Article
Oncology
Gilles Houvenaeghel, Monique Cohen, Pedro Raro, Jeremy De Troyer, Pierre Gimbergues, Christine Tunon de Lara, Vivien Ceccato, Veronique Vaini-Cowen, Christelle Faure-Virelizier, Frederic Marchal, Tristan Gauthier, Eva Jouve, Pierrick Theret, Claudia Regis, Philippe Gabelle, Julia Pernaut, Francesco Del Piano, Gauthier D'Halluin, Stephane Lantheaume, Emile Darai, Bassoodeo Beedassy, Caroline Dhainaut-Speyer, Xavier Martin, Sophie Girard, Richard Villet, Emilie Monrigal, Theophile Hoyek, Jean-Francois Le Brun, Pierre-Emmanuel Colombo, Agnes Tallet, Jean-Marie Boher
Summary: The study analyzed the treatment and pathological results of patients included in the SERC trial, a multicenter randomized non-inferiority phase-3 trial comparing completion axillary lymph node dissection (cALND) with sentinel lymph node biopsy alone in breast cancer patients. Patients with one or two involved sentinel nodes by micro- or macro-metastases may not require cALND, but further research is needed for those with more than two involved nodes.
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Xunxi Lu, Mengting He, Luoting Yu, Zongchao Gou
Summary: This cohort study found that receiving surgical axillary staging was associated with better survival for patients with ipsilateral breast tumor recurrence, and repeat sentinel lymph node biopsy had a similar long-term survival outcome as axillary lymph node dissection. Therefore, repeat sentinel lymph node biopsy may be considered for surgical axillary staging in patients with ipsilateral breast tumor recurrence after lumpectomy and initial sentinel lymph node biopsy.
Article
Oncology
Ji Young You, Eun Sook Lee, Siew Kuan Lim, Youngmee Kwon, So-Youn Jung
Summary: According to the study, performing sentinel lymph node biopsy (SLNB) without axillary lymph node dissection (ALND) may be a reasonable treatment option for patients with positive lymph nodes after breast cancer surgery. There was no significant difference in the loco-regional recurrence rates between SLNB with ALND and SLNB alone.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Zhao Bi, Jia-Jian Chen, Peng-Chen Liu, Peng Chen, Wei-Li Wang, Yan-Bing Liu, Chun-Jian Wang, Peng-Fei Qiu, Qing Lv, Jiong Wu, Yong-Sheng Wang
Summary: This study developed a predictive model based on a multi-center retrospective database to accurately predict whether HR+/HER2- patients can undergo genomic tests. Through multivariate logistic regression analysis, imaging abnormal nodes, the number of positive SLNs, the number of negative SLNs, pathological tumor stage, and lympho-vascular invasion were identified as independent predictors for patients having <= 3 total metastatic ALNs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Matilda Appelgren, Helena Sackey, Yvonne Wengstrom, Karin Johansson, Johan Ahlgren, Yvette Andersson, Leif Bergkvist, Jan Frisell, Dan Lundstedt, Lisa Ryden, Malin Sund, Sara Alkner, Birgitte Vrou Offersen, Tove Filtenborg Tvedskov, Peer Christiansen, Jana de Boniface
Summary: This report evaluates the impact of axillary lymph node dissection (ALND) on health related quality of life (HRQoL) and patient-reported arm morbidity one year after breast cancer surgery. The study found that ALND did not have a negative impact on HRQoL and could reduce arm morbidity in patients.
