Review
Oncology
Matteo Renzulli, Daryl Ramai, Jameel Singh, Samridhi Sinha, Nicolo Brandi, Anna Maria Ierardi, Elisa Albertini, Rodolfo Sacco, Antonio Facciorusso, Rita Golfieri
Summary: Cholangiocarcinoma and combined hepatocellular cholangiocarcinoma are aggressive primary malignancies with liver resection as the main treatment modality. Locoregional therapies can provide local tumor control and increase chances of survival.
Article
Gastroenterology & Hepatology
Maria Reig, Giuseppe Cabibbo
Summary: The potential impact of DAAs in BCLC-B/C stage patients with HCC is understudied, as HCC patients have been excluded from DAA trials. The decision on using DAAs should be made based on individual patient profiles.
JOURNAL OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Aurelie Beaufrere, Julien Calderaro, Valerie Paradis
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a tumor with both hepatocytic and biliary differentiation, whose diagnosis is primarily based on morphology and immunostaining, with a prognosis worse than hepatocellular carcinoma and treatment limited to surgery.
JOURNAL OF HEPATOLOGY
(2021)
Review
Oncology
Marcus Bahra, Ali Yahyazadeh
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare liver tumor with both hepatocellular and cholangiocellular differentiation. Accurate diagnosis is challenging, and radical oncological surgery is the only curative option. Factors such as clinicopathological characteristics and biological behavior are crucial in understanding this tumor.
Review
Oncology
Florian Rossner, Bruno Valentin Sinn, David Horst
Summary: This review discusses the histomorphological classification and diagnosis methods of combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA), as well as the molecular foundation for potential therapeutic approaches. cHCC-CCA is a rare primary liver cancer composed of hepatocellular and cholangiocellular differentiated cells. The classification of this cancer has evolved over time, with the latest WHO classification emphasizing morphological diagnosis and introducing new subtypes. Immunohistochemical markers have limited value for diagnosis, but recent discoveries in molecular pathway regulation may lead to new therapeutic approaches for this challenging disease.
Review
Biochemistry & Molecular Biology
Joon Hyuk Choi, Jae Y. Ro
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer with aggressive behavior and poor prognosis compared to classic hepatocellular carcinoma (HCC). The morphologic and phenotypic diversity of cHCC-CCA poses diagnostic challenges for pathologists. Accurate diagnosis is crucial for patient management and prognostication.
Article
Gastroenterology & Hepatology
You-Yin Tang, Yu-Nuo Zhao, Tao Zhang, Zhe-Yu Chen, Xue-Lei Ma
Summary: A radiomics nomogram was developed to predict post-resection survival of patients with combined hepatocellular carcinoma and cholangiocarcinoma. The nomogram showed better predictive performance compared to models based solely on radiomics score or clinical factors. It may help identify patients who are more likely to benefit from surgery.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Julien Calderaro, Luca Di Tommaso, Pascale Maille, Aurelie Beaufrere, Cong Trung Nguyen, Lara Heij, Viviane Gnemmi, Rondell P. Graham, Frederic Charlotte, Suzanne Chartier, Dominique Wendum, Mukul Vij, Daniela Allende, Alba Diaz, Carla Fuster, Benjamin Riviere, Astrid Herrero, Jeremy Augustin, Katja Evert, Diego Francesco Calvisi, Wei Qiang Leow, Howard Ho Wai Leung, Jan Bednarsch, Emmanuel Boleslawski, Mohamed Rela, Anthony Wing-Hung Chan, Alejandro Forner, Maria Reig, Anais Pujals, Loetitia Favre, Manon Allaire, Olivier Scatton, Arnaud Uguen, Eric Trepo, Lukas Otero Sanchez, Denis Chatelain, Myriam Remmelink, Camille Boulagnon-Rombi, Celine Bazille, Nathalie Sturm, Benjamin Menahem, Eric Frouin, David Tougeron, Christophe Tournigand, Emmanuelle Kempf, Haeryoung Kim, Massih Ningarhari, Sophie Michalak-Provost, Jakob Nikolas Kather, Annette S. H. Gouw, Purva Gopal, Raffaele Brustia, Eric Vibert, Kornelius Schulze, Darius F. Ruther, Soren A. Weidemann, Rami Rhaiem, Jean-Charles Nault, Alexis Laurent, Giuliana Amaddeo, Helene Regnault, Eleonora de Martin, Christine Sempoux, Pooja Navale, Jayendra Shinde, Ketan Bacchuwar, Maria Westerhoff, Regina Cheuk-Lam Lo, Mylene Sebbagh, Catherine Guettier, Marie Lequoy, Mina Komuta, Marianne Ziol, Valerie Paradis, Jeanne Shen, Stefano Caruso
Summary: Nestin protein is a valuable biomarker for diagnosis and prognosis assessment in cHCC-CCA. It can distinguish cHCC-CCA from HCC and has high prognostic value. Nestin immunohistochemistry may be used to refine risk stratification and improve treatment allocation for patients with this highly aggressive malignancy.
