Kim, Chang Hun Lee, Tae Hee Lee, Sang Hoon Ahn, Vincent Wai-Sun Wong, Terry Cheuk-Fung Yip, Lilian Yan Liang, In Hee Kim, Grace Lai-Hung Wong, Seung Up Kim
Summary: This study compared the predictive accuracy of three risk prediction models for hepatocellular carcinoma (HCC) development after 5 years of antiviral therapy in patients with chronic hepatitis B. The results showed that the SAGE-B and CAGE-B models might be better than the PAGE-B model in predicting HCC development after 5 years of treatment.
JOURNAL OF DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
David Sooik Kim, Beom Kyung Kim, Jae Seung Lee, Hye Won Lee, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Nikolaos Pyrsopoulos, Seung Up Kim
Summary: This study validated the predictive performance of the CHESS-ALARM model in patients with HBV-related liver cirrhosis and compared it with other TE-based models. The results showed that CHESS-ALARM had similar predictive performance as LSPS, PH, varices risk scores, ALBI, and ALBI-FIB-4.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Anatomy & Morphology
Michel Kmeid, Young Nyun Park, Taek Chung, Richard. R. R. Pacheco, Mustafa Erdem Arslan, Hwajeong Lee
Summary: The methylated SEPT9 DNA (mSEPT9) in plasma is an FDA-approved screening biomarker in colorectal cancer and is emerging as a promising diagnostic and prognostic biomarker in hepatocellular carcinoma (HCC). In this study, the SEPT9 protein expression in various hepatic tumors was evaluated using immunohistochemistry (IHC), and its correlation with demographics, risk factors, tumor characteristics, and oncologic outcomes was analyzed. The findings suggest that SEPT9 may be implicated in liver carcinogenesis and that SEPT9 staining by IHC could serve as an adjunct diagnostic biomarker with potential prognostic ramifications.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2023)
Article
Environmental Sciences
Oh Young Kwon, Seung Up Kim, Sang Hoon Ahn, Yeonsoo Jang
Summary: Self-management is crucial for controlling non-alcoholic fatty liver disease. This study explores the characteristics and levels of self-management in patients with this disease in Korea. The findings indicate that self-management levels are moderate and self-efficacy is significantly associated with self-management. This research could assist healthcare professionals in promoting self-management compliance and developing interventions for sustainable self-management.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)