Article
Endocrinology & Metabolism
Bingyan Xu, Wei Mo, Xiangliang Tan, Peizhen Zhang, Junlin Huang, Chensihan Huang, Dan Guo, Xueyun Wei, Yating Liu, Xuzhen Lei, Weijuan Dou, Jiayang Lin, Deying Liu, Linjie Yang, Yan Huang, Huijie Zhang, Yunfei Liao
Summary: This study found that lower levels of testosterone and free testosterone were associated with an increased risk of atrial fibrillation and bradyarrhythmia in men. Higher levels of free testosterone were associated with an increased risk of atrial fibrillation and ventricular arrhythmia. Higher SHBG concentrations were associated with an increased risk of atrial fibrillation, ventricular arrhythmia, and bradyarrhythmia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Bu B. Yeap, Ross J. Marriott, Leen Antonio, Yi X. Chan, Suchitra Raj, Girish Dwivedi, Christopher M. Reid, Bradley D. Anawalt, Shalender Bhasin, Adrian S. Dobs, Graeme J. Hankey, Alvin M. Matsumoto, Paul E. Norman, Terence W. O'Neill, Claes Ohlsson, Eric S. Orwoll, Dirk Vanderschueren, Gary A. Wittert, Frederick C. W. Wu, Kevin Murray
Summary: The study showed that lower serum testosterone levels were independently associated with higher all-cause and cancer-related mortality in middle-aged to older men, while lower SHBG levels were independently associated with lower all-cause, CVD-related, and cancer-related mortality. Confirmation of these associations and causality would require mechanistic studies and prospective trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Genetics & Heredity
Deborah A. Bilder, Whitney Worsham, Scott Sullivan, M. Sean Esplin, Paul Burghardt, Alison Fraser, Amanda V. Bakian
Summary: This study examines the link between early second trimester maternal steroid-related serum biomarkers and the risk of autism in offspring. Findings suggest that elevated levels of estradiol in male fetuses and decreased levels of sex hormone binding globulin in both sexes are associated with increased autism risk.
Article
Geriatrics & Gerontology
Pei Xu, Rong Zeng, Qiyou Wan, Yan Xie, Xingyan Liu, Songlin An, Jing Jiang, Jing Yang, Yuanzhong Zhou, Xubo Shen
Summary: This study investigated the association between serum sex hormone-binding globulin (SHBG) levels and synthesis-related factors in men of different age groups. The findings revealed that SHBG levels increased with age while the levels of hepatic nuclear factor 4α (HNF-4α) and peroxisome proliferator-activated receptor γ (PPAR-γ) decreased. Similar results were observed in rats, suggesting that the aging-related increase in SHBG levels is associated with increased SHBG synthesis.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Orthopedics
Zhongxin Zhu, Jin Zhao, Yanfei Fang, Rongwei Hua
Summary: The study found a positive association between serum E2 level and lumbar BMD, with an inverted U-shaped relationship identified with a inflection point at E2 level of 70 pg/mL. There was no significant association between SHBG level and lumbar BMD, but a U-shaped relationship was observed with a inflection point at SHBG level of 65 nmol/L.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Andrology
Guoqing Liang, Yuxuan Song, Li Liu, Kechong Zhou, Jia Tian, Jianhui Li, Huijuan Shi, Qianxi Zhu, Jun Wang, Junbiao Zheng, Xiaohua Yu, Shucheng Zhang, Zheng Li, Xiaoqiang Liu
Summary: The study found a significant association between serum hormone levels and hypogonadism symptoms in middle-aged and elderly Chinese men, with luteinising hormone and sex hormone-binding globulin showing the strongest correlation. Sexual and somatic symptoms were positively correlated with serum hormones, while psychological symptoms seemed to have no association.
Article
Medicine, General & Internal
Elif Aribas, Jeanine E. Roeters van Lennep, Yolanda B. De Rijke, Joop S. E. Laven, Mohammad Arfan Ikram, Robin P. Peeters, Maryam Kavousi
Summary: This study provides reference values for sex steroids and SHBG levels in men and women across different age groups, highlighting sex-specific trends with aging. These findings are important for investigating the impact of sex steroids and SHBG on health outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Benzheng Zhao, Zhenpeng Wang, Dongzhen Liu, Songling Zhang
Summary: This study analyzed the effects of testosterone related exposure factors on gynecological diseases using public genome-wide association studies. The results showed causal associations between serum testosterone level and ovarian cancer, endometrial cancer, endometriosis, PCOS, and premature ovarian failure (POF).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yutang Wang
Summary: This study established criteria for low SHBG among US adults and found the estimated national prevalence to be 3.3% in men and 2.7% in women. Risk factors for this condition include higher BMI, diabetes, ethnicity, COPD, coronary heart disease, and smoking.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Reproductive Biology
Bodil Strom Holst, Sanna Nilsson
Summary: Prostatic hyperplasia (PH) is an androgen-dependent condition common in intact dogs, similar to the condition in men. This study aimed to investigate the association between relative prostatic size and hormone concentrations, age, and weight of the dog. The results showed weak associations between hormone concentrations, age, and weight with prostatic size.
Article
Biochemistry & Molecular Biology
Ali Alquraini
Summary: This study evaluated the efficacy of hexaconazole to bind with sex hormone-binding globulin (SHBG) and found that it has a stable molecular interaction with SHBG, leading to significant endocrine disruption during agricultural work.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Nuozhou Liu, Ying Feng, Xinyao Luo, Xue Ma, Fang Ma
Summary: This study reveals an association between a proinflammatory diet and decreased levels of SHBG in women, particularly in premenopausal women.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Hui Xu, Qian Wang, Ting Li, Yuanyuan Wang, Ruiyao Cao, Xingwang Peng, Rongying Yao, Hui Han, Rui Zhou, Lianguo Fu
Summary: This study examines the association between prenatal androgens and cord blood androgens concentrations. The concentrations of T, FT, DHT, DHEA, and SHBG were measured in prenatal venous blood and cord blood of 342 pregnant women and their neonates. The results revealed gender differences in cord blood androgen concentrations, as well as differences between prenatal and cord blood androgens levels.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Ross J. Marriott, Kevin Murray, Charley A. Budgeon, Veryan Codd, Jennie Hui, Gillian M. Arscott, John P. Beilby, Graeme J. Hankey, Gary A. Wittert, Frederick C. W. Wu, Bu B. Yeap
Summary: Lower testosterone concentrations in middle-aged and older men are associated with shorter telomeres, suggesting that testosterone may contribute to biological aging in men.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
P. -P Niu, X. Wang, Y. -M Xu
Summary: This study found that higher testosterone levels in men were associated with larger gray matter volume in the brain, but had no significant effect on hippocampal volume. In contrast, testosterone levels in women and sex hormone-binding globulin in both sexes had no effect on brain volume.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
