Article
Multidisciplinary Sciences
Tung-Lin Lee, Yi-Hua Liao, Jau-Yu Liau, Yi-Shuan Sheen
Summary: This study found that specific clinicopathological characteristics are associated with poor prognosis of cutaneous melanoma, including patient age, tumor thickness, and ulceration, particularly in acral lentiginous melanoma (ALM) patients.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Ali Azimi, Ellis Patrick, Rachel Teh, Jennifer Kim, Pablo Fernandez-Penas
Summary: Despite advances in managing metastatic melanomas, patients' overall survival remains low. This study investigated the proteome-wide changes associated with melanoma metastasis using mass spectrometry-based proteomics and bioinformatics analysis. Protein signatures were identified that distinguished regional lymph node and distant organ metastatic melanomas from primary lesions, providing valuable information for potential targeted therapies.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Immunology
Alicia Ines Bravo, Mariana Aris, Marylou Panouillot, Martina Porto, Marie-Caroline Dieu-Nosjean, Jean-Luc Teillaud, Maria Marcela Barrio, Jose Mordoh
Summary: This study analyzed metastatic lymph nodes in patients with cutaneous melanoma and found a triad structure that favors antigen presentation in patients with good prognosis. In patients with poor prognosis, there were highly proliferating tumor cells, low tumor HLA-I expression, and abundant FoxP3+ lymphocytes. These results highlight the importance of analyzing lymph nodes in melanoma patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Junge Bai, Ming Yang, Zheng Liu, Sergey Efetov, Cuneyt Kayaalp, Audrius Dulskas, Darcy Shaw, Xishan Wang
Summary: Colorectal cancer is a major cause of cancer-related death globally, with distant metastatic lesions, primarily in the liver, being found in 20% of patients. Collaboration between interventional radiologists, medical oncologists, and surgeons is crucial for optimal treatment. The effectiveness of primary tumor resection (PTR) in improving overall survival and quality of life is still controversial. This minireview focuses on the treatment options for hepatic colorectal metastatic illness, specifically discussing the advancements and risks of PTR in stage IV CRC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Georgina Long, Susan M. Swetter, Alexander M. Menzies, Jeffrey E. Gershenwald, Richard A. Scolyer
Summary: Cutaneous melanoma is a malignancy derived from skin melanocytes, primarily caused by ultraviolet radiation. Diagnosis is based on clinical and histopathological findings, and treatment options vary depending on disease stage and characteristics. Multidisciplinary care, including systemic drug therapies, has significantly improved melanoma survival rates.
Article
Multidisciplinary Sciences
Charles Q. Yang, Huan Wang, Zhenqiu Liu, Matthew T. Hueman, Aadya Bhaskaran, Donald E. Henson, Li Sheng, Dechang Chen
Summary: This study introduces machine learning as a novel tool to integrate additional prognostic factors into the TNM staging system for more accurate risk classification and survival prediction in patients with cutaneous melanoma. By utilizing the Ensemble Algorithm for Clustering Cancer Data (EACCD), a more advanced prognostic system was developed that improved patient stratification and survival prediction accuracy. The integration of additional factors separated favorable from unfavorable clinical outcomes, enhancing cohort selection for clinical trials and treatment management.
Review
Medicine, General & Internal
Simone Amabile, Gabriele Roccuzzo, Valentina Pala, Luca Tonella, Marco Rubatto, Martina Merli, Paolo Fava, Simone Ribero, Maria Teresa Fierro, Paola Queirolo, Pietro Quaglino
Summary: This narrative review focuses on adjuvant studies for resected stage III/IV melanoma, specifically looking at distant metastasis-free survival (DMFS) trends and their correlation with relapse-free survival (RFS). The data shows that DMFS trends closely follow those of RFS, with most patients experiencing relapse at visceral sites rather than regional sites. DMFS could be considered a primary endpoint in adjuvant trials, identifying patients with a worse prognosis who may need further systemic treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Sarah Hanna, Serigne N. Lo, Robyn PM. Saw
Summary: Comparing narrow (1-2 cm) and wide (3-5 cm) excision margins, no significant differences were found in locoregional or distant recurrence, metastasis, death, or death due to melanoma. Wide margins (2-5 cm) increased the need for surgical reconstruction.
