Article
Oncology
Alexander C. J. van Akkooi, Dirk Schadendorf, Alexander M. M. Eggermont
Summary: Sentinel lymph node biopsy (SLNB) was introduced in the 1990s to identify patients who may benefit from completion lymph node dissection. SLNB staging has been found to be the best for staging melanoma. Adjuvant systemic therapy and biomarkers are emerging, which might reduce the need for SLNB staging in the future.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Jennine H. Weller, Carly Westermann, Palak Patel, Ross M. Beckman, Christine A. Pratilas, Carol D. Morris, Daniel S. Rhee
Summary: Synovial sarcoma has a lower incidence of lymph node metastasis compared to CCS and epithelioid sarcoma. Lymph node sampling can improve overall survival in children and young adults with CCS.
PEDIATRIC BLOOD & CANCER
(2022)
Review
Health Care Sciences & Services
Vincenzo Cuccurullo, Marco Rapa, Barbara Catalfamo, Giuseppe Lucio Cascini
Summary: With the advancements in sentinel lymph node technology, histopathological staging can be done using lymphatic mapping and selective lymphadenectomy. Structural imaging techniques like US, CT, and MR allow precise measurement of lymph node volume, which is strongly linked to cancerous involvement. While hybrid imaging has shown higher accuracy than standard imaging in visualizing the sentinel lymph node, it hasn't impacted surgical detection. Non-radiological fields such as ophthalmology and dermatology are introducing alternatives like fluorescence or opto-acoustic imaging. This paper analyzes the advantages and limitations of innovative methods in sentinel lymph node detection, including the continued importance of lymphoscintigraphy techniques.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Arielle P. Stafford, Judy C. Boughey
Summary: This study evaluated the rate of non-sentinel lymph node (NSLN) positivity and factors influencing this in patients with a positive sentinel lymph node (SLN) following neoadjuvant chemotherapy (NAC). The results showed a high rate of nodal positivity on completion axillary lymph node dissection (cALND) in the setting of positive SLN after NAC, supporting the current standard of routine cALND. In patients with cN+ disease, NSLN positivity varied based on tumor biology, multicentricity/multifocality, number of positive SLNs, and SLN metastasis size.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Juanito Gebruers, Laura Elst, Marcella Baldewijns, Liesbeth De Wever, Koen Van Laere, Maarten Albersen, Karolien Goffin
Summary: This study investigated the role of dynamic sentinel lymph node biopsy (DSNB) in cN0 penile cancer patients without palpable inguinal lymph node metastases. The results showed that DSNB had a high detection rate and negative predictive value, making it a valuable tool for early detection of inguinal lymph node metastases.
Article
Oncology
Petronilla Staubach, Anton Scharl, Atanas Ignatov, Olaf Ortmann, Elisabeth C. Inwald, Thomas Hildebrandt, Michael Gerken, Monika Klinkhammer-Schalke, Sophia Scharl, Thomas Papathemelis
Summary: The study demonstrates that indocyanine green can be as effective as the radioisotope for SLNB in early breast cancer patients, even among those who have undergone NACT. This offers a potential alternative to overcome the limitations associated with radioactive Technetium(99m) colloid, such as limited availability, high costs, and radioactivity exposure.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Xunxi Lu, Mengting He, Luoting Yu, Zongchao Gou
Summary: This cohort study found that receiving surgical axillary staging was associated with better survival for patients with ipsilateral breast tumor recurrence, and repeat sentinel lymph node biopsy had a similar long-term survival outcome as axillary lymph node dissection. Therefore, repeat sentinel lymph node biopsy may be considered for surgical axillary staging in patients with ipsilateral breast tumor recurrence after lumpectomy and initial sentinel lymph node biopsy.
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Medicine, General & Internal
Franco Picciotto, Gianluca Avallone, Federico Castellengo, Martina Merli, Virginia Caliendo, Rebecca Senetta, Adriana Lesca, Desiree Deandreis, Maria Teresa Fierro, Pietro Quaglino, Simone Ribero
Summary: Sentinel lymph node biopsy is an effective staging procedure, but the current classification may result in inaccurate staging. A new surgical technique combined with SPECT-CT can better guide surgeons to improve staging accuracy for melanoma patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Wenjing Cheng, Xiangbai Wu, Shi Yu, Chengwei Zhang, Yinhong Song, Xinzhi Li, Xiang Yu
Summary: This study developed a new technique for sentinel lymph node imaging using macrophage cell membrane-camouflaged ICG-loaded biomimetic nanoparticles, which achieved accurate lymph node imaging.
