Review
Oncology
Pia Weskamp, Dominic Ufton, Marius Drysch, Johannes Maximilian Wagner, Mehran Dadras, Marcus Lehnhardt, Bjoern Behr, Christoph Wallner
Summary: This systematic review and meta-analysis identified risk factors and prognostic indicators for the development and recurrence of soft tissue sarcomas (STS). Results showed that smoking, genetic predisposition, chronic inflammation, and toxins were associated with the development of STS, while margin of resection, chemotherapy, and radiation were associated with a higher risk of relapse.
Review
Oncology
Maria Danieli, Alessandro Gronchi
Summary: Reliable tools for prognosis prediction are crucially needed by oncologists to tailor individual treatments for sarcoma patients. Nomograms, which incorporate multiple risk factors and return a numerical probability of clinical events, could better account for the granularity of sarcomas compared to the widely used TNM staging system. New dynamic nomograms and prognostic tools have been developed, allowing doctors to recalculate prognosis based on time since primary surgery, event history, and the potential time-dependent effect of covariates. This review provides an overview of available nomograms for sarcomas to assist clinicians in selecting the most suitable tool for each patient.
Article
Oncology
Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
Summary: The purpose of this study was to clarify the clinical outcomes and prognostic factors in patients with STS who underwent unplanned excision (UE). The results showed that there was no significant difference in overall survival, local recurrence-free survival, or disease-free survival between the UE and planned excision (PE) groups. However, metastasis-free survival was significantly better in the UE group. Older age and larger primary tumor were associated with poorer disease-free survival in the UE group.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Surgery
Ryan D. Zeh, David Konieczkowski, Chengli Shen, Diamantis I. Tsilimigras, Alex Kim, Valerie P. Grignol, Carlo M. Contreras, Meng Welliver, Allan Tsung, Timothy M. Pawlik, Raphael E. Pollock, Joal D. Beane
Summary: The addition of radiation therapy to surgery for retroperitoneal sarcoma remains controversial. This analysis aimed to define prognostic factors among patients receiving radiation therapy and surgery to aid in patient selection for multimodal therapy. Machine learning analysis revealed that patients can be stratified into 5 cohorts with distinct survival outcomes based on factors such as age, tumor histology, and comorbidity score.
Article
Oncology
Franziska Willis, Julian Musa, Simon Schimmack, Ulf Hinz, Gunhild Mechtersheimer, Matthias Uhl, Thomas Schmidt, Stefan Froehling, Markus W. Buechler, Martin Schneider
Summary: LR and DM are common in RPS with longer time to recurrence and resection of recurrence associated with improved OS for first and second LR. Gross macroscopic incomplete resection of first, second, and third recurrences is an independent poor prognostic factor for OS. Patients benefit from tumor resection not only in case of first, but also in case of subsequent recurrences.
Article
Oncology
Do Weon Lee, Han-Soo Kim, Ilkyu Han
Summary: The study found that actual 5-year survival in stage III soft tissue sarcoma patients is associated with tumor size, histological grade, and ASA score. Nevertheless, the majority of long-term survivors still exhibit factors of poor prognosis.
Article
Veterinary Sciences
Andrea Regina Cardoso de Almeida Moreira, Mayara Simao Franzoni, Denner Santos dos Anjos, Paulo Cesar-Jark, Juliano Nobrega, Renee Laufer-Amorim, Marina Valsecchi Henriques, Osmar Pinto Neto, Carlos Eduardo Fonseca-Alves
Summary: A study evaluated the clinical and pathological staging as well as mitotic count in dogs with soft tissue sarcomas and found that these indicators were associated with patient prognosis.
