Article
Surgery
Mohamed K. Kamel, Sebron Harrison, Benjamin Lee, Jeffrey L. Port, Brendon M. Stiles, Nasser K. Altorki
Summary: This study explored the potential value of extended nodal dissection after neoadjuvant chemoradiation, using data from the National Cancer Database. The results showed that the number of dissected lymph nodes was associated with improved survival, suggesting the importance of extended nodal dissection for patients undergoing neoadjuvant treatment.
Article
Surgery
Eivind Gottlieb-Vedi, Joonas H. Kauppila, Fredrik Mattsson, Jakob Hedberg, Jan Johansson, David Edholm, Pernilla Lagergren, Magnus Nilsson, Jesper Lagergren
Summary: In esophageal cancer surgery, removing more lymph nodes can improve survival, but after reaching a certain number, further lymphadenectomy may decrease survival. A population-based cohort study in Sweden and Finland found that patients who had 4-30 lymph nodes removed had higher survival rates compared to those who had only 1 lymph node removed, especially for patients with advanced T-stages (T3/T4) and those who did not receive neoadjuvant therapy, removing 21-30 lymph nodes showed the best result.
Article
Oncology
Yan Zheng, Yin Li, Xianben Liu, Haibo Sun, Sining Shen, Yufeng Ba, Zongfei Wang, Shilei Liu, Wenqun Xing
Summary: This study found that McKeown-MIE was associated with better long-term survival than McKeown-OE for resectable EC patients. It had shorter operative time, postoperative stay, and comparable mortality rates, but significantly higher 60-month survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Siva Raja, Thomas W. Rice, Sudish C. Murthy, Usman Ahmad, Marie E. Semple, Eugene H. Blackstone, Hemant Ishwaran
Summary: This study demonstrates the importance of lymphadenectomy during esophagectomy for patients with adenocarcinoma of the esophagus and esophagogastric junction undergoing neoadjuvant therapy. Optimal range of nodes resected is associated with maximized survival, with a nonlinear relationship between lymph node resection and lifetime for different ypTNM cancer categories.
Article
Oncology
Bin Li, Yawei Zhang, Longsheng Miao, Longfei Ma, Xiaoyang Luo, Yiliang Zhang, Ting Ye, Hecheng Li, Jie Zhang, Yuan Li, Kuaile Zhao, Min Fan, Zhengfei Zhu, Jialei Wang, Jie Xu, Youjia Deng, Qiong Lu, Hang Li, Yang Zhang, Yunjian Pan, Shilei Liu, Longlong Shao, Yihua Sun, Jiaqing Xiang, Hong Hu, Haiquan Chen
Summary: The optimal extent of lymphadenectomy during esophagectomy for middle and lower thoracic esophageal cancer remains unclear. A trial comparing three-field and two-field lymphadenectomy showed no difference in overall survival (OS) or disease-free survival (DFS) between the two approaches. Advanced tumor stage was identified as the only significant risk factor for reduced OS.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Oncology
Yang Wang, Xiangwei Zhang, Xiufeng Zhang, Jing Liu-Helmersson, Lin Zhang, Wen Xiao, Yuanzhu Jiang, Keke Liu, Shaowei Sang
Summary: The extent of lymph node dissection is associated with cancer-specific survival in patients with T1 esophageal cancer, with a minimum of 14 lymph nodes needing to be removed. The number of negative lymph nodes and the lymph node ratio also have prognostic value after lymphadenectomy in T1 stage patients.
