Review
Oncology
Francisca dos S. Coelho, Diana E. Barros, Filipa A. Santos, Flavia C. Meireles, Francisca C. Maia, Rita A. Trovisco, Teresa M. Machado, Jose A. Barbosa
Summary: The paradigm of esophageal cancer treatment has shifted towards minimally invasive esophagectomy (MIE) over open esophagectomy (OE), with MIE showing trends towards decreased 30-day and 90-day postoperative mortality and fewer major cardiovascular and respiratory complications. Minor postoperative complications may also be reduced with MIE.
Article
Surgery
Wen-Quan Yu, Li-Xue Zhai, Guo-Dong Shi, Jia-Yu Tang, Hui-Jiang Gao, Yu-Cheng Wei
Summary: This study retrospectively analyzed the clinical outcomes of TMIE and HMIE in Ivor-Lewis esophagectomy. The results showed that TMIE had better short-term outcomes in terms of blood loss and postoperative complications compared to HMIE. Additionally, the HMIE group had higher pain scores and more patients requiring additional analgesia after surgery.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Stepan M. Esagian, Ioannis A. Ziogas, Konstantinos Skarentzos, Ioannis Katsaros, Georgios Tsoulfas, Daniela Molena, Michalis V. Karamouzis, Ioannis Rouvelas, Magnus Nilsson, Dimitrios Schizas
Summary: Robot-assisted minimally invasive esophagectomy (RAMIE) is a safe and feasible procedure that can reduce cardiopulmonary complications, wound infections, blood loss, and hospital stays compared to open esophagectomy.
Review
Cardiac & Cardiovascular Systems
Camila Bras Harriott, Cristian A. Angeramo, Maria A. Casas, Francisco Schlottmann
Summary: Hybrid and totally minimally invasive esophagectomy are associated with lower rates of overall morbidity, reduced postoperative mortality, and shorter length of hospital stay compared with open esophagectomy. Totally minimally invasive esophagectomy has lower mortality rates and shorter length of hospital stay compared with hybrid esophagectomy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Christopher P. Wang, Michael P. Rogers, Gregory Bach, Joseph Sujka, Rahul Mhaskar, Christopher DuCoin
Summary: The study found that a minimally invasive abdomen-only approach for esophageal resection in specific patient populations is as safe as a minimally invasive Ivor Lewis approach, with the added benefit of shorter operative duration.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Takashi Sakamoto, Michimasa Fujiogi, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
Summary: By comparing the surgical outcomes of MIE and OE for esophageal cancer, it was found that MIE had lower incidences of in-hospital mortality, morbidities, such as surgical site infection and anastomotic leakage, and a shorter postoperative length of stay; however, it also had higher incidences of vocal cord dysfunction and prolonged intubation period after esophagectomy.
Article
Oncology
Krashna Patel, Omar Abbassi, Cheuk Bong Tang, Bruno Lorenzi, Alexandros Charalabopoulos, Sritharan Kadirkamanathan, Naga Venkatesh Jayanthi
Summary: The study indicates that compared to hybrid esophagectomy, completely minimally invasive esophagectomy reduces postoperative pulmonary infections and overall complications in resectable esophageal and GEJ cancer cases. There were no significant differences in 6-month overall survival and disease-free survival rates between the two approaches.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Eivind Gottlieb-Vedi, Joonas H. H. Kauppila, Fredrik Mattsson, Mats Lindblad, Magnus Nilsson, Pernilla Lagergren, Ioannis Rouvelas, Jesper Lagergren, FINEGO Grp
Summary: This study suggests that minimally invasive esophagectomy (MIE) is associated with higher 5-year survival compared to open esophagectomy (OE) in patients with esophageal cancer, especially total MIE.
Article
Cardiac & Cardiovascular Systems
Chigozirim N. Ekeke, Gino M. Kuiper, James D. Luketich, Kristine M. Ruppert, Susan J. Copelli, Nicholas Baker, Ryan M. Levy, Omar Awais, Neil A. Christie, Rajeev Dhupar, Arjun Pennathur, Inderpal S. Sarkaria
Summary: The objective of this study is to compare the short-term and long-term outcomes of robotic-assisted minimally invasive esophagectomy and standard minimally invasive esophagectomy in patients with esophageal cancer. The results showed no significant differences in overall survival, disease-free survival, and major morbidity between the two surgeries. However, robotic-assisted minimally invasive esophagectomy had a higher lymph node yield.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Oncology
E. Tagkalos, P. C. van der Sluis, F. Berlth, A. Poplawski, E. Hadzijusufovic, H. Lang, M. I. van Berge Henegouwen, S. S. Gisbertz, B. P. Mueller-Stich, J. P. Ruurda, M. Schiesser, P. M. Schneider, R. van Hillegersberg, P. P. Grimminger
Summary: This study is a randomized controlled trial comparing RAMIE and MIE as surgical treatments for resectable esophageal adenocarcinoma or adenocarcinoma of the gastroesophageal junction in the Western World. The primary outcome is the total number of resected lymph nodes in the abdomen and mediastinum per lymph node station.
