Article
Oncology
Diana Zach, Katja Stenstroem Bohlin, Paivi Kannisto, Louise Moberg, Preben Kjoelhede
Summary: This study assessed the detection rates and negative predictive values of sentinel node biopsy in vulvar squamous cell carcinoma. The results showed that sentinel node biopsy has high detection rates and negative predictive values in women with tumors >= 4 cm and multifocal tumors, making it an effective method for detection.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Amy K. Schulze, Tanya L. Hoskin, Mary M. Mrdutt, Robert W. Mutter, Tina J. Hieken
Summary: This study explores the feasibility and therapeutic impact of repeat sentinel lymph node surgery in patients with local recurrence post-mastectomy. The results show that this approach is successful and informative, reducing axillary dissection rates and potentially guiding adjuvant radiation target volumes and systemic therapies.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Giorgio Bogani, Andrea Papadia, Alessandro Buda, Jvan Casarin, Violante Di Donato, Maria Luisa Gasparri, Francesco Plotti, Ciro Pinelli, Maria Chiara Paderno, Salvatore Lopez, Anna Myriam Perrone, Fabio Barra, Rocco Guerrisi, Claudia Brusadelli, Antonella Cromi, Debora Ferrari, Valentina Chiapp, Mauro Signorelli, Umberto Leone Roberti Maggiore, Antonino Ditto, Innocenza Palaia, Simone Ferrero, Pierandrea De Iaco, Roberto Angioli, Pierluigi Benedetti Panici, Fabio Ghezzi, Fabio Landoni, Michael D. Mueller, Francesco Raspagliesi
Summary: This study evaluated the outcomes of high-risk EC patients undergoing SNM, with or without back-up lymphadenectomy, and found that the type of nodal assessment did not impact survival outcomes. Back-up lymphadenectomy may help remove positive nodes, but its therapeutic value remains controversial.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Alejandra Garcia-Novoa, Benigno Acea-Nebril, Carlota Diaz Carballada, Alberto Bouzon Alejandro, Carmen Conde, Carmen Cereijo Garea, Jose Ramon Varela, Paz Santiago Freijanes, Silvia Antolin Novoa, Lourdes Calvo Martinez, Inma Diz, Sofia Rodriguez Martinez, Joaquin Mosquera Oses
Summary: The study analyzed the feasibility of wire/clip localization and sentinel lymph node biopsy for axillary staging in breast cancer patients, showing a high identification rate with combined marking techniques and enabling the avoidance of axillary lymph node dissection in a significant number of patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Xuefei Wang, Guochao Zhang, Zhichao Zuo, Qingli Zhu, Shafei Wu, Yidong Zhou, Feng Mao, Yan Lin, Songjie Shen, Xiaohui Zhang, Xue Qin, Cunli Yan, Xiaoying Ma, Yue Shi, Qiang Sun
Summary: This retrospective study found an association between SLN positive rate and non-SLN metastasis in breast cancer, with SLN-PR > 0.333 being a potential risk factor for non-SLN metastasis. The results provide valuable reference for guiding adjuvant treatment in breast cancer patients.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Oncology
Lise B. J. Thorsen, Jens Overgaard, Louise W. Matthiessen, Martin Berg, Lars Stenbygaard, Anders N. Pedersen, Mette H. Nielsen, Marie Overgaard, Birgitte Vrou Offersen
Summary: The Danish Breast Cancer Group's study showed that internal mammary node irradiation (IMNI) in node-positive early breast cancer patients led to improved overall survival (OS). Patients treated with IMNI had lower risk of distant recurrence and death from breast cancer, ultimately improving long-term survival.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Anastasia Bothou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Georgia Margioula-Siarkou, Stefanos Zervoudis, Alexandros Sotiriadis, Frederic Amant, Konstantinos Dinas
Summary: Sentinel lymph node biopsy (SLNB) appears to be a safe and effective technique for breast cancer during pregnancy, according to this systematic review. A total of 63 articles were included, with 47 strongly in favor of SLNB in pregnancy-related breast cancer (PABC), 4 partially in favor, 10 strongly against, and 2 partially against. Sub-categorization based on study type showed that the majority of studies in favor had higher levels of evidence. In total, 382 women with PABC underwent SLNB, and full data were reported for 237 cases. The overall live birth rate was 95.8%, while the overall neonatal complication rate was 3.4%. No cases of maternal side effects or anaphylactic reaction, maternal death, stillbirth, or neonatal death were reported (0%).
