Article
Neurosciences
Ke Li, Jiayu Wang, Lei Chen, Meimei Guo, Ying Zhou, Xiaofeng Li, Mian Peng
Summary: Postoperative delirium (POD) is a common and serious complication following surgery in elderly patients. The underlying mechanism of POD is not well understood and there is currently no effective therapy available. Recent research has suggested that neuroinflammation, particularly the damage to the blood-brain barrier (BBB), may play a role in the pathogenesis of POD. This study showed that prophylactic administration of netrin-1 (NTN-1) in aged mice reduced inflammation, protected the BBB, and improved behavioral symptoms associated with POD.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Wei Ran, Ning Liang, Ruixue Yuan, Zhiqiao Wang, Jin Gao
Summary: Postoperative delirium (POD) is a common complication in elderly patients, which seriously affects their recovery. This study investigated the differential expression profiles of circRNAs in the hippocampus of mice with tibial fracture, revealing potential pathological mechanisms involved in the development of POD. Specifically, the HOMER1 gene and its transcript mmu_circRNA_26701 were found to be specifically expressed in the glutamate synapse, providing new insights and potential intervention targets for this refractory disease.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Hu Shen, Jianyin Yang, Xu Chen, Yu Gao, Baoming He
Summary: Postoperative delirium is common in older patients and is associated with prolonged hospitalization, increased risk of complications, and high mortality. Cerebral desaturation and the inhibitory effects of anesthetics on hypoxia-inducible factor-1 (HIF-1) activity may play important roles in the pathophysiology of postoperative delirium in the elderly.
Article
Biochemistry & Molecular Biology
Chun-Yi Tsai, Keng-Hao Liu, Cheng-Chou Lai, Jun-Te Hsu, Shun -Wen Hsueh, Chia-Yen Hung, Kun-Yun Yeh, Yu-Shin Hung, Yung -Chang Lin, Wen-Chi Chou
Summary: This study aimed to investigate the association between frailty and postoperative delirium (POD) in aged cancer patients undergoing elective abdominal surgery. It found that frailty status was an independent risk factor for POD occurrence. Thus, preoperative assessment of frailty in older cancer patients is important in order to improve postoperative care.
BIOMEDICAL JOURNAL
(2023)
Article
Anesthesiology
Shu Li, Ruowen Li, Muhan Li, Qianyu Cui, Xingyue Zhang, Tingting Ma, Dexiang Wang, Min Zeng, Hao Li, Zhaoshi Bao, Yuming Peng, Daniel I. Sessler
Summary: This study aimed to investigate whether dexmedetomidine administration during intracerebral tumour resection could reduce the incidence of postoperative delirium. The results showed a significant reduction in the incidence of delirium during the initial 5 postoperative days in the dexmedetomidine group compared to the placebo group. Dexmedetomidine also improved postoperative pain scores with movement, and recovery and sleep quality. Therefore, the prophylactic use of dexmedetomidine during surgery can effectively reduce postoperative delirium in patients undergoing elective brain tumour resection.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Surgery
Cheng-Chou Lai, Keng-Hao Liu, Chun-Yi Tsai, Jun-Te Hsu, Shun-Wen Hsueh, Wen-Chi Chou, Chia-Yen Hung
Summary: This study in Taiwan evaluated the incidence of postoperative delirium (POD), its risk factors, and its association with adverse surgical outcomes in geriatric cancer patients after intra-abdominal cancer surgery. The results showed that the occurrence of POD was significantly associated with adverse surgical outcomes, highlighting the importance of early identification of POD in geriatric patients.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Katharina Theresa Obermeier, Moritz Kraus, Wenko Smolka, Jochen Henkel, Thomas Saller, Sven Otto, Paris Liokatis
Summary: This study evaluates the impact of intraoperative fluid administration on developing postoperative delirium and identifies other parameters leading to an increased risk of delirium.