Article
Dermatology
Kalle Mattila, Helmi Vihinen, Antti Karlsson, Heikki Minn, Pia Vihinen, Eetu Heervae
Summary: Previous studies have shown that persistent tobacco smoking is associated with lower survival rates in patients with cutaneous melanoma, but the effects of smoking and other prognostic factors have not been extensively studied. This study examined the relationship between smoking (persistent, former, or never) and melanoma-specific (MSS) and overall survival (OS) in patients with cutaneous melanoma treated in Southwest Finland from 2005 to 2019. The results showed that smoking remained an independent prognostic factor for inferior melanoma-specific survival, regardless of age, sex, stage, and comorbidities. The study also found that smoking was associated with increased melanoma-specific and overall mortality in stage IV patients. Therefore, healthcare professionals should actively inquire about smoking habits in order to support smoking cessation.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Multidisciplinary Sciences
Xiaoxia Ding, Wenwen Wang, Xiaohua Tao, Zhiming Li, Youming Huang
Summary: This study confirms the prognostic stratification and immune characteristics differences between different chemokine-related clusters in SKCM patients. A 14-gene prognostic model based on chemokines was established, which has important implications for treatment decision-making in SKCM patients.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Yu Min, Xiaoman Liu, Daixing Hu, Hang Chen, Jialin Chen, Ke Xiang, Guobing Yin, Yuling Han, Yang Feng, Haojun Luo
Summary: Breast cancer patients with no lymph node metastasis but distant metastasis present specific clinicopathological characteristics that are associated with the risk of distant metastasis and prognosis, including factors such as age, tumor size, race, tumor location, grade, and histology. A novel nomogram for predicting 1-, 3-, and 5- year CSS in T1-3N0M1 patients has been established and validated, which could assist clinicians in better stratifying patients and implementing relatively aggressive management.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Dermatology
Sumeyre Seda Ertekin, Sebastian Podlipnik, Constanza Riquelme-Mc Loughlin, Alicia Barreiro-capurro, Ana Arance, Cristina Carrera, Josep Malvehy, Susana Puig
Summary: This study found that the initial stage of melanoma plays a significant role in the pattern and timing of disease recurrence, with earlier stages associated with higher rates of locoregional recurrence. The time to first metastasis decreased with more advanced stages at initial diagnosis, suggesting a need for improved surveillance strategies for melanoma patients.
ACTA DERMATO-VENEREOLOGICA
(2021)
Review
Biochemistry & Molecular Biology
Thamila Kerkour, Catherine Zhou, Loes Hollestein, Antien Mooyaart
Summary: Studying primary melanoma and its metastasis is beneficial for understanding tumor biology and determining drug targets. This study analyzed literature systematically, evaluated gene concordance, and assessed heterogeneity. The results showed high concordance of drug targets during melanoma progression, but significant heterogeneity in gene consistency, requiring further validation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Guoqiao Zheng, Subhayan Chattopadhyay, Kristina Sundquist, Jan Sundquist, Asta Foersti, Akseli Hemminki, Kari Hemminki
Summary: Favorable survival in malignant cutaneous melanoma has led to an increase in the likelihood of developing second primary cancer. A significant proportion of patients developed other SPCs, with higher survival rates observed for women compared to men. Time-dependent analysis showed increased hazard ratios for fatal cancer types, but SPC-specific hazard ratios remained uniform regardless of when the SPC was diagnosed. Additional efforts are needed to improve survival rates for patients with various types of SPCs.
Article
Dermatology
Keon Hee Lee, Hyun Yi Suh, Mi Woo Lee, Woo Jin Lee, Sung Eun Chang
Summary: Positive EGFR expression in distant metastatic melanoma was significantly correlated with the absence of ulceration, and associated with poor survival outcomes. This study highlights the predictive value of EGFR immunostaining for survival outcome in male, non-ulcerated, or Breslow thickness 54.0 mm distant metastatic melanoma cases.
