Article
Gastroenterology & Hepatology
Mohammed Alsager, Shuet Fong Neong, Radhika Gandhi, Anouar Teriaky, Ephraim Tang, Anton Skaro, Karim Qumosani, Les Lilly, Zita Galvin, Nazia Selzner, Mamatha Pallavi Bhat, Klajdi Puka, Mayur Brahmania
Summary: This study reviewed the Ontario experience in LT for PCLD and found that most patients underwent LT due to symptoms of mass effect, with women being more likely than men to undergo the transplant. LT had excellent long-term survival outcomes for PCLD patients.
BMC GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Jan Bednarsch, Zoltan Czigany, Lara R. Heij, Dong Liu, Marcel den Dulk, Georg Wiltberger, Philipp Bruners, Tom Florian Ulmer, Ulf Peter Neumann, Sven Arke Lang
Summary: For patients with iCCA, preoperative radiological characteristics play a crucial role in predicting survival and recurrence-free survival. Patients with a single iCCA <= 3 cm demonstrate better overall survival and recurrence-free survival outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Mahak Chauhan, Talan Zhang, Paul J. Thuluvath
Summary: After LT/SLK for PLD, women had a 46% lower risk of mortality compared to men, with better survival rates and outcomes in various aspects regardless of receiving liver or liver/kidney transplantation.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Surgery
Tomoaki Yoh, Francois Cauchy, Olivier Soubrane
Summary: Laparoscopic liver resection (LLR) has become a popular alternative to conventional open surgery, especially for malignant tumors. While LLR offers short-term benefits such as reduced blood loss and postoperative complications, its oncological benefit depends on technical expertise and adherence to oncological rules. Easy LLRs can be performed by most surgeons, but intermediate or difficult LLRs require expertise and should be done in expert centers. Standardization is important to achieve oncological benefit with LLR.
Article
Surgery
Philipp Felgendreff, Hans-Michael Tautenhahn, Sascha Lux, Felix Dondorf, Rene Aschenbach, Falk Rauchfuss, Utz Settmacher
Summary: The modified simultaneous liver and kidney transplantation technique is a safe alternative for patients with ADPLKD, optimizing exposure of anatomical structures and simplifying the transplantation procedure.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Review
Gastroenterology & Hepatology
Sophie E. Aapkes, Lucas H. P. Bernts, Thijs R. M. Barten, Marjan van den Berg, Ron T. Gansevoort, Joost P. H. Drenth
Summary: This review summarizes the role of estrogens and other female hormones in polycystic liver disease, highlighting that female sex is an important risk factor for the disease and estrogen supplementation can increase liver growth. It suggests that blocking estrogen receptors or estrogen production is a promising target for new therapies.
LIVER INTERNATIONAL
(2021)
Article
Surgery
Dilmurodjon Eshmuminov, Debora J. Studer, Victor Lopez Lopez, Marcel A. Schneider, Jan Lerut, Mary Lo, Linda Sher, Thomas J. Musholt, Oana Lozan, Nabila Bouzakri, Carlo Sposito, Rosalba Miceli, Shoma Barat, David Morris, Helga Oehler, Teresa Schreckenbach, Peri Husen, Charles B. Rosen, Gregory J. Gores, Toshihiko Masui, Tan-To Cheung, Corina Kim-Fuchs, Aurel Perren, Philipp Dutkowski, Henrik Petrowsky, Espen Thiis-Evensen, Pal-Dag Line, Michal Grat, Stefano Partelli, Massimo Falconi, Lulu Tanno, Ricardo Robles-Campos, Vincenzo Mazzaferro, Pierre-Alain Clavien, Kuno Lehmann
Summary: This multicenter study compares the outcomes of liver resection (LR) and liver transplantation (LT) in patients with neuroendocrine liver metastasis (NELM). The results suggest that LT provides a survival benefit over LR, but adherence to selection criteria is important.
Review
Gastroenterology & Hepatology
Mureo Kasahara, Johnny C. Hong, Anil Dhawan
Summary: Living donor liver transplantation (LDLT) is an alternative treatment approach that can reduce waiting list mortality and increase the pool of donors. It has been increasingly used for familial hereditary liver diseases. There are certain indications and contraindications for living donors in paediatric parental LDLT. While heterozygous donors have shown no mortality or morbidity related to the recurrence of metabolic diseases, there are exceptions for specific cases and risks associated with donor human leukocyte antigen homozygosity. Genetic and enzymatic assays should be considered in the parental donor selection criteria in certain circumstances.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Thomas W. Smith, Ari Goldberg, Amy D. Lu
Summary: Management of symptomatic polycystic liver disease (PLD) includes various surgical options such as cyst sclerotherapy, hepatectomy, and liver transplant, with a recent trend towards early liver transplant. Medical management with somatostatin analogs is also being considered. There is currently no consensus on treatment, but a move towards early liver transplant with Model for End-Stage Liver Disease (MELD) score exception points is evident.
