Article
Surgery
Zhobin Moghadamyeghaneh, Alec F. Krosser, Vladimir Rubinshteyn, Lisa Dresner
Summary: Biliary leakage is relatively common following hepatectomy with hepaticojejunostomy for liver malignancy (33.4%), but most patients (90.4%) do not require re-exploration. Intraoperatively placed drains successfully controlled 46.7% of bile leakages. IR-guided drain placement had a 88.7% success rate for adequate leak control.
UPDATES IN SURGERY
(2021)
Article
Surgery
Sergio Calamia, Marco Barbara, Calogero Cipolla, Nello Grassi, Gianni Pantuso, Sergio Li Petri, Duilio Pagano, Salvatore Gruttadauria
Summary: The study aimed to identify risk factors for biliary leakage (BL) after liver surgery. The results showed that BL occurrence was associated with bilio-digestive anastomosis, neoadjuvant chemotherapy, body mass index, anatomical resection, and blood loss. Identifying high-risk patients can guide the positioning of drainage after surgery.
UPDATES IN SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Takahiro Yanagihara, Naoki Maki, Tomoyuki Kawamura, Naohiro Kobayashi, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Shiharu Watanabe, Tetsushi Taguchi, Yukio Sato
Summary: This study investigated the long-term efficacy and safety of ApGltn sealant using rats as a preclinical model. The results showed that ApGltn sealant demonstrated long-term sealing efficacy and safety in a pulmonary air leakage rat model.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Oncology
Yan Huang, Yihuai Hu, Yaobin Lin, Jianhua Fu, Jiadi Wu, Caiyan Fang, Min Liu, Yang Hong
Summary: This study demonstrated that intraoperative application of fibrin sealant can reduce the incidence of cervical anastomotic leakage after esophagectomy, serving as a safe and effective preventive measure.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Koki Hayashi, Yuta Abe, Masahiro Shinoda, Minoru Kitago, Hiroshi Yagi, Go Oshima, Shutaro Hori, Taiga Wakabayashi, Yuko Kitagawa
Summary: This study investigated the impact of intraoperative bile leakage (IOBL) during laparoscopic liver resection (LLR) on postoperative outcomes, finding that IOBL led to a higher incidence of postoperative bile leakage and identified predictors such as age, diabetes mellitus, indocyanine green retention rate, and the Glissonean approach. IOBL during LLR must be promptly identified and appropriately managed based on these predictive factors.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Ahmad S. Bahar, Mara R. Goetz, Faik G. Uzunoglu, Cenap Guengoer, Matthias Reeh, Jakob R. Izbicki, Maximilian Bockhorn, Asmus Heumann
Summary: This study assessed the feasibility of a new polyurethane-based sealant patch (PBSP) for hepato-pancreato-biliary (HPB) surgery and compared it with commercially available products. The results showed that PBSP had strong adherence to liver tissue, induced constant hemostasis, and prevented postoperative pancreatic fistulas and bile leakage. Promising preclinical data suggest the need for further evaluation through clinical trials.
Article
Surgery
Svenja Sliwinski, Jan Heil, Josephine Franz, Hanan El Youzouri, Michael Heise, Wolf O. O. Bechstein, Andreas A. A. Schnitzbauer
Summary: Biliary leakages should be defined if the drain/serum bilirubin ratio is > 2.0 on postoperative day 2.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Bahman Darkahi, Torgny Norden, Gabriel Sandblom
Summary: The study aimed to assess the safety of using fibrin sealant on the CBD incision. Although there were no significant differences in operative time and bile flow, the study suggests that incision closure may be an option to reduce the risk of leakage. Further studies are needed to confirm this finding.
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
(2022)
Article
Surgery
Takahiro Yoshikawa, Takeo Nomi, Daisuke Hokuto, Naoki Kamitani, Yasuko Matsuo, Masayuki Sho
Summary: Liver resection for HCC in patients with chronic kidney disease is associated with acceptable perioperative outcomes, but cardiovascular disease may negatively affect their overall survival post-surgery.
WORLD JOURNAL OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Christopher B. Nahm, Irinel Popescu, Florin Botea, Stephen Fenwick, Constantine Fondevila, Itxarone Bilbao, Daniel Reim, Giles J. Toogood
Summary: This study confirms the safety, efficacy, and ease of use of PuraStat (R) in the management of bleeding in liver surgery.