Article
Oncology
Isaac Cebrecos, Eduard Mension, Inmaculada Alonso, Helena Castillo, Esther Sanfeliu, Sergi Vidal-Sicart, Sergi Ganau, Maria Vidal, Francesco Schettini
Summary: In early stage breast cancer patients without lymph node metastasis, the presence of positive sentinel lymph nodes after primary systemic treatment directs axillary lymph node dissection. This study aimed to identify factors associated with non-sentinel lymph node involvement and develop a predictive score. The results showed that non-sentinel lymph node involvement was infrequent (22.2%) and associated with progesterone receptor levels and macrometastatic sentinel lymph nodes. The developed predictive score accurately predicted the absence of non-sentinel lymph node involvement, suggesting that unnecessary axillary lymph node dissection could be safely avoided in most patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Y. Andersson, L. Bergkvist, J. Frisell, J. de Boniface
Summary: The SENOMIC trial found that omitting axillary lymph node dissection in patients with breast cancer and sentinel node micrometastases had excellent 3-year event-free survival rates. However, patients who underwent mastectomy had worse tumor characteristics and higher risk of recurrence, especially without adjuvant radiotherapy. Long-term follow-up and enrollment of mastectomy patients are crucial.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Arielle P. Stafford, Judy C. Boughey
Summary: This study evaluated the rate of non-sentinel lymph node (NSLN) positivity and factors influencing this in patients with a positive sentinel lymph node (SLN) following neoadjuvant chemotherapy (NAC). The results showed a high rate of nodal positivity on completion axillary lymph node dissection (cALND) in the setting of positive SLN after NAC, supporting the current standard of routine cALND. In patients with cN+ disease, NSLN positivity varied based on tumor biology, multicentricity/multifocality, number of positive SLNs, and SLN metastasis size.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Ya Qiu, Xiang Zhang, Zhiyuan Wu, Shiji Wu, Zehong Yang, Dongye Wang, Hongbo Le, Jiaji Mao, Guochao Dai, Xuwei Tian, Renbing Zhou, Jiayi Huang, Lanxin Hu, Jun Shen
Summary: The MRI-clinical-radiomics nomograms developed in this study showed high predictive performance in determining axillary NSLN status in SLN-positive breast cancer patients, reducing overtreatment and optimizing personalized surgical strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ian Campbell, Neil Wetzig, Owen Ung, David Espinoza, Gelareh Farshid, John Collins, James Kollias, Val Gebski, Rebecca Mister, R. John Simes, Martin R. Stockler, Grantley Gill
Summary: For early breast cancer patients who are clinically node-negative, sentinel node-based management (SNBM) is the international standard of care. In the SNAC1 study, we report the rates of axillary recurrence, overall survival, and breast cancer-specific survival at 10 years.
Article
Oncology
Peiyong Li, Ciqiu Yang, Junsheng Zhang, Yitian Chen, Xiaoqi Zhang, Minting Liang, Na Huang, Yilin Chen, Kun Wang
Summary: Sentinel lymph node biopsy can provide survival results equivalent to axillary lymph node dissection for patients with cN0 and T1-2 breast cancer; however, whether it can be performed on patients with T3-4c breast cancer is still controversial.
Article
Oncology
Toralf Reimer
Summary: The local treatment of axilla in early breast cancer patients without clinically evident lymph node metastases is a subject of debate. Various prospective randomized surgical trials are currently being conducted to evaluate the safety of omitting sentinel lymph node biopsy in upfront breast-conserving surgery and neoadjuvant setting. These trials aim to determine whether it is possible to make therapeutic decisions without pathologic evaluation of nodal status. Additionally, ongoing trials are investigating the possibility of de-escalating surgery based on the response to neoadjuvant systemic therapy.
Article
Oncology
N. Cabioglu, H. Karanlik, N. Yildirim, M. Muslumanoglu, G. Cakmak Karadeniz, D. Trabulus Can, M. Tukenmez, Y. E. Ersoy, C. Uras, B. Zengel, S. Emiroglu, A. K. Polat, L. Yeniay, E. Ozkurt, H. Kara, K. Ibis, A. Aydiner, V Ozmen, A. Igci
Summary: This study evaluated factors affecting local outcome in cN+ breast cancer patients who underwent sentinel lymph node biopsy alone after neoadjuvant chemotherapy. The results suggest that axillary lymph node dissection may be avoided in selected cN+ patients who achieve breast and/or nodal pathological complete response, have low volume residual nodal disease with luminal characteristics, and receive axillary radiotherapy.
Article
Oncology
Christian Doll, Simon Bigus, Elena Hofmann, Friedrich Mrosk, Claudius Steffen, Felix Thiele, Jan Voss, Kilian Kreutzer, Holger Amthauer, Max Heiland, Steffen Koerdt
Summary: The potential of sentinel lymph node biopsy (SLNB) in patients with recurrent or secondary oral squamous cell carcinoma (OSCC) without clinical signs of lymph node metastases (cN0) was evaluated in this retrospective study. Results showed a detection rate of 88.2% for sentinel lymph nodes, with two cases showing positive SLN. The SLNB had a negative predictive value of 86.7% and a sensitivity of 50.0% as a neck staging procedure.
Article
Oncology
Lenka N. C. Boyd, Mahsoem Ali, Laura Kam, Jisce R. Puik, Stephanie M. Fraga Rodrigues, Eline S. Zwart, Freek Daams, Barbara M. Zonderhuis, Laura L. Meijer, Tessa Y. S. Le Large, Elisa Giovannetti, Hanneke W. M. van Laarhoven, Geert Kazemier
Summary: This study assessed the diagnostic potential of the ratio of CA19-9 with bilirubin in patients with cancer of the pancreatic head, distal bile duct cancer, and benign diseases of the periampullary region prior to treatment. The findings suggest that the ratio of CA19-9 and bilirubin has higher diagnostic power and could aid in early diagnosis and improved treatment.