ANNALS OF DERMATOLOGY
(2021)
Editorial Material
Oncology
Trine Schoenfeldt, John F. Thompson, Serigne Lo, Krzysztof T. Drzewiecki, Jonathan Stretch, Robyn P. M. Saw, Andrew Spillane, Kerwin Shannon, Roger F. Uren, Annette H. Chakera, Omgo E. Nieweg
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Trine Schoenfeldt, John F. Thompson, Serigne Lo, Krzysztof T. Drzewiecki, Jonathan Stretch, Robyn P. M. Saw, Andrew Spillane, Kerwin Shannon, Roger F. Uren, Annette H. Chakera, Omgo E. Nieweg
Summary: This study aimed to determine the clinical significance of sentinel nodes (SNs) in the triangular intermuscular space (TIS) in patients with melanoma. It found that 11% of patients with melanomas on their upper back had TIS SNs, and retrieval of these SNs was important for accurate staging and to minimize the risk of recurrence in the TIS.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
James S. Wilmott, Hussein Tawbi, Johnathan A. Engh, Nduka M. Amankulor, Brindha Shivalingam, Hiya Banerjee, Ismael A. Vergara, Hansol Lee, Peter A. Johansson, Peter M. Ferguson, Philippe Saiag, Caroline Robert, Jean -Jacques Grob, Lisa H. Butterfied, Richard A. Scolyer, John M. Kirkwood, Georgina V. Long, Michael A. Davies
Summary: The purpose of this study was to identify baseline clinical features associated with outcomes of V600 BRAF-mutant metastatic melanoma patients with melanoma brain metastases (MBM) treated with dabrafenib and trametinib. Exploratory biomarker analysis was also conducted to identify molecular and immunologic changes associated with dabrafenib in MBMs and extracranial metastases (ECM). The results showed that baseline corticosteroid treatment was associated with reduced intracranial response rate (ICRR) and progression-free survival (PFS). These findings highlight the importance of considering corticosteroid treatment in the management of MBM patients and clinical trial design.
CLINICAL CANCER RESEARCH
(2023)
Article
Dermatology
Zizhen Ming, Su Yin Lim, Ashleigh Stewart, Bernadette Pedersen, Elena Shklovskaya, Alexander M. Menzies, Matteo S. Carlino, Richard F. Kefford, Jenny H. Lee, Richard A. Scolyer, Georgina V. Long, Helen Rizos
Summary: Immunotherapy targeting PD-1 and/or CTLA4 can lead to durable responses in some melanoma patients. However, treatment resistance and lack of response are common. This study identifies a vulnerability in melanoma driven by immune cell activity, providing potential strategies for combination therapies.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
Nicholas C. Allen, Elizabeth C. Paver, Nita Agar, Richard A. Scolyer, Fergal J. Moloney
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Review
Oncology
Georgina V. Long, Alexander M. Menzies, Richard A. Scolyer
Summary: The role of neoadjuvant therapy is shifting in oncology, from reducing surgical morbidity to a life-saving treatment with curative promise. Recent studies suggest that checkpoint inhibitors administered in the neoadjuvant setting may have greater clinical efficacy compared to the adjuvant setting.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Talal El Zarif, Amin H. Nassar, Elio Adib, Bailey G. Fitzgerald, Jiaming Huang, Tarek H. Mouhieddine, Paul G. Rubinstein, Taylor Nonato, Rana R. McKay, Mingjia Li, Arjun Mittra, Dwight H. Owen, Robert A. Baiocchi, Michael Lorentsen, Christopher Dittus, Nazli Dizman, Adewunmi Falohun, Noha Abdel-Wahab, Adi Diab, Anand Bankapur, Alexandra Reed, Chul Kim, Aakriti Arora, Neil J. Shah, Edward El-Am, Elie Kozaily, Wassim Abdallah, Ahmad Al-Hader, Batool Abu Ghazal, Anwaar Saeed, Claire Drolen, Melissa G. Lechner, Alexandra Drakaki, Javier Baena, Caroline A. Nebhan, Tarek Haykal, Michael A. Morse, Alessio Cortellini, David J. Pinato, Alessia Dalla Pria, Evan Hall, Veli Bakalov, Nathan Bahary, Aarthi Rajkumar, Ankit Mangla, Vishal Shah, Parminder Singh, Frank Aboubakar Nana, Nerea Lopetegui-Lia, Danai Dima, Ryan W. Dobbs, Pauline Funchain, Rabia Saleem, Rachel Woodford, Georgina V. Long, Alexander M. Menzies, Carlo Genova, Giulia Barletta, Sonam Puri, Vaia Florou, Dame Idossa, Maristella Saponara, Paola Queirolo, Giuseppe Lamberti, Alfredo Addeo, Melissa Bersanelli, Dory Freeman, Wanling Xie, Erin G. Reid, Elizabeth Y. Chiao, Elad Sharon, Douglas B. Johnson, Ramya Ramaswami, Mark Bower, Brinda Emu, Thomas U. Marron, Toni K. Choueiri, Lindsey R. Baden, Kathryn Lurain, Guru P. Sonpavde, Abdul Rafeh Naqash
