Article
Oncology
Wang-Yang Ye, Hui-Ping Lu, Jian-Di Li, Gang Chen, Rong-Quan He, Hua-Yu Wu, Xian-Guo Zhou, Min-Hua Rong, Li-Hua Yang, Wei-Ying He, Qiu-Yu Pang, Shang-Ling Pan, Yu-Yan Pang, Yi-Wu Dang
Summary: The study confirmed the upregulation of E2F1 in hepatocellular carcinoma (HCC) patients, with elevated E2F1 level correlating with Asian race, tumor classification, neoplasm histologic grade, eastern cancer oncology group, and plasma AFP levels. E2F1 possessed moderate discriminatory capability in differentiating HCC patients from non-HCC controls. Furthermore, two putative targeted genes (CCNE1 and CCNA2) of E2F1 were identified for their potential roles in regulating cell cycle and promoting antiapoptotic activity in HCC patients.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Oncology
Zun-Yan Zhou, Ji-Yuan Yang, Cheng-Ze Shao, Fei Luo, Wei Du
Summary: By regulating the expression of E2F-1 and ATM, the resistance of human nasopharyngeal carcinoma cells to cisplatin can be reversed.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dana Saad, Cristina Paissoni, Antonio Chaves-Sanjuan, Marco Nardini, Roberto Mantovani, Nerina Gnesutta, Carlo Camilloni
Summary: E2F1 as a master regulator of cell-cycle progression binds DNA as a heterodimer with DP partners, with an asymmetric contribution of dynamics in the complex. Tumor mutations in the flexible regions of the complex could affect protein function context-dependently, suggesting fundamental contributions of DP proteins in distinct aspects of E2F biology.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Oncology
Xinxin Li, Mengzhen Han, Hongwei Zhang, Furong Liu, Yonglong Pan, Jinghan Zhu, Zhibin Liao, Xiaoping Chen, Bixiang Zhang
Summary: Zinc finger proteins, characterized by their different DNA binding motifs, play a significant role in gene regulation. In hepatocellular carcinoma (HCC), zinc finger proteins exhibit diverse functions in tumorigenesis and progression, and they are also of great significance in HCC diagnosis and prognostic evaluation.
BIOMARKER RESEARCH
(2022)
Article
Oncology
Shijie Qin, Jieyun Xu, Yunmeng Yi, Sizhu Jiang, Ping Jin, Xinyi Xia, Fei Ma
Summary: The study identified 114 dysregulated mature miRNAs in HCC, primarily influenced by dysregulated transcription factors or DNA methylation. Several up-regulated miRNAs were shown to promote tumorigenesis by inhibiting tumor suppressor genes, while down-regulated miRNAs suppress abnormal cell proliferation by inhibiting oncogenes. The interplay between transcription factors and miRNAs plays a significant role in the occurrence and development of HCC, and the transcription factor FOXO1 may be an effective therapeutic target for improving the survival of HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Maria Paula Zappia, Yong-Jae Kwon, Anton Westacott, Isabel Liseth, Hyun Min Lee, Abul B. M. M. K. Islam, Jiyeon Kim, Maxim V. Frolov
Summary: The transcription factor E2F is responsible for controlling the expression of cell cycle genes by binding to their promoters. However, its significance in the regulation of metabolic genes is not well understood. In this study, the researchers introduced mutations in the E2F sites of five metabolic genes in fruit flies and found varying effects on E2F recruitment and gene expression, with the glycolytic gene Pgk being the most affected. Loss of E2F regulation on the Pgk gene led to decreased glycolytic flux, ATP content, and abnormal mitochondrial morphology. The study highlights the importance of E2F regulation on metabolic genes and its impact on overall development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Jiansheng Li, Dongzhi Li, Xianhua Zhang, Cuijuan Li, Fengjuan Zhu
Summary: SLC9A3-AS1 is highly expressed in nasopharyngeal carcinoma (NPC) and affects patient overall survival. Through the modulation of the miR-486-5p/E2F6 axis, it regulates cell proliferation, migration, invasion, and apoptosis. The newly identified SLC9A3-AS1/miR-486-5p/E2F6 pathway may offer attractive therapeutic targets for future development.