Article
Oncology
Janneke van Roij, Natasja Raijmakers, Laurien Ham, Marieke Van den Beuken-van Everdingen, Ben van den Borne, Geert-Jan Creemers, Jarmo Cornelis Hunting, Evelien Kuip, Lobke van Leeuwen, Hanneke van Laarhoven, Caroline Mandigers, Peter Nieboer, Lilly-Ann Van der Velden, Lia van Zuylen, John Gelissen, Myrte Zijlstra, Linda Brom, Heidi P. Fransen, Lonneke Van de Poll-Franse
Summary: This study aims to assess the quality of life and quality of care experienced by patients with advanced cancer and their relatives, taking their interdependency into account. The results showed that patients and relatives had low levels of emotional functioning. Satisfaction with care and continuity of care were positively associated with emotional functioning. A family-centered approach is recommended to optimize palliative cancer care.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Health Care Sciences & Services
Annelieke Damen, Natasja J. H. Raijmakers, Janneke van Roij, Anja Visser, Marieke Van den Beuken-Everdingen, Eveline Kuip, Hanneke W. M. van Laarhoven, Lobke Van Leeuwen-Snoeks, Annemieke Van der Padt-Pruijsten, Tineke J. Smilde, Carlo Leget, George Fitchett
Summary: Dutch patients with advanced cancer experience medium to low levels of spiritual well-being (SWB), with factors such as spiritual needs affecting their SWB. More attention and support are needed.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Computer Science, Artificial Intelligence
Tim Ottens, Sebastiano Barbieri, Matthew R. Orton, Remy Klaassen, Hanneke W. M. van Laarhoven, Hans Crezee, Aart J. Nederveen, Xiantong Zhen, Oliver J. Gurney-Champion
Summary: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a promising technique for quantifying perfusion in clinical applications. In this study, physics-informed deep neural networks were investigated for estimating physiological parameters from DCE-MRI signal curves. The neural networks showed higher accuracy and precision compared to the traditional non-linear least squares method. Among the different network architectures, the GRU framework demonstrated the best performance in simulations and in vivo evaluation. It outperformed the non-linear least squares method in terms of precision, accuracy, and test-retest repeatability. The study suggests using the GRU framework for analyzing DCE-MRI data.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Oncology
Tiuri E. Kroese, Yuko Takahashi, Florian Lordick, Peter S. N. van Rossum, Jelle P. Ruurda, Sjoerd M. Lagarde, Richard van Hillegersberg, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Summary: This population-based cohort study evaluated the treatment and survival outcomes in gastric cancer patients with liver metastases. The study found that liver oligometastatic disease and trastuzumab treatment were associated with better overall survival, while triplet chemotherapy was not significantly different from doublet chemotherapy.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Naomi C. A. van der Velden, Ellen M. A. Smets, Mariet Hagedoorn, Allison J. Applebaum, Bregje D. Onwuteaka-Philipsen, Hanneke W. M. van Laarhoven, Inge Henselmans
Summary: This study investigates the extent of patient-caregiver discordance in prognostic information preferences and perceptions among advanced cancer patients. The results show that there are discordances in patients' and caregivers' preferences and perceptions regarding the likelihood of cure and mortality risk. Discordant prognostic information preferences and better physical functioning of caregivers are associated with discordant perceptions of one-year mortality risk.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Oncology
Tiuri E. Kroese, Hanneke W. M. van Laarhoven, Sebastian F. Schoppman, Pieter R. A. J. Deseyne, Eric van Cutsem., Karin Haustermans., Philippe. Nafteux, Melissa Thomas, Radka Obermannova, Hanna R. Mortensen, Marianne Nordsmark, Per Pfeiffer, Anneli Elme, Antoine Adenis, Guillaume Piessen, Christiane J. Bruns, Florian Lordick, Ines Gockel, Markus Moehler, Cihan Gani, Theodore Liakakos, John Reynolds, Alessio G. Morganti, Riccardo Rosati, Carlo Castoro, Francesco Cellini, Domenico D'Ugo, Franco Roviello, Maria Bencivenga, Giovanni de Manzoni, Mark I. van Berge Henegouwen, Maarten C. C. M. Hulshof, Jolanda van Dieren, Marieke Vollebergh, Johanna W. van Sandick, Paul Jeene, Christel T. Muijs, Marije Slingerland, Francine E. M. Voncken, Henk Hartgrink, Geert-Jan Creemers, Maurice J. C. van der Sangen, Grard Nieuwenhuijzen, Maaike Berbee, Marcel Verheij, Bas Wijnhoven, Laurens V. Beerepoot, Nadia H. Mohammad, Stella Mook, Jelle P. Ruurda, Piotr Kolodziejczyk, Wojciech P. Polkowski, Lucjan Wyrwicz, Maria Alsina, Manuel Pera, Tania F. Kanonnikoff, Andres Cervantes, Magnus Nilsson, Stefan Monig, Anna D. Wagner, Matthias Guckenberger, Ewen A. Griffiths, Elizabeth Smyth, George B. Hanna, Sheraz Markar, M. Asif Chaudry, Maria A. Hawkins, Edward Cheong, Richard van Hillegersberg, Peter S. N. van Rossum
Summary: This study aimed to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophago-gastric cancer. Through a series of discussions and expert evaluations, a consensus was reached, which can be used for future research in clinical trials.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Naomi Cornelia Anna van der Velden, Paul K. J. Han, Hanneke W. M. van Laarhoven, Filip Y. F. L. de Vos, Lizza E. L. Hendriks, Sjaak A. Burgers, Anne-Marie C. Dingemans, Jan Maarten W. van Haarst, Joyce Dits, Ellen M. A. Smets, Inge Henselmans
Summary: Discordance between physicians' and patients' prognostic perceptions in advanced cancer care threatens informed medical decision-making and end-of-life preparation, yet this phenomenon is poorly understood. This study examines the extent and predictors of physician-patient discordance in prognostic perceptions.