Article
Oncology
Carl-Jacob Holmberg, Rasmus Mikiver, Karolin Isaksson, Christian Ingvar, Marc Moncrieff, Kari Nielsen, Lars Ny, Johan Lyth, Roger Olofsson Bagge
Summary: This study aimed to determine whether sentinel lymph node status has prognostic value in T4 melanoma tumors. The results showed a significant difference in survival rates between patients with positive and negative sentinel lymph nodes, suggesting the importance of updating clinical guidelines to reflect this finding.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Glauco Baiocchi, Carlos Eduardo Mattos Cunha Andrade, Reitan Ribeiro, Renato Moretti-Marques, Audrey Tieko Tsunoda, Vanessa Alvarenga-Bezerra, Andre Lopes, Ronaldo Lucio Rangel Costa, Lillian Yuri Kumagai, Levon Badiglian-Filho, Carlos Chaves Faloppa, Henrique Mantoan, Louise De Brot, Ricardo Dos Reis, Bruna Tirapelli Goncalves
Summary: This study aims to investigate the impact of sentinel lymph node biopsy without systematic lymphadenectomy on oncological outcomes in endometrial cancer, and evaluate its effects on patient quality of life.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Medicine, General & Internal
Ane Gerda Z. Eriksson, Ben Davidson, Pernille Bjerre Trent, Brynhildur Eyjolfsdottir, Gunn Fallas Dahl, Yun Wang, Anne Cathrine Staff
Summary: Sentinel lymph node (SLN) biopsy is emerging as an alternative staging approach for early-stage endometrial carcinoma, introducing precision medicine to surgical management of gynecologic cancers. While recognized in Europe and the USA, ongoing debate surrounds its role in low-risk and high-risk patients, with uncertainties regarding the significance of low-volume metastasis and lack of standardized protocols for SLN evaluation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Ilaria Mattavelli, Andrea Maurichi, Carlotta Galeone, Gianfranco Gallino, Consuelo Barbieri, Andrea Leva, Elena Tolomio, Barbara Valeri, Mara Cossa, Roberto Patuzzo, Mario Santinami
Summary: This study evaluated the role of SNB in melanoma patients who developed first loco-regional recurrence. The SN positivity rate in patients with LR or IT was significantly higher than in primary tumors. Additionally, DFS was slightly higher in SN negative patients, but without statistically significant differences.
Article
Obstetrics & Gynecology
Emma C. Rossi, Edward Tanner
Summary: Sentinel lymph node biopsy is an accepted staging strategy for cervical and endometrial cancer surgeries; however, controversies remain in how it can be applied most safely and effectively. These issues ultimately need to be addressed through further clinical trials and observation of larger patient populations.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Editorial Material
Surgery
Callisia N. Clarke, Ugwuji N. Maduekwe
Article
Oncology
Akash A. Shah, Santiago A. Lozano-Calderon, Emily A. Berner, William G. Austen, Jonathan M. Winograd, Howard Y. Park, Nicholas M. Bernthal, Brooke M. Crawford, Francis J. Hornicek
Summary: This retrospective cohort study analyzed 28 patients who underwent reconstruction employing a pedicled vastus lateralis flap after wide resection of primary sacropelvic malignancies. The study found that even in a cohort with high baseline risk for wound complications, the use of a pedicled vastus lateralis flap is a safe reconstructive option.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Robert L. Walker, Francis J. Hornicek, Zhenfeng Duan
Summary: This review summarizes recent enhancements and improvements made to generate useful chordoma models and discusses their applications in drug discovery and precision medicine.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Oncology
Yang Wen, Fan Tang, Chongqi Tu, Francis Hornicek, Zhenfeng Duan, Li Min
Summary: This review discusses the use of immune checkpoint inhibitors (ICIs) in the treatment of osteosarcoma and their related mechanisms. Osteosarcoma treatment has had limited progress over the years, but the advent of ICIs provides a new therapeutic strategy. The current mechanisms of resistance to ICIs therapy in osteosarcoma are summarized, along with strategies to improve their efficacy and potential predictive biomarkers.
Review
Biotechnology & Applied Microbiology
Huali Ye, Xin Hu, Yang Wen, Chongqi Tu, Francis Hornicek, Zhenfeng Duan, Li Min
Summary: Exosomes play an important role in the tumor microenvironment of sarcoma, promoting cancer progression and metastasis through mediating cellular communications. Due to their unique characteristics, exosomes are regarded as potential biomarkers and vehicles for diagnosis and treatment of sarcoma.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Lucia Casadei, Patricia Sarchet, Fernanda Costas C. de Faria, Federica Calore, Giovanni Nigita, Sayumi Tahara, Luciano Cascione, Martin Wabitsch, Francis J. Hornicek, Valerie Grignol, Carlo M. Croce, Raphael E. Pollock
Summary: EVs have emerged as an important player in tumor initiation, progression, and metastasis. Detection of EV cargoes remains a challenge, and this study demonstrates the potential of using ultrasensitive ISH to examine embedded EVs as substrates for detecting DNA amplification, providing a more direct visualization of DNA targets.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Oncology
Matthew Ingham, Shing Lee, Brian A. Van Tine, Edwin Choy, Jay Oza, Sahil Doshi, Liner Ge, Peter Oppelt, Gregory Cote, Brian Corgiat, Naomi Sender, Sarah Sta Ana, Lavan Panchalingam, Emmanuel Petricoin, Gary K. Schwartz
Summary: This study evaluated the efficacy of sitravatinib, a multi-receptor tyrosine kinase inhibitor, in the treatment of well-differentiated/dedifferentiated liposarcoma. The results showed a progression-free rate at 12 weeks of 41% and meaningful disease control in a subset of patients.
