Article
Radiology, Nuclear Medicine & Medical Imaging
Keith B. Quencer, Abhilasha Singh, Anu Sharma
Summary: Primary hyperaldosteronism (PA) is the most common secondary form of hypertension in middle-aged adults. Treatment options depend on the extent of aldosterone secretion, with unilateral cases treated surgically and bilateral cases treated medically. Adrenal vein sampling (AVS) is crucial in determining the appropriate treatment approach, but there is variability in AVS techniques and guidelines regarding its use in young patients with unilateral adrenal findings on imaging.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Endocrinology & Metabolism
Tazuru Fukumoto, Hironobu Umakoshi, Masatoshi Ogata, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Misato Motoya, Hiromi Nagata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: This study aimed to explore the role of two confirmatory tests in the subtype diagnosis of primary aldosteronism (PA). The results showed that patients with discordant results between confirmatory tests are highly likely to have a bilateral subtype on adrenal vein sampling (AVS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Youichi Ohno, Mitsuhide Naruse, Felix Beuschlein, Florentine Schreiner, Mirko Parasiliti-Caprino, Jaap Deinum, William M. Drake, Francesco Fallo, Carmina T. Fuss, Marianne A. Grytaas, Takamasa Ichijo, Nobuya Inagaki, Miki Kakutani, Darko Kastelan, Ivana Kraljevic, Takuyuki Katabami, Tomaz Kocjan, Silvia Monticone, Paolo Mulatero, Sam O'Toole, Hiroki Kobayashi, Masakatsu Sone, Mika Tsuiki, Norio Wada, Tracy Ann Williams, Martin Reincke, Akiyo Tanabe
Summary: AVS is the standard lateralization technique in PA. International data showed lower rates of unilateral PA and adrenalectomy in Japanese centers compared to European centers. Reasons for not performing adrenalectomy in patients with unilateral PA were more likely to be physician-derived in Japan and patient-derived in Europe.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Gregory A. Kline, Alexander Ah-Chi Leung, Davis Sam, Alex Chin, Benny So
Summary: Repeat adrenal vein sampling (AVS) shows moderate correlation in biochemical results and diagnostic lateralization between the first and second procedures, indicating high repeatability and success rate in patients with primary aldosteronism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Masatoshi Ogata, Hironobu Umakoshi, Tazuru Fukumoto, Yayoi Matsuda, Maki Yokomoto-Umakoshi, Hiromi Nagata, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The study suggests that a significant left adrenal vein absolute aldosterone gradient may indicate unilateral excess aldosterone, especially in patients with spontaneous hypokalemia or left unilateral disease on computed tomography. This finding can be a useful tool in diagnosing the left unilateral subtype of primary aldosteronism during adrenal vein sampling.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Peripheral Vascular Disease
Yu-Ling Chang, Guan-Yuan Chen, Bo-Ching Lee, Po-Ting Chen, Kao-Lang Liu, Chin-Chen Chang, Te- Weng, Vin-Cent Wu, Yen-Hung Lin, TAIPAI Study Grp
Summary: Adrenal venous sampling (AVS) is the gold standard for identifying curable unilateral aldosterone excess in primary aldosteronism (PA). Liquid chromatography-tandem mass spectrometry (LC-MS/MS) steroid profiling in AVS interpretation has been shown to have value. LC-MS/MS outperformed immunoassay in assessing selectivity and lateralization. The secretion ratios of specific steroids can be used as indicators for identifying unilateral PA and discriminating the PA spectrum.
HYPERTENSION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Martina Tetti, Siyuan Gong, Franco Veglio, Martin Reincke, Tracy Ann Williams
Summary: Primary aldosteronism is the most common surgically curable form of hypertension. Recent advances in our understanding of the disease have focused on the underlying genetic variants that cause excess aldosterone production. The mechanisms of increased adrenal cortex mass are still not well understood, but the application of transcriptomics, metabolomics, and epigenetics has provided valuable insights.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Gian Paolo Rossi, Domenico Bagordo, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Chin-Chen Chang, Vin-Cent Wu, Zuzana Kratka, Michele Battistel, Giacomo Rossitto, Teresa Maria Seccia
Summary: This study investigates whether selectively unilateral adrenal vein sampling can identify the responsible adrenal gland.
