Article
Medicine, Research & Experimental
Xiang-nan Yu, Lu-ming Xu, Ya-wen Bin, Ye Yuan, Shao-bo Tian, Bo Cai, Kai-xiong Tao, Lin Wang, Guo-bin Wang, Zheng Wang
Summary: This study retrospectively analyzed data of rectal cancer patients undergoing anterior resection and found that being male and having T3-T4 stage were independent risk factors for anastomotic leakage (AL). Additionally, defunctioning stoma (DS) was found to reduce the occurrence of symptomatic AL.
CURRENT MEDICAL SCIENCE
(2022)
Article
Surgery
Zhao-liang Yu, Xuan-hui Liu, Hua-shan Liu, Jia Ke, Yi-feng Zou, Wu-teng Cao, Jian Xiao, Zhi-yang Zhou, Ping Lan, Xiao-jian Wu, Xian-rui Wu
Summary: The study evaluated the impact of pelvic dimensions on the risk of anastomotic leak in rectal cancer patients. The results showed that pelvic inlet and intertuberous distance were independent predictors for postoperative anastomotic leak. The incorporation of pelvic dimensions with other factors in the nomogram may provide a clinical tool for predicting anastomotic leak.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Haoran Wang, Xiao Wang, Peng Wang, Kai Lv, Haoqing He, Wenguang Yuan, Mofan Fu, Jingbo Chen, Hui Yang
Summary: This study found that DS is independently associated with AS, and postoperative anastomotic leakage increases the risk of AS. Furthermore, this study suggests that TEM could be a valuable treatment option for AS.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Nynke G. Greijdanus, Kiedo Wienholts, Sander Ubels, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, Francisco B. de Lacy, Jeremie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo O. Perez, Tsuyoshi Konishi, Yves Panis, Martin Rutegard, Roel Hompes, Camiel Rosman, Frans van Workum, Pieter J. Tanis, Johannes H. W. de Wilt
Summary: The study developed a prediction model for 1-year stoma-free survival in rectal cancer patients with anastomotic leakage. The model, consisting of 18 clinically relevant factors, showed good discrimination and calibration, providing guidance for patient counseling and future treatment strategies analysis.
Article
Oncology
V. T. Hoek, S. Buettner, C. L. Sparreboom, R. Detering, A. G. Menon, G. J. Kleinrensink, M. W. J. M. Wouters, J. F. Lange, J. K. Wiggers
Summary: This study aimed to develop a robust preoperative prediction model for anastomotic leakage after surgical resection for rectal cancer. Significant risk factors were identified and included in the prediction model, which can be used for patient counselling and risk-stratification before undergoing rectal resection for cancer.
Article
Surgery
E. Back, J. Haggstrom, K. Holmgren, M. M. Haapamaki, P. Matthiessen, J. Rutegard, M. Rutegard
Summary: Using preoperative data, the risk of permanent stoma after anterior resection for rectal cancer at 2 years can be predicted fairly accurately. Factors such as age, tumor metastasis, and preoperative treatment all play a role in influencing the stoma outcome.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Y. Shen, T. Yang, H. Zeng, W. Meng, X. Deng, M. Wei, Z. Wang
Summary: Patients who underwent intersphincteric resection had higher rates of bowel incontinence and anal pain compared to those who underwent LAR, but similar rates of LARS and major LARS. Thus, LAR may be the preferred approach when negative resection margins and a safe anastomosis are ensured.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Oncology
Tao Wang, Yan Zhao, Ming Wang, Peng Zhang, Guole Lin, Qian Liu, Fan Feng, Zhiguo Xiong, Junbo Hu, Bo Zhang, Yingjiang Ye, Lijian Xia, Kaixiong Tao
Summary: This study compared local excision (LE) and radical resection (RR) for low rectal gastrointestinal stromal tumors (GISTs) in a multicenter retrospective cohort study. The results showed that LE had better postoperative outcomes and comparable oncological safety for patients with tumors <= 2 cm. However, for tumors >2 cm, RR might be a more appropriate option with better recurrence-free survival (RFS).