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Surgery
Gabriele Martelli, Francesco Barretta, Rosalba Miceli, Secondo Folli, Ilaria Maugeri, Chiara Listorti, Gianfranco Scaperrotta, Paolo Baili, Giancarlo Pruneri, Giuseppe Capri, Cristina Ferraris
Summary: The study confirms that in cN0/1 breast cancer patients who undergo primary chemotherapy followed by sentinel node biopsy, if the sentinel nodes are clear (pN0), performing only SNB can be an effective axillary treatment without impacting overall survival or disease-free survival.
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Zhen Huang, Zhe Wu, Quan-qing Zou, Yu-jie Xie, Li-hui Li, Yan-ping Huang, Feng-ming Wu, Dong Huang, Yin-hua Pan, Jian-rong Yang
Summary: This study aimed to investigate the risk factors of non-sentinel lymph node metastasis in breast cancer patients with 1-2 sentinel lymph node macrometastases undergoing total mastectomy. The results showed that tumor size and ratio of sentinel lymph node macrometastases were independent risk factors for non-sentinel lymph node metastasis. The incidence of non-sentinel lymph node metastasis could be reduced to 17.1% for patients with tumor size ≤ 22 mm and ratio of sentinel lymph node macrometastases ≤ 0.33.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Xi'E Hu, Jingyi Xue, Shujia Peng, Ping Yang, Zhenyu Yang, Lin Yang, Yanming Dong, Lijuan Yuan, Ting Wang, Guoqiang Bao
Summary: This study developed a nomogram to preoperatively predict the risk of SLN metastasis in breast cancer patients, demonstrating high predictive performance and clinical usefulness.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Sean M. Hacking, Kara-Lynne Leonard, Dongling Wu, Mara Banks, Theresa Graves, Lijuan Wang, Evgeny Yakirevich, Yihong Wang
Summary: The use of sentinel lymph node biopsy (SLNB) in patients with microinvasive breast cancer (MIBC) has been debated. This study evaluated clinical and histological features to predict disease free survival (DFS) and factors influencing clinical decision making in MIBC patients. SLNB was found to be associated with mastectomy, high nuclear grade, and negativity for ER and HER-2. However, SLNB did not impact DFS in this study.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Qingyao Shang, Kexin Feng, Ya Wei, Kaipeng Wang, Chenxuan Yang, Shuangtao Zhao, Jiaxiang Liu, Xiangzhi Meng, Yalun Li, Chuang Du, Jing Wang, Guangdong Qiao, Jingruo Li, Xin Wang, Xiang Wang
Summary: This study evaluated the application of SLNB to provide information for the treatment of male breast cancer patients on a standardized basis.
Article
Medicine, General & Internal
Paolo Izzo, Claudia De Intinis, Simone Sibio, Luigi Basso, Andrea Polistena, Raimondo Gabriele, Massimo Codacci-Pisanelli, Luciano Izzo, Sara Izzo
Summary: This study proposed new techniques to prevent complications of sentinel lymph node biopsy and presented initial data from our experience. The identification rates of sentinel lymph node detection using radioactive tracers and the magnetic tracer technology (Sentimag) were 88.9% and 89.5% respectively.
Article
Oncology
Swadha D. Guru, Tanya L. Hoskin, Dana H. Whaley, Mark A. Nathan, James W. Jakub
Summary: There are limited data on the optimal injection technique for repeat sentinel lymph node (rSLN) surgery. Preoperative lymphoscintigraphy is beneficial in patients with recurrent breast cancer. Periareolar and peritumoral injections had similar incidence of sentinel lymph node identification and aberrant drainage.
CLINICAL BREAST CANCER
(2021)
Article
Surgery
Sanne-Marije Hazen, Tania Sluckin, Geerard Beets, Roel Hompes, Pieter Tanis, Miranda Kusters
Summary: There is significant variation among Dutch colorectal surgeons in the assessment and treatment of lateral lymph nodes in rectal cancer patients, highlighting the need for further research and international guidelines.
