Article
Physiology
Ming Deng, Yi-teng Huang, Jian-qing Xu, Xiao Ke, Yi-fei Dong, Xiao-shu Cheng
Summary: The study found that patients with severe OSAHS were more likely to have hypertension and higher LV mass and LV mass index. The association between intermittent hypoxia and left ventricular remodeling was significant, with oxygen desaturation index (ODI) being the most relevant parameter to LV remodeling among various intermittent hypoxia parameters.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Mahmoud I. Mahmoud, Raed K. Alotaibi, Rayyan Almusally, Hanaa Shafiek, Yasir Elamin, Ziad Alhaj, Waleed AlBaker, Alaeldin Elfaki, Hatem Qutub, Suha J. Albahrani, Fatima M. Alabdrabalnabi, Zahra A. Al Saeed, Reem Al Argan, Fatima Al Rubaish, Yousef D. Alqurashi, Noor-Ahmed Jatoi, Abdullah H. Alharmaly, Zainab Z. Almubarak, Abir H. Al Said, Nada Albahrani
Summary: This study investigated the association between glycosylated hemoglobin (HbA1c) levels and nocturnal hypoxemia and apnea-hypopnea index (AHI) in Saudi patients with obstructive sleep apnea (OSA) and diabetes mellitus (DM). The findings suggest that nocturnal hypoxemia may be an important factor affecting glycemic control in patients with OSA and DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Tianfeng Peng, Shan Yuan, Wenjing Wang, Zhuanyun Li, Ayshat Mussa Jumbe, Yaling Yu, Zhenghao Hu, Ruijie Niu, Xiaorong Wang, Jinnong Zhang
Summary: This study aimed to analyze the clinical characteristics of patients with COPD and OSA overlap syndrome (OS) and develop a nomogram for predicting OSA. The results identified several valuable predictors for predicting OSA, including age, type 2 diabetes, neck circumference, dyspnea scale, sleep apnea clinical score, and C-reactive protein. The nomogram showed good discrimination and calibration.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Piero Giuseppe Meliante, Federica Zoccali, Francesca Cascone, Vanessa Di Stefano, Antonio Greco, Marco de Vincentiis, Carla Petrella, Marco Fiore, Antonio Minni, Christian Barbato
Summary: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by intermittent hypoxia (IH) during sleep due to recurrent upper airway obstruction. The associated oxidative stress (OS) leads to various complications that affect both sleep-wake rhythm and systemic functions. This literature review investigates the molecular changes, diagnostic markers, and potential medical therapies for OSAS. The findings suggest that IH increases oxygen free radicals (ROS) and impairs antioxidant capacities, resulting in endothelial dysfunction, osteoporosis, systemic inflammation, increased cardiovascular risk, pulmonary remodeling, and neurological alterations in OSAS patients. The most promising pharmacological therapies include N-acetylcysteine (NAC), Vitamin C, Leptin, Dronabinol, or Atomoxetine + Oxybutynin, but further research is needed. Continuous positive airway pressure (CPAP) remains the approved therapy for reversing most molecular changes, while future drugs may target the remaining dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Li-Pang Chuang, Huang-Pin Wu, Li-Ang Lee, Li-Chung Chiu, Shih-Wei Lin, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Jung-Wei Tsai, Jong-Hwei Su Pang
Summary: This study found that under intermittent hypoxia conditions, the expression of IL-8 was enhanced in monocytes of adult OSA patients, leading to an increase in the migration ability of monocytes towards IL-8.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Ting Xie, Dan Guo, Jinmei Luo, Zijian Guo, Sumei Zhang, Anqi Wang, Xiaoxi Wang, Xiaona Wang, Wenhao Cao, Linfan Su, Junwei Guo, Rong Huang, Yi Xiao
Summary: This study investigated the relationship between hypoxia-inducible factor 1 alpha, circadian clock genes, and obstructive sleep apnea. The findings suggest that patients with OSA or nocturnal hypoxemia tend to develop circadian rhythm disorders that may be induced by the hypoxia-mediated augmentation of HIF1 alpha gene expression.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Medicine, General & Internal