ANNALS OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rebecca Roediger, Douglas Dieterich, Pramodh Chanumolu, Priya Deshpande
Summary: ADPKD is a genetic disorder that leads to kidney and liver diseases. PCLD is the most common extrarenal manifestation of ADPKD, and its treatment options include tolvaptan, somatostatin analogs, and liver transplantation.
CLINICS IN LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Erika Faride Rodriguez-Aguilar, Lydia Sastre, Jordi Colmenero, Juan Carlos Garcia-Valdecasas, Constantino Fondevila, Ignacio Garcia Juarez, Miguel Navasa
Summary: The study evaluated the results of isolated liver and combined liver and kidney transplantation in 32 patients with hepatorenal liver and kidney disease, showing excellent outcomes in selected patients with high transplant and patient survival rates, with few complications.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2021)
Review
Genetics & Heredity
Ziqi Yu, Xiang Shen, Chong Hu, Jun Zeng, Aiyao Wang, Jianyong Chen
Summary: Polycystic liver disease is a rare genetic disorder that includes two distinct forms: autosomal dominant polycystic kidney disease and isolated polycystic liver disease. This review focuses on the candidate genes of polycystic liver disease and discusses other genes that may contribute to the disease.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Amy Y. Li, John R. Bergquist, Auriel T. August, Monica M. Dua, George A. Poultsides, Brendan C. Visser
Summary: The study reviewed patients undergoing surgery for PCLD and grouped them by operative approach. The results showed that laparoscopic hepatectomy had good efficacy and fewer postoperative complications in patients, with a mean volume reduction of 56% in all resections.
Article
Urology & Nephrology
Kyongtae T. Bae, Cheng Tao, Robert Feldman, Alan S. L. Yu, Vicente E. Torres, Ronald D. Perrone, Arlene B. Chapman, Godela Brosnahan, Theodore I. Steinman, William E. Braun, Michal Mrug, William M. Bennett, Peter C. Harris, Avantika Srivastava, Douglas P. Landsittel, Kaleab Z. Abebe
Summary: This study aimed to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient's age, height-adjusted liver cystic volume, and height-adjusted liver volume. The use of height-adjusted liver cystic volume showed greater separations in volumetric progression of polycystic liver disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Oncology
Berend R. Beumer, Roeland F. de Wilde, Herold J. Metselaar, Robert A. de Man, Wojciech G. Polak, Jan N. M. Ijzermans
Summary: For patients with early-stage hepatocellular carcinoma, comparing liver transplantation and liver resection poses challenges due to different patient characteristics. Current studies show conflicting results on the survival benefits of the two treatments, but suggest that liver transplantation may offer longer disease-free survival. Further research using a treatment guideline and causal inference methods may provide clearer evidence on the superior treatment option.
Article
Surgery
L. Barbier, M. Calmels, M. Lagadec, T. Gauss, P-S Abback, F. Cauchy, M. Ronot, O. Soubrane, C. Paugam-Burtz
JOURNAL OF VISCERAL SURGERY
(2019)
Article
Anesthesiology
Tobias Gauss, Paul Balandraud, Julien Frandon, Julio Abba, Francois Xavier Ageron, Pierre Albaladejo, Catherine Arvieux, Sandrine Barbois, Benjamin Bijok, Xavier Bobbia, Jonathan Charbit, Fabrice Cook, Jean-Stephane David, Guillaume De Saint Maurice, Jacques Duranteau, Delphine Garrigue, Emmanuel Gay, Thomas Geeraerts, Julien Ghelfi, Sophie Hamada, Anatole Harrois, Hicham Kobeiter, Marc Leone, Albrice Levrat, Sebastien Mirek, Abdel Nadji, Catherine Paugam-Burtz, Jean Francois Payen, Sebastien Perbet, Romain Pirracchio, Isabelle Plenier, Julien Pottecher, Sylvain Rigal, Bruno Riou, Dominique Savary, Thierry Secheresse, Karim Tazarourte, Frederic Thony, Jerome Tonetti, Christophe Tresallet, Pierre-Francois Wey, Julien Picard, Pierre Bouzat
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2019)
Editorial Material
Gastroenterology & Hepatology
V. Paradis, A. Quaglia
JOURNAL OF HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Elia Gigante, Maxime Ronot, Caroline Bertin, Maria Ciolina, Mohamed Bouattour, Federica Dondero, Francois Cauchy, Olivier Soubrane, Valerie Vilgrain, Valerie Paradis
LIVER INTERNATIONAL
(2019)
Editorial Material
Gastroenterology & Hepatology
Lila Ghannem, Aurelie Beaufrere, Jessica Zucman-Rossi, Valerie Paradis
LIVER INTERNATIONAL
(2020)
Review
Pathology
Aurelie Beaufrere, Valerie Paradis
Summary: Hepatocellular adenoma (HCA) is a rare benign liver neoplasm that mainly occurs in women of reproductive age who take oral contraceptives. HCA can be classified into 5 subtypes based on genotype-phenotype characteristics, with the main complications being bleeding and malignant transformation. Management requires a multidisciplinary approach considering gender, tumor size, and HCA subtyping.
