Article
Medicine, Research & Experimental
Josef Madrigal, Laith Mukdad, Albert Y. Han, Zachary Tran, Peyman Benharash, Maie A. St John, Keith E. Blackwell
Summary: High-volume centers for head and neck cancer resection with flap reconstruction are associated with lower rates of surgical and medical complications, shorter hospital stays, and reduced costs for patients. However, hospital volume does not impact 90-day readmission rates.
Article
Oncology
Chandler J. Rygalski, Zachary M. Huttinger, Songzhu Zhao, Guy Brock, Kyle VanKoevering, Matthew O. Old, Theodoros N. Teknos, James W. Rocco, Sidharth V. Puram, Nolan B. Seim, Brian Swendseid, Catherine T. Haring, Antoine Eskander, Stephen Y. Kang
Summary: This study examined the association between hospital volume and overall mortality in HNSCC patients. The findings suggest that patients treated at hospitals with an annual volume above 50% had significantly improved survival rates.
Article
Oncology
Jennifer Siu, Rebecca Griffiths, Christopher W. Noel, Peter C. Austin, Jesse Pasternak, David Urbach, Eric Monteiro, David P. Goldstein, Jonathan C. Irish, Anna M. Sawka, Antoine Eskander
Summary: The study showed that the surgical case volume of lateral neck dissection performed by surgeons is associated with disease-free survival (DFS) for thyroid cancer patients, with patients operated on by surgeons with lower case volumes demonstrating poorer DFS.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Kerstin Clasen, Marcel Nachbar, Sergios Gatidis, Daniel Zips, Daniela Thorwarth, Stefan Welz
Summary: This study investigated the impact of diagnostic MRI on target volume delineation in curative radiochemotherapy for head and neck cancer. The results showed that MRI resulted in visually relevant changes in the gross tumor volume in 69% of the patients. However, the 3-year local control rate was still 94%.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Nicole C. Schmitt, Martha Ryan, Tyler Halle, Amy Sherrod, J. Trad Wadsworth, Mihir R. Patel, Mark W. El-Deiry
Summary: This study demonstrates that transitioning from surgeon-specific scheduling to a team-based approach can enhance operating room utilization and reduce delays in cancer care, potentially leading to improved oncologic outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Leila S. Musavi, Darya Fadavi, Waverley He, Justin M. Sacks, Oluseyi Aliu
Summary: The study found that Medicaid beneficiaries have similar chances as privately-insured individuals in receiving care at high-volume centers and undergoing reconstruction surgery, but they have poorer outcomes in terms of post-operative complications.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Sean C. Sheppard, Lukas Frech, Roland Giger, Lluis Nisa
Summary: This study investigated the impact of head and neck cancers on neck lymph nodes and surgical treatment. Previous irradiation was found to lead to reduced lymph node yield, while lymph node ratio had a prognostic impact in modified radical neck dissection.
Article
Medicine, General & Internal
Maria Goncalves, Christina Gsaxner, Andre Ferreira, Jianning Li, Behrus Puladi, Jens Kleesiek, Jan Egger, Victor Alves
Summary: Head and neck cancer, with its complex anatomical structures, can be accurately predicted for prognosis using radiomics and machine learning techniques.
Article
Oncology
Chengwen Gan, Yannan Wang, Yan Tang, Kai Wang, Bincan Sun, Mengxue Wang, Feiya Zhu
Summary: This study analyzed data from 632 head and neck cancer patients and identified diabetes mellitus, primary tumor site (floor of mouth), flap failure, preoperative radiotherapy, and bilateral neck dissection as risk factors for SSI. Machine learning consistently ranked diabetes mellitus, primary tumor site (floor of mouth), and flap failure as the top three among the 26 SSI-related risk factors.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Obstetrics & Gynecology
K. Matsuo, A. C. Youssefzadeh, R. S. Mandelbaum, R. N. Sangara, S. Matsuzaki, K. Matsushima, M. Klar, J. G. Ouzounian, J. D. Wright
Summary: The study found that in performing caesarean hysterectomy for PAS patients, hospitals with higher surgical volume may have better surgical outcomes. Patients in high-volume hospitals were more likely to be Black, have lower median household income, medical comorbidities, previous caesarean deliveries, placenta previa or placenta percreta, and undergo surgeries at large urban teaching hospitals compared to low-volume hospitals.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Oncology
Ines Leao, Catarina Garcia, Pedro Antunes, Ana Campolargo, Isabel Dias, Edite Coimbra, Pedro Oliveira, Horacio Zenha, Horacio Costa, Andreia Capela, Sofia Viamonte, Alberto J. Alves, Ana Joaquim
Summary: Head and neck cancer treatment can have negative impact on health-related quality of life and treatment efficacy. Exercise training may bring benefits to these patients. This study aimed to analyze the acute effects of treatment on patients and their preferences for exercise training. The findings suggest that an exercise training program can improve the physical fitness of patients and reduce toxicities.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Medicine, Research & Experimental
Douglas R. Farquhar, Maheer M. Masood, Nicholas R. Lenze, Siddharth Sheth, Samip N. Patel, Catherine Lumley, Adam M. Zanation, Mark C. Weissler, Andrew F. Olshan, Trevor G. Hackman
Summary: Patients with HPV-negative HNSCC treated at community cancer centers had better 5-year overall survival, while those treated at academic hospitals showed a trend towards better survival, especially for advanced stage patients. In terms of surgical volume, centers in the top third by volume had significantly better 5-year survival outcomes.
Article
Oncology
Saad A. Khan, Michael Burke, Fang Zhu, Dong-Hua Yang, Cara Dubyk, Ranee Mehra, Miriam J. Lango, John A. Ridge, David J. Sher, Barbara Burtness
Summary: High expression of Survivin is associated with shorter overall survival in head and neck squamous cell carcinoma, including patients treated with chemotherapy or radiation. There is no correlation between p16 expression and Survivin levels.
Article
Oncology
Sebastian Starke, Alexander Zwanenburg, Karoline Leger, Klaus Zoephel, Joerg Kotzerke, Mechthild Krause, Michael Baumann, Esther G. C. Troost, Steffen Loeck
Summary: This study investigates the predictive ability of machine learning-based radiomics models using imaging data obtained during the course of treatment. Features were extracted from pre-treatment CT and FDG-PET images, as well as images obtained two and three weeks after the start of radiochemotherapy. Models comprised of combined features from both modalities and multiple timepoints were evaluated. The results show that predictive model performance is improved when features from in-treatment imaging are used.