ACTA CHIRURGICA BELGICA
(2023)
Article
Oncology
Delal Akdeniz, Iris Kramer, Carolien H. M. van Deurzen, Bernadette A. M. Heemskerk-Gerritsen, Michael Schaapveld, Pieter J. Westenend, Adri C. Voogd, Agnes Jager, Ewout W. Steyerberg, Stefan Sleijfer, Marjanka K. Schmidt, Maartje J. Hooning
Summary: Lobular and lobular mixed primary breast cancer histology are associated with modestly increased risk of contralateral breast cancer (CBC), and personalized risk assessment needs to consider the histology of the primary cancer as well as the impact of systemic therapy.
Article
Oncology
Sanne A. L. Bartels, Mila Donker, Coralie Poncet, Nicolas Sauve, Marieke E. E. Straver, Cornelis J. H. van de Velde, Robert E. E. Mansel, Charlotte Blanken, Lorenzo Orzalesi, Jean H. G. Klinkenbijl, Huub C. J. van der Mijle, Grard A. P. Nieuwenhuijzen, Sanne C. C. Veltkamp, Thijs van Dalen, Andreas Marinelli, Herman Rijna, Marko Snoj, Nigel J. J. Bundred, Jos W. S. Merkus, Yazid Belkacemi, Patrick Petignat, Dominic A. X. Schinagl, Corneel Coens, Geertjan van Tienhoven, Frederieke van Duijnhoven, Emiel J. T. Rutgers
Summary: This clinical trial compared axillary lymph node dissection (ALND) with axillary radiotherapy (ART) in patients with cT1-2, node-negative breast cancer. The study found that both modalities had comparable axillary control, but ART was associated with less morbidity. Additionally, patients in the ART group had a higher risk of developing second primary cancers.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Josephine M. N. L. Cardozo, Irene L. E. Andrulis, Stig E. Bojesen, Thilo M. Doerk, Diana M. A. Eccles, Peter A. J. Fasching, Maartje J. Hooning, Renske Keeman, Heli Nevanlinna, Emiel J. T. F. Rutgers, Douglas F. Easton, Per Hall, Paul D. P. J. Pharoah, Laura J. K. van't Veer, Marjanka K. Schmidt
Summary: A polygenic risk score (PRS) consisting of 313 common genetic variants (PRS313) is associated with risk of breast cancer and contralateral breast cancer. This study aimed to evaluate the association of the PRS313 with clinicopathologic characteristics of, and survival following, breast cancer. The results showed that PRS313 is associated with favorable tumor characteristics but not independently associated with prognosis. Rating: 8/10.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Surgery
Martine A. van Huizum, J. Joris Hage, Astrid N. Scholten, Emiel J. Rutgers
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Oncology
Annemiek K. E. van Hemert, Josefien P. P. van Olmen, Liesbeth J. J. Boersma, John H. H. Maduro, Nicola S. S. Russell, Jolien Tol, Ellen G. G. Engelhardt, Emiel J. Th. Rutgers, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke H. H. van Duijnhoven
Summary: The purpose of this study is to show that omitting adjuvant radiotherapy in breast cancer patients with pCR after NST can result in low rates of local recurrence and good quality of life.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Oncology
Marjanka K. Schmidt, Jennifer E. Kelly, Anne Bredart, David A. Cameron, Jana de Boniface, Douglas F. Easton, Birgitte Offersen, Fiorita Poulakaki, Isabel T. Rubio, Francesco Sardanelli, Rita Schmutzler, Tanja Spanic, Britta Weigelt, Emiel J. T. Rutgers
Summary: After a unilateral breast cancer diagnosis, more and more patients are choosing to have contralateral prophylactic mastectomy (CPM), the removal of the healthy breast. Breast cancer specialists need to provide guidance to women considering CPM. This manifesto discusses the challenges of CPM and offers recommendations to improve outcomes for women with unilateral breast cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Lonneke A. van Tuijl, Maartje Basten, Kuan-Yu Pan, Roel Vermeulen, Luetzen Portengen, Alexander de Graeff, Joost Dekker, Mirjam I. Geerlings, Adriaan Hoogendoorn, Femke Lamers, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Trynke R. de Jong, Melanie R. Keats, Almar A. L. Kok, Steinar Krokstad, Flora E. van Leeuwen, Annemarie I. Luik, Nolwenn Noisel, N. Charlotte Onland-Moret, Yves Payette, Brenda W. J. H. Penninx, Ina Rissanen, Annelieke M. Roest, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Emma L. Twait, Alison Teyhan, W. M. Monique Verschuren, Kimberly D. van der Willik, Judith G. M. Rosmalen, Adelita V. Ranchor
Summary: A meta-analysis of individual participant data from 18 cohorts found no associations between depression or anxiety and most types of cancer, except for lung cancer and smoking-related cancers. The associations with lung and smoking-related cancers were attenuated when adjusting for known risk factors.