Article
Surgery
Jung Cheol Kuk, Dae Ro Lim, Eung Jin Shin
Summary: This study retrospectively analyzed data from 556 patients with rectal cancer and found that the placement of a transanal drainage tube (TDT) can reduce the occurrence of anastomotic leakage (AL) following low anterior resection (LAR). Logistic analysis identified the non-use of a TDT as a risk factor for AL.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Henrik Jutesten, Pamela L. Buchwald, Eva Angenete, Martin Rutegard, Marie-Louise Lydrup
Summary: This retrospective observational cohort study found a significant association between anastomotic leakage and the occurrence of major low anterior resection syndrome.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Health Care Sciences & Services
Fei Tan, Kai Xu, Xinyu Qi, Pin Gao, Maoxing Liu, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui, Xiangqian Su
Summary: This study aimed to explore the role of postoperative neutrophil-to-lymphocyte ratio in predicting symptomatic anastomotic leakage in patients who underwent laparoscopic low anterior resection for rectal cancer. The study found that patients with symptomatic anastomotic leakage had significantly higher neutrophil-to-lymphocyte levels on postoperative day 5 compared to those without leakage. In conclusion, neutrophil-to-lymphocyte ratio can serve as a predictive biomarker for symptomatic anastomotic leakage, helping to increase the clinical suspicion of this complication.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Liang Yu, Tian-Lei Xu, Lin Zhang, Shuo-Hao Shen, Yue-Lu Zhu, Hui Fang, Hai-Zeng Zhang
Summary: This study found that the predominant sites of distant metastases were the lung and liver for both the NCRT and PCRT groups, with NCRT group developing local recurrence and distant metastases later than the PCRT group. Therefore, patients receiving NCRT may require longer follow-up.
CHINESE MEDICAL JOURNAL
(2021)
Article
Surgery
Kevin Talboom, Nynke G. Greijdanus, Cyriel Y. Ponsioen, Pieter J. Tanis, Wilhelmus A. Bemelman, Roel Hompes
Summary: Early initiation of EVASC for anastomotic leakage after rectal cancer resection yields high rates of healed and functional anastomosis. EVASC shows increasing success with the implementation of highly selective diversion and early diagnosis of the leak.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Wei Jiang, Huaiming Wang, Jixiang Zheng, Yandong Zhao, Shuoyu Xu, Shuangmu Zhuo, Hui Wang, Jun Yan
Summary: This study aimed to quantitatively analyze collagen structural changes caused by preoperative chemoradiotherapy and investigate the relationship between collagen changes and anastomotic leakage (AL). The results showed that preoperative chemoradiotherapy significantly increased the risk of AL. The study also developed an AL-SVM classifier to predict the risk of AL in rectal cancer patients undergoing preoperative chemoradiotherapy.
GASTROENTEROLOGY REPORT
(2022)
Article
Gastroenterology & Hepatology
Frans van Workum, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, Borja F. de Lacy, Jeremie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo Oliva Perez, Tsuyoshi Konishi, Yves Panis, Camiel Rosman, Roel Hompes, Pieter J. Tanis, Johannes H. W. de Wilt
Summary: This study aims to investigate the factors contributing to the severity of anastomotic leakage after low anterior resection for rectal cancer, create a severity score, and evaluate the effects of different treatment approaches on outcome parameters. The international multicentre retrospective cohort study, TENTACLE-Rectum, will provide valuable evidence-based recommendations for improving outcomes in patients with severe treatment-related morbidity.