Review
Oncology
Anas Dabsha, Ismail A. M. H. Elkharbotly, Mohammad Yaghmour, Amr Badr, Fady Badie, Sherif Khairallah, Yomna M. Esmail, Shon Shmushkevich, Mohamed Hossny, Amr Rizk, Amgad Ishak, Jessica Wright, Abdelrahman Mohamed, Mohamed Rahouma
Summary: Minimally invasive surgery is a growing field that has replaced many open surgical techniques. Mediastinoscope-assisted esophagectomy is a promising technique that aims to decrease the surgical burden and enhance recovery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Leticia Nogueira Datrino, Marina Feliciano Orlandini, Maria Carolina Andrade Serafinn, Clara Lucato dos Santos, Victoria Andrade Modesto, Guilherme Tavares, Luca Schilird Tristao, Wanderley M. Bernardo, Francisco Tustunni
Summary: This study aimed to assess the impact of prophylactic cervical lymphadenectomy on the outcomes of esophageal cancer treatment. A systematic literature review and meta-analysis of 28 articles including 9180 patients revealed that prophylactic neck lymphadenectomy is associated with worse short-term results and does not improve long-term survival.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yuan Tian, Peigang Yang, Yecheng Lin, Yiyang Hu, Huiyan Deng, Wenqian Ma, Honghai Guo, Yang Liu, Ze Zhang, Pingan Ding, Yong Li, Liqiao Fan, Zhidong Zhang, Dong Wang, Qun Zhao
Summary: This study compared the number of lymph nodes detected in gastric cancer patients receiving carbon nanoparticle suspension injection (CNSI) versus no injection. The results showed that CNSI led to a significantly higher number of lymph nodes detected. Carbon nanoparticle suspension-guided lymphography may be an alternative to conventional systematic lymphadenectomy for distal gastrectomy.
Article
Surgery
Smita Sihag, Tamar Nobel, Meier Hsu, Kay See Tan, Rebecca Carr, Yelena Y. Janjigian, Laura H. Tang, Abraham J. Wu, Matthew J. Bott, James M. Isbell, Manjit S. Bains, David R. Jones, Daniela Molena
Summary: The study aimed to determine the optimal extent of lymphadenectomy in patients with locally advanced esophageal adenocarcinoma treated with neoadjuvant chemoradiotherapy followed by esophagectomy. The results showed that removing 20 to 25 lymph nodes improved the survival rate of patients.
Article
Oncology
Phillip M. Kemp Bohan, Anne E. O'Shea, Oriana Ellis, Robert C. Chick, Alex M. Clem, Derek T. Kirby, Julia O. Bader, Timothy E. Newhook, G. Travis Clifton, Ching-Wei D. Tzeng, Daniel W. Nelson, Timothy J. Vreeland
Summary: Lymphadenectomy (LND) is associated with a 48% reduction in risk of death in resectable non-metastatic GBC patients, with the greatest impact seen in pT2-3 patients. Patients without LND have similar overall survival to those with node-positive disease, highlighting the importance of LND. Underutilization of LND may lead to undertreatment of patients with undiagnosed nodal disease and contribute to unfavorable oncologic outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Kai Kang, Sheng Wang, Fei Xiong, Jindan Kai, Jianjian Wang, Binfeng Li
Summary: This article reports a case of esophageal cancer coexisting with DAA and reviews relevant cases in the literature. The article extensively analyzes the clinical manifestations, diagnosis, surgical approaches, and reconstruction routes for esophageal cancer with DAA.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)
Article
Oncology
Shanjin Ma, Jian Zhao, Zhiwei Liu, Tao Wu, Sheng Wang, Chengwen Wu, Lei Pan, Xiaoye Jiang, Zhihao Guan, Yanjun Wang, Dian Jiao, Fengqi Yan, Keying Zhang, Qisheng Tang, Jianjun Ma
Summary: This study investigated the optimal timing of prophylactic inguinal lymphadenectomy for penile cancer patients with clinically normal inguinal lymph nodes. The results showed that prophylactic inguinal lymphadenectomy within 3.5 months after resection of the primary tumor significantly improved survival for high-risk cN0 patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Sofie P. G. Henckens, Eliza R. C. Hagens, Mark I. van Berge Henegouwen, Sybren L. Meijer, Wietse J. Eshuis, Suzanne S. Gisbertz
Summary: This study investigates the impact of lymph node yield after transthoracic esophagectomy on lymph node metastasis, complications, and survival in patients with esophageal adenocarcinoma. The results demonstrate that a lymph node yield of 31 or higher is associated with an increased number of positive lymph nodes, improved disease-free survival, and overall survival, without increasing morbidity.
