Review
Oncology
Runkai Huang, Zhenbin Qiu, Chunwen Zheng, Ruijie Zeng, Wanxian Chen, Simeng Wang, Enmin Li, Yiwei Xu
Summary: Esophageal carcinoma is a highly aggressive malignant disease. Neoadjuvant chemotherapy and chemoradiotherapy are considered the standard treatments for locally advanced esophageal cancers, but there are uncertainties regarding the optimal regimen and evaluation methods.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jun Yin, Jingnan Yuan, Yunjin Li, Yong Fang, Ruoxi Wang, Heng Jiao, Han Tang, Shaoyuan Zhang, Siyun Lin, Feng Su, Jianmin Gu, Tian Jiang, Dong Lin, Zhiliang Huang, Chaoxiang Du, Kui Wu, Lijie Tan, Qing Zhou
Summary: This study reported a phase 1b trial of neoadjuvant PD-L1 blockade with adebrelimab in resectable esophageal squamous cell carcinoma (ESCC). The results showed that the use of adebrelimab was safe and feasible, with some patients achieving a complete pathologic response. Responsive patients had an improved immune microenvironment at baseline.
Review
Oncology
Sicong Hou, Ziyin Pan, Xin Hao, Qinglei Hang, Yanbing Ding
Summary: Neoadjuvant therapy, including chemotherapy and chemoradiotherapy, has been shown to improve overall survival in patients with locally advanced resectable esophageal cancer. However, controversies persist regarding the optimal combination of neoadjuvant treatments and the need for further investigations to optimize protocols and surveillance strategies.
Article
Oncology
Huilai Lv, Yang Tian, Jiachen Li, Chao Huang, Bokang Sun, Chunyue Gai, Zhenhua Li, Ziqiang Tian
Summary: This study evaluated the efficacy and safety of neoadjuvant sintilimab plus chemotherapy in patients with resectable locally advanced esophageal squamous cell carcinoma (ESCC). The results showed that this treatment approach achieved a good pathological complete response rate and had good tolerability.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Wenwei Yang, Yaru Niu, Yongkun Sun
Summary: Locally advanced esophageal cancer has a poor prognosis, and neoadjuvant therapy has become a hot topic in improving its survival benefit. Various studies have confirmed the efficacy of neoadjuvant therapy followed by surgery, including chemoradiotherapy and chemotherapy. Newer treatments like targeted therapy and immunotherapy are being evaluated for their effectiveness in combination with neoadjuvant therapy. Surrogate endpoints are being developed to speed up the approval of neoadjuvant drugs. This review discusses the research progress and primary endpoints in neoadjuvant therapy for locally advanced esophageal cancer.
Article
Surgery
Smita Sihag, Tamar Nobel, Meier Hsu, Kay See Tan, Rebecca Carr, Yelena Y. Janjigian, Laura H. Tang, Abraham J. Wu, Matthew J. Bott, James M. Isbell, Manjit S. Bains, David R. Jones, Daniela Molena
Summary: The study aimed to determine the optimal extent of lymphadenectomy in patients with locally advanced esophageal adenocarcinoma treated with neoadjuvant chemoradiotherapy followed by esophagectomy. The results showed that removing 20 to 25 lymph nodes improved the survival rate of patients.