Review
Oncology
Shuai Xue, Haichuan Wang, Xiangzheng Chen, Yong Zeng
Summary: This meta-analysis aimed to analyze the risk factors for postoperative bile leakage (POBL) after hepatectomy. The study identified several factors, including gender, partial hepatectomy, repeat of hepatectomy, extended hepatectomy, abdominal drain, diabetes, Child=B, solitary tumor, and chemotherapy, as risk factors for POBL. Meanwhile, cirrhosis, benign diseases, left hepatectomy, and Segment 1 resection were not significant risk factors for POBL.
Article
Biophysics
Colleen A. Roosa, Ismaeel Muhamed, Ashlyn T. Young, Kimberly Nellenbach, Michael A. Daniele, Frances S. Ligler, Ashley C. Brown
Summary: A new high throughput method for generating fibrin nanoparticles using probe sonication was reported in this study, which can promote clot formation and cell migration. When combined with fibrinogen, sonicated fibrin nanoparticles can form a fibrin gel and support cell migration, which is relevant for wound healing. The results suggest that sonicated fibrin nanoparticles may be a promising therapy for wound healing that is easy to produce and deliver in a flowable formulation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Surgery
Davide Citterio, Marta Vaiani, Carlo Sposito, Roberta Elisa Rossi, Maria Flores, Carlo Battiston, Vincenzo Mazzaferro
Summary: This study shows that gadoxetic acid disodium-enhanced magnetic resonance cholangiography is highly accurate in detecting and locating postoperative biliary leaks, especially in peripheral locations, reducing the need for invasive cholangiography by 50%. Patients with peripheral leaks can avoid invasive procedures and have shorter hospital stays when managed conservatively.
Article
Immunology
Luciana P. F. Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Ana Beatriz B. de C. O. Lima, Gabriela R. Haddad, Marcia A. N. Gatti, Natalia Bronzatto Medolago, Marcia Tonin Rigotto Carneiro, Lucilene Delazari dos Santos, Rui Seabra Ferreira, Benedito Barraviera
Summary: The study evaluated the safety and efficacy of HFS in treating chronic venous ulcers, showing promising results in healing ulcers. However, further multicentric phase III clinical trials are needed to confirm these findings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Mossaab Ghannouchi, Hawas Rodayna, Mohamed Ben Khalifa, Karim Nacef, Moez Boudokhan
Summary: The purpose of this study was to assess the specific risk factors for morbidity of hepatic hydatid cyst after conservative surgery. A retrospective study was conducted on 102 patients over a 13-year period. The results showed that preoperative hydatid cyst infection, compressive cysts, and preoperative fever and jaundice could be predictor factors of morbidity after conservative surgery for liver hydatid cyst.
Article
Radiology, Nuclear Medicine & Medical Imaging
Marjaneh Taghavi, Stefano Trebeschi, Rita Simoes, David B. Meek, Rianne C. J. Beckers, Doenja M. J. Lambregts, Cornelis Verhoef, Janneke B. Houwers, Uulke A. van der Heide, Regina G. H. Beets-Tan, Monique Maas
Summary: A machine learning-based radiomics model was able to predict the occurrence of colorectal liver metastases in patients with colorectal cancer and provide valuable biomarkers for identifying high-risk patients. The predictive models including radiomics features, clinical features, and a combination of both showed promising results with AUC values of 86%, 71%, and 86% in the validation cohort, respectively.
ABDOMINAL RADIOLOGY
(2021)
Review
Oncology
Jeske R. E. Boeding, Winesh Ramphal, Arjen M. Rijken, Rogier M. P. H. Crolla, Cornelis Verhoef, Paul D. Gobardhan, Jennifer M. J. Schreinemakers
Summary: Treatment options for obstructing colon cancer are controversial, with emergency resection resulting in higher mortality and complication rates compared to staged treatment for potentially curable right-sided OCC. Staged treatment appears to have lower mortality rates, fewer complications, and fewer anastomotic leaks and stomas created compared to emergency resection in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Enrico Martin, Ritchie T. J. Geitenbeek, J. Henk Coert, David F. Hanff, Laura H. Graven, Dirk J. Grunhagen, Cornelis Verhoef, Walter Taal
Summary: Noninvasive tests like MRI, FDG-PET, and liquid biopsies are useful for distinguishing MPNST from BPNST, with MRI showing high sensitivity and specificity for certain features, and FDG-PET having an ideal SUVmax threshold of >=3.5 for accuracy.