Article
Multidisciplinary Sciences
Marte Sofie Wang-Hansen, Hege Kersten, Jurate Saltyte Benth, Torgeir Bruun Wyller
Summary: This study aimed to assess the risk of early readmission for multimorbid patients over 75 years old treated in a geriatric ward compared to medical wards, and to identify risk factors for 30-day readmissions. The main risk factors for 30-day readmission among old patients with multimorbidity were found to be lower age, female gender, and higher cognitive function. Geriatric care did not have an impact on the readmission rate.
Article
Anesthesiology
Kevin G. Burfeind, Yalda Zarnegarnia, Praveen Tekkali, Avital Y. O'Glasser, Joseph F. Quinn, Katie J. Schenning
Summary: The study found that perioperative PIM administration was common in older surgical patients, especially in frail patients, and was associated with increased hospital length of stay, but not with discharge disposition.
ANESTHESIA AND ANALGESIA
(2022)
Article
Medicine, General & Internal
Jing Liu, Meinv Liu, Jianli Li, Junfang Rong
Summary: This article describes a research plan on postoperative delirium in thoracic and abdominal surgery. The study aims to explore the incidence and potential risk factors of postoperative delirium and develop a predictive model to prevent its occurrence.
Article
Geriatrics & Gerontology
Lin Bao, Taotao Liu, Zhenzhen Zhang, Qian Pan, Lifang Wang, Guohui Fan, Zhengqian Li, Yiqing Yin
Summary: This study investigated the predictive value of preoperative bispectral (BIS) index in postoperative delirium (POD) for patients aged over 75 years. The study found that preoperative BIS was lower in delirious patients. Furthermore, integrating BIS, mini-mental state examination, anemia, activities of daily living, and blood urea nitrogen could effectively predict postoperative delirium in patients aged over 75.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Geriatrics & Gerontology
Jing Liu, Jianli Li, Jing Wang, Meng Zhang, Shuang Han, Yanru Du
Summary: This meta-analysis aims to identify the risk factors of postoperative delirium (POD) after major abdominal surgery. The study found that age, American Society of Anesthesiologists grade, preoperative cognitive impairment, preoperative Katz-ADL score, preoperative and postoperative hypoalbuminemia, preoperative insulin-like growth factor-1 levels, and longer anesthesia duration were significantly associated with POD.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Annelies Heylen, Yannick Vermeiren, Sophia E. De Rooij, Rikie M. Scholtens, Barbara C. Van Munster, Debby Van Dam, Peter P. De Deyn
Summary: The study found that there is a disturbance in serotonin levels in postoperative patients with cognitive impairment regardless of whether they have delirium or not. This serotonergic disturbance is more pronounced in patients with both delirium and cognitive impairment.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Qianqian Fan, Chong Lei, Yonghui Wang, Nannan Yu, Lini Wang, Jingwen Fu, Hailong Dong, Zhihong Lu, Lize Xiong
Summary: Transcutaneous electrical acupoint stimulation combined with auricular acupressure can reduce the incidence of in-hospital delirium in elderly patients undergoing major abdominal surgery compared to standard care.
