Article
Oncology
Limei Luo, Qin Li, Zhenzhen Su, Lixin Li, Bei Cai, Yufu Peng, Yangjuan Bai, Fei Liu
Summary: This study investigated the relationship between CD35 polymorphisms and hepatocellular carcinoma (HCC) in the Chinese Han population. The results suggest that CD35 rs7525160 polymorphism may contribute to the susceptibility and prognosis of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hongmeng Su, Shihui Shu, Wenqing Tang, Chuqian Zheng, Luyu Zhao, Hong Fan
Summary: ETV4 plays a crucial role in promoting angiogenesis and tumor invasion in hepatocellular carcinoma (HCC), and it induces angiogenesis in HCC by regulating the transcription level of MMP14.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Maha M. Allam, Karema A. Diab, Fatma O. Khalil, Fatma A. Khalaf, Mohamed Abdel-Samiee, Nashwa Sheble, Mohamed A. Eljaky, Essam Zayed, Warda Othman, Mervat Abd-Elkreem, Eman Abdelsameea
Summary: This study aims to investigate the association between microRNA gene polymorphisms and the development of HCC in Egyptian patients. The results show a significant association between rs10061133 miR-499b and the risk of HCC. The GG genotype or G allele is associated with an increased risk of HCC.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Genetics & Heredity
Dongwei Gong, Shizong Li, Zhiwei Yu, Kaiqiong Wang, Xin Qiao, Changxiong Wu
Summary: This study found an association between specific single nucleotide polymorphisms of the PNPLA3 gene and susceptibility to hepatocellular carcinoma (HCC), particularly the G allele and GG genotype of rs2896019 being significantly correlated with increased HCC susceptibility. Furthermore, all four SNPs were found to be related to increased HCC susceptibility in individuals over the age of 55.
BMC MEDICAL GENOMICS
(2022)
Article
Medicine, General & Internal
Yuting Shi, Lihua Zhang, Yang Bao, Pengfei Wu, Xiaoli Zhang
Summary: This study revealed an association between TNIP1 polymorphisms and increased risk of HCC in a Northwest Chinese Han population, particularly the G allele of rs7708392. Additionally, the GC haplotype was also significantly correlated with higher occurrence of HCC. Further research is warranted to explore these associations.
Review
Oncology
Qimeng Zhang, Xueying Xu, Mingcheng Wu, Tiantian Qin, Shaoning Wu, Hongbo Liu
Summary: The study conducted a network meta-analysis on four single nucleotide polymorphisms in miRNAs and found that miR-196a2 rs11614913 was significantly associated with the susceptibility of HCC, especially in HBV-related cases, while the other three miRNA genes did not show significant associations. MiR-196a2 could serve as the best predictor of susceptibility in HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lan-Ting Yuan, Yi-Chieh Yang, Hsiang-Lin Lee, Pei-Chun Shih, Li-Hsin Chen, Chih-Hsin Tang, Lun-Ching Chang, Hsiang-Ling Wang, Shun-Fa Yang, Ming-Hsien Chien
Summary: The genetic variant rs9914618 of the LINC00673 gene may serve as a promising biomarker for hepatocellular carcinoma (HCC), especially in elderly populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Hossein Ghaderi-Zefrehi, Maryam Rezaei, Farzin Sadeghi, Mohammad Heiat
Summary: Hepatocellular carcinoma (HCC) is closely related to risk factors such as chronic hepatitis B or C infections and alcohol addiction. Defects in DNA repair systems can increase susceptibility to cancer, and genetic polymorphisms in DNA repair genes may affect DNA repair capacity and modulate cancer risk. Identifying these polymorphisms and their association with HCC risk can help improve prevention and treatment strategies.
