Review
Oncology
Ismail Jatoi, Ian H. Kunkler
Summary: Before abandoning the sentinel node biopsy (SNB) procedure in breast cancer management, additional studies and considerations must be taken into account. Specifically, there is a need for level I evidence to demonstrate that omitting the SNB procedure will improve patient quality of life, and suitable alternatives as a guide for adjuvant radiotherapy decision making need to be validated.
Article
Health Care Sciences & Services
Virginia Garcia-Pineda, Alicia Hernandez, Sonia Garrido-Mallach, Elena Rodriguez-Gonzalez, Maria Alonso-Espias, Myriam Gracia, Rocio Arnedo, Ignacio Zapardiel
Summary: This study evaluated the impact of surgical treatment of endometrial cancer with sentinel lymph node biopsy (SLNB) on patients' quality of life (QoL). The results showed that the SLNB group had a better QoL in terms of functional and symptom aspects, as well as sexual health.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Surgery
Eirini Pantiora, Marios Konstantinos Tasoulis, Antonios Valachis, Staffan Eriksson, Thorsten Kuehn, Andreas Karakatsanis, Isabel T. Rubio
Summary: Superparamagnetic iron oxide nanoparticles (SPIO) have been used as a tracer for sentinel lymph node (SLN) localization in breast cancer, demonstrating comparable performance to the combination of radioisotope (RI) and blue dye (BD). The detection rate for SPIO is slightly higher than RI +/- BD, and preoperative injection over 24 hours increases the detection rate.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Xuefei Wang, Guochao Zhang, Zhichao Zuo, Qingli Zhu, Shafei Wu, Yidong Zhou, Feng Mao, Yan Lin, Songjie Shen, Xiaohui Zhang, Xue Qin, Cunli Yan, Xiaoying Ma, Yue Shi, Qiang Sun
Summary: This retrospective study found an association between SLN positive rate and non-SLN metastasis in breast cancer, with SLN-PR > 0.333 being a potential risk factor for non-SLN metastasis. The results provide valuable reference for guiding adjuvant treatment in breast cancer patients.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Surgery
Nur Amalina Che Bakri, Richard M. Kwasnicki, Naairah Khan, Omar Ghandour, Alice Lee, Yasmin Grant, Aleksander Dawidziuk, Ara Darzi, Hutan Ashrafian, Daniel R. Leff
Summary: This study evaluated the impact of axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) on upper limb morbidity in breast cancer patients. The results showed that ALND patients had higher prevalence of lymphedema, pain, reduced strength, and range of motion compared with SLNB patients. These findings support the continued de-escalation of axillary surgery.
Article
Multidisciplinary Sciences
Sean M. Hacking, Kara-Lynne Leonard, Dongling Wu, Mara Banks, Theresa Graves, Lijuan Wang, Evgeny Yakirevich, Yihong Wang
Summary: The use of sentinel lymph node biopsy (SLNB) in patients with microinvasive breast cancer (MIBC) has been debated. This study evaluated clinical and histological features to predict disease free survival (DFS) and factors influencing clinical decision making in MIBC patients. SLNB was found to be associated with mastectomy, high nuclear grade, and negativity for ER and HER-2. However, SLNB did not impact DFS in this study.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Sang Il Youn, Sang Yong Son, Kanghaeng Lee, Yongjoon Won, Sahong Min, Young Suk Park, Sang-Hoon Ahn, Hyung-Ho Kim
Summary: The study revealed that the postoperative quality of life in patients with stage I gastric cancer was significantly better in those who underwent laparoscopic gastrectomy combined with SNNS compared to conventional laparoscopic distal gastrectomy.
Article
Medicine, General & Internal
Piotr Kedzierawski, Artur Bocian, Agnieszka Radowicz-Chil, Anna Huruk-Kuchinka, Ryszard Mezyk
Summary: The purpose of this study was to determine the correlation between the biological subtype of breast cancer and the risk of metastasis to a sentinel lymph node. In the analyzed group of 1018 women with breast cancer, 57% were classified as Luminal A subtype. A positive sentinel lymph node was found in 26.5% of the women.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Paolo Izzo, Claudia De Intinis, Simone Sibio, Luigi Basso, Andrea Polistena, Raimondo Gabriele, Massimo Codacci-Pisanelli, Luciano Izzo, Sara Izzo
Summary: This study proposed new techniques to prevent complications of sentinel lymph node biopsy and presented initial data from our experience. The identification rates of sentinel lymph node detection using radioactive tracers and the magnetic tracer technology (Sentimag) were 88.9% and 89.5% respectively.