Article
Oncology
Cas de Jongh, Lianne Triemstra, Arjen van der Veen, Lodewijk AA. Brosens, Grard AP. Nieuwenhuijzen, Jan HMB. Stoot, Wobbe O. de Steur, Jelle P. Ruurda, Richard van Hillegersberg
Summary: This study assessed the quality of gastric cancer surgery using a photo-scoring method and implemented quality control measures during the LOGICA trial. The results showed that high radicality and nodal yield were indicators of good quality D2-gastrectomy. However, the photo-scoring method used in the study needs further improvement.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eline L. van der Veer, Joost Lameijer, Angela M. P. Coolen, Adriana M. J. Bluekens, Joost Nederend, Maaike Gielens, Adri Voogd, Lucien Duijm
Summary: This study aimed to investigate the prevalence, causes, and consequences of delayed breast cancer diagnosis in the screening population. The results showed that a primary diagnostic delay in breast cancer diagnosis resulted in less favorable tumor characteristics and a higher rate of mastectomy compared to no delay in diagnosis and a delay in diagnostic work-up after recall.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Surgery
Stefi Nordkamp, Jan M. van Rees, Kim van den Berg, David M. Mens, Davy M. J. Creemers, Heike M. U. Peulen, Geert-Jan Creemers, Grard A. P. Nieuwenhuijzen, Jip L. Tolenaar, Johanne G. Bloemen, Joost Rothbarth, Harm J. T. Rutten, Cornelis Verhoef, Jacobus W. A. Burger
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Stefi Nordkamp, Floor Piqeur, Kim van den Berg, Jip L. Tolenaar, Irene E. G. van Hellemond, Geert-Jan Creemers, Mark Roef, Gesina van Lijnschoten, Jeltsje S. Cnossen, Grard A. P. Nieuwenhuijzen, Johanne G. Bloemen, Lien Coolen, Joost Nederend, Heike M. U. Peulen, Harm J. T. Rutten, Jacobus W. A. Burger
Summary: This study aimed to evaluate the oncological outcomes of patients with locally recurrent rectal cancer with a pCR, and compare them with patients without a pCR. Patients with a pCR had superior oncological outcomes. A watch-and-wait approach may be considered in highly selected patients to improve quality of life without compromising oncological outcomes.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Anouk Hiensch, Elles Steenhagen, Jonna K. van Vulpen, Jelle P. Ruurda, Grard A. P. Nieuwenhuijzen, Ewout A. Kouwenhoven, Richard P. R. Groenendijk, Donald L. van der Peet, Camiel Rosman, Bas P. L. Wijnhoven, Mark I. van Berge Henegouwen, Hanneke W. M. van Laarhoven, Richard van Hillegersberg, Peter D. Siersema, Anne M. May
Article
Oncology
Yuwei Wang, Annegien Broeks, Daniele Giardiello, Michael Hauptmann, Katarzyna Jozwiak, Esther A. Koop, Mark Opdam, Sabine Siesling, Gabe S. Sonke, Nikolas Stathonikos, Natalie D. ter Hoeve, Elsken van der Wall, Carolien H. M. van Deurzen, Paul J. van Diest, Adri C. Voogd, Willem Vreuls, Sabine C. Linn, Gwen M. H. E. Dackus, Marjanka K. Schmidt
Summary: This study validated the reliability of the PREDICT breast cancer prognostic model and assessed its clinical utility in young women with node-negative breast cancer. The results showed that PREDICT was not reliable in predicting outcomes for this patient subset and further updates are needed.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristien B. I. M. Keymeulen, Sandra M. E. Geurts, Loes F. S. Kooreman, Lucien E. M. Duijm, Sanne Engelen, Sigrid Vanwetswinkel, Ernest Luiten, Sabine Siesling, Adri C. Voogd, Vivianne C. G. Tjan-Heijnen
Summary: Breast MRI at primary DCIS diagnosis can detect additional synchronous cDCIS and cIBC, and is associated with a higher rate of metachronous cDCIS without decreasing the rate of metachronous cIBC. This finding is most evident in younger patients.
EUROPEAN RADIOLOGY
(2023)