Article
Oncology
Marieke S. Walma, Lilly J. Brada, Susana I. S. Patuleia, Joost G. Blomjous, Thomas L. Bollen, Koop Bosscha, Rutger C. Bruijnen, Olivier R. Busch, Geert-Jan Creemers, Freek Daams, Ronald van Dam, Sebastiaan Festen, Derk Jan de Groot, Jan Willem de Groot, Nadia Haj Mohammad, John J. Hermans, Ignace H. de Hingh, Emile D. Kerver, Maarten S. van Leeuwen, Christiaan van der Leij, Mike S. Liem, Krijn P. van Lienden, Maartje Los, Vincent E. de Meijer, Martijn R. Meijerink, Leonie J. Mekenkamp, Joost Nederend, C. Yung Nio, Gijs A. Patijn, Marco B. Polee, Johannes F. Pruijt, Nomdo S. Renken, Steffi J. Rombouts, Thijs J. Schouten, Martijn W. J. Stommel, Maaike E. Verweij, Judith de Vos-Geelen, Jan J. J. de Vries, Annelie Vulink, Frank J. Wessels, Johanna W. Wilmink, Hjalmar C. van Santvoort, Marc G. Besselink, I. Quintus Molenaar
Summary: This multicenter study on unselected patients with locally advanced pancreatic cancer showed a median overall survival of 14 months and a resection rate of 13% after FOLFIRINOX treatment.
Review
Oncology
Lorraine J. Lauwerends, Hidde A. Galema, Jose A. U. Hardillo, Aniel Sewnaik, Dominiek Monserez, Pieter B. A. A. van Driel, Cornelis Verhoef, Robert J. Baatenburg de Jong, Denise E. Hilling, Stijn Keereweer
Summary: Laryngeal cancer is a common head and neck malignancy with poor prognosis, especially in advanced stages. Current optical imaging techniques are limited in deep margin assessment, highlighting the need for new technologies to guide surgical resection and reduce local recurrence rates.
Article
Clinical Neurology
Enrico Martin, Courtney Pendleton, Cornelis Verhoef, Robert J. Spinner, J. Henk Coert
Summary: This study aimed to investigate postoperative morbidity and the use and outcomes of functional reconstructions in patients with malignant peripheral nerve sheath tumors (MPNSTs). The results showed that the incidence of postoperative motor and sensory deficits is still unknown, and the use of functional reconstructions is infrequent.
Article
Oncology
Anne-Rose W. Schut, Milea J. M. Timbergen, Emma Lidington, Dirk J. Grunhagen, Winette T. A. van der Graaf, Stefan Sleijfer, Winan J. van Houdt, Johannes J. Bonenkamp, Eugenie Younger, Alison Dunlop, Robin L. Jones, Cornelis Verhoef, Spyridon Gennatas, Olga Husson
Summary: Desmoid-type fibromatosis (DTF) is a rare soft tissue tumor with high recurrence rates, causing significant symptom burden. The QUALIFIED study aims to validate a DTF-specific HRQoL questionnaire, assess HRQoL issues in adult patients, and identify subgroups at risk of impaired HRQoL.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martijn P. A. Starmans, Milea J. M. Timbergen, Melissa Vos, Michel Renckens, Dirk J. Grunhagen, Geert J. L. H. van Leenders, Roy S. Dwarkasing, Francois E. J. A. Willemssen, Wiro J. Niessen, Cornelis Verhoef, Stefan Sleijfer, Jacob J. Visser, Stefan Klein
Summary: In this study, radiomics was used to distinguish gastrointestinal stromal tumors (GISTs) from other intra-abdominal tumors and predict the mutational status and mitotic index of GISTs. The results showed that the radiomics model performed similarly to three radiologists in distinguishing GISTs from non-GISTs, but it was less observer dependent. However, the model was unable to predict any genetic or molecular features, limiting its use in treatment planning.