Article
Surgery
Timothee Vignaud, Gregory Baud, Claire Nomine-Criqui, Gianluca Donatini, Nicolas Santucci, Antoine Hamy, Jean-Christophe Lifante, Laure Maillard, Muriel Mathonnet, Nathalie Chereau, Francois Pattou, Robert Caiazzo, Christophe Tresallet, Paulina Kuczma, Fabrice Menegaux, Delphine Drui, Sebastien Gaujoux, Laurent Brunaud, Eric Mirallie, Claire Douillard, Cecile Caillard
Summary: This study analyzed the diagnostic workup and postoperative results of adrenalectomy for primary aldosteronism in France. The surgery was found to achieve complete resolution of hypertension in some patients, but the clinical effects were not persistent in the long term.
Article
Peripheral Vascular Disease
Lucie S. Meyer, Laura Handgriff, Jung Soo Lim, Aaron M. Udager, Isabella-Sabrina Kinker, Roland Ladurner, Moritz Wildgruber, Thomas Knoesel, Martin Bidlingmaier, William E. Rainey, Martin Reincke, Tracy Ann Williams
Summary: In surgically treated patients with unilateral primary aldosteronism, there are differences in histopathology, genotype, and postsurgical outcomes between classical and nonclassical groups. Patients with nonclassical histopathology have a higher incidence of postsurgical disease persistence and increased aldosterone production from the unresected gland.
Article
Medicine, General & Internal
Ruveena Kaur, Simon Young
Summary: AVS in most patients at Waitemata District Health Board (WDHB) is successful on first attempt. AVS is essential in the management of PHA for those deemed to be surgical candidates, regardless of age.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Peripheral Vascular Disease
Siyuan Gong, Na Sun, Lucie S. Meyer, Martina Tetti, Christina Koupourtidou, Stefan Krebs, Giacomo Masserdotti, Helmut Blum, William E. Rainey, Martin Reincke, Axel Walch, Tracy Ann Williams
Summary: In this study, spatial transcriptomics and metabolomics were used to analyze APAs, revealing intratumoral transcriptional heterogeneity and identifying transcriptional markers for different biological pathways. The study also found transcriptomic differences between APA-KCNJ5(MUT) and APA-KCNJ5(WT), as well as a correlation between the accumulation of oxidative stress-promoting metabolites and cell death in APA-KCNJ5(WT) and the abundance of antioxidant metabolites in APA-KCNJ5(MUT) . These findings provide insights into the pathogenesis of APA and its genotype-dependent capacities for tumor expansion.
Article
Peripheral Vascular Disease
Zhenjie Liu, Minzhi He, Xiaoxiao Song, Fangfang Xu, Binna Zhang, Bin Chen, Peng Yu, Hanlei Zhou, Lizhen Shan, Hongya Wang, Zheng Gu, Shan Zhong, Xiaohong Xu, Zhihua Tao, Bing Chen, Wei Gu
Summary: The AVS-CCF technique significantly improves success rates, shortens procedure time, reduces radiation exposure, and decreases contrast medium volume during AVS, demonstrating its effectiveness in improving the implementation of the procedure.
JOURNAL OF HYPERTENSION
(2021)
Article
Endocrinology & Metabolism
Adina F. Turcu, Richard Auchus
Summary: Recent studies have shown that primary aldosteronism (PA) has a higher prevalence among hypertensive patients than previously assumed, with the most common subtypes being aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). Screening and distinguishing between different subtypes can be costly, and it is important to assess the likelihood of benefit from imaging and adrenal vein sampling before embarking on these studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Nabeel Mansour, Andreas Mittermeier, Roman Walter, Balthasar Schachtner, Jan Rudolph, Bernd Erber, Vanessa F. Schmidt, Daniel Heinrich, Denise Bruedgam, Lea Tschaidse, Hanna Nowotny, Martin Bidlingmaier, Sonja L. Kunz, Christian Adolf, Jens Ricke, Martin Reincke, Nicole Reisch, Moritz Wildgruber, Michael Ingrisch
Summary: The aim of this study was to investigate an integrated diagnostics approach for prediction of the source of aldosterone overproduction in primary hyperaldosteronism (PA). Radiomic features were calculated from CT images after segmentation of adrenal glands to predict the result of AVS. Integration of clinical parameters into the model improved the prediction of the source of aldosterone overproduction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Andrea G. Maria, Mari Suzuki, Annabel Berthon, Crystal Kamilaris, Andrew Demidowich, Justin Lack, Mihail Zilbermint, Fady Hannah-Shmouni, Fabio R. Faucz, Constantine A. Stratakis
AMERICAN JOURNAL OF HYPERTENSION
(2020)
Editorial Material
Pediatrics
Constantine A. Stratakis, Scott A. Rivkees
PEDIATRIC RESEARCH
(2020)
Article
Oncology
Emilia Modolo Pinto, Fabio R. Faucz, Luana Z. Paza, Gang Wu, Elizabeth S. Fernandes, Jerome Bertherat, Constantine A. Stratakis, Enzo Lalli, Raul C. Ribeiro, Carlos Rodriguez-Galindo, Bonald C. Figueiredo, Gerard P. Zambetti
Review
Endocrinology & Metabolism
Fady Hannah-Shmouni, Constantine A. Stratakis
HORMONE AND METABOLIC RESEARCH
(2020)
Article
Pediatrics
Amanda C. Swart, Therina du Toit, Evgenia Gourgari, Martin Kidd, Meg Keil, Fabio R. Faucz, Constantine A. Stratakis
Summary: Using UPC2-MS/MS technology, a distinct subgroup of PCOS patients with adrenal abnormalities has been successfully identified, showing significant changes in steroid ratios. The newly discovered steroid metabolites may serve as novel biomarkers for diagnosing PCOS patients with adrenal abnormalities.
