Article
Engineering, Biomedical
Ye Li, Jiankun Xu, Jie Mi, Xuan He, Qi Pan, Lizhen Zheng, Haiyue Zu, Ziyi Chen, Bingyang Dai, Xu Li, Qianqian Pang, Li Zou, Liangbin Zhou, Le Huang, Wenxue Tong, Gang Li, Ling Qin
Summary: This study demonstrated the mechanisms of magnesium nail implantation in promoting critical size bone defect repair, showing that the CGRP-FAK-VEGF signaling axis could accelerate new bone and vessel formation, enhancing the therapeutic effect.
Review
Cell Biology
Ze Liu, Qi Liu, Hongbin Guo, Jieyu Liang, Yi Zhang
Summary: Distraction osteogenesis (DO) is a bone regeneration technology that promotes new bone formation through continuous and stable traction force. However, the long consolidation course of DO can lead to complications. Current treatment strategies include gene, growth factor, stem-cell, physical, and pharmacological therapies, with physical and pharmacological therapies being considered safe and effective. Recent research provides evidence for the effectiveness of physical and pharmacological therapies in promoting bone healing during DO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Li Zhang, Jiayi Yao, Yucheng Yao, Kristina I. Bostrom
Summary: Vascular calcification (VC) is a highly regulated process triggered by endothelial cell transitions and differentiation, including direct contributions and secretion of pro-osteogenic growth factors. High phosphate levels and endothelial activation are also significant factors in VC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Physiology
Kai Liu, Sulong Wang, Ainizier Yalikun, Peng Ren, Aihemaitijiang Yusufu
Summary: This study observed the effect of the accordion technique (AT) during the distraction phase on chondrogenesis and bone regeneration. It was found that low amplitude AT can enhance chondrogenesis and bone regeneration by activating the angiogenesis factor pathway and upregulating the expression of osteogenic-related biomarkers.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Engineering, Biomedical
Cheol Hee Jeong, Song-Yi Lim, Jo Eun Um, Hyo Won Lim, Kyu Ho Hwang, Kyeong-Mee Park, Jun Seop Yun, Dohun Kim, Jong-Ki Huh, Hyun Sil Kim, Jong In Yook, Nam Hee Kim, Yoon Hae Kwak
Summary: This study introduces micellized bone morphogenetic protein-2 (mPTD-BMP-2), a next-generation osteogenic supplement that combines protein transduction domain (PTD) and nano-sized micelle formulation technique to improve transduction efficiency and stability. The use of PTD represents a novel approach, and our results demonstrate the superiority of mPTD-BMP-2 over rh-BMP-2 in terms of in vivo pharmacokinetic profile and osteogenic potential, particularly in a rat tibial model of distraction osteogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Ilia Y. Bozo, Alexey Y. Drobyshev, Nikolay A. Redko, Vladimir S. Komlev, Artur A. Isaev, Roman Deev
Summary: This study developed a gene-activated bone substitute, which was proven feasible, safe, and effective for jaw bone grafting in both animal models and clinical trials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell & Tissue Engineering
Weidong Jiang, Peiqi Zhu, Tao Zhang, Fengchun Liao, Yangyang Yu, Yan Liu, Huijuan Shen, Zhenchen Zhao, Xuanping Huang, Nuo Zhou
Summary: MiR-205 is identified as a significant regulator in the MDO process, with inhibition of this miRNA shown to accelerate MDO-related mineralization. These findings offer new insights into the mechanistic basis for this procedure, highlighting potential targets for therapeutic clinical intervention.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Akiko Miki, Sentaro Kusuhara, Tsuyoshi Otsuji, Yu Kawashima, Katsuaki Miki, Hisanori Imai, Makoto Nakamura, Akitaka Tsujikawa
Summary: This study suggests that a combination of photodynamic therapy (PDT) and anti-vascular endothelial growth factor (VEGF) therapy can significantly improve visual acuity and reduce choroidal and retinal thickness in patients with pachychoroid neovasculopathy (PNV) in the short term, with effects maintained for up to 12 months.
Article
Biotechnology & Applied Microbiology
Yanshi Liu, Feiyu Cai, Kai Liu, Jialin Liu, Xiaoxu Zhang, Aihemaitijiang Yusufu
Summary: The CDC technique has been found to improve bone regeneration during distraction osteogenesis, with better outcomes achieved by increasing the amplitude and slowing down the rate of the technique. The mechanism may involve the activation of the HIF pathway and enhancement of the osteogenic-angiogenic coupling.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Youlu Chen, Zuoguan Chen, Jianwei Duan, Liang Gui, Huiyang Li, Xiaoyu Liang, Xinxin Tian, Kaijing Liu, Yongjun Li, Jing Yang
Summary: The research demonstrated that VEGF/NGF-NPs, by co-delivering VEGF and NGF genes, eliminating excessive H2O2, and promoting stable angiogenesis, enhanced the treatment effects of PVD.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Cell & Tissue Engineering
Huan Wu, Guangfu Yin, Ximing Pu, Juan Wang, Xiaoming Liao, Zhongbing Huang
Summary: This study demonstrated the inhibitory effects of BMP-2, VEGF, and bFGF on osteoclasts when used in combination, suggesting new insights for bone repair and regeneration.
TISSUE ENGINEERING PART A
(2021)
Article
Biotechnology & Applied Microbiology
Shahrokh Hatefi, Milad Sh Etemadi, Javad Alizargar, Venous Behdadipour, Khaled Abou-El-Hossein
Summary: The application of Distraction Osteogenesis (DO) techniques in reconstruction surgeries is advantageous with fewer side effects. However, the development of automatic devices for controlled continuous force still requires further research. A two-axis continuous distractor is proposed for mandibular reconstruction, meeting the current requirements.
BIOENGINEERING-BASEL
(2022)
Article
Acoustics
Arzu Hizay, Umut Ozsoy, Kamil Savas, Sezin Yakut-Uzuner, Ozlem Ozbey, Simla Su Akkan, Pinar Bahsi
Summary: This study aimed to investigate the effect of ultrasound treatment on the expression of vascular endothelial growth factor (VEGF), its receptors, and new vessel formation after facial nerve injury. The results showed that ultrasound treatment significantly increased the levels of VEGF, VEGFR1, VEGFR2, and CD31, promoting facial nerve regeneration and functional improvement.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Cell Biology
Marion Mesnieres, Anna-Marei Bohm, Nicolas Peredo, Dana Trompet, Roger Valle-Tenney, Manmohan Bajaj, Nikky Corthout, Elena Nefyodova, Ruben Cardoen, Pieter Baatsen, Sebastian Munck, Andras Nagy, Jody J. Haigh, Satish Khurana, Catherine M. Verfaillie, Christa Maes
Summary: The balanced local crosstalk within the skeletal niche is crucial for the successful settlement of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow, with overproduction of VEGF by osteoprogenitor cells impacting stromal-vessel interface and vascular architecture, resulting in impaired HSPC homing and survival. These findings highlight potential targets for improving stem cell therapies, as similar osteo-angiogenic niche changes are induced by irradiation in adult mice.