VETERINARY SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Tomoki Nakamura, Akihiro Sudo
Summary: Trabectedin is a safe and effective therapeutic option for patients with advanced STS. While it may be effective as first-line treatment in selected patients, doxorubicin remains the preferred choice for locally advanced or metastatic STS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Dorian Yarih Garcia-Ortega, Alethia Alvarez-Cano, Miguel Angel Clara-Altamirano, Claudia Caro-Sanchez, Cuauhtemoc De la Cruz Ruvalcaba-Gonzalez, Carlo Cesar Cortes-Gonzalez, Kuauhyama Luna-Ortiz
Summary: This study analyzed the incidence and clinical impact of histologically proven bone invasion in individuals with soft tissue sarcomas. Results showed that bone invasion was associated with lower overall survival (OS) and disease-free survival (DFS), while high histological grade was also related to worse OS.
SURGICAL ONCOLOGY-OXFORD
(2022)
Review
Oncology
Arthur Lebas, Clara Le Fevre, Waisse Waissi, Isabelle Chambrelant, David Brinkert, Georges Noel
Summary: This article provides a systematic review of studies on soft tissue sarcomas of the extremities treated with radiotherapy. The analysis reveals the great heterogeneity among these studies and the difficulty in identifying significant prognostic factors for the benefit of radiotherapy. The review provides valuable insights for optimizing radiotherapy treatment for patients with soft tissue sarcomas of the extremities.
Article
Oncology
Danielle J. Maes, Motaz Alaqeel, Michael Parry, Rajesh Botchu, Vaiyapuri Sumathi, Lee M. Jeys, Jonathan D. Stevenson
Summary: This study aims to describe the oncological outcomes and prognostic factors of haemorrhagic soft-tissue sarcomas (HSTS). The results showed that the median overall survival was 12 months, with a two-year survival rate of 15.9% to 52.9%. Factors associated with improved survival included negative resection margins, radiotherapy, neoadjuvant radiotherapy, and amputation. Local recurrence occurred in 35.3% of surgically treated patients with localized disease. Radiotherapy and negative margins significantly affected local recurrence.
Article
Oncology
Marcos R. Gonzalez, Marilee J. Clunk, Angad D. S. Bedi, Joseph O. Werenski, Julian H. H. Lang, Daniel Karczewski, Alisha Sodhi, Santiago A. Lozano-Calderon
Summary: Undifferentiated pleomorphic sarcoma (UPS) is an aggressive type of soft tissue sarcoma (STS) with high rates of metastatic disease and local recurrence. Age >= 60 and size >= 7 cm are significant risk factors for overall death, while lymph node involvement is an important risk factor for both local recurrence and distant metastasis.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Orthopedics
Savas Yildirim, Mert Ciftdemir, Fethi Emre Ustabasioglu, Funda Ustun, Ufuk Usta
Summary: This study evaluated the factors affecting local recurrence and survival in patients with soft-tissue sarcomas located in the thigh. The size of the tumor, presence of necrosis, high Ki-67 index, positive surgical margins, and metastasis were found to be the main factors affecting survival.
JOINT DISEASES AND RELATED SURGERY
(2023)
Review
Oncology
Andrea Sambri, Emilia Caldari, Michele Fiore, Riccardo Zucchini, Claudio Giannini, Maria Giulia Pirini, Paolo Spinnato, Alberta Cappelli, Davide Maria Donati, Massimiliano De Paolis
Summary: There is still lack of standardized description for assessing margin status of soft tissue sarcomas, highlighting the need for uniform classification and standardization.
Article
Oncology
Alessandra Buja, Massimo Rugge, Matteo Barillaro, Andrea Miatton, Saveria Tropea, Claudia Cozzolino, Manuel Zorzi, Antonella Vecchiato, Paolo Del Fiore, Antonella Brunello, Vincenzo Baldo, Carlo Riccardo Rossi, Simone Mocellin
Summary: This study aimed to compare the pathological and clinical features of retroperitoneal soft-tissue sarcomas (RPS) and non-RPS, and analyze if the hazard ratio for short-term mortality differs between RPS and non-RPS after adjusting for baseline differences. The analysis found that RPS accounted for 22.8% of cases, with different characteristics compared to non-RPS. The retroperitoneum site was an independent prognostic factor associated with worse overall survival in sarcoma patients.
