Article
Gastroenterology & Hepatology
Kavish R. Patidar, Mobasshir A. Naved, Ananth Grama, Mohammad Adibuzzaman, Arzina Aziz Ali, James E. Slaven, Archita P. Desai, Marwan S. Ghabril, Lauren Nephew, Naga Chalasani, Eric S. Orman
Summary: This study investigated hospitalized patients with cirrhosis and acute kidney injury in the US and found that acute kidney disease developed in 1 in 3 patients, which was associated with worse survival and chronic kidney disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Geriatrics & Gerontology
Amjad Bani Hani, Mahmoud Abu Abeeleh, Sondos Al-Najjar, Abdulla Alzibdeh, Shahd Mansour, Isam Bsisu, Nour Awamleh, Randa Farah
Summary: This study investigated the incidence, risk factors, and outcomes of acute kidney injury (AKI) in patients aged 80 years or older in a surgical intensive care unit (SICU). The study found that the incidence of AKI was 32.7%, and it was significantly associated with the use of beta blockers, mechanical ventilation, and inotropes. Further research is needed to assess the incidence of AKI in this population and identify preventive measures and strategies.
Article
Pharmacology & Pharmacy
Yan Guangyu, Lou Jingfeng, Liu Xing, Yuan Hong, Lu Yao
Summary: Postoperative AKI in hypertensive patients undergoing noncardiac surgery is associated with a significantly higher risk of fatal stroke, fatal MI, and all-cause mortality within 5 years. The risk is even higher in patients receiving ACEI/ARB and CCB perioperatively.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Chien-Wen Yang, Si Li, Yishan Dong, Nitpriya Paliwal, Yichen Wang
Summary: This study analyzed data from the HCUP database from 2016 to 2018 and found that rhabdomyolysis patients with AKI were more likely to be older, have Medicare insurance, and have a higher comorbidity index. AKI was associated with higher mortality, longer hospital stays, and higher hospital costs in patients with rhabdomyolysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Sunil Pillai, Akshay Kriplani, Arun Chawla, Bhaskar Somani, Akhilesh Pandey, Ravindra Prabhu, Anupam Choudhury, Shruti Pandit, Ravi Taori, Padmaraj Hegde
Summary: This study analyzed the incidence, risk factors, and outcomes of post-PNL AKI. Older age, hypertension, diabetes, ACE inhibitor use, lower preoperative hemoglobin, higher serum uric acid, larger stone volume and density, staghorn stones, multiple punctures, and longer operative time were identified as significant factors associated with postoperative AKI. Patients with AKI had longer hospital stays and a portion progressed to CKD. Early identification and management of these risk factors can help improve outcomes and prevent further kidney damage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Emaad M. Abdel-Rahman, Faruk Turgut, Jitendra K. Gautam, Samir C. Gautam
Summary: AKI is a common clinical syndrome characterized by rapid impairment of kidney function. The outcomes of AKI-D can vary from partial or complete recovery to transitioning to chronic kidney disease, end stage kidney disease, or even death. Predicting outcomes of patients with AKI is crucial for guiding adequate management and offering the best long-term options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Andrea Lisotti, Romano Linguerri, Igor Bacchilega, Anna Cominardi, Gianmarco Marocchi, Pietro Fusaroli
Summary: The study aimed to evaluate predictive factors for mortality in high-risk surgical patients who underwent EUS-GBD for AC. Severe comorbidities and AKI were independent predictive factors confirming long-term mortality after EUS-GBD. Outcomes of EUS-GBD appear more influenced by patients' conditions rather than by procedure success.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Urology & Nephrology
Zaid K. Yousif, Jejo D. Koola, Etienne Macedo, Jorge Cerda, Stuart L. Goldstein, Rajasekara Chakravarthi, Andrew Lewington, David Selewski, Michael Zappitelli, Dinna Cruz, Ashita Tolwani, Melanie S. Joy, Vivekanand Jha, Raja Ramachandran, Marlies Ostermann, Bhavna Pandya, Anjali Acharya, Patrick Brophy, Daniela Ponce, Julia Steinke, Josee Bouchard, Carlos E. Irarrazabal, Romina Irarrazabal, Andres Boltansky, David Askenazi, Nitin Kolhe, Rolando Claure-Del Granado, Nadine Benador, Clare Castledine, Andrew Davenport, Jonathan Barratt, Sunil Bhandari, Alyssa A. Riley, T. K. Davis, Christopher Farmer, Michael Hogarth, Mark Thomas, Patrick T. Murray, Cassianne Robinson-Cohen, Paola Nicoletti, Sucheta Vaingankar, Ravindra Mehta, Linda Awdishu
Summary: Drug-induced acute kidney injury (DI-AKI) is a common adverse event, and its diagnosis is challenging. This study aims to describe the clinical characteristics and predictive variables of DI-AKI.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Surgery
Tezcan Ozrazgat-Baslanti, Tyler J. Loftus, Rajesh Mohandas, Quran Wu, Scott Brakenridge, Babette Brumback, Philip A. Efron, Stephen Anton, Frederick A. Moore, Lyle L. Moldawer, Mark S. Segal, Azra Bihorac
Summary: This study aims to characterize the endothelial function, inflammation, and immunosuppression in surgical patients with different clinical trajectories of AKI, and determine the impact of persistent kidney injury and non-recovery of renal function. The results showed that persistent AKI and non-recovery of renal function are associated with early and sustained immunologic and endothelial biomarker abnormalities, as well as reduced long-term physical function and survival.