Review
Gastroenterology & Hepatology
Aurelie Beaufrere, Julien Calderaro, Valerie Paradis
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a tumor with both hepatocytic and biliary differentiation, whose diagnosis is primarily based on morphology and immunostaining, with a prognosis worse than hepatocellular carcinoma and treatment limited to surgery.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Jerome Raffenne, Fernando A. Martin, Remy Nicolle, Marina Konta, Yuna Blum, Jerome Torrisani, Francesco Puleo, Jean Baptiste Bachet, Magali Svrcek, Armel Bardier-Dupas, Jean Francois Emile, Peter Demetter, Miroslav Radman, Jean Luc Van Laethem, Pascal Hammel, Vinciane Rebours, Valerie Paradis, Anne Couvelard, Jerome Cros
Summary: Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed in the 7th decade, but around 10% of patients are diagnosed before the age of 55. Molecular features of early-onset tumors (<= 55 y.o.) were found to be similar to late-onset tumors (>= 70 y.o.), indicating that younger patients can serve as a good molecular surrogate model for the general older population with PDAC. The study also highlighted the impact of ageing on DNA methylation and proteome integrity, as well as the association of oxidative stress responses with PDAC.
Article
Gastroenterology & Hepatology
Stephen A. Harrison, Samer Gawrieh, Katharine Roberts, Christopher J. Lisanti, Ryan B. Schwope, Katherine M. Cebe, Valerie Paradis, Pierre Bedossa, Jennifer M. Aldridge Whitehead, Aymeric Labourdette, Veronique Miette, Stefan Neubauer, Celine Fournier, Angelo H. Paredes, Naim Alkhouri
Summary: In a cohort of asymptomatic middle-aged Americans, the prevalence of NAFLD was 38%, NASH was 14%, and significant liver fibrosis was present in 6% of the participants.
JOURNAL OF HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Valerie Paradis
Summary: The molecular analysis of primary liver malignancies helps refine pathological diagnosis and identify increasing subtypes of hepatocellular proliferation, aiding in patient prognosis and treatment selection. Hepatocellular carcinomas are heterogeneous malignant hepatocellular proliferations, occurring in patients with chronic liver diseases and fibrosis, some arising from malignant transformation of pre-existing hepatocellular adenomas. TERT promoter mutations are common genomic alterations that occur early in liver carcinogenesis, underscoring the importance of a more active biopsy strategy.
LIVER INTERNATIONAL
(2021)
Letter
Gastroenterology & Hepatology
Aurelie Beaufrere, Valerie Vilgrain, Valerie Paradis
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Adel Hammoutene, Marion Tanguy, Melanie Calmels, Riccardo Pravisani, Miguel Albuquerque, Christophe Casteleyn, Lotfi Slimani, Jeremy Sadoine, Chantal M. Boulanger, Valerie Paradis, Helene Gilgenkrantz, Pierre-Emmanuel Rautou
Summary: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired liver regeneration due to a defect in autophagy of liver endothelial cells. This study aimed to determine the role of endothelial autophagy in liver regeneration following liver resection in NAFLD.
LIVER INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
David Nam, Julius Chapiro, Valerie Paradis, Tobias Paul Seraphin, Jakob Nikolas Kather
Summary: Clinical routine in hepatology involves diagnosing and treating various liver diseases. Advances in artificial intelligence have made it possible to extract clinically relevant information from complex clinical datasets, particularly histopathology and radiology data. AI systems have potential as decision support tools in clinical routine, but further clinical validation and regulatory approval are needed.
Article
Gastroenterology & Hepatology
Roberto Cannella, Marco Dioguardi Burgio, Aurelie Beaufrere, Loic Trapani, Valerie Paradis, Christian Hobeika, Francois Cauchy, Mohamed Bouattour, Valerie Vilgrain, Riccardo Sartoris, Maxime Ronot
Summary: In this study, the distribution of LI-RADS major features and categories did not differ among different histological subtypes of hepatocellular carcinoma in high-risk patients. However, tumour-in-vein, LR-M features, and ancillary features can provide valuable information for the non-invasive diagnosis of hepatocellular carcinoma subtypes.
Article
Gastroenterology & Hepatology
Margaux Sala, Delphine Gonzales, Thierry Leste-Lasserre, Nathalie Dugot-Senant, Valerie Paradis, Sylvaine Di Tommaso, Jean-William Dupuy, Vincent Pitard, Cyril Dourthe, Amedeo Sciarra, Christine Sempoux, Linda D. Ferrell, Andrew D. Clouston, Gregory Miller, Mathew M. Yeh, Swan Thung, Annette S. H. Gouw, Alberto Quaglia, Jing Han, Ji Huan, Cathy Fan, James Crawford, Yasuni Nakanuma, Kenichi Harada, Brigitte le Bail, Claire Castain, Nora Frulio, Herve Trillaud, Laurent Possenti, Jean-Frederic Blanc, Laurence Chiche, Christophe Laurent, Charles Balabaud, Paulette Bioulac-Sage, Anne Aurelie Raymond, Frederic Saltel
HEPATOLOGY COMMUNICATIONS
(2020)