Article
Oncology
Yang Zhang, Duo Chen, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wei-Cheng You, Kai-Feng Pan
Summary: This study identified potential H.pylori-associated methylation biomarkers in blood leukocyte and gastric mucosa, showing that GNAS and MTERFI methylation levels may be affected by H.pylori infection. GNAS may be involved in the advanced stage of gastric cancer development, with a negative relationship found between GNAS methylation and mRNA expression as well as worse survival outcomes in GC cases with higher GNAS expression levels.
Article
Health Care Sciences & Services
Seunghyup Jeong, Unyong Kim, Myungjin Oh, Jihyeon Nam, Sehoon Park, Yoonjin Choi, Dongho Lee, Jaehan Kim, Hyunjoo An
Summary: This study developed a middle-up-down glycoproteome platform for monitoring haptoglobin glycosylation, demonstrating its potential for identifying differences between gastric cancer and healthy controls, as well as significant discovery of potential biomarkers and diagnostic efficacy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kanghui Liu, Peng Xu, Jialun Lv, Han Ge, Zhengyuan Yan, Shansong Huang, Bowen Li, Hao Xu, Li Yang, Zekuan Xu, Diancai Zhang
Summary: Peritoneal metastasis (PM) is a significant mode of metastasis in gastric cancer (GC), associated with poor prognosis. However, the molecular mechanism of PM remains unclear. This study revealed that NSUN2, an RNA modifier, is upregulated in PM and patients with high NSUN2 expression have a worse prognosis. Mechanistically, NSUN2 regulates ORAI2 mRNA stability through m5C modification, promoting ORAI2 expression and resulting in peritoneal metastasis and colonization in GC.
Article
Oncology
Yujin Kim, Bo Bin Lee, Dongho Kim, Sang-Won Um, Joungho Han, Young Mog Shim, Duk-Hwan Kim
Summary: This study analyzed samples from lung cancer patients and cancer-free patients, and found that SLIT2 gene showed aberrant methylation in tumor tissues and plasma, which could serve as a biomarker for the early detection and prognosis prediction of non-small cell lung cancer.
Article
Oncology
Zhilong Yu, ZeYin Rong, Jinxin Sheng, Zai Luo, Jianming Zhang, Tengfei Li, Zhonglin Zhu, Zhongmao Fu, Zhengjun Qiu, Chen Huang
Summary: Recent studies have shown that non-coding RNAs (ncRNAs) may serve as novel biomarkers for predicting the occurrence and prognosis of gastric cancer. By analyzing the expression profiles of miRNA, lncRNA, and cirRNA in gastric cancer patients, it was found that these ncRNAs could potentially be promising molecular markers for the diagnosis and prognosis of gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Irina V. Bure, Marina V. Nemtsova
Summary: Despite recent progress, gastric cancer remains a common and deadly cancer with aberrant DNA methylation and deregulation of noncoding RNA expression playing a significant role in tumorigenesis. Interactions among these epigenetic regulators form a complex network that has potential implications for diagnosis, prognosis, and treatment of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xiao-Han Fan, Yang Zhang, Pei Wang, Qian-Qian Song, Mona Wang, Raquel Mejias-Luque, Zhe-Xuan Li, Tong Zhou, Jing-Ying Zhang, Wei-Dong Liu, Lan-Fu Zhang, Wen-Qing Li, Wei-Cheng You, Markus Gerhard, Yu-Chen Jiao, Xiao-Bing Wang, Kai-Feng Pan
Summary: This study explores noninvasive multianalytical biomarkers and constructs integrative models for risk assessment and gastric cancer (GC) screening. Methylation, mutation, and H. pylori-specific antibody panels were established and validated, and integrated models incorporating these biomarkers outperformed traditional models for risk assessment and GC detection. This study provides new insights for a more precise GC screening strategy in the future.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Ling Lv, Jianzhong Ma, Lina Wu, Chao Zhang, Yueping Wang, Guang Wang