Article
Medicine, General & Internal
Jesus Abelardo Barea-Mendoza, Mario Chico-Fernandez, Manuel Quintana-Diaz, Lluis Servia-Goixart, Ana Fernandez-Cuervo, Maria Bringas-Bollada, Maria Angeles Ballesteros-Sanz, Iker Garcia-Saez, Jon Perez-Barcena, Juan Antonio Llompart-Pou
Summary: The aim of this study was to analyze the impact of acute kidney injury (AKI) on mortality in patients with isolated traumatic brain injury (TBI) and identify associated risk factors. The results showed that 10.6% of patients developed AKI, which was significantly associated with increased mortality. Age, hemodynamic instability, rhabdomyolysis, trauma-associated coagulopathy, and transfusion of packed red-blood-cell concentrates were identified as the main risk factors for AKI in isolated TBI patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Christina Montgomerie, Jonas Spaak, Marie Evans, Stefan H. Jacobson
Summary: This study provides a detailed description of community-acquired acute kidney injury (AKI) and comprehensive analyses of integrated clinical and laboratory data associated with kidney recovery. Features related to anemia, albuminuria, malnutrition, inflammation, and acidosis are associated with partial or moderate short-term recovery of kidney function, disturbances in potassium homeostasis, and in-hospital mortality.
Letter
Medicine, General & Internal
Dominique Vodovar, Bruno Megarbane, Stephane Gaudry, Didier Dreyfuss, Paul M. Palevsky
Summary: This article discusses the importance and effectiveness of using extracorporeal kidney-replacement therapy in poisonings, even in the absence of acute kidney injury, to rapidly remove toxicants and save lives.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Urology & Nephrology
T. Alp Ikizler, Chirag R. Parikh, Jonathan Himmelfarb, Vernon M. Chinchilli, Kathleen D. Liu, Steven G. Coca, Amit X. Garg, Chi-yuan Hsu, Edward D. Siew, Mark M. Wurfel, Lorraine B. Ware, Georgia Brown Faulkner, Thida C. Tan, James S. Kaufman, Paul L. Kimmel, Alan S. Go
Summary: AKI is associated with adverse outcomes such as incident CKD, CKD progression, heart failure events, and all-cause death, but not major atherosclerotic cardiovascular events. Considering kidney function recovery and proteinuria status three months after AKI provides important prognostic information for long-term clinical outcomes.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Conrado Lysandro Rodrigues Gomes, Thais Lyra Cleto-Yamane, Frederico Ruzani, Jose Hermogenes Rocco Suassuna
Summary: Although socioeconomic deprivation is associated with a higher incidence of acute kidney injury (AKI) and worse outcomes in high-income countries, the impact of these epidemiologic factors in developing countries is limited. This study analyzed pediatric and adult patients with dialysis-requiring AKI in private and public hospitals in Brazil and found no independent influence of hospital governance or socioeconomic factors on mortality. Baseline characteristics and disease severity primarily determined the prognosis of AKI.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Anesthesiology
Hongbin Hu, Sheng An, Tong Sha, Feng Wu, Yinghui Jin, Lulan Li, Zhenhua Zeng, Jie Wu, Zhongqing Chen
Summary: This retrospective cohort study found that dexmedetomidine administration was associated with improvements in renal function recovery and in-hospital survival in critically ill patients with sepsis-associated acute kidney injury. It also resulted in prolonged ICU and hospital stay.
JOURNAL OF CLINICAL ANESTHESIA
(2022)