Review
Oncology
Emily Z. Keung, Kate J. Krause, Jessica Maxwell, Carol D. Morris, Aimee M. Crago, Matthew T. Houdek, John Kane, Valerae Lewis, Dario Callegaro, Benjamin Miller, Alexander J. Lazar, Rebecca Gladdy, Chandrajit P. Raut, Nicola Fabbri, Waddah Al-Refaie, Mark Fairweather, Sandra L. Wong, Christina L. Roland
Summary: Regional lymph node metastasis (RLNM) is uncommon in patients with soft tissue sarcoma (STS), although certain STS subtypes are more prone to RLNM. The impact of node-positive disease on patient survival is still controversial. There is ongoing debate about the benefits of sentinel lymph node biopsy (SLNB) in STS patients. Further multicenter prospective studies are needed to determine the true incidence and potential benefits of SLNB in patients with clinically occult RLNM.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Raymond S. Traweek, Allison N. Martin, Nikita F. Rajkot, B. Ashleigh Guadagnolo, Andrew J. Bishop, Alexander J. Lazar, Emily Z. Keung, Keila E. Torres, Kelly K. Hunt, Barry W. Feig, Christina L. Roland, Christopher P. Scally
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Raymond S. Traweek, Allison N. Martin, Nikita F. Rajkot, B. Ashleigh Guadagnolo, Andrew J. Bishop, Alexander J. Lazar, Emily Z. Keung, Keila E. Torres, Kelly K. Hunt, Barry W. Feig, Christina L. Roland, Christopher P. Scally
Summary: This study aimed to evaluate the short-term outcomes and morbidity after re-resection of unplanned excision of trunk and extremity soft tissue sarcoma (STS) to better understand the risks and benefits of this treatment strategy. The results showed that the rate of wound complications after re-resection was 45%, and radiation therapy and plastic surgery involvement were independently associated with wound complications. Additionally, 67% of patients had no evidence of residual disease in the re-resection specimen. Therefore, treatment plans and discussions with patients should include information about the expected pathological findings and morbidity of surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Emily Z. Keung, Kate J. Krause, Jessica Maxwell, Carol D. Morris, Aimee M. Crago, Matthew T. Houdek, John Kane, Valerae Lewis, Dario Callegaro, Benjamin Miller, Alexander J. Lazar, Rebecca Gladdy, Chandrajit P. Raut, Nicola Fabbri, Waddah Al-Refaie, Mark Fairweather, Sandra L. Wong, Christina L. Roland
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Andrew W. Hahn, Ashley Menk, Dayana B. Rivadeneira, Ryan C. Augustin, Mingchu Xu, Jun Li, Xiaogang Wu, Aditya K. Mishra, Tuba N. Gide, Camelia Quek, Yan Zang, Christine N. Spencer, Alexander M. Menzies, Carrie R. Daniel, Courtney W. Hudgens, Theodore Nowicki, Lauren E. Haydu, M. A. Wadud Khan, Vancheswaran Gopalakrishnan, Elizabeth M. Burton, Jared Malke, Julie M. Simon, Chantale Bernatchez, Nagireddy Putluri, Scott E. Woodman, Y. N. Vashisht Gopal, Renato Guerrieri, Grant M. Fischer, Jian Wang, Khalida M. Wani, John F. Thompson, Jeffrey E. Lee, Patrick Hwu, Nadim Ajami, Jeffrey E. Gershenwald, Georgina Long, Richard A. Scolyer, Michael T. Tetzlaff, Alexander J. Lazar, Dirk Schadendorf, Jennifer A. Wargo, John M. Kirkwood, Ralph J. DeBerardinis, Han Liang, Andrew Futreal, Jianhua Zhang, James S. Wilmott, Weiyi Peng, Michael A. Davies, Greg M. Delgoffe, Yana G. Najjar, Jennifer L. McQuade
Summary: This study investigated the association between body mass index (BMI) and tumor or microbiome characteristics in patients with metastatic melanoma. The findings suggest that the host metabolic phenotype influences melanoma metabolism and may explain the improved outcomes observed in overweight/obese patients treated with immune checkpoint inhibitors and targeted therapies.