Article
Oncology
Victor Lago, Beatriz Montero, Susana Lopez, Pablo Padilla-Iserte, Luis Matute, Tiermes Marina, Marta Gurrea, Guillermina Montoliu, Pilar Bello, Santiago Domingo
Summary: The objective of this study is to determine the role of sentinel lymph node ultrastaging in apparent early-stage ovarian cancer. The study shows that a uniform protocol for ultrastaging is essential for lower-volume metastasis detection and to provide reproducible information for future studies.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Surgery
Alexander Harris, James Butterworth, Piers R. Boshier, Hugh MacKenzie, Masanori Tokunaga, Hideki Sunagawa, Stella Mavroveli, Melody Ni, Sameh Mikhail, Chi-Chuan Yeh, Natalie S. Blencowe, Kerry N. L. Avery, Richard Hardwick, Arnulf Hoelscher, Manuel Pera, Giovanni Zaninotto, Simon Law, Donald E. Low, Jan J. B. van Lanschot, Richard Berrisford, Christopher Paul Barham, Jane M. Blazeby, George B. Hanna
Summary: A reliable surgical quality assurance system for 2-stage esophagectomy has been developed, which includes an operation manual, video, and photographic assessment tools. It aims to ensure surgical quality in surgical oncology randomized controlled trials.
Letter
Cardiac & Cardiovascular Systems
Hemant Ishwaran, Robert O'Brien
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Oncology
Yihuai Hu, Chenyi Xie, Hong Yang, Joshua W. K. Ho, Jing Wen, Lujun Han, Ka-On Lam, Ian Y. H. Wong, Simon Y. K. Law, Keith W. H. Chiu, Varut Vardhanabhuti, Jianhua Fu
Summary: The study demonstrates that a CT-based model using deep learning features can effectively predict pathologic complete response to neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma. The deep learning model achieved better performance in the testing cohort compared to the radiomics model.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Hin Chu, Bingjie Hu, Xiner Huang, Yue Chai, Dongyan Zhou, Yixin Wang, Huiping Shuai, Dong Yang, Yuxin Hou, Xi Zhang, Terrence Tsz-Tai Yuen, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Kelvin Kai-Wang To, Ivy Hau-Yee Chan, Ko-Yung Sit, Dominic Chi-Chung Foo, Ian Yu-Hong Wong, Ada Tsui-Lin Ng, Tan To Cheung, Simon Ying-Kit Law, Wing-Kuk Au, Melinda A. Brindley, Zhiwei Chen, Kin-Hang Kok, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
Summary: Understanding the factors contributing to efficient SARS-CoV-2 infection in human cells can provide insights into the virus's transmissibility and pathogenesis. The study identifies heparan sulfate as an important attachment factor, while sialic acids on ACE2 may restrict efficient spike/ACE2 interaction in lung tissues. Moreover, the presence of a furin-like cleavage site in SARS-CoV-2 spike is crucial for efficient virus replication in human lungs.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Velda L. Y. Chow, Valerie W. Y. Ho, Ian Y. H. Wong, Fion S. Y. Chan, Simon Y. K. Law, Jimmy Y. W. Chan
Summary: This study introduced an anterior transcervical transtracheal approach for resecting smooth muscle tumors in the cervical esophagus, aiming to avoid risks of injuries and improve surgical outcomes.
ANNALS OF THORACIC SURGERY
(2021)
Article
Computer Science, Artificial Intelligence
Alejandro Mantero, Hemant Ishwaran
Summary: The sidClustering algorithm involves sidification of features followed by prediction using a multivariate random forest, able to handle continuous and categorical variables. This method can effectively identify clusters from various types of variables while retaining the advantages of random forests.
STATISTICAL ANALYSIS AND DATA MINING
(2021)
Article
Gastroenterology & Hepatology
Han Kwang Yang, Jiafu Ji, Sang Uk Han, Masanori Terashima, Guoxin Li, Hyung Ho Kim, Simon Law, Asim Shabbir, Kyo Young Song, Woo Jin Hyung, Nik Ritza Kosai, Koji Kono, Kazunari Misawa, Hiroshi Yabusaki, Takahiro Kinoshita, Peng Choong Lau, Young Woo Kim, Jaideep Raj Rao, Enders Ng, Takanobu Yamada, Kazuhiro Yoshida, Do Joong Park, Bee Choo Tai, Jimmy Bok Yan So
Summary: This study aimed to evaluate the survival benefit of extensive intraoperative peritoneal lavage (EIPL) in patients with gastric cancer undergoing curative gastrectomy. After various analyses, it was concluded that EIPL and surgery did not have a survival benefit compared with surgery alone, and is not recommended for patients undergoing curative gastrectomy for gastric cancer.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
George R. Marzouka, Harold Rivner, Vijay Mehta, Juan Lopez, Igor Vaz, Fei Tang, Hemant Ishwaran, Jeffrey J. Goldberger
Summary: The study showed that the CHA(2)DS(2)-VASc score can effectively stratify the risk of stroke in HF patients and predict the occurrence of stroke in HF patients, regardless of whether they have AF. Patients with higher CHA(2)DS(2)-VASc scores, with or without AF, have increased risk of stroke, thromboembolism, and death.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Ngar Woon Kam, Ka Chun Wu, Wei Dai, Ying Wang, Leo Yik Chun Yan, Reshma Shakya, Rajiv Khanna, Yanru Qin, Simon Law, Anthony Wing Ip Lo, Victor Ho Fun Lee, Xin-Yuan Guan, Dora Lai-Wan Kwong
Summary: Different functions and profiles of B-cell subsets in various cancers have been reported. In esophageal squamous cell carcinoma (ESCC), proliferating B cells are predominantly found in the peritumoral region with high expression of HMGB1. Cancer-derived HMGB1 modulates B cells to promote angiogenesis in ESCC microenvironment.