JOURNAL OF HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyang Liu, Farzad Khalvati, Khashayar Namdar, Sandra Fischer, Sara Lewis, Bachir Taouli, Masoom A. Haider, Kartik S. Jhaveri
Summary: Machine learning analysis on MRI and CT radiomics features showed promising predictive performance in differentiating cHCC-CC from other liver cancers, with MRI features demonstrating the best performance. Radiologists read had a high misdiagnosis rate for cHCC-CC.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Wen-qiang Wang, Jian Li, Bin-yong Liang, Xing Lv, Rong-hua Zhu, Jin-lin Wang, Zhi-yong Huang, Shu-hong Yang, Er-lei Zhang
Summary: This study compared the prognostic outcomes of anatomical resection (AR) and non-anatomical resection (NAR) for patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA). The results showed that AR had better 5-year overall survival and recurrence-free survival rates compared to NAR, especially for patients with tumors smaller or equal to 5 cm in diameter.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Gui-min Hou, Chuang Jiang, Jin-peng Du, Ke-fei Yuan
Summary: This study found that sarcopenia is an independent and stable risk factor for the prognosis of cHCC-CC patients after surgery. The nomogram developed in this study outperformed primary liver cancer stages in prognostic prediction.
Article
Oncology
Daw-Shyong Perng, Chao-Ming Hung, Hung-Yu Lin, Paul Morgan, Yao-Chun Hsu, Tsung-Chin Wu, Pei-Min Hsieh, Jen-Hao Yeh, Pojen Hsiao, Chih-Yuan Lee, Yu-Chan Li, Ya-Chin Wang, Yaw-Sen Chen, Chih-Wen Lin
Summary: The study found that high LC3 expression in tumors of cHCC-CC patients is significantly associated with favorable clinical prognosis, including prolonged overall survival and disease-free survival.
Article
Medicine, General & Internal
Yu-Jen Chen, Chien-Wei Su, Cheng-Yi Wei, Gar-Yang Chau, Ping-Hsien Chen, Yee Chao, Yi-Hsiang Huang, Jaw-Ching Wu, Tsung-Chieh Yang, Pei-Chang Lee, Ming-Chih Hou
Summary: Cirrhotic patients with hepatocellular carcinoma (HCC) and esophageal varices (EV) are prone to posthepatectomy decompensation, but cirrhosis is not a poor prognostic factor for overall survival and recurrence-free survival in HCC patients after surgical resection.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Oncology
Po-Da Chen, Li-Ju Chen, Yao-Jen Chang, Yun-Jau Chang
Summary: HCC-CC demonstrates clinical characteristics and malignant behaviors between HCC and CC, with surgical treatment and TAcE potentially benefitting patient survival. Limited literature calls for further understanding of HCC-CC.
Article
Oncology
Zhen Yang, Guangjun Shi
Summary: Patients with combined hepatocellular-cholangiocarcinoma (CHC) who underwent surgical intervention showed better long-term survival outcomes compared to non-surgical treatments. The overall survival rate of CHC patients was different from that of intrahepatic cholangiocarcinoma (ICC) patients before and after a 3-year follow-up.