Review
Immunology
Defa Huang, Dingyu Rao, Qing Jin, Mi Lai, Jiali Zhang, Zhonghong Lai, Haibin Shen, Tianyu Zhong
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with a poor prognosis. CD147, a glycoprotein, plays a crucial role in HCC invasion, metastasis, and angiogenesis. This review discusses the molecular structure of CD147 and its potential as a diagnostic and therapeutic target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yue Li, Hui-Chan He, Da-Lei Zhou, Qing Liu, Xiao Zhang, Xin-Hua Yang, Zu-lu Ye, Jun-Ling Peng, Tao Tang, Xuan Su, Cai-Yun He
Summary: The study revealed that the long non-coding RNA-related SNPs rs7315438 and rs10795668 are potential biomarkers for HCC susceptibility, especially when evaluated based on optimal genetic models.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Xiaoyuan Chen, Yiwei Lu, Xiaoli Shi, Guoyong Han, Long Zhang, Chuangye Ni, Jie Zhao, Yun Gao, Xuehao Wang
Summary: This study aimed to describe the epidemiological and clinical spectrum of five rare subtypes of hepatocellular carcinoma (HCC) and develop a competing risk nomogram for cancer-specific survival prediction. The results showed that these rare subtypes have unique clinicopathological features and biological behavior compared with classic HCC. The constructed nomogram showed good performance in predicting prognoses, providing valuable reference for clinicians and individualized management.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Haoting Shi, Jingxuan Huang, Xue Wang, Runchuan Li, Yiqing Shen, Bowen Jiang, Jinjun Ran, Rong Cai, Fang Guo, Yufei Wang, Gang Ren
Summary: In this study, a prognostic signature related to copper-related genes (CRGs) was developed and validated for predicting hepatocellular carcinoma (HCC). The signature, constructed using differentially expressed CRGs with prognostic value, showed that patients in the high-risk group had lower overall survival rates, and the signature performed well in prediction assessment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Katherine A. McGlynn, Jessica L. Petrick, Hashem B. El-Serag
Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), is a major global health concern. While HBV and HCV remain important risk factors for HCC, efforts in vaccination and treatment are showing promise. However, the increasing prevalence of metabolic risk factors like obesity and diabetes, as well as other factors like excessive alcohol consumption, present ongoing challenges in the prevention of liver cancer.
Article
Genetics & Heredity
Jiankai Wei, Zhangxiu Liao, Ying Tao, Shuaiting Liu
Summary: This study evaluated the effects of PDCD-1 and LAG3 gene polymorphisms on HCC risk and found that these polymorphisms did not influence the risk of HCC. However, certain genotypes of PDCD-1 were associated with lower AFP levels and HCC tumor grades.
BMC MEDICAL GENOMICS
(2023)
Review
Immunology
Tanghua Li, Jiapeng Jiao, Haoteng Ke, Wenshan Ouyang, Luobin Wang, Jin Pan, Xin Li
Summary: Despite improved treatment methods, hepatocellular carcinoma (HCC) still has a high mortality rate. Recent studies have shown the potential of immunotherapy in cancer treatment. Exosomes play a role in regulating the immune system in HCC, and understanding their role can improve the effectiveness of immunotherapy. Engineered exosomes can deliver drugs and RNA molecules to regulate the immune microenvironment of HCC, improving the mortality rate. This study aims to declare the role of exosomes in HCC and provide potential treatment options for clinical transformation therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ophthalmology
Chia-Chen Lin, Chia-Yi Lee, Jing-Yang Huang, Sheng-Min Hsu, Jia-Horung Hung, Shun-Fa Yang
Summary: This study provides an in-depth analysis of the trends in DR, DME, and related comorbidities in patients with T2DM. It shows that the prevalence and incidence of DR and PDR decreased over time, while the prevalence and incidence of DME increased. Additionally, the percentage of patients with hyperlipidaemia increased in all forms of DR, while the percentage of patients with ESRD increased only in DME.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kang-Hsi Wu, Ju-Pi Li, Wan-Ru Chao, Yi-Ju Lee, Shun-Fa Yang, Ching-Chang Cheng, Yu-Hua Chao
Summary: The study found that human umbilical cord-derived MSCs effectively attenuated the cytokine storm and lung injury in mice after LPS-induced ALI by down-regulating the MyD88-NFκB signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Hung-Ju Chien, Chung-Jung Liu, Tsung-Ho Ying, Pei-Ju Wu, Jiunn-Wei Wang, Yi-Hsuan Ting, Yi-Hsien Hsieh, Shih-Chiang Wang
Summary: This study aimed to evaluate Timosaponin AIII (TSAIII) as a potential therapeutic approach for cervical cancer. The results showed that TSAIII suppresses cell migration, invasion, p38 activation, and uPA expression in cervical cancer. Additionally, TSAIII demonstrated antimetastatic properties and inhibited the growth of cervical cancer stem cells. These findings suggest that TSAIII may be a potential auxiliary therapy for cervical cancer.
Article
Cell Biology
Chu-Che Lee, Jen-Pi Tsai, Hsiang-Lin Lee, Yung-Jen Chen, Yong-Syuan Chen, Yi-Hsien Hsieh, Jin-Cherng Chen
Summary: In this study, Timosaponin AIII (TSAIII) was found to inhibit the growth of glioma cells by inducing cell death, mitochondrial dysfunction, and autophagy activation. The results suggest that TSAIII exhibits antitumor effects and may have potential as a therapy for glioma.