Article
Psychiatry
Lloyd D. Balbuena, Marilyn Baetz, Joseph Andrew Sexton, Douglas Harder, Cindy Xin Feng, Kerstina Boctor, Candace LaPointe, Elizabeth Letwiniuk, Arash Shamloo, Hemant Ishwaran, Ann John, Anne Lise Brantsaeter
Summary: This study utilizes machine learning models to identify risk and protective factors for suicide deaths in the general population and clinical samples. It suggests that suicide prevention requires individual actions with governmental incentives, and machine learning can help identify early prevention targets.
Article
Gastroenterology & Hepatology
Fang Jiang, Chuan-Guo Guo, Ka Shing Cheung, Bofei Li, Simon Y. K. Law, Wai K. Leung
Summary: The failure rates of clarithromycin-containing triple therapy for H. pylori have been increasing over the past 15 years in Hong Kong. Younger patients have higher failure rates, which could undermine the potential benefits of early H. pylori eradication.
Article
Gastroenterology & Hepatology
Yin Tong, Priscilla S. W. Cheng, Chung Sze Or, Sarah S. K. Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Y. K. Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma, Siu Po Lee, Annie S. Y. Chan, April S. Chan, Shui Wa Yun, Ho Sang Hui, Siu Tsan Yuen, Suet Yi Leung, Helen H. N. Yan
Summary: Cell-cell and cell-matrix adhesions play a critical role in gastric cancer progression, especially in gastric cancer with dysregulated RHO signaling.
Article
Oncology
Josephine Mun Yee Ko, Ka On Lam, Dora Lai Wan Kwong, Ian Yu-Hong Wong, Fion Siu-Yin Chan, Claudia Lai-Yin Wong, Kwan Kit Chan, Tsz Ting Law, Keith Wan Hang Chiu, Candy Chi Shan Lam, Jean Chrysei Wong, Henry Chun Hung Fong, Faith Sin Fai Choy, Andy Lo, Simon Law, Maria Li Lung
Summary: Esophageal cancer is a aggressive disease with low survival rates. Circulating tumor cells (CTCs) can be used as predictive and prognostic biomarkers for therapeutic responses and disease progression. Longitudinal CTC monitoring can provide useful information for prediction of treatment efficacies and disease progression, and it can be used as a non-invasive liquid biopsy for supplementary information with clinical imaging.
Article
Oncology
Wing-Lok Chan, Xiaodong Liu, Carlos King-Ho Wong, Michael Siu-Nam Wong, Ian Yu-Hong Wong, Ka-On Lam, Bryan Ho-Kwan Yun, Emina Edith Cheung, Rosa Pui-Ying Tse, Fion Chan, Simon Law, Dora Kwong
Summary: This study aimed to evaluate the efficacy of adjuvant chemotherapy in older patients (aged ≥65 years old) after D2-gastrectomy for gastric cancer. The results showed that adjuvant chemotherapy was associated with improved overall survival (OS) and cancer-specific survival (CSS) compared to surgery alone. There was no significant difference in survival benefit between monotherapy and doublets chemotherapy.
Article
Statistics & Probability
Donald K. K. Lee, Ningyuan Chen, Hemant Ishwaran
Summary: This study introduces a generic gradient boosting procedure for survival processes, implemented using regression trees, with regularization methods to prevent overfitting. The research reveals that stepsize restriction serves as a mechanism to prevent risk curvature from derailing convergence.
ANNALS OF STATISTICS
(2021)