Article
Medicine, General & Internal
Shuang-long Cai, Ran-mei Wei, Lei Han, Xiao-geng Chen, Guo-xian Gong, Xiu-quan Lin, Jin Zhang, Hong-dan Chen
Summary: By analyzing the risk factors of non-sentinel lymph node (NSLN) metastasis in breast cancer patients with sentinel lymph node (SLN) positive, this study found that primary tumor size, number of positive SLNs, ratio of positive SLNs, and SLN metastasis type were independent risk factors. These factors can effectively predict NSLN metastasis and guide appropriate surgical treatments.
Article
Oncology
Bruna Tirapelli Goncalves, Ricardo Dos Reis, Reitan Ribeiro, Renato Moretti-Marques, Fernanda Karoline Schamme, Gabriela Silva Oliveira, Audrey Tieko Tsunoda, Vanessa Alvarenga-Bezerra, Andre Lopes, Caroline Batista Pinheiro Pastore, Lillian Yuri Kumagai, Carlos Chaves Faloppa, Henrique Mantoan, Levon Badiglian-Filho, Louise De Brot, Carlos Eduardo Mattos Cunha Andrade, Glauco Baiocchi
Summary: This study aimed to evaluate the prevalence of post-operative complications and quality of life in patients with endometrial cancer who underwent sentinel lymph node biopsy or systematic lymphadenectomy. The results showed that the group undergoing systematic lymphadenectomy had a higher overall rate of complications, as well as higher rates of lymphocele and lymphedema. However, there was no difference in overall quality of life between the two groups.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Chemistry, Analytical
Fahime Shahsavari, Mohsen Bakhshi Kashi, Saeed Farzanefar, Elisabeth Eppard, Nasim Vahidfar
Summary: Breast cancer is a deadly malignancy, and early and accurate diagnosis is crucial for long-term survival. Nuclear medicine has recently introduced a novel method for evaluating breast cancer at both early and advanced stages. This method is based on sentinel lymph node scintigraphy, which is preferable to axillary lymphadenectomy due to its lower postoperative complications. Radiocolloids have shown superior effectiveness in detecting metastatic lymph nodes. In this short review, we will introduce the important role of radiopharmaceuticals in the clinical application of breast cancer lymphoscintigraphy.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Oncology
Fatima Cardoso, Amelia McCartney, Antonio Ponti, Lorenza Marotti, Conny Vrieling, Alexandru Eniu, Berta Sousa, Carla Ripamonti, Luzia Travado, Sabine Spitz, Eva Jolly, Giuseppe Curigliano, Frederique Penault-Llorca, Frederic Lecouvet, Isabel T. Rubio, Laura Biganzoli
Summary: The European Society of Breast Cancer Specialists and the Advanced Breast Cancer Global Alliance have developed the first set of quality indicators for metastatic breast cancer (MBC) with the aim of ensuring high-quality care and adherence to guidelines in breast cancer centers.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Ya Qiu, Xiang Zhang, Zhiyuan Wu, Shiji Wu, Zehong Yang, Dongye Wang, Hongbo Le, Jiaji Mao, Guochao Dai, Xuwei Tian, Renbing Zhou, Jiayi Huang, Lanxin Hu, Jun Shen
Summary: The MRI-clinical-radiomics nomograms developed in this study showed high predictive performance in determining axillary NSLN status in SLN-positive breast cancer patients, reducing overtreatment and optimizing personalized surgical strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Min Kyeong Jang, Sue Kim, Chang Gi Park, Eileen G. Collins, Lauretta T. Quinn, Carol Estwing Ferrans
Summary: Breast cancer survivors in South Korea experience lower quality of life compared to other countries, with common issues being depression and anxiety symptoms, as well as physical fatigue and poor sleep quality. Although Korean survivors have longer working hours, it does not significantly affect their quality of life.