Article
Oncology
Megan E. Tesch, Shoshana M. Rosenberg, Laura C. Collins, Julia S. Wong, Laura Dominici, Kathryn J. Ruddy, Rulla Tamimi, Lidia Schapira, Virginia F. Borges, Ellen Warner, Steven E. Come, Ann H. Partridge
Summary: This study described clinicopathologic features, treatment, and oncologic outcomes in young women with DCIS. The findings showed a high proportion of young women undergoing mastectomy and low recurrence rates.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Amy Hatton, Natalie Heriot, John Zalcberg, Darshini Ayton, Jill Evans, David Roder, Boon H. Chua, Jolyn Hersch, Jocelyn Lippey, Jane Fox, Christobel Saunders, G. Bruce Mann, Jane Synnot, Robin J. Bell
Summary: The management diversity of women with DCIS cannot solely be explained by tumor characteristics, as patient preferences and underlying factors also play a significant role. A study on Australian women diagnosed with DCIS found that understanding of diagnosis, involvement in decision-making, and factors such as psychosexual impact of mastectomy and perceptions of radiotherapy influenced treatment decisions. It is important to recognize that treatment decisions are not solely determined by disease characteristics, but also by patient preferences and individual factors.
Article
Oncology
Jennifer A. A. Ligibel, Yue Zheng, William T. T. Barry, Tal Sella, Kathryn J. J. Ruddy, Mary L. L. Greaney, Shoshana M. M. Rosenberg, Karen M. M. Emmons, Ann H. H. Partridge
Summary: This study investigates weight patterns and physical activity in young breast cancer survivors, and finds that obesity and inactivity are negative prognostic factors for breast cancer. Despite an educational intervention, there was no significant impact on physical activity and weight.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shinn-Huey S. Chou, Justin Romanoff, Constance D. Lehman, Seema A. Khan, Ruth Carlos, Sunil S. Badve, Jennifer Xiao, Ralph L. Corsetti, Sara H. Javid, Derrick W. Spell, Linda K. Han, Jennifer L. Sabol, John R. Bumberry, Ilana F. Gareen, Bradley S. Snyder, Constantine Gatsonis, Lynne Wagner, Antonio C. Wolff, Kathy D. Miller, Joseph A. Sparano, Christopher E. Comstock, Habib Rahbar
Summary: This study analyzed MRI features of DCIS patients in the ECOG-ACRIN E4112 trial, finding that most DCIS cases showed nonmass enhancement on MRI scans and that MRI could increase the additional cancer detection rate. However, MRI features were not predictive of pathological or genomic outcomes for DCIS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shin Ae Lee, Youkyoung Lee, Han Suk Ryu, Myoung-Jin Jang, Woo Kyung Moon, Hyeong-Gon Moon, Su Hyun Lee
Summary: A predictive model based on diffusion-weighted breast MRI can accurately identify women with DCIS at high risk of upstaging, aiding in preoperative surgical planning and decision-making regarding sentinel lymph node biopsy.
Article
Oncology
Tae-Kyung Yoo, Sang Hyun Park, Kyung Do Han, Byung Joo Chae
Summary: This study analyzed 13,740 women diagnosed with DCIS between 2007 and 2013 using the Korean National Health Insurance Service database. The findings showed that DCIS patients had a lower risk of myocardial infarction and stroke compared to the control group, despite having a higher prevalence of underlying diseases, higher incomes, and urban residence.
Article
Oncology
Luca Nicosia, Anna Carla Bozzini, Silvia Penco, Chiara Trentin, Maria Pizzamiglio, Matteo Lazzeroni, Germana Lissidini, Paolo Veronesi, Gabriel Farante, Samuele Frassoni, Vincenzo Bagnardi, Cristiana Fodor, Nicola Fusco, Elham Sajjadi, Enrico Cassano, Filippo Pesapane
Summary: This study aimed to create a model based on radiological and pathological criteria to predict the risk of low-grade in situ ductal carcinoma (DCIS) upgrading to invasive carcinoma after vacuum-assisted breast biopsy (VABB) and subsequent surgical excision. Through retrospective analysis of data from 295 patients with low-grade DCIS, it was found that factors such as older age, absence of residual lesions after biopsy, smaller size of residual lesions, and presence of low-grade DCIS only in specimens with microcalcifications were significantly associated with a lower risk of upgrading. Ultimately, a nomogram for predicting the upstage at surgery was developed, and the model demonstrated good calibration.
Letter
Medicine, General & Internal
Connor J. Kinslow, David M. DeStephano, Christine H. Rohde, Lisa A. Kachnic, Simon K. Cheng, Alfred I. Neugut, David P. Horowitz
Summary: This study investigates the risk of ALCL after postmastectomy implant reconstruction among US women with breast cancer and DCIS.