CLINICAL CANCER RESEARCH
(2023)
Article
Dermatology
Shira Ronen, Jennifer S. Ko, Brian P. Rubin, Scott E. Kilpatrick, Wei-Lien Wang, Alexander J. Lazar, John R. Goldblum, Steven D. Billings
Summary: This study reviewed cases of superficial LGFMS diagnosed between 2008 and 2020 and found that these tumors are more common in the extremities of children and young adults, and may have a better clinical outcome. All cases tested positive for MUC4 and/or FUS gene rearrangement. Follow-up showed no evidence of recurrence or distant metastasis in 14 cases.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Oncology
Yize Li, Tung-Shing M. Lih, Saravana M. Dhanasekaran, Rahul Mannan, Lijun Chen, Marcin Cieslik, Yige Wu, Rita Jiu-Hsien Lu, David J. Clark, Iga Koodziejczak, Runyu Hong, Siqi Chen, Yanyan Zhao, Seema Chugh, Wagma Caravan, Nataly Naser Al Deen, Noshad Hosseini, Chelsea J. Newton, Karsten Krug, Yuanwei Xu, Kyung-Cho Cho, Yingwei Hu, Yuping Zhang, Chandan Kumar-Sinha, Weiping Ma, Anna Calinawan, Matthew A. Wyczalkowski, Michael C. Wendl, Yuefan Wang, Shenghao Guo, Cissy Zhang, Anne Le, Aniket Dagar, Alex Hopkins, Hanbyul Cho, Felipe da Veiga Leprevost, Xiaojun Jing, Guo Ci Teo, Wenke Liu, Melissa A. Reimers, Russell Pachynski, Alexander J. Lazar, Arul M. Chinnaiyan, Brian A. Van Tine, Bing Zhang, Karin D. Rodland, Gad Getz, D. R. Mani, Pei Wang, Feng Chen, Galen Hostetter, Mathangi Thiagarajan, W. Marston Linehan, David Fenyo, Scott D. Jewell, Gilbert S. Omenn, Rohit Mehra, Maciej Wiznerowicz, Ana I. Robles, Mehdi Mesri, Tara Hiltke, Eunkyung An, Henry Rodriguez, Daniel W. Chan, Christopher J. Ricketts, Alexey I. Nesvizhskii, Hui Zhang, Li Ding
Summary: By integrating histopathologic, proteogenomic, and metabolomic analyses, this study reveals the inter- and intratumoral heterogeneity of clear cell renal cell carcinomas (ccRCCs). It identifies high-risk disease subsets based on tumor grade, BAP1 mutation, genome instability, hypermethylation, and protein glycosylation signature. RNA sequencing provides insights into gene signatures and potential targeted therapies, while in vitro cell line studies validate the efficacy of inhibiting identified phosphoproteome targets.
Article
Oncology
Tuyen Duong Thanh Nguyen, Yan Wang, Tuyen N. Bui, Rossana Lazcano, Davis R. Ingram, Min Yi, Varshini Vakulabharanam, Linjie Luo, Marc A. Pina, Cansu Karakas, Mi Li, Nicole M. Kettner, Neeta Somaiah, Peter J. Hougton, Osama Mawlawi, Alexander J. Lazar, Kelly K. Hunt, Khandan Keyomarsi
Summary: Treatment strategies with CDK4/6 inhibitors followed by DNA-damaging agents showed synergistic killing of Rb-positive sarcomas and can be noninvasively monitored using functional imaging and serum biomarkers. This approach provides a potential avenue for novel targeted therapies in sarcomas with intact Rb signaling.
Article
Oncology
Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W. Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J. Lazar, J. Andrew Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C. Daw, Nicholas E. Navin, Richard Gorlick, Joseph A. Ludwig
Summary: Single-cell RNA-seq is an innovative technology to study complex tissues and characterize cell types, states, and lineages. However, recent evidence suggests that the methods used for tissue processing and cell disaggregation may introduce biases in gene expression and alter observed cell types. This study evaluated the impact of dissociation methods on sarcomas and demonstrated the feasibility of computational correction.