Article
Gastroenterology & Hepatology
Man-Fung Yuen, Chi-Yi Chen, Chun-Jen Liu, Wen-Juei Jeng, Magdy Elkhashab, Carla S. Coffin, Won Kim, Susan Greenbloom, Alnoor Ramji, Young S. Lim, Yoon J. Kim, Scott K. Fung, Dong J. Kim, Jeong-Won Jang, Kwan Sik Lee, Radhakrishnan P. Iyer, Chelsea Macfarlane, Kathy Jackson, Stephen A. Locarnini, Henry L. Y. Chan, Nezam H. Afdhal
Summary: Treatment with Inarigivir for HBV infection showed a trend of reducing viral load and antigen levels. A greater reduction in HBsAg was observed in patients pre-treated with Inarigivir after switching to tenofovir.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Dongsub Jeon, Ye-Jee Kim, Seonok Kim, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
Summary: This study aimed to determine the risk of herpes zoster in patients with liver cirrhosis, finding that the incidence rates of herpes zoster and herpes zoster-related hospitalization were significantly higher in patients with liver cirrhosis compared to the general population.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Hyeyeon Hong, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
Summary: In this study, 873 Korean patients who achieved a sustained virologic response (SVR) following direct-acting antivirals (DAAs) treatment were analyzed. The aMAP and mPAGE-B scores demonstrated the highest predictive performance for de novo hepatocellular carcinoma (HCC) in these SVR-achieving patients, suggesting their potential use in identifying low-risk patients exempt from HCC surveillance.
Article
Oncology
Yoon Jung Jang, Eo Jin Kim, Hyung-Don Kim, Kyu-Pyo Kim, Min-Hee Ryu, Sook Ryun Park, Won-Mook Choi, Danbi Lee, Jonggi Choi, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Baek-Yeol Ryoo, Changhoon Yoo
Summary: This retrospective study evaluated the effectiveness and safety of immune checkpoint inhibitors (ICIs) in patients with unresectable or metastatic combined hepatocellular- cholangiocarcinoma (cHCC-CCA). The results showed that ICIs demonstrated clinical anti-cancer effectiveness in cHCC-CCA patients, consistent with prior prospective studies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jonggi Choi, Won-Mook Choi, Young-Suk Lim
CLINICS IN LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Won-Mook Choi, Gi-Ae Kim, Jonggi Choi, Gwang Hyeon Choi, Yun Bin Lee, Dong Hyun Sinn, Young-Suk Lim
Summary: This study aimed to investigate the association between baseline HBV viral load and on-treatment HCC risk in patients with CHB without cirrhosis. The study found that patients with moderate baseline viral load had the highest HCC risk.
Editorial Material
Gastroenterology & Hepatology
Young-Suk Lim, Allison Kwong, Alina M. Allen
Article
Gastroenterology & Hepatology
Hyeyeon Hong, Minjoo Cho, Chaeyeon Lim, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
Summary: Patients with chronic hepatitis B (CHB) on nucleos(t)ide analogues (NUCs), especially those on tenofovir disoproxil fumarate (TDF), face a higher risk of chronic kidney disease (CKD) progression compared with untreated patients. However, patients treated with entecavir and tenofovir alafenamide (TAF) have comparable CKD progression risks to untreated patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Hyun Jun Um, Jonggi Choi, Young-Suk Lim, Won-Mook Choi
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Ji Won Yang, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Man-Fung Yuen, Young-Suk Lim, Ki Tae Yoon, Tien Huey Lim, Jeong Heo, Pisit Tangkijvanich, Won Young Tak, Vaidehi Thanawala, Daniel Cloutier, Shenghua Mao, Andre Arizpe, Andrea Cathcart, Sneha V. Gupta, Carey Hwang, Edward J. Gane
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Man-Fung Yuen, Jeong Heo, Ronald G. Nahass, Grace Lai-Hung Wong, Tatiana Burda, Kalyan Ram Bhamidimarri, Tsung-Hui Hu, Tuan Nguyen, Young-Suk Lim, Chi-Yi Chen, Stuart C. Gordon, Jacinta Holmes, Wan-Long Chuang, Anita Kohli, Naim Alkhouri, Kevin Gray, Emily P. Thi, Elina Medvedeva, Timothy Eley, Karen Sims
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Young-Suk Lim, Henry L. Y. Chan, Kosh Agarwal, Patrick Marcellin, Maurizia Brunetto, Wan-Long Chuang, Harry Janssen, Scott Fung, Namiki Izumi, Maciej Jablkowski, Frida Abramov, Hongyuan Wang, Leland Yee, John F. Flaherty, Calvin Pan, Shalimar, Wai-Kay Seto, Edward J. Gane, Maria Buti
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Hyo Jin Nam, Jonggi Choi, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Kanghee Park, Euichang Kim, Ji Won Yang, Won-Mook Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
JOURNAL OF HEPATOLOGY
(2023)