PEDIATRIC RESEARCH
(2021)
Editorial Material
Endocrinology & Metabolism
Sarantis Livadas, Constantine A. Stratakis, Djuro Macut
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Surgery
Whitney Sutton, Philip K. Crepeau, Joseph K. Canner, Shkala Karzai, Dorry L. Segev, Aarti Mathur
Summary: The impact of the 2015 ATA guidelines on treatment for differentiated thyroid cancer differs among age groups, with decreasing rates of total thyroidectomy in younger and older adults, but increasing rates in the super-elderly. Older adults and the super-elderly are more likely to undergo hemithyroidectomy and active surveillance compared to younger adults following the guideline changes in 2015.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Whitney Sutton, Joseph K. Canner, Jessica B. Shank, Abbey L. Fingeret, Shkala Karzai, Dorry L. Segev, Jason D. Prescott, Aarti Mathur
Summary: Based on the study findings, older patients are more likely to meet objective criteria prior to undergoing parathyroidectomy and are less likely to experience peri-operative complications compared to younger patients.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Transplantation
Aarti Mathur, JiYoon B. Ahn, Whitney Sutton, Nadia M. Chu, Alden L. Gross, Dorry L. Segev, Mara McAdams-DeMarco
Summary: Receiving treatment for secondary hyperparathyroidism (SHPT) was associated with a lower risk of incident dementia among older patients with end-stage renal disease (ESRD). The beneficial effect of SHPT treatment differed by sex and race, with females and those of Asian or Black race experiencing the greatest reduction in dementia risk.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Surgery
Aarti Mathur, JiYoon B. Ahn, Whitney Sutton, Martha A. Zeiger, Dorry L. Segev, Mara McAdams-DeMarco
Summary: Despite the advancement of medical treatments for secondary hyperparathyroidism and an increase in the use of calcimimetics, the rate of parathyroidectomy has been steadily increasing among dialysis patients.
Article
Surgery
Philip Crepeau, Xiaomeng Chen, Rhea Udyavar, Lilah F. Morris-Wiseman, Dorry L. Segev, Mara McAdams-DeMarco, Aarti Mathur
Summary: This study evaluated the association between post-transplant hyperparathyroidism and kidney transplantation outcomes. The results showed that patients with post-transplant hyperparathyroidism had a higher risk of graft loss.
Article
Surgery
N. Rhea Udyavar, JiYoon Ahn, Philip Crepeau, Lilah F. Morris-Wiseman, Valerie Thompson, Yusi Chen, Dorry L. Segev, Mara McAdams-DeMarco, Aarti Mathur
Summary: This study found racial and socioeconomic differences in the timing and likelihood of parathyroidectomy in dialysis patients with secondary hyperparathyroidism. Black patients were more likely to undergo parathyroidectomy with shorter intervals between dialysis initiation and parathyroidectomy. These disparities were partially explained by patient characteristics and socioeconomic factors.
Article
Transplantation
Fatima Warsame, Nadia M. Chu, Jingyao Hong, Aarti Mathur, Deidra C. Crews, George Bayliss, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Long sleep duration is associated with worse cognitive function only among persons with chronic kidney disease (CKD), specifically global cognition, delayed recall, and verbal fluency. Among participants without CKD, sleep was not associated with any measures of cognitive function.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Rachel Wurth, Crystal Kamilaris, Naris Nilubol, Samira M. Sadowski, Annabel Berthon, Martha M. Quezado, Fabio R. Faucz, Constantine A. Stratakis, Fady Hannah-Shmouni
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2020)
Meeting Abstract
Medicine, General & Internal
M. Rescigno, C. Tatsi, C. Lyssikatos, E. Belyavskaya, M. Keil, G. Papadakis, C. Stratakis
JOURNAL OF INVESTIGATIVE MEDICINE
(2020)