Article
Immunology
Lei Xu, Xiu-feng Wei, Can-jun Li, Zhao-yang Yang, Yong-kui Yu, Hao-miao Li, Hou-nai Xie, Ya-fan Yang, Wei-wei Jing, Zhen Wang, Xiao-zheng Kang, Rui-xiang Zhang, Jian-jun Qin, Li-yan Xue, Nan Bi, Xian-kai Chen, Yin Li
Summary: This study compares the treatment response and postoperative complications of neoadjuvant immunochemotherapy (NICT) with conventional neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced esophageal squamous cell carcinoma (ESCC). The study finds that NICT has comparable R0 resection rate and pathological complete response (pCR) rate to NCRT, without increased incidence of postoperative complications and mortality. Notably, NICT may bring a better treatment response in metastatic lymph nodes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhi-Nuan Hong, Zhixin Huang, Kai Weng, Jihong Lin, Mingqiang Kang
Summary: This study aimed to investigate the impact of prolonged time to surgery (TTS) on the outcomes of patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant immunochemotherapy (nICT). The results showed that prolonged TTS did not significantly affect pathological complete response rate, disease-free survival, and short-term postoperative outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Bin Chen, Xing Liu, Yiyi Zhang, Jinfu Zhuang, Yong Peng, Ye Wang, Yong Wu, Shoufeng Li, Yuanfeng Yang, Guoxian Guan
Summary: This study assesses the prognostic value of lymph node metastasis distribution in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. It concludes that LND is an independent prognostic factor and can be used as a supplementary indicator for the ypTNM staging system in patients with LARC after nCRT.
FRONTIERS IN SURGERY
(2021)
Review
Immunology
Hao Qin, Futao Liu, Yaozhong Zhang, Yuxiang Liang, Yuan Mi, Fan Yu, Haidi Xu, Kuankuan Li, Chenxi Lin, Lei Li, Ziqiang Tian, Lei Wang
Summary: A comprehensive meta-analysis compared the efficacy and safety of neoadjuvant immune checkpoint inhibitor combined with chemotherapy or chemoradiotherapy with routine neoadjuvant strategies in locally advanced esophageal cancer. The results showed that the new immunotherapy approach significantly increased the rates of pathological complete response and major pathological response, with acceptable toxicity. However, larger randomized studies are needed to confirm these findings.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Filippo Crimi, Giulio Cabrelle, Cristina Campi, Alessio Schillaci, Quoc Riccardo Bao, Alessia Pepe, Gaya Spolverato, Salvatore Pucciarelli, Federica Vernuccio, Emilio Quaia
Summary: This study compares the diagnostic accuracy of different MRI dimensional criteria for nodal staging in patients with LARC after nCRT, and finds that measurement of the long axis and volume of the largest lymph node is not inferior to the ESGAR criteria, providing a faster and reliable alternative.
EUROPEAN RADIOLOGY
(2023)
Editorial Material
Oncology
Manish A. Shah, Wayne L. Hofstetter, Erin B. Kennedy
Summary: The ASCO Rapid Recommendations Updates aim to disseminate updated recommendations in a timely manner to provide better information on cancer care.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Wenwu He, Xuefeng Leng, Tianqin Mao, Xi Luo, Lingxiao Zhou, Jiaxin Yan, Lin Peng, Qiang Fang, Guangyuan Liu, Xing Wei, Kangning Wang, Chenghao Wang, Sha Zhang, Xudong Zhang, Xudong Shen, Depei Huang, Huan Yi, Ting Bei, Xueke She, Wenguang Xiao, Yongtao Han
Summary: This study focuses on locally advanced resectable esophageal squamous cell carcinoma (ESCC), investigating the safety, feasibility, and efficacy of neoadjuvant toripalimab plus paclitaxel and carboplatin treatment. The results indicate that this combination therapy shows potential as a neoadjuvant treatment for ESCC, with increased CD8(+) T cells and decreased M2-type tumor-associated macrophages in responders. Furthermore, certain molecular signatures were associated with treatment response.