Article
Chemistry, Medicinal
Je-Chiuan Ye, Yih-Shou Hsieh, Pei-Ni Chen, Jer-Yuh Liu, Yi-Hsien Hsieh
Summary: Our study shows that PKCa regulates the PA and MMPs systems in liver cancer cells through the p38 MAPK signaling pathway, promoting cell progression. MMP-1 and u-PA play critical roles in this pathway, and targeting these genes may be a potential treatment approach for liver cancer.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Environmental Sciences
Pei-Ju Wu, Hui-Ling Chiou, Yi-Hsien Hsieh, Chia-Liang Lin, Hsiang-Lin Lee, I-Chun Liu, Tsung-Ho Ying
Summary: Licoricidin, an active compound of Glycyrrhiza uralensis, was found to significantly inhibit cell viability and induce apoptosis in cervical cancer cells. It also triggered endoplasmic reticulum stress and upregulated the protein expression of GRP78 (Bip), CHOP, and IRE1 alpha, ultimately leading to immunogenic cell death. These findings suggest that Licoricidin may be a potential inducer of immunotherapy in advanced cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tsai-Yi Tseng, Chien-Hsing Lee, Hsiang-Lin Lee, Chien-Yu Su, Cheng-Yen Kao, Jen-Pi Tsai, Yi-Hsien Hsieh
Summary: Licochalcone A (LicA) is a potent anti-inflammatory, antioxidant, and anticarcinogenic substance that shows therapeutic potential against renal cell carcinoma (RCC). LicA limits cell growth, induces cell cycle arrest, promotes autophagy and LC3B expression, and inhibits migration and invasion of RCC cells. The chemotherapeutic effects of LicA on RCC are mediated through the activation of LC3B expression, ultimately modulating the FAK/Src signaling pathway-mediated Sp1 expression.
Article
Environmental Sciences
Kuan-Chun Hsueh, Po-Chung Ju, Yi-Hsien Hsieh, Shih-Chi Su, Chao-Bin Yeh, Chiao-Wen Lin
Summary: HO-3867 triggers cell cycle arrest and apoptotic responses in liver cancer, possibly involving p38-mediated activation of caspase cascades.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Tsai-Kun Wu, Tung-Wei Hung, Yong-Syuan Chen, Ying-Ru Pan, Yi-Hsien Hsieh, Jen-Pi Tsai
Summary: Corosolic acid inhibits the migration and invasion of renal cell carcinoma cells by reducing MMP2 expression and stimulating ERK1/2 phosphorylation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Chun Sun, Chia-Liang Lin, Tzong-Huei Lee, Chia-Hao Chang, Ann-Zhi Ong, Yen-Hsiu Yeh, Chen-Lin Yu, Guang-Wei Chen, Yi-Hsien Hsieh, Shih-Wei Wang
Summary: In this study, Chaetoglobosin A (ChA) was identified as a potent and selective antitumor agent in human colorectal cancer (CRC). ChA inhibited CRC cell growth and induced apoptotic cell death through mitochondrial intrinsic and caspase-dependent pathways. The expression of Heme oxygenase-1 (HO-1) was found to be associated with ChA-induced cell death, and inhibition of HO-1 increased the sensitivity of CRC cells to ChA.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Jia-Sin Yang, Chia-Hsuan Chou, Yi-Hsien Hsieh, Peace Wun-Ang Lu, Ya-Chiu Lin, Shun-Fa Yang, Ko-Hsiu Lu
Summary: The study found that Morin can suppress the migration and invasion capabilities of human osteosarcoma cells, playing an anti-metastatic role by reducing uPA expression. Therefore, Morin may be a potential drug candidate for the treatment of human osteosarcoma.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Huang-Ming Hu, Hsiang-Lin Lee, Chung-Jung Liu, Yi-Hsien Hsieh, Yong-Syuan Chen, Kuan-Chun Hsueh
Summary: The study found that MTA2 regulates HCC progression through the MTA2-FAK-MMP7 pathway. PTK7, as a downstream factor of MTA2, affects the migration and invasion abilities of HCC cells by regulating MMP7 expression. The expression level of PTK7 is correlated with tumor stage, grade, and overall survival in HCC patients, and may have diagnostic value for HCC patients.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Kwei-Jing Chen, Ming-Hong Hsieh, Yen-You Lin, Michael Yuan-Chien Chen, Ming-Yu Lien, Shun-Fa Yang, Chih-Hsin Tang
Summary: Oral cancer is a common cancer in Taiwanese males, and elevated levels of visfatin, a pro-inflammatory adipocytokine, have been found in oral squamous cell carcinoma (OSCC) patients. This study investigated the effects of visfatin gene polymorphisms and carcinogenic lifestyle factors on the risk of developing OSCC, as well as their associations with prognostic factors. The results show that certain visfatin gene polymorphisms and lifestyle factors may be associated with the development and prognosis of OSCC.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)