Article
Cell Biology
Jacqueline E. Birkness-Gartman, Sintawat Wangsiricharoen, Alexander J. Lazar, John M. Gross
Summary: This study describes the clinicopathologic features of three oesophageal glomus tumours diagnosed at two large academic institutions between 1984 and 2022. These tumours exhibited aggressive behavior with metastases to multiple sites. Management by a multidisciplinary sarcoma team is recommended for optimal outcome.
Article
Oncology
Alessandro La Ferlita, Nipin Sp, Marina Goryunova, Giovanni Nigita, Raphael E. Pollock, Carlo M. Croce, Joal D. Beane
Summary: Soft-tissue sarcomas (STS), a rare and diverse group of tumors, have various subtypes characterized by differences in tumor biology and clinical outcomes. Small non-coding RNAs (sncRNAs), including miRNAs and tRNA-derived ncRNAs, play important roles in STS tumorigenesis and differentiation. However, the translation of these findings into clinical applications, such as biomarkers or therapeutic targets, remains challenging. This review summarizes the current understanding of sncRNAs in STS, with a focus on liposarcoma, and discusses their potential as novel biomarkers and therapeutic targets.
MOLECULAR CANCER RESEARCH
(2023)
Article
Cell Biology
Sayumi Tahara, Fernanda Costas C. de Faria, Patricia Sarchet, Federica Calore, Joe Sharick, Jennifer L. Leight, Lucia Casadei, Raphael E. Pollock
Summary: This study aimed to establish 3D cell culture of liposarcomas using two different methods: scaffold-based (Matrigel extracellular matrix [ECM] scaffold method) and scaffold-free (Ultra-low attachment [ULA] plate). The distinctive differences in structures and different responses of cell lines to 3D culture were observed. The upregulation of MDM2 was confirmed after treatment with MDM2 inhibitor SAR405838, and DDLPS spheroids showed different sensitivity patterns from 2D models. The 3D models have the potential to provide a new predictability of efficacy and toxicity, and are considered as an important process in the pre-clinical phase.
Article
Oncology
Gabriele Romano, Francesca Paradiso, Peng Li, Pooja Shukla, Lindsay N. Barger, Olivia El Naggar, John P. Miller, Roger J. Liang, Timothy L. Helms, Alexander J. Lazar, Jennifer A. Wargo, Francesca Taraballi, James C. Costello, Lawrence N. Kwong
Summary: Patients with BRAF-mutant melanoma respond well to combined BRAF and MEK inhibition, but relapse is common within 2 years. Minimal residual disease (MRD), which consists of drug-tolerant tumor cells in a dormant state, is a major cause of drug resistance. By studying a mouse model, researchers found that sustaining chemokine signaling can impair MRD maintenance by increasing the recruitment of effector T cells.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Dermatology
Woo Cheal Cho, Wen Li, Jun Gu, Wei-Lien Wang, Jing Ning, Steven Sfamenos, Pavandeep Gill, Priyadharsini Nagarajan, Jonathan L. Curry, Alexander J. Lazar, Victor G. Prieto, Carlos A. Torres-Cabala, Phyu P. Aung
Summary: The clinical utility of TERT IHC to predict TGA status in AMs appears to be limited given its low specificity and positive predictive value.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Review
Oncology
Samantha M. Ruff, Valerie P. Grignol, Carlo M. Contreras, Raphael E. Pollock, Joal D. Beane
Summary: Retroperitoneal sarcoma (RPS) is a rare disease with various histologic types. The Transatlantic RPS Working Group (TARPSWG) in Europe and North America aims to study and establish best practices for managing this disease. Complete resection of all macro and microscopic disease is the gold standard, but it often requires multi-visceral resection. Recent evidence suggests en bloc compartmental resections can reduce local recurrence, but the potential for added morbidity must be considered.