Article
Immunology
Jiahan Cheng, Minzhang Guo, Yushang Yang, Yilin Liu, Weipeng Hu, Qixin Shang, Chuan Li, Liang Xia, Yun Wang, Wenping Wang, Dong Tian, Yong Yuan, Yang Hu, Longqi Chen
Summary: Neoadjuvant combination of chemotherapy and immunotherapy (NCI) may lead to better treatment outcomes and reduced complications for patients with locally advanced esophageal squamous cell carcinoma (ESCC).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Huilai Lv, Chao Huang, Jiachen Li, Fan Zhang, Chunyue Gai, Zhao Liu, Shi Xu, Mingbo Wang, Zhenhua Li, Ziqiang Tian
Summary: This study reports the survival follow-up outcomes of locally advanced esophageal squamous cell carcinoma patients treated with neoadjuvant sintilimab combined with chemotherapy. The 2-year disease-free survival rate was 78.3% and the 2-year overall survival rate was 88.0%. Postoperative pathological stage, pCR, MPR, and tumor down-staging were associated with favorable survival outcome. The number of neoadjuvant treatment cycles was identified as an independent predictor of disease-free survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Berend J. van der Wilk, Ben M. Eyck, Wayne L. Hofstetter, Jaffer A. Ajani, Guillaume Piessen, Carlo Castoro, Rita Alfieri, Jong H. Kim, Sung-Bae Kim, Heidi Furlong, Thomas N. Walsh, Daan Nieboer, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, J. Jan B. van Lanschot
Summary: This study compared the overall survival of patients with a complete pathological response (cCR) after chemoradiotherapy who underwent active surveillance or standard esophagectomy. The study found that overall survival was comparable between the two groups. It suggests that diagnostic follow-up is necessary in active surveillance, and postponed esophagectomy should be considered for operable patients in case of locoregional recurrence.
Article
Oncology
Tiuri E. Kroese, Richard van Hillegersberg, Sebastian Schoppmann, Pieter R. A. J. Deseyne, Philippe Nafteux, Radka Obermannova, Marianne Nordsmark, Per Pfeiffer, Maria A. Hawkins, Elizabeth Smyth, Sheraz Markar, George B. Hanna, Edward Cheong, Asif Chaudry, Anneli Elme, Antoine Adenis, Guillaume Piessen, Cihan Gani, Christiane J. Bruns, Markus Moehler, Theodore Liakakos, John Reynolds, Alessio Morganti, Riccardo Rosati, Carlo Castoro, Domenico D'Ugo, Franco Roviello, Maria Bencivenga, Giovanni de Manzoni, Paul Jeene, Johanna W. van Sandick, Christel Muijs, Marije Slingerland, Grard Nieuwenhuijzen, Bas Wijnhoven, Laurens Beerepoot, Piotr Kolodziejczyk, Wojciech P. Polkowski, Maria Alsina, Manuel Pera, Tania F. Kanonnikoff, Magnus Nilsson, Matthias Guckenberger, Stefan Monig, Dorethea Wagner, Lucjan Wyrwicz, Maaike Berbee, Ines Gockel, Florian Lordick, Ewen A. Griffiths, Marcel Verheij, Peter S. N. van Rossum, Hanneke W. M. van Laarhoven
Summary: There is a lack of consensus on the definition and treatment of oligometastatic oesophagogastric cancer. A study was conducted to assess the definition and treatment strategies among multidisciplinary tumour boards (MDTs) in Europe. The study found a broad consensus on the definition of oligometastatic disease but high practice variability in treatment strategies.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Oncology
Armando De Virgilio, Andrea Costantino, Bianca Maria Festa, Giuseppe Mercante, Davide Franceschini, Ciro Franzese, Marta Scorsetti, Andrea Marrari, Raffaele Cavina, Salvatore Marano, Carlo Castoro, Giuseppe Spriano
Summary: Definitive chemoradiotherapy is a valuable first-line treatment for cervical esophageal squamous cell carcinoma (CESCC) with favorable oncological outcomes. Further research is needed to identify survival predictors for stage-based clinical guidelines.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Valentina Mari, Valentina Angerilli, Giada Munari, Marco Scarpa, Quoc Riccardo Bao, Salvatore Pucciarelli, Matteo Fassan, Gaya Spolverato
Summary: This review outlines the molecular pathways involved in peritoneal metastatic dissemination in gastric cancer, highlighting the lack of comprehensive understanding of the complex molecular landscape of this disease. The integration of molecular profiling and histological evaluation is recommended for risk prediction assessment of peritoneal dissemination.
DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
Swathikan Chidambaram, Nikhil M. Patel, Viknesh Sounderajah, Rita Alfieri, Luigi Bonavina, Edward Cheong, Andy Cockbain, Xavier Benoit D'Journo, Lorenzo Ferri, Ewen A. Griffiths, Peter Grimminger, Caroline Gronnier, Christian Gutschow, Jakob Hedberg, Joonas H. Kauppila, Sjoerd Lagarde, Donald Low, Philippe Nafteux, Grard Nieuwenhuijzen, Magnus Nilsson, Riccardo Rosati, Wolfgang Schroeder, B. Mark Smithers, Mark I. van Berge Henegouwen, Richard van Hillegesberg, David Watson, Ravinder Vohra, Nick Maynard, Sheraz R. Markar
Summary: Currently, there is a lack of evidence-based guidelines for surveillance of recurrence after esophageal and gastric (OG) cancer surgical resection. This study used a modified Delphi consensus process to identify eight symptoms that should prompt further investigations for suspected recurrent malignancy.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Oncology
N. Schuring, E. Jezerskyte, M. I. van Berge Henegouwen, M. A. G. Sprangers, P. Lagergren, A. Johar, S. R. Markar, S. S. Gisbertz
Summary: This study aimed to investigate the relationship between postoperative complications and long-term health-related quality of life (HRQL) in patients who underwent esophagectomy for cancer. The study found that patients with complications reported more dyspnea compared to those without complications, but these differences were not clinically significant. The severity of complications also had an impact on the patients' mood. Overall, HRQL in esophageal cancer patients is more likely affected by the complexity of the surgical procedure itself.
Review
Otorhinolaryngology
Armando De Virgilio, Andrea Costantino, Bianca Maria Festa, Giuseppe Mercante, Davide Franceschini, Ciro Franzese, Marta Scorsetti, Andrea Marrari, Raffaele Cavina, Salvatore Marano, Carlo Castoro, Giuseppe Spriano
Summary: The study aims to determine the oncological outcomes of surgery for cervical esophageal cancer. The results showed different survival rates between larynx preserving surgery and non-preserving surgery, and further research is needed to compare the effects of surgery and chemoradiotherapy.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Surgery
Ylenia Camilla Spolverato, Romeo Bardini, Mario Gruppo, Cesare Ruffolo, Imerio Angriman, Mario Plebani, Marco Scarpa
Summary: The study identified pre-operative biomarkers, including serum amylase, platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and prognostic nutritional index (PNI), which can accurately predict occult advanced disease (OAD) in pancreatic cancer patients.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Andromachi Kotsafti, Matteo Fassan, Francesco Cavallin, Valentina Angerilli, Luca Saadeh, Matteo Cagol, Rita Alfieri, Pierluigi Pilati, Carlo Castoro, Ignazio Castagliuolo, Melania Scarpa, Marco Scarpa
Summary: This study found that immune marker expression, oncogene status, and intra- and peritumoral immune infiltrating cells are associated with lymph node metastasis in patients with esophageal adenocarcinoma. These results suggest that immune surveillance failure is the key driver of lymph node metastasis.