Summary: This study found that the transcriptional inactivation of the FBN1 gene may start from normal colonic epithelium, and the FBN1 gene methylation catalyzed by DNMT gradually generates powerful force, accelerates expansion, and eventually leads to colorectal cancer (CRC). FBN1 methylation is a promising biomarker, and the FBN1 methylation risk size in feces reflects the non-invasive detection results in tissue.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiangjing Yuan, Zhanrui Mao, Qi Lu, Peng Xu, Chengyang Wang, Xiaona Xu, Zhaowei Zhou, Tongsheng Zhang, Wenqiang Yu, Shihua Dong, Yudong Wang, Weiwei Cheng
Summary: This study explored the possibility of using DNA methylation markers from endometrial brush and cervical scrape samples for the early detection of endometrial cancer. The researchers used MSRE-qPCR for methylation detection and found that PCDHGB7 was highly methylated in EC, which was verified in clinical samples. The combination of Tao and Pap brush samples significantly increased the sensitivity of detection.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Xuan Li, Du Cai, Yaoyi Huang, Yumo Xie, Dingcheng Shen, Ze Yuan, Xiaoxia Liu, Meijin Huang, Yanxin Luo, Huichuan Yu, Xiaolin Wang
Summary: This study developed a DNA methylation biomarker to evaluate the prognosis of colorectal cancer (CRC) by identifying hypermethylated genes in cancer tissue from Illumina EPIC methylation arrays. The study found that RIMS2 was frequently hypermethylated and lowly expressed in CRC, and its methylation was associated with less frequent KRAS mutation and high differentiation. RIMS2 methylation showed independent predictive value for survival outcome and could predict prognosis better when combined with KRAS status.
Article
Gastroenterology & Hepatology
Yan Zhang, Shunxia Hu, Jun Li, Duo Shi, Bing Luo
Summary: This study found that hypermethylation of the TMEM130 gene may affect the migration ability of GC cells and is associated with EBV infection. TMEM130 shows promise as a potential biomarker for the diagnosis of GC.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Cheng Zhang, Yong-Zhi Li, Dong-Qiu Dai
Summary: This study revealed that FOXF2 is downregulated in gastric cancer due to aberrant DNA methylation, and the degree of methylation in the FOXF2 promoter region is related to patient prognosis. Additionally, FOXF2 may play a vital biological regulation role in gastric cancer through the FOXF2/miRNAs/target genes axis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medical Laboratory Technology
Kun-Lin Wu, Che-Yi Chou, Hui-Yin Chang, Chih-Hsun Wu, An-Lun Li, Chien-Lung Chen, Jen-Chieh Tsai, Yi-Fan Chen, Chiung-Tong Chen, Chin-Chung Tseng, Jin-Bor Chen, I-Kuan Wang, Yu-Juei Hsu, Shih-Hua Lin, Chiu-Ching Huang, Nianhan Ma
Summary: This study developed a novel noninvasive miRNA test for diagnosing EPS. By screening miRNA profiles and combining clinical characteristics, machine learning models were able to accurately predict the occurrence of EPS.
CLINICA CHIMICA ACTA
(2022)
Article
Oncology
Yunfeng Zhang, Qian Wu, Linhao Xu, Hong Wang, Xin Liu, Sihui Li, Tianliang Hu, Yanying Liu, Quanzhou Peng, Zhiwei Chen, Xianrui Wu, Jian-Bing Fan
Summary: Colorectal cancer is a major cause of cancer-related deaths worldwide. A new qPCR-based assay combining the detection of the DNA methylation status of ten candidate genes showed promising results in detecting CRC patients. A 4-marker methylation model including two novel markers (kcnj12 and znf132) provided a non-invasive option for CRC screening with high performance.
CLINICAL EPIGENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Jie-Pin Li, Shu-Hong Zeng, Yong-Hua Zhang, Yuan-Jie Liu
Summary: The study evaluated the expression of the CHN1 gene in gastric cancer tissue and cells, finding that high CHN1 levels were associated with poor survival rates and potentially involved in carcinogenic pathways. Additionally, CHN1 expression was correlated with immune cell infiltration and immunotherapeutic response, indicating its role in cancer progression and treatment.