CLINICAL CANCER RESEARCH
(2023)
Review
Orthopedics
David S. Constantinescu, William Pavlis, Juan J. Lizardi, Jonathan Weinerman, Thomas M. Best, Francis J. Hornicek, Seth D. Dodds
Summary: The purpose of this review was to analyze the types of questions in the Orthopaedic In-Training Examination. The study found that musculoskeletal trauma had the highest number of questions, and residents should focus on clinical management topics and primary journal sources for studying.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2023)
Article
Pathology
Stefan C. Halvorsen, Yair Benita, Megan Hopton, Brooke Hoppe, Hilmar O. Gunnlaugsson, Parimal Korgaonkar, Charles R. Vanderburg, G. Petur Nielsen, Nicole Trepanowski, Jaime H. Cheah, Matthew P. Frosch, Joseph H. Schwab, Andrew E. Rosenberg, Francis J. Hornicek, Slim Sassi
Summary: This study compared the gene expression profiles of chordoma and notochord, and found consistency between the two, identifying a 12-gene diagnostic signature for chordoma. The TBXT/TGF-B/SOX6/SOX9 pathway was hyperactivated in the tumor, suggesting that chondrogenesis-related pathways play a key role in chordoma development. This research provided the first molecular connection between notochord and chordoma and identified potential therapeutic targets.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Review
Cell Biology
Michael G. G. Rizzo, Thomas M. M. Best, Johnny Huard, Marc Philippon, Francis Hornicek, Zhenfeng Duan, Anthony J. J. Griswold, Lee D. D. Kaplan, Joshua M. M. Hare, Dimitrios Kouroupis
Summary: Osteoarthritis (OA) is the leading cause of disability among the elderly and is increasingly affecting younger individuals. Recent advancements in understanding the pathology of OA have led to the identification of potential therapeutic approaches targeting specific molecular pathways, such as inflammation and cellular senescence. Stem cell therapies and senolytics show promise in controlling patient symptoms and slowing disease progression.
Article
Oncology
Aaron R. Weiss, Yen-Lin Chen, Thomas J. Scharschmidt, Wei Xue, Zhengya Gao, Jennifer O. Black, Edwin Choy, Jessica L. Davis, Julie C. Fanburg-Smith, Simon C. Kao, Mark L. Kayton, Sandy Kessel, Ruth Lim, Lynn Million, Scott H. Okuno, Andrew Ostrenga, Marguerite T. Parisi, Daniel A. Pryma, R. Lor Randall, Mark A. Rosen, Barry L. Shulkin, Stephanie Terezakis, Rajkumar Venkatramani, Eduardo Zambrano, Dian Wang, Douglas S. Hawkins, Sheri L. Spunt
Summary: Clinical Trial Updates provide an opportunity to disseminate additional results when key planned co-primary or secondary analyses are not yet available.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Daniel E. Mcloughlin, Nicholas Chevalier, Edwin Choy, Gregory M. Cote, Xin Gao, Dejan Juric, Kerry L. Reynolds
Summary: Appropriate selection of first-line therapy is crucial for prolonging survival in rapidly progressing cancers. Comprehensive genomics, including whole exome and transcriptome sequencing, can improve diagnostic accuracy and guide therapeutic management. This case report highlights the importance of early comprehensive molecular-based testing in aiding diagnosis and critical therapeutic decision-making for patients with rapidly progressing malignancies.
Meeting Abstract
Oncology
Kevin M. Turner, Mackenzie C. Morris, Aaron M. Delman, Dennis Hanseman, Fabian M. Johnston, Jonathan Greer, Daniel Abbott, Mustafa Raoof, Travis Grotz, Keith Fournier, Sean P. Dineen, Jula Veerapong, Ugwuji Maduekwe, Anai Kothari, Charles A. Staley, Shishir Maithel, Laura Lambert, Alex Kim, Jordan Cloyd, Gregory C. Wilson, Jeffrey J. Sussman, Syed A. Ahmad, Sameer H. Patel
ANNALS OF SURGICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Taylor J. Jaraczewski, Sam Thalji, Gopika SenthilKumar, Callisia N. Clarke, T. Clark Gamblin, Ugwuji Maduekwe, Anai Kothari
ANNALS OF SURGICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Eliza W. Beal, Shruthi Srinivas, Chengli Shen, Alex Kim, Fabian M. Johnston, Jonathan Greer, Daniel Abbott, Courtney Pokrzywa, Mustafa Raoof, Travis Grotz, Jennifer L. Leiting, Keith Fournier, Sean P. Dineen, Jula Veerapong, Anai Kothari, Ugwuji Maduekwe, Shishir Maithel, Sameer H. Patel, Gregory C. Wilson, Laura Lambert, Sherif R. Abdel-Misih, Jordan Cloyd
ANNALS OF SURGICAL ONCOLOGY
(2022)