Article
Oncology
Po-Kuei Hsu, Yi-Chen Yeh, Ling- Chien, Chien-Sheng Huang, Han-Shui Hsu
Summary: Pathologic complete lymph node regression may be an indicator of sensitivity to neoadjuvant treatment and serves as a good prognostic factor in patients with esophageal squamous cell carcinoma.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
M. Redegalli, M. Schiavo Lena, M. G. Cangi, C. E. Smart, M. Mori, C. Fiorino, P. G. Arcidiacono, G. Balzano, M. Falconi, M. Reni, C. Doglioni
Summary: This study aimed to identify a new quantitative prognostic index based on tumor morphology to predict the prognosis of patients with PDAC undergoing neoadjuvant chemotherapy followed by surgery. The results showed that perineural invasion and lymph node ratio were associated with shorter overall survival and disease-free survival, while high stroma to neoplasia ratio predicted longer overall survival and disease-free survival. These variables were combined to generate a semi-quantitative prognostic index that significantly distinguished patients with poor outcomes from those with a good outcome.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Dany Barrak, Anthony M. Villano, Nicole Villafane-Ferriol, Leah G. Stockton, Maureen Hill, Mengying Deng, Elizabeth A. Handorf, Sanjay S. Reddy
Summary: This study found that total neoadjuvant therapy (TNT) may be more likely to achieve a pathologic complete response (pCR) in the treatment of pancreatic adenocarcinoma compared to chemotherapy (CT) or chemoradiation (CRT), potentially improving overall survival (OS).
Article
Oncology
Felix Ho, Robert J. Torphy, Chloe Friedman, Stephen Leong, Sunnie Kim, Sachin Wani, Tracey Schefter, Christopher D. Scott, John D. Mitchell, Michael J. Weyant, Robert A. Meguid, Ana L. Gleisner, Karyn A. Goodman, Martin D. McCarter
Summary: In patients with esophageal and gastroesophageal junction adenocarcinoma, induction chemotherapy before neoadjuvant chemotherapy with concurrent radiotherapy was associated with significantly improved overall survival and higher pathological complete response rate. Furthermore, in patients diagnosed from 2013 to 2015, induction chemotherapy with neoadjuvant chemotherapy and concurrent radiotherapy was also linked to a higher odds of achieving pathological complete response.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Robyn D. Gartrell, Thomas Enzler, Pan S. Kim, Benjamin T. Fullerton, Ladan Fazlollahi, Andrew X. Chen, Hanna E. Minns, Subha Perni, Stuart P. Weisberg, Emanuelle M. Rizk, Samuel Wang, Eun Jeong Oh, Xinzheng Guo, Codruta Chiuzan, Gulam A. Manji, Susan E. Bates, John Chabot, Beth Schrope, Michael Kluger, Jean Emond, Raul Rabadan, Donna Farber, Helen E. Remotti, David P. Horowitz, Yvonne M. Saenger
Summary: Despite complete surgical resection and intense systemic therapies, patients with pancreatic ductal adenocarcinoma (PDAC) have a poor prognosis. Immunotherapies have almost uniformly failed in the treatment of PDAC. This study found that while chemoradiation therapy (CRT) can achieve high T cell densities in PDAC compared to melanoma, the phenotype and spatial organization of T cells may limit the benefit of T cell infiltration in this immunotherapy-resistant tumor.