Article
Surgery
Marianne C. Kalff, Laura F. C. Fransen, Eline M. de Groot, Suzanne S. Gisbertz, Grard A. P. Nieuwenhuijzen, Jelle P. Ruurda, Rob H. A. Verhoeven, Misha D. P. Luyer, Richard van Hillegersberg, Mark I. van Berge Henegouwen
Summary: This study compared long-term survival between minimally invasive esophagectomy (MIE) and open surgery (OE) for esophageal cancer. The results showed that the long-term survival rates were similar for MIE and OE in patients undergoing transthoracic or transhiatal procedures. MIE resulted in a more extensive lymphadenectomy, but transhiatal MIE had more postoperative complications.
Article
Oncology
Masaru Hayami, Nelson Ndegwa, Mats Lindblad, Gustav Linder, Jakob Hedberg, David Edholm, Jan Johansson, Jesper Lagergren, Lars Lundell, Magnus Nilsson, Ioannis Rouvelas
Summary: The study demonstrates that MIE offers better survival and improved short-term postoperative outcomes compared with OE in patients with esophageal and GEJ cancers, including shorter operation time, less intraoperative bleeding, higher number of resected lymph nodes, shorter hospital stay, and fewer complications.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Shigeru Tsunoda, Kazutaka Obama, Shigeo Hisamori, Tatsuto Nishigori, Ryosuke Okamura, Hisatsugu Maekawa, Yoshiharu Sakai
Summary: This retrospective study compared 165 esophageal carcinoma patients who underwent esophagectomy with either RAMIE or conventional MIE. RAMIE had longer operative times but showed better outcomes in terms of postoperative complications and pulmonary complications compared to conventional MIE.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Benjamin Babic, Dolores T. Muller, Jin-On Jung, Lars M. Schiffmann, Paula Grisar, Thomas Schmidt, Seung-Hun Chon, Wolfgang Schroeder, Christiane J. Bruns, Hans F. Fuchs
Summary: This study compares the short-term outcomes of standardized RAMIE and HE and confirms the safety and feasibility of both procedures in a high-risk European population. RAMIE patients had a shorter ICU stay and a lower rate of postoperative complications. Both procedures showed excellent results in terms of lymph node harvest and R0 resection rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Yajie Zhang, Dong Dong, Yuqin Cao, Maosheng Huang, Jian Li, Jiahao Zhang, Jules Lin, Inderpal S. Sarkaria, Lerut Toni, Rice David, Jie He, Hecheng Li
Summary: This article provides a comprehensive review of the literature comparing perioperative outcomes and long-term survival between robotic-assisted minimally invasive esophagectomy (RAMIE) and minimally invasive esophagectomy (MIE) for esophageal cancer. The results suggest that RAMIE is comparable to MIE in perioperative outcomes, but may have advantages in lymph node dissection in the abdominal cavity, lymph nodes dissected along the left recurrent laryngeal nerve, and 3-year disease-free survival.
Article
Surgery
George B. Hanna, Hugh Mackenzie, Danilo Miskovic, Melody Ni, Susannah Wyles, Paul Aylin, Amjad Parvaiz, Tom Cecil, Andrew Gudgeon, John Griffith, Jonathan M. Robinson, Chelliah Selvasekar, Tim Rockall, Austin Acheson, Charles Maxwell-Armstrong, John T. Jenkins, Alan Horgan, Chris Cunningham, Ian Lindsey, Tan Arulampalam, Roger W. Motson, Nader K. Francis, Robin H. Kennedy, Mark G. Coleman
Summary: This study examines the impact of The National Training Program for Lapco on the rate of laparoscopic surgery and clinical outcomes. The results show that Lapco increased the rate of laparoscopic surgery and reduced mortality and morbidity.
Article
Health Care Sciences & Services
Alex Bottle, Puji Faitna, Paul P. Aylin
Summary: During England's first wave of COVID-19, there was modest variation in mortality rates between hospitals after risk adjustment and accounting for random variation, in contrast to early media reports. Early-period mortality did not predict late-period mortality.