Article
Oncology
Hongbo Wang, Fang Chu, Li Zhijie, Qian Bi, Li Lixin, Yunlong Zhuang, Zhang Xiaofeng, Xiaofeng Niu, Dali Zhang, He Xi, Bo-an Li
Summary: This study reveals that MTBP functions as a co-activator of ETS-1, promoting HCC cell proliferation. The correlation between MTBP and downstream genes of ETS-1 is confirmed in clinical specimens.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Tongyue Zhang, Danfei Liu, Yijun Wang, Mengyu Sun, Limin Xia
Summary: ETS transcription factors are implicated in hepatocellular carcinoma, and understanding their molecular mechanisms may offer novel therapeutic strategies for cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lili Zhang, Guangyao Hu
Summary: This study found that NSD2 is highly expressed in oral squamous cell carcinoma (OSCC) and plays an oncogenic role by activating E2F1 and YBX2. Silencing of NSD2, E2F1 or YBX2 may help suppress the progression of OSCC.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Genetics & Heredity
Wenmin Hu, Yongmei Shi, Tongqin Han, Caiyun Liu, Xipeng Cao, Guangjun Shi, Wenjing Zhu
Summary: This study identified a panel of E2F target gene signature including five genes that can predict the prognosis of hepatocellular carcinoma, and high risk scores are closely related to overall survival of patients.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Hongmin Li, Haitao Lan, Ming Zhang, Fen Zhao, Ning An, Cheng Yi
Summary: This study found that TEAD1 is highly expressed in HCC tissues and its overexpression promotes the proliferation, migration, and invasion of HCC cells, while inhibiting ferroptosis. Silencing TEAD1 can inhibit tumor growth and enhance the anti-tumor activity of sorafenib.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yue Wang, Shuo Liu, Qin Chen, Yixin Ren, Zhongxiang Li, Shuang Cao
Summary: The study found that OCT1 expression is higher in HCC patients and may be a potential therapeutic target, with the novel drug SMIO-1 showing promise in inhibiting HCC cell proliferation and metastasis by targeting OCT1 activation.
Article
Biochemistry & Molecular Biology
Selase D. Deletsu, Haruki Kitamura, Takaomi Ishida, Jin Gohda, Shoji Yamaoka, Hiroaki Takeuchi
Summary: RNA interference screening identified STMN1 as a host factor required for maintaining HIV-1 latency. Depletion of STMN1 enhances HIV-1 expression and may contribute to HIV-1 transcription. STNM1 depletion is suggested as a potential therapeutic target to eradicate HIV-1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Baozhu Zhang, Boyang Chang, Lu Wang, Yuzhong Xu
Summary: This study identified an E2F target signature that can predict prognosis of hepatocellular carcinoma (HCC). The signature is associated with tumor stem cell characteristics, immune evasion, and drug sensitivity. The findings highlight the potential of the E2F target pathway for personalized identification and treatment of HCC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biology
Tzu-Ju Chen, Seyedeh Zahra Dehghanian, Ti-Chun Chan, Hong-Lin He, Wan-Shan Li, Sina Abdollahi, Nai-Yu Chen, Chien-Feng Li, Yow-Ling Shiue
Summary: Data mining and immunohistochemistry analysis revealed that upregulation of GNB4 protein is associated with poor prognosis in UC patients. High GNB4 expression levels were correlated with clinicopathological features and predicted decreased disease-specific and metastasis-free survival rates. Multiple signaling pathways were enriched in GNB4-related UC progression, emphasizing the significance of GNB4 in UC development.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Oncology