COLORECTAL DISEASE
(2021)
Article
Oncology
Seung-Hoon Beom, Jong Gwang Kim, Seung Hyuk Baik, Seong Hoon Shin, Inkeun Park, Young Suk Park, Myung-Ah Lee, Soohyeon Lee, So-Yeon Jeon, Sae-Won Han, Myoung Hee Kang, Jisu Oh, Jin Soo Kim, Jin Young Kim, Mi Sun Ahn, Dae Young Zang, Byung-Noe Bae, Hong Jae Jo, Hee Kyung Kim, Jung-Han Kim, Ji Ae Yoon, Dong Han Kim
Summary: The study aimed to evaluate the safety and effectiveness of aflibercept in combination with FOLFIRI regimen in Korean patients with metastatic colorectal cancer. The results showed that the treatment was effective and had an acceptable safety profile in daily clinical practice.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Hong Bae Jeon, Ji Hyuk Jung, Sang Hee Im, Yong Bae Kim, Jee Suk Chang, Seung Yong Song, Dae Hyun Lew, Tai Suk Roh, Won Jai Lee, Dong Won Lee
Summary: This study aimed to investigate the impact of immediate breast reconstruction on the risk of breast cancer-related lymphedema. The results showed that immediate breast reconstruction can reduce the incidence of lymphedema.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Geriatrics & Gerontology
Yerim Kim, Jae-Hoon Lee, Eun-Suk Cho, Hye Sun Lee, Su-Jin Shin, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
Summary: This study aimed to examine the individual and synergistic effects of different prognostic markers related to skeletal muscle quality and serum albumin levels in patients with colorectal cancer (CRC). The albumin-myosteatosis gauge (AMG) was found to be a meaningful predictor of survival, with superior prognostic value compared to skeletal muscle index (SMI), skeletal muscle radiodensity (SMD), and albumin alone. Further studies are needed to determine their significance in different ethnic groups.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Oncology
Harin Kim, Dong-Min Shin, Jae-Hoon Lee, Eun-Suk Cho, Hye Sun Lee, Su-Jin Shin, Eun Jung Park, Seung Hyuk Baik, Kang Young Lee, Jeonghyun Kang
Summary: This study compared various nutritional and inflammatory indicators and found that P-CONUT may be a better prognostic indicator for patients with colorectal cancer, compared to inflammatory markers such as neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jeongseok Jeon, Da Bin Lee, Sang Joon Shin, Dai Hoon Han, Jee Suk Chang, Yoon Dae Han, Hyunwook Kim, Joon Seok Lim, Han Sang Kim, Joong Bae Ahn
Summary: This study found that high-frequency abdominopelvic computed tomography (AP-CT) testing is associated with a higher proportion of surgery plus chemo- or radiotherapy as postrecurrence treatment, but does not improve the 5-year overall survival rate of patients with stage II-III colon cancer.
CLINICAL COLORECTAL CANCER
(2023)
Article
Oncology
Jong Min Lee, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Nam Kyu Kim, Byung Soh Min
Summary: Although perioperative outcomes and overall survival were similar between neoadjuvant chemotherapy (NAC) and upfront surgery-treated patients, better postrecurrence survival was observed in patients with NAC. Additionally, NAC may benefit patients with worse prognoses; therefore, physicians should consider patient disease risk before initiating treatment to identify patients who are most likely to benefit from chemotherapy.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Hyun-Chang Kim, Jinyoung Park, Jinyoung Oh, Minjae Kim, Eun Jung Park, Seung Hyuk Baik, Young Song
Summary: This study evaluated the analgesic efficacy of a four-quadrant transversus abdominis plane (4QTAP) block and a combination of 4QTAP block with needle electrical twitch and intramuscular electrical stimulation (NETOIMS) in patients undergoing cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC). The results showed that the combination of 4QTAP block with NETOIMS provided better pain control and improved functional restoration and quality of recovery in patients.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Gowoon Yang, Chang Young Lee, Eun Young Kim, Chang Geol Lee, Min Hee Hong, Byung Jo Park, Hong In Yoon, Kyung Hwan Kim, Sang Hoon Lee, Hwa Kyung Byun, Jaeho Cho
Summary: This study aimed to determine the role of radiotherapy (RT) and the optimal RT target volume in the treatment of thymic carcinoma. A total of 116 patients who received multimodal treatment were included. The target volume was defined as the tumor bed or gross tumor with margin, and selective irradiation of the regional nodal area was performed when involved. The results showed a high local control rate with RT, and a target volume confined to the tumor bed or gross tumor plus margin with the involved lymph node stations seems reasonable.
