Review
Oncology
Federica Galiandro, Salvatore Agnes, Giovanni Moschetta, Armando Orlandi, George Clarke, Emilio Bria, Gianluca Franceschini, Giorgio Treglia, Francesco Giovinazzo
Summary: Surgical resection of liver metastases in patients with breast cancer liver metastasis (BCLM) remains controversial. This systematic review and meta-analysis found that resection of BCLM may provide a survival benefit for selected patients. Factors such as negative axillary lymph nodes, a single hepatic lesion, a longer time interval between breast and hepatic diagnosis, and a realizable R0 liver resection should be considered for surgical selection. However, further research is needed to validate these findings.
Article
Oncology
Tobias S. Schiergens, Moritz Drefs, Maximilian Doersch, Florian Kuehn, Markus Albertsmeier, Hanno Niess, Markus B. Schoenberg, Matthias Assenmacher, Helmut Kuechenhoff, Wolfgang E. Thasler, Markus O. Guba, Martin K. Angele, Markus Rentsch, Jens Werner, Joachim Andrassy
Summary: The use of pedicle clamping during liver resection for colorectal cancer liver metastases showed favorable long-term outcomes and lower rates of increased transfusion demand without increasing postoperative morbidity. Further prospective evaluation is needed to fully understand the potential oncologic benefits of this technique for patients undergoing curative resection.
Article
Biochemistry & Molecular Biology
Juan Carlos Celis-Pinto, Adela Alonso Fernandez-Velasco, Maria Daniela Corte-Torres, Jorge Santos-Juanes, Noelia Blanco-Agudin, Kelvin Manuel Pina Batista, Jesus Merayo-Lloves, Luis M. Quiros, Ivan Fernandez-Vega
Summary: The study investigated the expression of PTEN-induced kinase-1 (PINK1) in surgical specimens from ninety patients with metastatic colorectal adenocarcinoma (CRC) to the liver. The results showed that positive PINK1 expression was observed in all tumoral tissues, and there were no differences between different CRCs. However, a significant under-expression of PINK1 was found in CRLMs derived from the rectum compared to other sites. Altered PINK1 expression in CRCs was associated with worse overall survival due to abnormal mitophagy function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Alexandra Nassar, Stylianos Tzedakis, Alix Dhote, Marie Strigalev, Romain Coriat, Mehdi Karoui, Anthony Dohan, Martin Gaillard, Ugo Marchese, David Fuks
Summary: This literature review aimed to assess the feasibility of laparoscopic liver resection for multiple colorectal liver metastases. The minimally invasive approach for liver cancer has become a new standard of oncological care, and laparoscopic liver resection is a significant indication for multiple colorectal liver metastases. The purpose of this paper was to highlight the novelty and updates in the field of multiple minimally invasive liver resections and discuss the feasibility and outcomes of laparoscopic concomitant multiple liver resections for colorectal liver metastases.
Article
Oncology
Yoshinori Takeda, Yoshihiro Mise, Yu Takahashi, Hiromichi Ito, Yosuke Inoue, Ryuji Yoshioka, Yoshihiro Ono, Akio Saiura
Summary: The study found that in patients undergoing hepatectomy for colorectal liver metastases, the prognostic value of the KRAS gene depends on whether patients received preoperative chemotherapy or their tumor burden.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Katharina Joechle, Iakovos Amygdalos, Felix Schmidt, Jan Bednarsch, Alexandros Chrysos, Franziska A. Meister, Zoltan Czigany, Daniel Heise, Marie-Luise Berres, Philipp Bruners, Tom F. Ulmer, Ulf P. Neumann, Sven A. Lang
Summary: This study evaluated the prognostic value of nine predictive scoring systems for patients with recurrent colorectal liver metastases (recCRLM). The results showed that the Nagashima score had the best predictive ability for recurrence and survival.
Article
Medicine, General & Internal
Sven H. Loosen, Christoph Roderburg, Patrick H. Alizai, Anjali A. Roeth, Sophia M. Schmitz, Mihael Vucur, Mark Luedde, David Schoeler, Pia Paffenholz, Frank Tacke, Christian Trautwein, Tom Luedde, Ulf P. Neumann, Tom F. Ulmer
Summary: Surgical tumor resection is potentially curative for patients with resectable colorectal liver metastases, but disease recurrence is common. Elevated levels of CEA, CA19-9, and CRP are associated with unfavorable prognosis after CRLM resection, with CEA being an independent prognostic marker.