Chu-An Wang, Chien-Feng Li, Rho-Chi Huang, Yo-Hua Li, Jing-Ping Liou, Shaw-Jenq Tsai
Summary: The study showed that a selective HDAC1/2 inhibitor (B390) has multifaceted therapeutic potential in PDAC by restoring the expression and function of DUSP2. In vitro experiments demonstrated that B390 inhibited growth and migration abilities of PDAC cells, decreased VEGF-C expression, and suppressed lymphatic endothelial cell proliferation.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Pathology
Pei-Hang Lee, Yu-Chien Kao, Tsung-Han Hsieh, Jia-Bin Liao, Chien-Feng Li, Jen-Chieh Lee, Yi-Ming Chang, Ching-Di Chang, Shih-Chiang Huang, Tzu-Ju Chen, Ting-Ting Liu, Shih-Chen Yu, Hsuan-Ying Huang
Summary: Studying the clinicopathologic and genetic spectrum of extracranial myxoid mesenchymal tumors with fusions between EWSR1/FUS and CREB transcription factors revealed similarities and differences among groups, highlighting the morphologic overlap with myxoid angiomatoid fibrous histiocytoma and myoepithelial tumor/carcinoma. The relationships between fusion types and histology, immunoprofile, and outcome remain unclear.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cell Biology
Ti-Chun Chan, Chung-Hsi Hsing, Yow-Ling Shiue, Steven K. Huang, Kun-Lin Hsieh, Yu-Hsuan Kuo, Chien-Feng Li
Summary: This study uncovers the biological significance of the CEBPD/hsa-miR-429/VEGFA axis in angiogenesis and tumor growth in urothelial carcinoma (UC). By inhibiting hsa-miR-429, CEBPD stabilizes the expression of VEGFA, leading to the progression of UC.
Article
Oncology
Hong-Yue Lai, Li-Ching Wu, Po-Hsin Kong, Hsin-Hwa Tsai, Yen-Ta Chen, Yuan-Tso Cheng, Hao-Lun Luo, Chien-Feng Li
Summary: The high prevalence of dialysis and incidence of upper urinary tract urothelial carcinoma (UTUC) in Taiwan may be related to aristolochic acid (AA) exposure. This study developed a fast and cost-effective AA detection platform and found correlations between AA detection and clinical outcomes, suggesting it as a predictive and prognostic biomarker.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yu-Wei Hsiao, Jhih-Ying Chi, Chien-Feng Li, Lei-Yi Chen, Yi-Ting Chen, Hsin-Yin Liang, Yu-Chih Lo, Jhen-Yi Hong, Chin-Pin Chuu, Liang-Yi Hung, Jyun-Yi Du, Wen-Chang Chang, Ju-Ming Wang
Summary: Targeting vital protumour factors found in stromal cells in the tumour microenvironment may be an effective strategy in cancer therapy. Loss of PTX3 in stromal cells has been shown to decrease the metastasis and growth of cancer cells. Clinically, stromal PTX3 expression is associated with adverse prognostic features and worse survival outcomes in TNBC. Furthermore, TGF-beta 1 induces PTX3 expression by activating CEBPD in stromal fibroblasts, leading to the metastasis and invasion of TNBC MDA-MB-231 cells.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jiunn-Jye Sheu, Han-Tan Chai, John Y. Chiang, Pei-Hsun Sung, Yi-Ling Chen, Hon-Kan Yip
Summary: This study found that cellular prion protein played a crucial role in cell stress signaling and myocardial regeneration, but did not offer significant benefits for heart function recovery in the setting of takotsubo cardiomyopathy.