Article
Oncology
Seung Yeun Chung, Jee Suk Chang, Yong Bae Kim
Summary: This study aimed to train a deep learning-based auto-segmentation model for OAR/CTVs for patients with cervical cancer undergoing radiotherapy and to evaluate the model's feasibility and efficacy. The results showed that the deep learning model can reduce heterogeneity and save contouring time.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Han-Back Shin, Changhwan Kim, Min Cheol Han, Chae-Seon Hong, Seyjoon Park, Woong Sub Koom, Jin Sung Kim
Summary: The study aims to compare plan robustness at different beam angles in gantry-based carbon-ion radiation therapy for prostate cancer. 10 patients were included and multiple angle pairs were evaluated. The results showed that oblique beam fields were superior in terms of minimizing dose to the rectum compared to conventional lateral opposed fields.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jaeyong Shin, Jee Suk Chang, Jin Sung Kim, Ji-Yeon An, Seung Yeun Chung, So-Yeon Yoon, Yong Bae Kim
Summary: The study aims to evaluate the effects of virtual reality (VR) on reducing anxiety in breast cancer patients undergoing adjuvant radiation therapy (RT). The results show that VR significantly reduces patient anxiety and improves knowledge and satisfaction with the RT procedure.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Sun Jung Kim, Yong Joon Lee, Min Young Park, Seung Yoon Yang, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Joon Seok Lim, Byung Soh Min
Summary: This study reviewed the MRI features of LRC patients undergoing preoperative CRT and found that MRI plays a crucial role in predicting the success and feasibility of sphincter preservation as well as oncological outcomes in these patients.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jee Suk Chang, Heejoo Ko, Sang Hee Im, Jin Sung Kim, Hwa Kyung Byun, Yong Bae Kim, Wonguen Jung, Goeun Park, Hye Sun Lee, Wonmo Sung, Robert Olsen, Chae-Seon Hong, Kyubo Kim
Summary: This study aimed to validate the relationship between the dose at the axillary-lateral thoracic vessel juncture (ALTJ) and the rate of lymphedema in patients with breast cancer, and explore whether incorporating ALTJ dose-distribution parameters improves the accuracy of the prediction model. The results showed that adding dose parameters to the prediction model can improve its accuracy in predicting lymphedema development.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Medicine, General & Internal
Min Soo Cho, Hyeon Woo Bae, Jee Suk Chang, Seung Yoon Yang, Tae Hyun Kim, Woong Sub Koom, Sang Joon Shin, Gyu-Seog Choi, Nam Kyu Kim
Summary: This study aimed to compare the short-term outcomes and cost-effectiveness of long-course chemoradiotherapy (LCRT) and short-course radiotherapy (SCRT) for rectal cancer. The results showed that SCRT achieved a significantly higher pathological complete response rate and had lower total costs compared to LCRT, while also showing fewer recurrences and complications.
YONSEI MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Soyoung Kim, Jae-Hoon Lee, Eun Jung Park, Hye Sun Lee, Seung Hyuk Baik, Tae Joo Jeon, Kang Young Lee, Young Hoon Ryu, Jeonghyun Kang
Summary: This study investigated the feasibility of using preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/ computed tomography (CT) radiomics with machine learning to predict microsatellite instability (MSI) status in colorectal cancer (CRC) patients. A predictive model incorporating PET radiomic features, called rad_score, was established and evaluated for its ability to predict MSI status. The rad_score showed similar predictive performance in both the training and test sets, and it was found to be an independent predictor of MSI status in CRC. Furthermore, the rad_score outperformed conventional PET parameters in predicting MSI status.
YONSEI MEDICAL JOURNAL
(2023)