Article
Gastroenterology & Hepatology
Fenella K. S. Welsh, Caoimhe M. Walsh, Kandiah Chandrakumaran, Wasula S. Rathnaweera, Ashok Roy, Jane Needham, Adrian B. Cresswell, John H. McVey, Myrddin Rees
Summary: This study observed patients undergoing hepatectomy for colorectal metastases and found that there is a risk of thrombosis before the surgery, which is further increased by the hepatectomy. Based on the results, it is suggested that chemical thromboprophylaxis should be considered early in the patient pathway.
Review
Oncology
Winifred M. M. Lo, Samer T. T. Tohme, David A. A. Geller
Summary: Minimally invasive surgery, including laparoscopic and robotic approaches, is a safe and effective option for treating liver metastases from colorectal cancer. Laparoscopic liver resection (LLR) is associated with shorter hospital stays and similar post-operative complications compared to open techniques. LLR allows for early initiation of chemotherapy and simultaneous resection of colorectal and liver tumors can be safe in selected patients. Robotic liver resection (RLR) has comparable safety and may improve resection rates. It is important to carefully select patients and ensure surgeon experience when considering minimally invasive liver surgery for colorectal liver metastases.
Review
Biochemistry & Molecular Biology
Dongchan Kim, Bhavya Gupta, Geoffrey Yuet Mun Wong
Summary: The liver is the most common site of metastasis in colorectal cancer. Multimodal treatment, including liver resection, is potentially curative and prolongs survival for selected patients with colorectal liver metastases (CRLM). However, the treatment of CRLM remains challenging because recurrence is common, and prognosis varies widely between patients despite curative-intent treatment. Clinicopathological features and tissue-based molecular biomarkers, either alone or in combination, are insufficient for accurate prognostication. As most of the functional information in cells resides in the proteome, circulating proteomic biomarkers may be useful for rationalising the molecular complexities of CRLM and identifying potentially prognostic molecular subtypes. High-throughput proteomics has accelerated a range of applications including protein profiling of liquid biopsies for biomarker discovery. Moreover, these proteomic biomarkers may provide non-invasive prognostic information even before CRLM resection. This review evaluates recently discovered circulating proteomic biomarkers in CRLM. We also highlight some of the challenges and opportunities with translating these discoveries into clinical applications. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
Lily J. Park, Julian F. Daza, Vivian Li, Aklile Workneh, Victoria Zuk, Marco P. A. Claasen, Julie Hallet, Guillaume Martel, Gonzalo Sapisochin, Pablo E. Serrano
Summary: This study validates the significance of shorter time to recurrence as a predictor of worse overall survival in patients with colorectal cancer liver metastases following hepatectomy.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Qichen Chen, Rui Zhang, Baocai Xing, Cong Li, Dianrong Xiu, Jinghua Chen, Yiqiao Deng, Xiao Chen, Rui Guo, Fenglin Chen, Jianhong Peng, Tao Sun, Hangyan Wang, Muxing Li, Qiwen Zheng, Xinyu Bi, Jianjun Zhao, Jianguo Zhou, Zhiyu Li, Zhen Huang, Yefan Zhang, Yizhou Zhang, Jianqiang Cai, Hong Zhao
Summary: There is no significant difference in postoperative infection rate between patients who undergo colorectal resection first and those who undergo liver resection first. Patients who undergo colorectal resection first have some better short-term outcomes and comparable progression-free survival (PFS) compared to those who undergo liver resection first.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Daniel-Clement Osei-Bordom, Sivesh Kamarajah, Niki Christou
Summary: In the clinical management of liver metastasis of colorectal cancer, surgeons and oncologists categorize the metastasis into resectable and non-resectable groups to initiate tailored therapeutics. The combination of targeted therapies and biotherapies around these two entities is being actively explored to determine the ideal conditions for their application to improve patient survival and quality of life.
Article
Surgery
Haiping Lin, Yang Bai, Mengqiu Yin, Zewei Chen, Shian Yu
Summary: All four DSSs showed significant differences in predicting perioperative outcomes for LLR, with only the IWATE-DSS able to predict conversion rates for HCC patients. This DSS can also assist surgeons in choosing appropriate cases and guiding clinical practices during the LLR learning curve.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Health Care Sciences & Services
Sternschuss Michal, Goshen-Lago Tal, Perl Gali, Goldenfeld Miki, Brook Elana, Brenner Baroch, Kashtan Hanoch, Ben Aharon Irit, Haddad Riad
Summary: Proteomic analysis revealed a distinct protein signature in patients who benefited from colorectal cancer liver metastases resection, which was correlated with extracellular matrix pathways. Further research is needed to define the role of extracellular matrix pathways in prognostics and patient selection for colorectal cancer liver metastases surgical procedures.
JOURNAL OF PERSONALIZED MEDICINE
(2021)