Review
Medicine, General & Internal
Philippe Taupin, Ankur Gandhi, Sunil Saini
Summary: Integra Dermal Regeneration Template is a bilayer membrane made of cross-linked type I collagen and glycosaminoglycans, with a semi-permeable silicone sheet cover. It guides wound repair towards a regenerative pathway through stages such as imbibition, fibroblast migration, neovascularization, and remodeling/maturation. Its application has expanded from burn treatment to reconstructive surgery.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Yujia Shang, Guanhuier Wang, Yonghuan Zhen, Na Liu, Fangfei Nie, Zhenmin Zhao, Hua Li, Yang An
Summary: This review provides an overview of the application of the decellularization-recellularization technique in the field of plastic and reconstructive surgery, highlighting its potential in promoting the regeneration of diseased or damaged tissues and organs by using decellularized extracellular matrix as a scaffold.
CHINESE MEDICAL JOURNAL
(2023)
Review
Dentistry, Oral Surgery & Medicine
G. Romano, J. Bouaoud, A. Moya-Plana, N. Benmoussa, J. -F. Honart, N. Leymarie
Summary: The study compared the use of Integra dermal regeneration template in scalp reconstruction after tumor resection by analyzing literature and a series of 20 patients. Results showed that in large scalp full thickness defects after cancer resection, DRT appears to be a suitable reconstruction option for patients with comorbidities and aggressive tumors. This technique allows immediate coverage of the calvarium with short operative time and prevents healing delay, while maintaining oncologic follow-up and facilitating the diagnosis of cancer recurrences.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2021)
Review
Surgery
Burak Ozkan, Burak Ergun Tatar, Abbas Albayati, Cagri Ahmet Uysal
Summary: The study presents PAT grafting as an alternative method for burn patients with small-to-medium-sized defects and exposed bone and tendon. The survival rate of PAT grafts was high, especially in cases where skin grafting was not possible. PAT grafting can be a valuable option for extremity burn reconstruction.
JOURNAL OF INVESTIGATIVE SURGERY
(2023)
Article
Otorhinolaryngology
Mac Kenzie Reece, Hannah Walker, Isabella Benintendi, Stacey Ward, Ashley Thatcher, R. Michael Johnson, Sameep P. Kadakia
Summary: The clinical use of Integra(TM) has expanded to include scalp reconstruction since its FDA approval in 1996. In this study, the authors aim to describe their protocol for delaying scalp reconstruction with skin grafting following dermal regeneration using Integra(TM), and the results have been predictable and reproducible.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Surgery
Malke Asaad, Sahil K. Kapur, Donald P. Baumann, Jun Liu, Charles E. Butler
Summary: In this study, we investigated the long-term outcomes of ventral hernia repair using biologic mesh. We found that biologic mesh provides durable results with relatively low rates of hernia recurrence. There were no differences in recurrence rates and surgical site occurrences between different types of mesh.
Review
Oncology
Hannah Trostrup, Amir K. Bigdeli, Christina Krogerus, Ulrich Kneser, Grethe Schmidt, Volker J. Schmidt
Summary: Knowledge of cutaneous or dermal sarcomas is crucial due to the initially peaceful appearance of skin tumors, causing delays in accurate diagnoses. Effective treatment requires a multidisciplinary approach involving adequate resection and reconstructive surgical planning. The advancements in reconstructive surgery provide hope for managing complex dermal sarcomas.
Article
Engineering, Biomedical
Delphine B. Maurel, Mathilde Fenelon, Rachida Aid-Launais, Laurent Bidault, Alice Le Nir, Martine Renard, Jean-Christophe Fricain, Didier Letourneur, Joelle Amedee, Sylvain Catros
Summary: The study evaluated the bone formation after injection of microbeads reconstituted with saline buffer or autologous blood in two different preclinical models. Results showed similar mineralization process and bone formation in both groups, indicating that reconstitution with autologous blood did not enhance the regenerative capacity of the microbeads compared to saline buffer group.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Surgery
Magdalena Swensson, Thomas Grundmann, Karl Mauss
Summary: This study retrospectively evaluated the surgical use of IDRT-SL Thin in septorhinoplasty. The results showed no notable complications within the patient cohort during the 14-week postoperative observation period. Although there were limitations in the study, the 6 and 14-week observation periods provided preliminary evidence of the suitability and tolerability of IDRT-SL Thin in septorhinoplasty.
HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
(2023)
Article
Engineering, Biomedical
Li Yan, Haoyu Wang, Hui Xu, Rui Zheng, Zhengyu Shen
Summary: In this study, a novel nano-scale material ES-GT/PCL nanofiber was fabricated using coaxial electrospinning technique, which possessed a highly porous structure and qualified mechanical properties for transplantation. By adding multiple bioactive factors to nanometre biomaterials, it optimized the advantages of compositions as a promising potential dermal substitute construct, promoting cell proliferation and accelerating skin wound healing rate.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Review
Dermatology
Gustavo E. Prezzavento, Rodrigo N. Juarez Calvi, Juan A. Rodriguez, Philippe Taupin
Summary: Objective: This study aimed to evaluate the use of Integra Dermal Regeneration Template (IDRT) in the reconstruction of skin tumor defects. The results showed that IDRT is a valid option for reconstructing oncologic surgical defects of the skin in different anatomical locations. Patients reported satisfaction with the results and no cases of infection were encountered.
JOURNAL OF WOUND CARE
(2022)
Article
Clinical Neurology
Andrea Scotti, Elisa Benanti, Federica Augelli, Franz Wilhelm Baruffaldi Preis
Summary: Aplasia cutis congenita is a rare congenital abnormality characterized by the absence of a portion of skin at birth. Treatment options vary, and the use of Integra(R) Dermal regeneration template can be effective in treating this condition.
PEDIATRIC NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Arkadii K. Beilin, Nadezhda A. Evtushenko, Daniil K. Lukyanov, Nikolay N. Murashkin, Eduard T. Ambarchian, Alexander A. Pushkov, Kirill V. Savostyanov, Andrey P. Fisenko, Olga S. Rogovaya, Andrey V. Vasiliev, Ekaterina A. Vorotelyak, Nadya G. Gurskaya
Summary: The recessive form of dystrophic epidermolysis bullosa, caused by impairments in the junctions of the dermis and the basement membrane, is associated with mutations in the COL7A1 gene. Specific mutations in COL7A1 were identified through analysis of RDEB fibroblast lines, showing distinct morphological features and contraction capacity compared to control fibroblasts. RNA-seq data analysis and gene expression studies revealed differential gene expression and potential mechanisms involved in disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Marco Falcone, Mirko Preto, Davide Ciclamini, Federica Peretti, Anna Scarabosio, Gideon Blecher, Lorenzo Cirigliano, Ilaria Ferro, Natalia Plamadeala, Martina Scavone, Massimiliano Timpano, Paolo Gontero
Summary: The combination of acellular dermal matrix with split thickness skin grafts shows significant advantages in terms of operative, functional and cosmetic outcomes for phalloplasty, including shorter healing time, improved graft take, shorter operative time, reduced hospital stay, and higher satisfaction with cosmesis.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Article
Genetics & Heredity
Fedele Lembo, Domenico Parisi, Liberato Roberto Cecchino, Francesco Ciancio, Alessandro Innocenti, Aurelio Portincasa
Summary: The study presented the experience in microsurgical treatment of pseudosyndactylies in recessive dystrophic epidermolysis bullosa (RDEB) patients, comparing traditional dressing with vaseline gauze with an innovative glove protocol using Integra((R)) dermal regeneration template. The new protocol showed significant advantages in reducing hospital stay time, healing time, dressing pain and increasing recurrence-free interval, providing consistent and successful long-term results for the patients.
ORPHANET JOURNAL OF RARE DISEASES
(2021)