Article
Multidisciplinary Sciences
Tomokazu Tanaka, Yoshihiko Kitajima, Shuusuke Miyake, Kazuyoshi Yanagihara, Hiromitsu Hara, Aki Nishijima-Matsunobu, Koichi Baba, Masaaki Shida, Kota Wakiyama, Jun Nakamura, Hirokazu Noshiro
Article
Oncology
Hiroshi Kubo, Yoshihiko Kitajima, Keita Kai, Jun Nakamura, Shuusuke Miyake, Kazuyoshi Yanagihara, Kiyoto Morito, Tomokazu Tanaka, Masaaki Shida, Hirokazu Noshiro
Article
Oncology
Masaaki Shida, Yoshihiko Kitajima, Jun Nakamura, Kazuyoshi Yanagihara, Koichi Baba, Kota Wakiyama, Hirokazu Noshiro
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Review
Biotechnology & Applied Microbiology
Tomokazu Tanaka, Jun Nakamura, Hirokazu Noshiro
EXPERT OPINION ON BIOLOGICAL THERAPY
(2017)
Editorial Material
Oncology
Shuichi Fukui, Ken Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Jun Nakamura, Masanori Masuda, Hiroyuki Irie
Article
Oncology
Kiyoto Morito, Jun Nakamura, Yoshihiko Kitajima, Keita Kai, Tomokazu Tanaka, Hiroshi Kubo, Shuusuke Miyake, Hirokazu Noshiro
INTERNATIONAL JOURNAL OF ONCOLOGY
(2015)
Article
Oncology
Takashi Okumura, Jun Nakamura, Keita Kai, Yasushi Ide, Hiroaki Nakamura, Hiroki Koga, Takao Ide, Atsushi Miyoshi, Kenji Kitahara, Hirokazu Noshiro
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2014)
Article
Multidisciplinary Sciences
Koichi Baba, Yoshihiko Kitajima, Shuusuke Miyake, Jun Nakamura, Kota Wakiyama, Hirofumi Sato, Keiichiro Okuyama, Hiroshi Kitagawa, Tomokazu Tanaka, Masatsugu Hiraki, Kazuyoshi Yanagihara, Hirokazu Noshiro
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Kota Wakiyama, Yoshihiko Kitajima, Tomokazu Tanaka, Masao Kaneki, Kazuyoshi Yanagihara, Shinichi Aishima, Jun Nakamura, Hirokazu Noshiro
SCIENTIFIC REPORTS
(2017)
Editorial Material
Oncology
Miki Yukimoto, Ken Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Jun Nakamura, Yasue Matsumoto, Hiromi Kimura, Mihoko Yamamoto, Hiroyuki Irie
Review
Oncology
Jun Nakamura, Tomoyo M. Nishi, Shun Yamashita, Hiroaki Nakamura, Ken Sato, Yoshimasa Oda, Akihiro Iyama
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2020)
Article
Oncology
Jun Nakamura, Futoshi Tanaka, Kazuma Ohtaka, Ken Sato, Akihiro Iyama
Summary: Granulomatous mastitis is a chronic inflammatory disease that usually occurs in women of reproductive age. We report an extremely rare case of granulomatous mastitis in the accessory axillary breast of a pregnant woman. The mass was surgically removed after childbirth and histopathologically confirmed as granulomatous mastitis.
EUROPEAN JOURNAL OF BREAST HEALTH
(2022)
Article
Gastroenterology & Hepatology
Noriyuki Egawa, Jun Nakamura, Tatsuya Manabe, Hironori Iwasaki, Hirokazu Noshiro
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2019)
Article
Oncology
Jun Nakamura, Keiichiro Okuyama, Hirofumi Sato, Yukie Yoda, Keita Kai, Hirokazu Noshiro
MOLECULAR AND CLINICAL ONCOLOGY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ken Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Yoshiaki Komori, Jun Nakamura, Tomoyuki Noguchi, Hiroyuki Irie
MAGNETIC RESONANCE IN MEDICAL SCIENCES
(2017)