Qilin Zhu, Fei Han, Jin Wang, Chaohong Chen, Tong Su, Qiaojun Wang, Rui Chen
Summary: Obstructive sleep apnea syndrome (OSAS) leads to cognitive dysfunction, possibly through the characteristics of sleep spindle activity. This study found that OSAS patients had slower sleep spindle activity compared to the control group. Decreased complexity of spindles in prefrontal and central regions, as well as increased complexity in the occipital region, were observed in OSAS patients. Sleep spindle activity was positively correlated with logical and working memory. These findings suggest that abnormal sleep spindle activity may contribute to cognitive dysfunction in OSAS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Evangelia Chalkiadaki, Konstantinos Andreanos, Chrysoula Florou, Konstantinos Droutsas, Chrysoula Maniou, Anastasia Amfilochiou, Ilias Georgalas, Dimitrios Papaconstantinou, Chrysanthi Koutsandrea
Summary: The study found greater pleomorphism and polymegathism of corneal endothelium in patients with severe obstructive sleep apnea-hypopnea syndrome compared to healthy subjects. There was no significant difference in central endothelial cell density and central corneal thickness between the groups, but a significant negative correlation was observed between central corneal thickness and percentage of REM sleep.
Article
Medicine, General & Internal
Pedro Landete, Carlos Ernesto Fernandez-Garcia, Beatriz Aldave-Orzaiz, Marta Hernandez-Olivo, Carmen M. Acosta-Gutierrez, Enrique Zamora-Garcia, Julio Ancochea, Agueda Gonzalez-Rodriguez, Carmelo Garcia-Monzon
Summary: This study found that hepatosteatosis and NASH are highly prevalent in patients with OSA, and indicates that patients with a Tc90% higher than 10% are at increased risk for NASH.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Gino S. Panza, Shipra Puri, Ho-Sheng Lin, M. Safwan Badr, Jason H. Mateika
Summary: Daily exposure to mild intermittent hypoxia (MIH) shows beneficial cardiovascular and autonomic outcomes in males with obstructive sleep apnea (OSA) and concurrent hypertension. This study demonstrates that after 15 days of MIH treatment, participants experienced a reduction in blood pressure, accompanied by increased parasympathetic activity and decreased sympathetic activity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Kimberly L. Sterling, Jean-Louis Pepin, Walter Linde-Zwirble, Jiaming Chen, Adam Benjafield, Peter A. Cistulli, Kate Cole, Hussein Emami, Caleb Woodford, Jeff P. Armitstead, Carlos M. Nunez, Jadwiga A. Wedzicha, Atul Malhotra
Summary: This study investigated the effects of positive airway pressure (PAP) on patients with overlap syndrome. The results showed that PAP usage was associated with significant reductions in emergency room visits, hospitalizations, and severe acute exacerbations, as well as healthcare costs.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Clinical Neurology
Tien Hoang-Anh, Quy Duong-Minh, Nhi Nguyen-Thi-Y, Sy Duong-Quy
Summary: This study aims to assess the prevalence and general characteristics of obstructive sleep apnea syndrome in patients with cerebral infarction and investigate the relationship between obstructive sleep apnea syndrome and the severity of cerebral infarction. The results show that obstructive sleep apnea syndrome is a factor in the prognosis of cerebral infarction and it is important to work with a doctor to diagnose and treat sleep apnea.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jonathan D. Santoro, Justin Del Rosario, Beth Osterbauer, Emily S. Gillett, Debra M. Don
Summary: An analysis of sleep positions in children with both Down syndrome and obstructive sleep apnea found a preference for lateral sleeping positions, potentially optimizing airflow but not correlated with the severity of OSA.