Summary: Compared with people living without HIV, people living with HIV and cancer have been excluded from immune checkpoint inhibitor trials. There is also a lack of real-world data on the use of ICIs in this population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Lodewijka H. J. Holtkamp, Serigne N. Lo, John F. Thompson, Andrew J. Spillane, Jonathan R. Stretch, Robyn P. M. Saw, Kerwin F. Shannon, Omgo E. Nieweg, Angela M. Hong
Summary: This study evaluated the long-term node field control and survival of melanoma patients with node field recurrence following prior node dissection who underwent salvage surgery with adjuvant radiotherapy. The results showed that while adjuvant radiotherapy achieved control of the node field, disease progression at distant sites was common and the survival outcomes were poor.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Prachi Bhave, Angela Hong, Serigne N. Lo, Rebecca Johnson, Johanna Mangana, Douglas B. Johnson, Ozgecan Dulgar, Zeynep Eroglu, Hui-Ling Yeoh, Andrew Haydon, Georg C. Lodde, Elisabeth Livingstone, Adnan Khattak, Katharina Kaehler, Axel Hausschild, Grant A. McArthur, Alexander Maxwell Menzies, Georgina Long, Wei Wang, Matteo S. Carlino
Summary: This study investigates the role of adjuvant radiation therapy (RT) in patients with melanoma who experience locoregional disease recurrence during or after adjuvant anti-PD-1-based immunotherapy. The results show that adjuvant RT is associated with improved locoregional disease control, but does not affect the risk of distant recurrence.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Tuba N. Gide, Elizabeth C. Paver, Zarwa Yaseen, Nigel Maher, Nurudeen Adegoke, Alexander M. Menzies, Ines Pires da Silva, James S. Wilmott, Georgina V. Long, Richard A. Scolyer
Summary: This study evaluated the association between LAG-3 expression and clinical outcomes in metastatic melanoma patients treated with anti-LAG-3 and anti-PD-1 immunotherapy. The results showed that LAG-3 expression was related to treatment response and tumor-infiltrating lymphocytes, and patients with ≥ 1% LAG-3+ cells had longer progression-free survival.
Article
Oncology
Nurudeen A. Adegoke, Tuba N. Gide, Yizhe Mao, Camelia Quek, Ellis Patrick, Matteo S. Carlino, Serigne N. Lo, Alexander Maxwell Menzies, Ines Pires da Silva, Ismael A. Vergara, Georgina Long, Richard A. Scolyer, James S. Wilmott
Summary: This study developed a method for unsupervised classification of tumor microenvironment (TME) in metastatic melanoma and used multiplex immunohistochemistry and quantitative pathology to assess immune cell compositions for classification in relation to response to immune checkpoint inhibitors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Meeting Abstract
Oncology
Srikanth Manda, Adel T. Aref, Erin K. Sykes, Steven G. Williams, Jennifer M. Koh, Erin M. Humphries, Daniel Bucio-Noble, Daniela Lee-Smith, Natasha Lucas, Dylan Xavier, Alexander Menzies, Ines Da Silva, Felicity Newell, Rosemary Balleine, Peter G. Hains, Graham Mann, Phil J. Robinson, Georgina V. Long, James Wilmott, Qing Zhong, Richard A. Scolyer, Roger R. Reddel
Meeting Abstract
Dermatology
W. Pruessmann, J. Rytlewski, J. Wilmott, M. C. Mimh, G. H. Atrill, B. Dyring-Andersen, P. Fields, Q. Zhan, A. J. Colebatch, P. M. Ferguson, J. F. Thompson, K. Kallenbach, E. Yusko, R. Clark, H. Robbins, R. A. Scolyer, T. S. Kupper
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)