Article
Oncology
Chad W. Wagoner, Christine M. Friedenreich, Kerry S. Courneya, Qinggang Wang, Jeff K. Vallance, Charles E. Matthews, Lin Yang, Margaret L. Mcneely, Gordon J. Bell, Andria R. Morielli, Jessica Mcneil, Leanne Dickau, S. Nicole Culos-Reed
Summary: This study aimed to identify the correlates of physical activity and sedentary behavior in individuals recently diagnosed with breast cancer. The results showed that higher sedentary behavior was associated with higher body fat percentage and being single. Lower light physical activity was associated with higher body fat percentage, higher body mass index, greater disease barrier influence, a HER2-positive diagnosis, and being single. Lower moderate-to-vigorous physical activity was associated with higher body fat percentage, greater disease barrier influence, and being of Asian or Indian/South American descent. Greater moderate-to-vigorous physical activity was associated with having greater intentions and planning towards physical activity.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Nutrition & Dietetics
Andrea Greco, Agostino Brugnera, Roberta Adorni, Marco D'Addario, Francesco Fattirolli, Cristina Franzelli, Cristina Giannattasio, Alessandro Maloberti, Francesco Zanatta, Patrizia Steca
Summary: The study found that patients showed significant changes in adopting healthier behaviors early on, but experienced significant declines in healthy behaviors soon after six months. Physical activity and red/processed meat intake were modulated by the season of assessment and anxiety symptoms.
Review
Oncology
Renee S. J. M. Schmitz, Erica A. Wilthagen, Frederieke van Duijnhoven, Marja van Oirsouw, Ellen Verschuur, Thomas Lynch, Rinaa S. Punglia, E. Shelley Hwang, Jelle Wesseling, Marjanka K. Schmidt, Eveline M. A. Bleiker, Ellen G. Engelhardt
Summary: The quality and clinical utility of decision support tools for ductal carcinoma in situ (DCIS) are still in need of improvement. Most existing tools lack features to facilitate discussion with healthcare providers and lack high-quality validation studies. Therefore, there is a need for well-validated decision support tools to meet the treatment needs of DCIS.
Article
Oncology
Christopher Li, Meghan R. Flanagan, Mei-Tzu C. Tang, Peggy L. Porter, Kathleen E. Malone
Summary: This study demonstrates that bisphosphonate use is associated with a lower risk of subsequent invasive breast cancer among women with a history of DCIS, suggesting a potential preventative approach for this high-risk population.
Review
Oncology
Anna K. Casasent, Mathilde M. Almekinders, Charlotta Mulder, Proteeti Bhattacharjee, Deborah Collyar, Alastair M. Thompson, Jos Jonkers, Esther H. Lips, Jacco van Rheenen, E. Shelley Hwang, Serena Nik-Zainal, Nicholas E. Navin, Jelle Wesseling
Summary: This article reviews the basic knowledge of ductal carcinoma in situ (DCIS) and explores the fundamental biology of DCIS, including the impact of genomic events in neoplastic cells and the surrounding microenvironment on the progression of DCIS to invasive breast cancer. Additionally, it discusses the information needed to prevent overtreatment of indolent DCIS lesions and ensure adequate treatment for high-risk patients.
NATURE REVIEWS CANCER
(2022)
Article
Cardiac & Cardiovascular Systems
Konstantinos Iliodromitis, Zsuzsanna Balogh, Filippos Triposkiadis, Spyridon Deftereos, Dimitrios Vrachatis, Nana-Yaw Bimpong-Buta, Fabian Schiedat, Harilaos Bogossian
Summary: In this study, the wearable cardioverter defibrillator (WCD) was used to monitor the physical activity of patients with newly diagnosed heart failure, and it was found that the daily steps of patients significantly increased. Additionally, an improvement in ejection fraction was observed. However, there was no correlation between the improvement in ejection fraction and the improvement in physical activity. Therefore, the WCD can provide useful information for early adjustment of heart failure treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Yufei Zeng, Weiqi Gao, Xiaosong Chen, Kunwei Shen
Summary: Patients with invasive ductal carcinoma (IDC) accompanied by ductal carcinoma in situ (DCIS) have a lower 21-gene recurrence score (RS) possibly due to lower expression of proliferation and invasion genes. The proportion and grade of DCIS independently influence the 21-gene RS in IDC/DCIS patients. Further evaluation is needed to determine the impact of the DCIS component in IDC on prognosis due to the relatively short follow-up period and low recurrence rate.
BRITISH JOURNAL OF CANCER
(2021)