BMJ QUALITY & SAFETY
(2022)
Article
Gastroenterology & Hepatology
Nishani Jayasooriya, Jonathan Blackwell, Sonia Saxena, Alex Bottle, Irene Petersen, Hanna Creese, Matthew Hotopf, Richard C. G. Pollok
Summary: This study found that the use of antidepressants among individuals diagnosed with inflammatory bowel disease (IBD) has been increasing over the years. However, a majority of patients did not adhere to the recommended treatment duration according to international guidelines. Younger patients were more likely to discontinue antidepressant treatment earlier.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Primary Health Care
Kimberley A. Foley, Edward J. Maile, Alex Bottle, Francesca K. Neale, Russell M. Viner, Simon E. Kenny, Azeem Majeed, Dougal S. Hargreaves, Sonia Saxena
Summary: COVID-19 had a significant impact on GP contacts with children and young people in England. Face-to-face assessments decreased while remote contacts increased. The decrease in contacts may be attributed to a lower incidence of respiratory illnesses due to reduced social contacts and changing health-seeking behavior.
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Article
Cardiac & Cardiovascular Systems
Alex Bottle, Roger Newson, Puji Faitna, Benedict Hayhoe, Martin R. Cowie
Summary: The study aimed to estimate the long-term survival of two cohorts of people diagnosed with heart failure at different time points and assess differences in patient characteristics, clinical guideline compliance, and survival by diagnosis setting. The study found that there was an improvement in survival rates over 10 years, but there was only modest improvement in national clinical guideline compliance, starting from a low baseline.
Article
Respiratory System
Thomas Woodcock, Geva Greenfield, Ajit Lalvani, Azeem Majeed, Paul Aylin
Summary: This study compares posthospitalisation outcomes and health system resource use between patients hospitalised with COVID-19 and influenza. The findings show that COVID-19 patients are more likely to die, have longer hospital stays, and interact more with primary care after discharge compared to influenza patients.
Article
Medicine, General & Internal
Alex Bottle, Francesca K. Neale, Kimberley A. Foley, Russell M. Viner, Simon Kenny, Paul Aylin, Sonia Saxena, Dougal S. Hargreaves
Summary: The COVID-19 pandemic has had a significant impact on outpatient appointments for children and young people, leading to a decrease in attendance and an increase in telephone appointments. The effects of these changes on patient outcomes are still unknown, and the differential impact on different social demographic groups may provide insights for future design of pediatric outpatient services.
Article
Medicine, General & Internal
Alex Bottle, Puji Faitna, Stephen Brett, Paul Aylin
Summary: This study assessed patient-level and hospital-level predictors of death and variation in death rates following admission for COVID-19 in England's first two waves. The results showed that there was moderate interhospital variation in death rates and length of stay, but overall variation was modest.
Review
Gastroenterology & Hepatology
Nishani Jayasooriya, Samantha Baillie, Jonathan Blackwell, Alex Bottle, Irene Petersen, Hanna Creese, Sonia Saxena, Richard C. C. Pollok, POP IBD study grp
Summary: This systematic review found that diagnostic delay is associated with negative clinical outcomes in inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). The median time to diagnosis was 8.0 months for CD and 3.7 months for UC, with longer diagnostic intervals observed in low-middle-income countries. Furthermore, delayed diagnosis was associated with increased risks of stricturing, penetrating disease, and intestinal surgery in CD, and increased risk of colectomy in UC.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Health Care Sciences & Services
Alex Bottle, Alex Liddle
BMJ QUALITY & SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Alex Bottle, Roger Newson, Puji Faitna, Benedict Hayhoe, Martin R. Cowie
Summary: This study aimed to explore risk prediction models for heart failure based on general practitioners' electronic health records and compare the data from two different cohorts. The results showed that the survival rates were similar in different years, but the later population was older, frailer, and had more comorbidities. The study also found consistent predictors including age, sex, blood pressure, body mass index, GP visits before diagnosis, and some comorbidities.
Article
Primary Health Care
Nishani Jayasooriya, Richard C. Pollok, Jonathan Blackwell, Alex Bottle, Irene Petersen, Hanna Creese, Sonia Saxena
Summary: Rates of discontinuation and adherence to oral 5-ASA in adolescents and young adults with ulcerative colitis were determined in a cohort study. The study found that a significant proportion discontinued within the first year and adherence was lower among young adults compared to adolescents. Risk factors for discontinuation included older age and living in deprived areas, while early corticosteroid use lowered the likelihood of discontinuation.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Emergency Medicine
Thomas Beaney, Jonathan Clarke, Ahmed Alboksmaty, Kelsey Flott, Aidan Fowler, Jonathan Benger, Paul P. Aylin, Sarah Elkin, Ara Darzi, Ana Luisa Neves
Summary: The impact of a national pulse oximetry remote monitoring program on the use of health services and mortality in COVID-19 patients attending Emergency Departments was investigated. The results showed that enrolled patients had a 52% lower death rate, but a 37% and 59% higher probability of ED attendance and hospital admission, respectively. This study suggests that pulse oximetry remote monitoring may be an effective and safe model for early detection and escalation of hypoxia.
EMERGENCY MEDICINE JOURNAL
(2023)