Article
Medicine, Research & Experimental
Pei-Hsun Sung, Han-Tan Chai, Chih-Chao Yang, John Y. Chiang, Chih-Hung Chen, Yi-Ling Chen, Hon-Kan Yip
Summary: This study demonstrates the superiority of combined levosimendan and Sac/Val therapy in protecting the heart and kidney against double ischemia-reperfusion injury. This finding is of significant importance for the prevention and treatment of cardiorenal syndrome.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Meng-Ta Sung, Yeh-Han Wang, Chien-Feng Li
Summary: This review emphasizes the importance of harmonization and standardization of tumor mutational burden (TMB) panels in clinical applications, and summarizes the various factors that affect the estimation of TMB, such as preanalytic, sequencing, bioinformatics, and interpretative factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Ya Yue, Jui-Ning Yeh, John Y. Chiang, Pei-Hsun Sung, Yi-Ling Chen, Fanna Liu, Hon-Kan Yip
Summary: This experimental study investigated the effect of intrarenal arterial transfusion of human umbilical cord-derived mesenchymal stem cells (HUCDMSCs) on diabetic kidney disease (DKD) in rats. The results showed that this therapy effectively preserved the residual renal function and architectural integrity, reducing creatinine levels and kidney injury.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Ting-Ting Liu, Chien-Feng Li, Kien-Thiam Tan, Yi-Hua Jan, Pei-Hang Lee, Chih-Hao Huang, Shih-Chen Yu, Cheng-Feng Tsao, Jui-Chu Wang, Hsuan-Ying Huang
Summary: Genetic aberrations involving DNA damage repair in gastrointestinal stromal tumors (GISTs) have not been well studied. This study characterized DDR abnormalities using sequencing and amplification techniques, and validated the findings using immunofluorescence and immunohistochemistry. The results showed that heterozygous deletions frequently targeted DNA damage-sensing genes and were associated with age, risk levels, and biomarker expression. These findings are important for identifying potential DDR-defective GISTs and assessing prognosis.
Article
Microbiology
Po-Hsin Kong, Cheng-Hsiung Chiang, Ting-Chia Lin, Shu-Chen Kuo, Chien-Feng Li, Chao A. Hsiung, Yow-Ling Shiue, Hung-Yi Chiou, Li-Ching Wu, Hsiao-Hui Tsou
Summary: This study explores a machine learning-based mass spectrometry analysis method for rapid discrimination of methicillin-resistant Staphylococcus aureus (MRSA) in Staphylococcus aureus bacteremia (SAB). By establishing and calibrating the model, this method can identify MRSA 24 hours earlier and adjust the treatment accordingly.
Article
Cell & Tissue Engineering
Jui-Po Yeh, Pei-Hsun Sung, John Y. Chiang, Chi-Ruei Huang, Yi-Ling Chen, Jui-Pin Lai, Jiunn-Jye Sheu
Summary: This study found that overexpression of cellular prion protein in endothelial progenitor cells was more effective than using endothelial progenitor cells alone in treating critical limb ischemia induced by chronic kidney disease.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biology
Kuan-Hua Huang, Ching-Ping Chang, Lan-Hsiang Chien, Chien-Feng Li, Ling-Yu Tang, Yu-Yi Chan, Ting-Feng Wu
Summary: This study aimed to investigate the inhibitory molecular process of pomegranate peel on urinary bladder urothelial carcinoma using a proteomics strategy. The results revealed that pomegranate peel extract can regulate various proteins involved in cell apoptosis, cell proliferation, and signaling pathways, thus inhibiting the growth and spread of cancer cells. These findings suggest that pomegranate might serve as a potential chemopreventive resource for UBUC carcinogenesis.
Article
Oncology
Kwang-Yu Chang, Nai-Jung Chiang, Shang-Yin Wu, Chia-Jui Yen, Shang-Hung Chen, Yu-Min Yeh, Chien-Feng Li, Xiaoxing Feng, Katherine Wu, Amanda Johnston, John S. Bomalaski, Bor-Wen Wu, Jianjun Gao, Sumit K. Subudhi, Ahmed O. Kaseb, Jorge M. Blando, Shalini S. Yadav, Peter W. Szlosarek, Li-Tzong Chen
Summary: The study showed that the combination of ADI-PEG 20 and pembrolizumab is safe and feasible, but may lead to neutropenia. ADI-PEG 20 treatment increased T cell infiltration in the tumor microenvironment with low PD-L1 expression.