Review
Oncology
Irit Ben-Aharon, Hanneke W. M. van Laarhoven, Elisa Fontana, Radka Obermannova, Magnus Nilsson, Florian Lordick
Summary: Data shows a significant increase in the incidence of colorectal cancer in younger populations, as well as similar trends in gastric, pancreatic, and biliary tract cancers. The majority of these cases are sporadic and not hereditary, suggesting a potential role for behavioral, lifestyle, nutritional, microbial, and environmental factors. This review explores the current understanding and challenges of early-onset gastrointestinal cancer, and emphasizes the need for further research to develop preventive strategies and tailored early detection.
Letter
Oncology
Lenka N. C. Boyd, Mahsoem Ali, Jisce R. Puik, Laura L. Meijer, Tessa Y. S. Le Large, Hanneke W. M. van Laarhoven, Elisa Giovannetti, Geert Kazemier
CLINICAL CANCER RESEARCH
(2023)
Article
Health Care Sciences & Services
Niels W. L. Peeters, Rick A. Vreman, Geert A. Cirkel, Marie Jose Kersten, Hanneke W. M. van Laarhoven, Lonneke Timmers
Summary: This study aimed to gain insight into patient volumes per hospital of patients treated with systemic anticancer treatment in the Netherlands. The results showed that the majority of Dutch hospitals treat small numbers of patients in oncology, indicating a high level of fragmentation. Further exploration and discussion on how to organize care to improve efficiency and quality is needed.
Review
Oncology
Angelica Petrillo, Elizabeth C. Smyth, Hanneke W. M. van Laarhoven
Summary: Gastroesophageal adenocarcinoma is a heterogeneous disease with a poor prognosis. Chemotherapy has been the mainstay of treatment, but immunotherapy has shown promise in improving survival outcomes. This review discusses emerging targets in GEA, such as fibroblast growth factor receptor and Claudin 18.2, as well as novel agents targeting HER2 and angiogenesis. Cellular therapies like CAR-T and SPEAR-T cells are also explored.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Review
Oncology
Joachim Kikomeko, Tim Schutte, Merel J. M. van Velzen, Rianne Seefat, Hanneke W. M. van Laarhoven
Summary: Many cancer patients use alternative and complementary treatments such as short-term fasting (STF) and fasting mimicking diets (FMDs) to improve their anticancer treatment and reduce side effects. Recent studies have shown promising results of dietary interventions in combination with chemotherapy, slowing down tumor growth and reducing side effects. This review summarizes the current evidence on the feasibility and effects of STF and FMDs in cancer patients receiving chemotherapy.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Marieke Pape, Pauline A. J. Vissers, Willemieke P. M. Dijksterhuis, David Bertwistle, Laura McDonald, Bianca Mostert, Sarah Derks, Irma M. M. Oving, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Summary: This retrospective cohort study investigated the treatment and survival of patients with advanced esophageal adenocarcinoma (EAC), gastroesophageal junction adenocarcinoma (GEJC), and gastric adenocarcinoma (GAC). Despite differences in clinical characteristics and treatment strategies, the survival of patients with advanced EAC, GEJC, and GAC was similar. Therefore, excluding EAC patients from clinical trials for patients with molecularly similar GEJC/GAC should be reconsidered.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Simone Augustinus, Hanneke W. M. van Laarhoven, Geert A. Cirkel, Jan Willem B. de Groot, Bas Groot Koerkamp, Teresa Macarulla, Davide Melisi, Eileen M. O'Reilly, Hjalmar C. van Santvoort, Tara M. Mackay, Marc G. Besselink, Johanna W. Wilmink
Summary: The use of imaging is increasing, leading to an increase in the number of asymptomatic patients diagnosed with metastatic pancreatic cancer (mPDAC). Most medical oncologists prefer immediate chemotherapy initiation following diagnosis, but delayed treatment is considered in specific clinical contexts.