JOURNAL OF DIGITAL IMAGING
(2022)
Article
Oncology
Anne-Rose W. Schut, Emma Lidington, Milea J. M. Timbergen, Eugenie Younger, Winette T. A. van der Graaf, Winan J. van Houdt, Johannes J. Bonenkamp, Robin L. Jones, Dirk. J. Grunhagen, Stefan Sleijfer, Cornelis Verhoef, Spyridon Gennatas, Olga Husson
Summary: Desmoid-type fibromatosis (DTF) is a rare soft-tissue tumor that can negatively impact health-related quality of life (HRQoL). A specific HRQoL tool, the DTF-QoL, was previously developed for assessing DTF-specific issues. This study pre-tested the DTF-QoL and selected 96 questions to form the final questionnaire, which can be used to evaluate HRQoL of DTF patients in clinical and research settings, aiming to personalize care and improve patient experience.
Article
Oncology
Gijsbert M. Kalisvaart, Ruben P. J. Meijer, Okker D. Bijlstra, Hidde A. Galema, Wobbe O. de Steur, Henk H. Hartgrink, Cornelis Verhoef, Lioe-Fee de Geus-Oei, Dirk J. Grunhagen, Yvonne M. Schrage, Alexander L. Vahrmeijer, Jos A. van der Hage
Summary: This study assessed the potential and limitations of near-infrared fluorescence imaging with indocyanine green in intraoperative tumor identification of GISTs. The results showed that GISTs typically have similar fluorescence intensity to the surrounding tissue, indicating that intraoperatively administered indocyanine green is currently not suitable for adequate tumor identification.
Article
Oncology
Evalyn E. A. P. Mulder, Iva Johansson, Dirk J. Grunhagen, Dennie Tempel, Barbara Rentroia-Pacheco, Jvalini T. Dwarkasing, Danielle Verver, Antien L. Mooyaart, Astrid A. M. van der Veldt, Marlies Wakkee, Tamar E. C. Nijsten, Cornelis Verhoef, Jan Mattsson, Lars Ny, Loes M. Hollestein, Roger Olofsson Bagge
Summary: This study assessed the performance of a clinicopathologic and gene expression model to identify patients with stage I-II melanoma at risk of disease relapse. The model successfully stratified patients into high risk and low risk groups, suggesting its potential usefulness in clinical practice.
Article
Oncology
Anne-Rose W. Schut, Emma Lidington, Milea J. M. Timbergen, Eugenie Younger, Winette T. A. van der Graaf, Winan J. van Houdt, Johannes J. Bonenkamp, Robin L. Jones, Dirk J. Grunhagen, Stefan Sleijfer, Cornelis Verhoef, Spyridon Gennatas, Olga Husson
Summary: Desmoid-type fibromatosis (DTF) is a rare soft tissue tumor that significantly impacts the health-related quality of life (HRQoL) of patients. This study evaluated HRQoL among different groups of DTF patients and identified factors such as age, sex, presence of comorbidities, and treatment type that were associated with DTF-specific HRQoL.
Article
Oncology
Ibtissam Acem, Veroniek M. van Praag, Cassidy Q. B. Mostert, Robert J. P. van der Wal, Ralph M. L. Neijenhuis, Cornelis Verhoef, Dirk J. Grunhagen, Michiel A. J. van de Sande
Summary: This study aimed to assess the ability of an easy-to-use electronic nose to differentiate between patients with soft tissue sarcoma (STS) and those without STS based on their exhaled breath. It is the first pilot study to show that an electronic nose could serve as a diagnostic tool for STS detection with good performance. Future studies are needed to validate these findings in larger cohorts.
Article
Health Care Sciences & Services
N. J. M. C. Vrancken Peeters, Z. L. R. Kaplan, M. E. Clarijs, M. A. M. Mureau, C. Verhoef, T. van Dalen, O. Husson, L. B. Koppert
Summary: This study examined the long-term effects of axillary treatments on health-related quality of life in breast cancer patients. Except for axillary lymph node dissection (ALND) with axillary radiotherapy, other axillary treatments showed no significant impact on physical and psychosocial wellbeing. Patients who received ALND with radiotherapy experienced a significant decrease in physical and psychosocial wellbeing postoperatively.
QUALITY OF LIFE RESEARCH
(2023)
Article
Surgery
Hidde A. Galema, Tessa M. van Ginhoven, Gaston J. H. Franssen, Johannes Hofland, Claire G. O. T. Bouman, Cornelis Verhoef, Alexander L. Vahrmeijer, Merlijn Hutteman, Denise E. Hilling, Stijn Keereweer
BRITISH JOURNAL OF SURGERY
(2023)