Article
Surgery
Gaya Spolverato, Matteo Fassan, Giulia Capelli, Melania Scarpa, Silvia Negro, Valentina Chiminazzo, Andromachi Kotsafti, Imerio Angriman, Michela Campi, Ottavia De Simoni, Cesare Ruffolo, Stepanyan Astghik, Chiara Vignotto, Federico Scognamiglio, Giulia Becherucci, Giorgio Rivella, Francesco Marchegiani, Luca Facci, Francesca Bergamo, Stefano Brignola, Gianluca Businello, Vincenza Guzzardo, Luca Dal Santo, Roberta Salmaso, Marco Massani, Anna Pozza, Ivana Cataldo, Tommaso Stecca, Angelo Paolo Dei Tos, Vittorina Zagonel, Pierluigi Pilati, Boris Franzato, Antonio Scapinello, Giovanni Pirozzolo, Alfonso Recordare, Roberto Merenda, Giovanni Bordignon, Silvio Guerriero, Chiara Romiti, Giuseppe Portale, Chiara Cipollari, Maurizio Zizzo, Andrea Porzionato, Marco Agostini, Francesco Cavallin, Barbara Di Camillo, Romeo Bardini, Isacco Maretto, Ignazio Castagliuolo, Salvatore Pucciarelli, Marco Scarpa
Summary: This study evaluated the sex differences in the immune microenvironment of rectal cancer patients and found that male patients had more frequent oncogene mutations associated with lower expression of T-cell activation genes, while female patients had more Th1 cells and cytotoxic T cells in the healthy mucosa, suggesting a potentially better immune response to the tumor.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Oncology
Astghik Stepanyan, Matteo Fassan, Gaya Spolverato, Ignazio Castagliuolo, Melania Scarpa, Marco Scarpa, IMMUNOREACT Study Grp
Summary: Neoadjuvant therapy (NT) followed by surgery is the main treatment for rectal cancer patients. Immune biomarkers are being recognized as potential predictors of NT response. A meta-analysis was performed to estimate their predictive significance.
Review
Oncology
Alessandro Massano, Luisa Bertin, Fabiana Zingone, Andrea Buda, Pierfrancesco Visaggi, Lorenzo Bertani, Nicola de Bortoli, Matteo Fassan, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Cristina Bezzio, Valentina Casini, Davide Giuseppe Ribaldone, Edoardo Vincenzo Savarino, Brigida Barberio
Summary: This review summarizes the evidence on the association between inflammatory bowel disease (IBD) and extraintestinal cancers (EICs), as well as the safety and management of immunomodulators and biologics for IBD patients with prior or current EICs.
Article
Oncology
Ottavia De Simoni, Luca Dal Santo, Marco Scarpa, Giada Munari, Ylenia Camilla Spolverato, Antonio Scapinello, Sara Lonardi, Caterina Solda, Francesca Bergamo, Alberto Fantin, Romeo Bardini, Pierluigi Pilati, Matteo Fassan, Mario Gruppo
Summary: The aim of this study is to determine the potential significant tumor microenvironment (TME) immune markers of long-term survival in pancreatic ductal adenocarcinoma (PDAC) patients. Immunohistochemical staining was performed to characterize the TME using tissue microarray. The results showed that high density of CD8+ lymphocytes and low density of FOXP3+ and iNOS+ tumor-associated macrophages (TAMs) are predictors of good prognosis in PDAC patients.
Article
Psychology, Multidisciplinary
Eleonora Pinto, Alessandro Fabbian, Rita Alfieri, Anna Da Roit, Salvatore Marano, Genny Mattara, Pierluigi Pilati, Carlo Castoro, Marco Cavarzan, Marta Silvia Dalla Riva, Luisa Orru, Gian Piero Turchi
Summary: This study improved patients' postoperative daily life management after esophageal, gastric, and colorectal cancer surgery through psychological intervention, resulting in a higher rate of job retention and lower need for financial support post-surgery.
BEHAVIORAL SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Gian Piero Turchi, Alessandro Fabbian, Rita Alfieri, Anna Da Roit, Salvatore Marano, Genny Mattara, Pierluigi Pilati, Carlo Castoro, Davide Bassi, Marta Silvia Dalla Riva, Luisa Orru, Eleonora Pinto
Summary: Cancer surgery and treatment have negative effects on patients' life and working ability, which can be aggravated by postoperative symptoms. This study proposes a method to evaluate the competences of patients and caregivers in dealing with postoperative course and improving their abilities. The findings reveal that patients and caregivers have low to medium competences in areas such as future planning and resource utilization, leading to unexpected critical situations.
BEHAVIORAL SCIENCES
(2022)