FRONTIERS IN MEDICINE
(2022)
Article
Geriatrics & Gerontology
Qingqing Huang, Qin Li, Fuen Qin, Libang Yuan, Zhihong Lu, Huang Nie, Gu Gong
Summary: The repeated preoperative intranasal administration of insulin significantly reduced the incidence of postoperative delirium and levels of serum pro-inflammatory markers in elderly patients undergoing laparoscopic radical gastrointestinal surgery.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Oncology
Karina Vychnevskaia, Frederic Dumont, Julie Agostini, Catherine Julie, Peggy Dartigues, Thierry Lazure, Valerie Boige, Diane Goere, Antoine Brouquet, Christophe Penna, Frederique Peschaud, Stephane Benoist
ANNALS OF SURGICAL ONCOLOGY
(2017)
Article
Oncology
Julie Hallet, Antonio Sa Cunha, Rene Adam, Diane Goere, Daniel Azoulay, Jean-Yves Mabrut, Fabrice Muscari, Christophe Laurent, Francis Navarro, Patrick Pessaux
ANNALS OF SURGICAL ONCOLOGY
(2016)
Article
Surgery
J. Hallet, A. Sa Cunha, R. Adam, D. Goere, P. Bachellier, D. Azoulay, A. Ayav, E. Gregoire, F. Navarro, P. Pessaux
BRITISH JOURNAL OF SURGERY
(2016)
Article
Gastroenterology & Hepatology
S. Abdalla, A. Brouquet, T. Lazure, B. Costaglioli, C. Penna, S. Benoist
COLORECTAL DISEASE
(2016)
Article
Oncology
F. Jeune, A. Brouquet, C. Caramella, M. Gayet, S. Abdalla, A. -L. Verin, A. Thirot Bidault, C. Penna, S. Benoist
Article
Gastroenterology & Hepatology
Jonathan Catry, Antoine Brouquet, Frederique Peschaud, Karina Vychnevskaia, Solafah Abdalla, Robert Malafosse, Benoit Lambert, Bruno Costaglioli, Stephane Benoist, Christophe Penna
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2016)
Article
Gastroenterology & Hepatology
Nathan Beaupel, Antoine Brouquet, Solafah Abdalla, Franck Carbonnel, Christophe Penna, Stephane Benoist
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2017)
Article
Gastroenterology & Hepatology
Francois Cauchy, Solafah Abdalla, Christophe Penna, Benjamin Angliviel, Benoit Lambert, Bruno Costaglioli, Antoine Brouquet, Stephane Benoist
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2017)
Article
Gastroenterology & Hepatology
Mathieu Uzzan, Julien Kirchgesner, Nadia Oubaya, Aurelien Amiot, Jean-Marc Gornet, Philippe Seksik, Stephane Nancey, Eddy Cotte, Matthieu Allez, Gilles Boschetti, David Laharie, Nicola de Angelis, Maria Nachury, Anne-Laure Pelletier, Vered Abitbol, Mathurin Fumery, Antoine Brouquet, Anthony Buisson, Romain Altwegg, Jacques Cosnes, Yves Panis, Xavier Treton
JOURNAL OF CROHNS & COLITIS
(2017)
Article
Surgery
Julie Hallet, Antonio Sa Cunha, Daniel Cherqui, Brice Gayet, Diane Goere, Philippe Bachellier, Alexis Laurent, David Fuks, Francis Navarro, Patrick Pessaux
WORLD JOURNAL OF SURGERY
(2017)
Article
Surgery
Riccardo Memeo, Vito de Blasi, Rene Adam, Diane Goere, Tullio Piardi, Emilie Lermite, Olivier Turrini, Francis Navarro, Nicola de'Angelis, Antonio Sa Cunha, Patrick Pessaux, French Colorectal Liver
WORLD JOURNAL OF SURGERY
(2018)
Review
Surgery
C. Mariette, A. Brouquet, D. Tzanis, A. Laurenzi, A. de la Rochefordiere, P. Mariani, G. Piessen, A. Sa Cunha, C. Penna
JOURNAL OF VISCERAL SURGERY
(2017)
Article
Surgery
Antoine Brouquet, Leon Maggiori, Philippe Zerbib, Jeremie H. Lefevre, Quentin Denost, Adeline Germain, Eddy Cotte, Laura Beyer-Berjot, Nicolas Munoz-Bongrand, Veronique Desfourneaux, Amine Rahili, Jean-Pierre Duffas, Karine Pautrat, Christine Denet, Valerie Bridoux, Guillaume Meurette, Jean-Luc Faucheron, Jerome Loriau, Francoise Guillon, Eric Vicaut, Stephane Benoist, Yves Panis
Article
Gastroenterology & Hepatology
A. Brouquet, A. -S. Rangheard, J. Ifergan, T. Lazure, F. Carbonnel, C. Penna, S. Benoist
COLORECTAL DISEASE
(2017)
Article
Gastroenterology & Hepatology
Z. Lakkis, G. Manceau, V. Bridoux, A. Brouquet, S. Kirzin, L. Maggiori, C. de Chaisemartin, J. H. Lefevre, Y. Panis
COLORECTAL DISEASE
(2017)