Article
Oncology
D. J. Crull, M. C. H. Hogenes, R. Hoekstra, E. M. Hendriksen, M. J. van Det, E. A. Kouwenhoven
Summary: Adenocarcinoma subtype and grade did not impact overall survival (OS) or disease-free survival (DFS) in esophageal adenocarcinoma patients. However, combining a three-tier MTR with eighth AJCC staging improved the prognostic value for DFS after esophagectomy for neoadjuvant chemoradiotherapy-treated esophageal adenocarcinoma.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lieven Depypere, Gert De Hertogh, Johnny Moons, An-Lies Provoost, Toni Lerut, Xavier Sagaert, Willy Coosemans, Hans Van Veer, Philippe Nafteux
Summary: In cN+ esophageal adenocarcinoma patients treated with nCRT, those with ypN0 and no signs of lymph node response (LNR) have a tripled median overall survival compared to those with LNR, and their survival is comparable to cN+/pN0 upfront esophagectomy patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Gastroenterology & Hepatology
Puja G. Khaitan, Tyler Holliday, Austin Carroll, Wayne L. Hofstetter, Erin M. Bayley, Nicolas Zhou, Sameer Desale, Thomas J. Watson
Summary: This study assessed the correlation between clinical complete response (ycCR) and pathologic complete response (ypCR) and found that current restaging tools cannot reliably predict ypCR after neoadjuvant chemoradiotherapy (nCRT). Although multimodal restaging appears to be a more accurate predictor of ypCR than any individual testing modality, ycCR cannot be relied upon to determine the need for esophagectomy.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Oncology
Jonathan L. Moore, Michael Green, Aida Santaolalla, Harriet Deere, Richard P. T. Evans, Mona Elshafie, Anita Lavery, Damian T. McManus, Andrew McGuigan, Rosalie Douglas, Joanne Horne, Robert Walker, Hira Mir, Monica Terlizzo, Sivesh K. Kamarajah, Mieke Van Hemelrijck, Nick Maisey, Ailsa Sita-Lumsden, Sarah Ngan, Mark Kelly, Cara R. Baker, Sacheen Kumar, Jesper Lagergren, William H. Allum, James A. Gossage, Ewen A. Griffiths, Heike I. Grabsch, Richard C. Turkington, Tim J. Underwood, Elizabeth C. Smyth, Rebecca C. Fitzgerald, David Cunningham, Andrew R. Davies
Summary: This study aimed to evaluate the influence of lymph node (LN) regression on survival after surgery for esophageal adenocarcinoma. The results showed that patients with complete LN regression, partial LN regression, or negative LNs had a lower mortality rate compared to those with poor/no LN regression.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
James Tankel, Henna Soderstrom, Edouard Reizine, Giovanni Artho, Alexander Calderone, Carmen Mueller, Sara Najmeh, Jonathan Spicer, Lorenzo Ferri, Jonathan Cools-Lartigue
Summary: This study aimed to explore the relationship between changes in tumor size and density during neoadjuvant chemotherapy (NCT) and overall survival in patients with esophageal adenocarcinoma. The study found that changes in tumor density, rather than size, were independently associated with overall survival during NCT, suggesting a potential clinical significance for assessing patient prognosis.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Pathology
Aaron J. Sohn, Mehran Taherian, Matthew H. G. Katz, Laura R. Prakash, Deyali Chatterjee, Hua Wang, Michael Kim, Ching-Wei D. Tzeng, Jeffrey E. Lee, Naruhiko Ikoma, Asif Rashid, Robert A. Wolff, Dan Zhao, Eugene J. Koay, Ryan Sun, Anirban Maitra, Huamin Wang
Summary: A multifactorial prognostic score, the integrated pathologic score (IPS), combining pathologic features including ypT, ypN, and TRG, can provide improved prognostic information for patients with preoperatively treated PDAC compared with AJCC staging. Higher IPS is associated with shorter DFS and OS.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Smita Sihag, Samuel C. Nussenzweig, Henry S. Walch, Meier Hsu, Kay See Tan, Sergio De La Torre, Yelena Y. Janjigian, Steven B. Maron, Geoffrey Y. Ku, Laura H. Tang, Pari M. Shah, Abraham Wu, David R. Jones, David B. Solit, Nikolaus Schultz, Karuna Ganesh, Michael F. Berger, Daniela Molena
Summary: MDM2 amplification and TP53 status are associated with response to therapy in patients with esophageal adenocarcinoma. Worsening TP53 dysfunction is directly correlated with worse treatment outcomes.
CLINICAL CANCER RESEARCH
(2022)
Article
Surgery
Erin M. Bayley, Megan L. Ivy, Jitesh B. Shewale, Phillip S. Ge, Mara B. Antonoff, Ashleigh M. Francis, Wayne L. Hofstetter, Reza J. Mehran, Ravi Rajaram, David C. Rice, Jack A. Roth, Boris Sepesi, Ara A. Vaporciyan, Garrett L. Walsh, J. Jack Lee, Brian E. Louie, Stephen G. Swisher
Summary: Clinical predictors of pathological complete response are unreliable for identifying patients suitable for organ-sparing treatment after neoadjuvant chemoradiation in esophageal cancer. This study aimed to identify high-risk predictors of residual carcinoma that may exclude patients from a selective surgical approach.
Article
Oncology
David T. Pointer, Jordan A. McDonald, Samer A. Naffouje, Rutika Mehta, Jason B. Fleming, Jacques P. Fontaine, Gregory Y. Lauwers, Jessica M. Frakes, Sarah E. Hoffe, Jose M. Pimiento
Summary: This study aimed to evaluate the association between histologic grade and prognosis in esophageal cancer patients who received neoadjuvant chemoradiation followed by resection. The study found that patients with post-neoadjuvant therapy histologic grade 1-2 had improved survival. Integrating histologic grade into postneoadjuvant staging may be necessary.
JOURNAL OF SURGICAL ONCOLOGY
(2022)