Article
Endocrinology & Metabolism
Zeynep Gokce Gayretli Aydin, Aysun Bideci, Hamdi C. Emeksiz, Nurullah Celik, Esra Doger, Neslihan Bukan, Ummugulsum Yildiz, Orhun M. Camurdan, Peyami Cinaz
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2015)
Article
Biochemistry & Molecular Biology
Funda Dogruman-Al, Ayse Basak Engin, Neslihan Bukan, Seda Evirgen-Bostanci, Kemal Ceber
Article
Medical Laboratory Technology
Mustafa Altay, Mehmet Ayhan Karakoc, Nuri Cakir, Canan Yilmaz Demirtas, Ethem Turgay Cerit, Mujde Akturk, Ihsan Ates, Neslihan Bukan, Metin Arslan
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2017)
Article
Endocrinology & Metabolism
U. Yildiz, N. Bukan, B. Aktas, F. Toruner
ACTA ENDOCRINOLOGICA-BUCHAREST
(2013)
Article
Cardiac & Cardiovascular Systems
Ahmet Akyel, Asife Sahinarslan, Emrullah Kiziltunc, Ummugulsum Yildiz, Yakup Alsancak, Mehmet Kadri Akboga, Cagri Yayla, Salih Topal, Neslihan Bukan, Murat Ozdemir
CANADIAN JOURNAL OF CARDIOLOGY
(2011)
Article
Obstetrics & Gynecology
Neslihan Bukan, Omer Kandemir, Tuncay Nas, Ozlem Gulbahar, Adem Unal, Banu Cayci
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2012)
Article
Rehabilitation
Zeynep Hazar Kanik, Seyit Citaker, Canan Yilmaz Demirtas, Neslihan Celik Bukan, Bulent Celik, Gurkan Gunaydin
JOURNAL OF SPORT REHABILITATION
(2019)
Article
Pharmacology & Pharmacy
Ozhan Yalcin, Elvan Iseri, Neslihan Bukan, Ugur Ercin
KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
(2014)
Article
Parasitology
Ayse Basak Engin, Funda Dogruman-Al, Ugur Ercin, Bekir Celebi, Cahit Babur, Neslihan Bukan
PARASITOLOGY RESEARCH
(2012)
Article
Obstetrics & Gynecology
Koray Aslan, M. Anil Onan, Canan Yilmaz, Neslihan Bukan, Mehmet Erdem
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2020)
Article
Clinical Neurology
Yasemin Gunduztepe, Neslihan Bukan, Enishan Zorlu, Yahya Karaman, Tugberk Andac Topkan, Neslihan Gurbuz, Salim Neselioglu, Ozcan Erel
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Article
Ophthalmology
Rukiye Kilic Ucgul, Serdal Celebi, Niyazi Samet Yilmaz, Neslihan Bukan, Ahmet Yucel Ucgul
Summary: In the study, it was found that intrastromal administration of anti-VEGF agents was more effective in regressing suture-induced corneal neovascularization in rabbits compared to subconjunctival administration, regardless of the type of anti-VEGF agent used.
Article
Urology & Nephrology
Emre Yasar, Hasan Selcuk Ozger, Haci Hasan Yeter, Cigdem Yildirim, Zakir Osmanov, Taha Enes Cetin, Omer Faruk Akcay, Neslihan Bukan, Ulver Derici
Summary: The study found that in patients with COVID-19 infection, even without developing acute kidney injury, the level of urinary Kidney Injury Molecule-1 (uKIM-1) significantly increased and was correlated with other biochemical markers. In some patients, proteinuria regressed to normal levels after several weeks, despite not meeting the criteria for AKI.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Meryem Gunes, Neslihan Bukan
GYNECOLOGICAL ENDOCRINOLOGY
(2015)
Article
Peripheral Vascular Disease
Asife Sahinarslan, Bulent Boyaci, Sinan Altan Kocaman, Salih Topal, Ugur Ercin, Kaan Okyay, Neslihan Bukan, Ridvan Yalcin, Atiye Cengel
INTERNATIONAL JOURNAL OF ANGIOLOGY
(2012)